De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

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Adams, R. L. F., Burdon, R. H., McKinnon, K. and Rinaldi, A (1983). Stimulation of de novo methylation following limited proteolysis of mouse ascites DNA methylase. FEBS lett 163, 194-198.[Medline]

Ariel, M., Robinson E., McCarrey, J. R. and Cedar, H (1995). Gamete-specific methylation correlates with imprinting of the murine Xist gene. Nature Genet 9, 312-315.[Medline]

Beard, C., Li, E. and Jaenisch, J (1995). Loss of methylation activates Xist in somatic but not in embryonic cells. Genes Dev 9, 2325-2334.[Abstract/Free Full Text]

Bestor, T. H. and Ingram, V. M (1983). Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. Proc. Natl. Acad. Sci. USA 80, 559-5563.

Bestor, T. H., Laudano, A. P., Mattaliano, R. and Ingram, V. M (1988). Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J. Mol. Biol 203, 971-983.[Medline]

Bestor, T. H (1992). Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. EMBO J 11, 2611-2617.[Medline]

Brandeis, C. V., Kafri, T., Ariel, M., Chaillet, J. R., McCarrey, J. R., Razin, A. and Cedar, H (1993). The ontogeny of allele-specific methylation associated with imprinted genes in the mouse. EMBO J 12, 3669-3677.[Medline]

Cedar, H., Solage, A., Glaser, G. and Razin, A (1979). Direct detection of methylated cytosine in DNA by use of the restriction enzyme MspI. Nucl. Acids Res 6, 2125-2132.[Abstract/Free Full Text]

Chaillet, J. R., Vogt, T. F., Beier, D. R. and Leder, P (1991). Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis. Cell 66, 77-83.[Medline]

Chapman, V., Forrester, L., Sanford, J., Hastie, N. and Rossant, J (1984). Cell lineage-specific undermethylation of mouse repetitive DNA. Nature 307, 284-286.[Medline]

Chen, L., MacMillan, A. M., Chang, W., Ezaz-Nikpay, K., Lane, W. S. and Verdine, G. L (1991). Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase. Biochemistry 30, 11018-11025.[Medline]

DeChiara, T. M., Robertson, E. J. and Efstradis, A (1991). Parental imprinting of the mouse insulin-like growth factor II gene. Cell 64, 859-859.

Eden, S. and Cedar, H (1994). Role of DNA methylation in the regulation of transcription. Curr. Opinion Genet. & Dev 4, 255-259.[Medline]

Friedman, S. and Ansari, N (1992). Binding of the EcoRII methyltransferase to 5-fluorocytosine-containing DNA. Isolation of a bound peptide. Nucl. Acids Res 20, 3241-3248.[Abstract/Free Full Text]

Gruenbaum, Y., Cedar, H. and Razin, A (1982). Substrate and sequence specificity of a eukaryotic DNA methylase. Nature 295, 620-622.[Medline]

J\212hner, D., Stuhlmann, H., Stewart, C. L., Harbers, K., L\232hler, J., Simon, I. and Jaenisch, R (1982). De novo methylation and expression of retroviral genomes during mouse embryogenesis. Nature 298, 623-628.[Medline]

Jeppesen, P. and Turner, B. M (1993). The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression. Cell 74, 281-289.[Medline]

Kafri, T., Ariel, M., Brandeis, M., Shemer, R., Urven, L., McCarrey, J., Cedar, H. and Razin, A (1992). Developmental pattern of gene specific DNA methylation in the mouse embryo and germ line. Genes Dev 6, 705-715.[Abstract/Free Full Text]

Kumar, S., Cheng, X., Klimasauskas, S., Mi, S., Posfai, J., Roberts, R. and Wilson, G. G (1994). The DNA (cytosine-5) methyltransferases. Nucl. Acids Res 22, 1-10.[Free Full Text]

Lau, M. M. H., Stewart, C. E. H., Liu, Z., Bhatt, H., Rotwein, P. and Stewart, C. L (1995). Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev 8, 2953-2963.[Abstract/Free Full Text]

Lauster, R., Trautner, T. A. and Noyer-Widner, M (1989). Cytosine-specific type II DNA methyltransferases. A conserved enzyme core with variable target-recognizing domains. J. Mol. Biol 206, 305-312.[Medline]

