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Ambros, V. and Horvitz, H. R (1984). Heterochronic mutants of the nematode Caenorhabditis elegans. Science 226, 409-416.[Abstract/Free Full Text]

Ambros, V. and Horvitz, H. R (1987). The lin-14 locus of Caenorhabditis_Fb_Fig. 5. A model for the regulation of stage-specific transcription of hypodermal cell genes by the heterochronic gene pathway. Epistasis relationships (Ambros, 1989) indicate that lin-29 acts most directly on the adult-specific terminal differentiation program of hypodermal cells. Since lin-29 encodes a probable transcription factor (Rougvie and Ambros, 1995), the lin-29 gene product may directly repress and activate, respectively, the transcription of larval-and adult-specific genes. According to this model, lin-4 , lin-14 and lin-28 act to ensure the proper stage-specific activation of lin-29 . elegans controls the time of expression of specific post-embryonic developmental events. Genes Dev 1, 398-414.[Abstract/Free Full Text]

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Rougvie, A. R. and Ambros, V. R (1995). The heterochronic gene lin-29 encodes a zinc-finger protein that triggers a terminal differentiation event in C. elegans. Development 121, 2492-2500.

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This Article
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