Leighton, P. L, Ingram, R. S., Eggenschwiler, J., Efstratiadis, A. and Tilghman S. M (1995). Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature 375, 34-39.[Medline]

Leonhardt, H., Page, A. W., Weier, H.-U. and Bestor, T. H (1992). A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71, 865-873.[Medline]

Li, E., Bestor, T. H. and Jaenisch, R (1992). Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926.[Medline]

Li, E., Beard, C. and Jaenisch, R (1993). Role for DNA methylation in genomic imprinting. Nature 366, 362-365.[Medline]

Monk, M., Boubelik, M. and Lehnert, S (1987). Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development 99, 371-382.[Abstract]

Nan, X., Tate, P., Li, E. and Bird, A (1996). DNA methylation specifies chromosomal localization of MeCP2. Mol. Cell. Biol 16, 414-421.[Abstract]

Posfai, J., Bhagwat, A. S., Posfai, G. and Roberts, R. J (1989). Predictive motifs derived from cytosine methyltransferases. Nucl. Acids Res 17, 2421-2435.[Abstract/Free Full Text]

Reik, W., Weiher, H. and Jaenisch, R (1987). Replication-competent Moloney murine leukemia virus carrying a bacterial suppressor tRNA gene: Selective cloning of proviral and flanking host sequences. Proc. Natl. Acad. Sci. USA 82, 1141-1145.

Stewart, C., Stuhlmann, H., J\212hner, D. and Jaenisch, R (1982). De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells. Proc. Natl. Acad. Sci. USA 79, 4098-4102.[Abstract/Free Full Text]

St\232ger, R., Kubicka, P., Liu, C.-G., Kafri, T., Razin, A., Cedar, H. and Barlow, D. P (1993). Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell 73, 61-71.[Medline]

Tazi, J. and Bird, A (1990). Alternative chromatin structure at CpG islands. Cell 60, 909-920.[Medline]

Tremblay, K. D., Saam, J. R., Ingram, R. S., Tilghman, S. M. and Bartolomei, M. S (1995). A paternal-specific methylation imprinting marks the alleles of the mouse H19 gene. Nature Genet 9, 407-413.[Medline]

Tucker, K. L., Beard, C., Dausman, J., Jackson-Grusby, L., Laird, P.W., Lei, H., Li, E. and Jaenisch, R (1996). Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. Genes Dev 10, 1008-1020.[Abstract/Free Full Text]

Wang, Z., Fung, M. R., Barlow, D. P. and Wagner, E. F (1995). Regulation of embryonic growth and lysosomal targeting by the imprinted Igf-2/Mpr gene. Nature 372, 464-467.

Wu, J. C. and Santi, D. V (1987). Kinetic and catalytic mechanism of HhaI methyltransferase. J. Biol. Chem 262, 4778-4786.[Abstract/Free Full Text]

Wyszynski, M. W., Gabbara, S., Kubareva, E. A., Oretskaya, T. S., Gromova, E. S., Shabaraova, E. A. and Bhagwat, A. S (1993). The cytosine conserved among DNA methylases is required for transfer, but not for specific DNA binding. Nucl. Acids. Res 21, 295-301.[Abstract/Free Full Text]

Zuccotti, M. and Monk, M (1995). Methylation of the mouse Xist gene in sperm and eggs correlates with imprinted Xist expression and paternal X-inactivation. Nature Genet 9, 316-320.[Medline]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells
Development, March 6, 2003; 129(8): 1807 - 1817.
[Abstract] [Full Text] [PDF]

				R. Hirasawa, H. Chiba, M. Kaneda, S. Tajima, E. Li, R. Jaenisch, and H. Sasaki Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development Genes & Dev., June 15, 2008; 22(12): 1607 - 1616. [Abstract] [Full Text] [PDF]

				V. Dion, Y. Lin, L. Hubert Jr., R. A. Waterland, and J. H. Wilson Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline Hum. Mol. Genet., May 1, 2008; 17(9): 1306 - 1317. [Abstract] [Full Text] [PDF]

				C. Maeda, S. Sato, N. Hattori, S. Tanaka, S. Yagi, and K. Shiota DNA Hypomethylation Circuit of the Mouse Oocyte-Specific Histone H1foo Gene in Female Germ Cell Lineage Biol Reprod, May 1, 2008; 78(5): 816 - 821. [Abstract] [Full Text] [PDF]

				A. M. Giraldo, D. A. Hylan, C. B. Ballard, M. N. Purpera, T. D. Vaught, J. W. Lynn, R. A. Godke, and K. R. Bondioli Effect of Epigenetic Modifications of Donor Somatic Cells on the Subsequent Chromatin Remodeling of Cloned Bovine Embryos Biol Reprod, May 1, 2008; 78(5): 832 - 840. [Abstract] [Full Text] [PDF]

				D. Strathdee, C. B. A. Whitelaw, and A. J. Clark Distal Transgene Insertion Affects CpG Island Maintenance during Differentiation J. Biol. Chem., April 25, 2008; 283(17): 11509 - 11515. [Abstract] [Full Text] [PDF]

				M. Endoh, T. A. Endo, T. Endoh, Y.-i. Fujimura, O. Ohara, T. Toyoda, A. P. Otte, M. Okano, N. Brockdorff, M. Vidal, et al. Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity Development, April 15, 2008; 135(8): 1513 - 1524. [Abstract] [Full Text] [PDF]

				D. S. Dunican, A. Ruzov, J. A. Hackett, and R. R. Meehan xDnmt1 regulates transcriptional silencing in pre-MBT Xenopus embryos independently of its catalytic function Development, April 1, 2008; 135(7): 1295 - 1302. [Abstract] [Full Text] [PDF]

				L. Yang, M. F. Andrade, S. Labialle, S. Moussette, G. Geneau, D. Sinnett, A. Belisle, C. M. T. Greenwood, and A. K. Naumova Parental Effect of DNA (Cytosine-5) Methyltransferase 1 on Grandparental-Origin-Dependent Transmission Ratio Distortion in Mouse Crosses and Human Families Genetics, January 1, 2008; 178(1): 35 - 45. [Abstract] [Full Text] [PDF]

				J.-Y. Li, M.-T. Pu, R. Hirasawa, B.-Z. Li, Y.-N. Huang, R. Zeng, N.-H. Jing, T. Chen, E. Li, H. Sasaki, et al. Synergistic Function of DNA Methyltransferases Dnmt3a and Dnmt3b in the Methylation of Oct4 and Nanog Mol. Cell. Biol., December 15, 2007; 27(24): 8748 - 8759. [Abstract] [Full Text] [PDF]

				S.-i. Takebayashi, T. Tamura, C. Matsuoka, and M. Okano Major and Essential Role for the DNA Methylation Mark in Mouse Embryogenesis and Stable Association of DNMT1 with Newly Replicated Regions Mol. Cell. Biol., December 1, 2007; 27(23): 8243 - 8258. [Abstract] [Full Text] [PDF]

				Y. Kanai and S. Hirohashi Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state Carcinogenesis, December 1, 2007; 28(12): 2434 - 2442. [Abstract] [Full Text] [PDF]

				M. Wiznerowicz, J. Jakobsson, J. Szulc, S. Liao, A. Quazzola, F. Beermann, P. Aebischer, and D. Trono The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis J. Biol. Chem., November 23, 2007; 282(47): 34535 - 34541. [Abstract] [Full Text] [PDF]

				C. C. Oakes, T. L. J. Kelly, B. Robaire, and J. M. Trasler Adverse Effects of 5-Aza-2'-Deoxycytidine on Spermatogenesis Include Reduced Sperm Function and Selective Inhibition of de Novo DNA Methylation J. Pharmacol. Exp. Ther., September 1, 2007; 322(3): 1171 - 1180. [Abstract] [Full Text] [PDF]

				L. Schermelleh, A. Haemmer, F. Spada, N. Rosing, D. Meilinger, U. Rothbauer, M. C. Cardoso, and H. Leonhardt Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation Nucleic Acids Res., July 26, 2007; 35(13): 4301 - 4312. [Abstract] [Full Text] [PDF]

				M. Damelin and T. H. Bestor Biological Functions of DNA Methyltransferase 1 Require Its Methyltransferase Activity Mol. Cell. Biol., June 1, 2007; 27(11): 3891 - 3899. [Abstract] [Full Text] [PDF]

				N. Gilbert, I. Thomson, S. Boyle, J. Allan, B. Ramsahoye, and W. A. Bickmore DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction J. Cell Biol., May 7, 2007; 177(3): 401 - 411. [Abstract] [Full Text] [PDF]

				Y. Tadokoro, H. Ema, M. Okano, E. Li, and H. Nakauchi De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells J. Exp. Med., April 16, 2007; 204(4): 715 - 722. [Abstract] [Full Text] [PDF]

				S. Kobayakawa, K. Miike, M. Nakao, and K. Abe Dynamic changes in the epigenomic state and nuclear organization of differentiating mouse embryonic stem cells Genes Cells, April 1, 2007; 12(4): 447 - 460. [Abstract] [Full Text] [PDF]

				F. Spada, A. Haemmer, D. Kuch, U. Rothbauer, L. Schermelleh, E. Kremmer, T. Carell, G. Langst, and H. Leonhardt DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells J. Cell Biol., February 26, 2007; 176(5): 565 - 571. [Abstract] [Full Text] [PDF]

				H. Niwa How is pluripotency determined and maintained? Development, February 15, 2007; 134(4): 635 - 646. [Abstract] [Full Text] [PDF]

				M. Oda, A. Yamagiwa, S. Yamamoto, T. Nakayama, A. Tsumura, H. Sasaki, K. Nakao, E. Li, and M. Okano DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner Genes & Dev., December 15, 2006; 20(24): 3382 - 3394. [Abstract] [Full Text] [PDF]

				A. H. Ting, K. M. McGarvey, and S. B. Baylin The cancer epigenome--components and functional correlates Genes & Dev., December 1, 2006; 20(23): 3215 - 3231. [Abstract] [Full Text] [PDF]

				S. R. L. Young, C. Mumaw, J. A. Marrs, and D. G. Skalnik Antisense Targeting of CXXC Finger Protein 1 Inhibits Genomic Cytosine Methylation and Primitive Hematopoiesis in Zebrafish J. Biol. Chem., December 1, 2006; 281(48): 37034 - 37044. [Abstract] [Full Text] [PDF]

				A. Lewis, K. Green, C. Dawson, L. Redrup, K. D. Huynh, J. T. Lee, M. Hemberger, and W. Reik Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo Development, November 1, 2006; 133(21): 4203 - 4210. [Abstract] [Full Text] [PDF]

				D. M. Maatouk, L. D. Kellam, M. R. W. Mann, H. Lei, E. Li, M. S. Bartolomei, and J. L. Resnick DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages Development, September 1, 2006; 133(17): 3411 - 3418. [Abstract] [Full Text] [PDF]

				N. Nikolettos, B. Asimakopoulos, and I. S. Papastefanou Intracytoplasmic Sperm Injection-An Assisted Reproduction Technique That Should Make Us Cautious About Imprinting Deregulation Reproductive Sciences, July 1, 2006; 13(5): 317 - 328. [Abstract] [PDF]

				A. Tsumura, T. Hayakawa, Y. Kumaki, S.-i. Takebayashi, M. Sakaue, C. Matsuoka, K. Shimotohno, F. Ishikawa, E. Li, H. R. Ueda, et al. Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells, July 1, 2006; 11(7): 805 - 814. [Abstract] [Full Text] [PDF]

				A. Loriot, E. De Plaen, T. Boon, and C. De Smet Transient Down-regulation of DNMT1 Methyltransferase Leads to Activation and Stable Hypomethylation of MAGE-A1 in Melanoma Cells J. Biol. Chem., April 14, 2006; 281(15): 10118 - 10126. [Abstract] [Full Text] [PDF]

				M. Pedram, C. N. Sprung, Q. Gao, A. W. I. Lo, G. E. Reynolds, and J. P. Murnane Telomere Position Effect and Silencing of Transgenes near Telomeres in the Mouse. Mol. Cell. Biol., March 1, 2006; 26(5): 1865 - 1878. [Abstract] [Full Text] [PDF]

				Y. Ueda, M. Okano, C. Williams, T. Chen, K. Georgopoulos, and E. Li Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development, March 1, 2006; 133(6): 1183 - 1192. [Abstract] [Full Text] [PDF]