Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice

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[Abstract] [Full Text] [PDF]

V. V. Vasilyev, F. Pernasetti, S. B. Rosenberg, M. J. Barsoum, D. A. Austin, N. J. G. Webster, and P. L. Mellon
Transcriptional Activation of the Ovine Follicle-Stimulating Hormone-{beta} Gene by Gonadotropin- Releasing Hormone Involves Multiple Signal Transduction Pathways
Endocrinology, May 1, 2002; 143(5): 1651 - 1659.
[Abstract] [Full Text] [PDF]

F. Liu, D. A. Austin, P. L. Mellon, J. M. Olefsky, and N. J. G. Webster
GnRH Activates ERK1/2 Leading to the Induction of c-fos and LH{beta} Protein Expression in L{beta}T2 Cells
Mol. Endocrinol., March 1, 2002; 16(3): 419 - 434.
[Abstract] [Full Text] [PDF]

M. L. Brinkmeier, J. H. Stahl, D. F. Gordon, B. D. Ross, V. D. Sarapura, J. M. Dowding, S. K. Kendall, R. V. Lloyd, E. C. Ridgway, and S. A. Camper
Thyroid Hormone-Responsive Pituitary Hyperplasia Independent of Somatostatin Receptor 2
Mol. Endocrinol., December 1, 2001; 15(12): 2129 - 2136.
[Abstract] [Full Text] [PDF]

L. K. Bachir, J.-N. Laverriere, and R. Counis
Isolation and Characterization of a Rat Nitric Oxide Synthase Type I Gene Promoter that Confers Expression and Regulation in Pituitary Gonadotrope Cells
Endocrinology, November 1, 2001; 142(11): 4631 - 4642.
[Abstract] [Full Text] [PDF]

E. J. Lee, F. Martinson, T. Kotlar, B. Thimmapaya, and J. L. Jameson
Adenovirus-Mediated Targeted Expression of Toxic Genes to Adrenocorticotropin-Producing Pituitary Tumors Using the Proopiomelanocortin Promoter
J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3400 - 3409.
[Abstract] [Full Text] [PDF]

F. Pernasetti, V. V. Vasilyev, S. B. Rosenberg, J. S. Bailey, H.-J. Huang, W. L. Miller, and P. L. Mellon
Cell-Specific Transcriptional Regulation of Follicle-Stimulating Hormone-{beta} by Activin and Gonadotropin-Releasing Hormone in the L{beta}T2 Pituitary Gonadotrope Cell Model
Endocrinology, June 1, 2001; 142(6): 2284 - 2295.
[Abstract] [Full Text] [PDF]

L. J. Cushman, D. E. Watkins-Chow, M. L. Brinkmeier, L. T. Raetzman, A. L. Radak, R. V. Lloyd, and S. A. Camper
Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility
Hum. Mol. Genet., May 1, 2001; 10(11): 1141 - 1153.
[Abstract] [Full Text] [PDF]

H. Pincas, K. Amoyel, R. Counis, and J.-N. Laverrière
Proximal cis-Acting Elements, Including Steroidogenic Factor 1, Mediate the Efficiency of a Distal Enhancer in the Promoter of the Rat

				N. A. Ciccone, C. T. Lacza, M. Y. Hou, S. J. Gregory, K.-Y. Kam, S. Xu, and U. B. Kaiser A Composite Element that Binds Basic Helix Loop Helix and Basic Leucine Zipper Transcription Factors Is Important for Gonadotropin-Releasing Hormone Regulation of the Follicle-Stimulating Hormone {beta} Gene Mol. Endocrinol., August 1, 2008; 22(8): 1908 - 1923. [Abstract] [Full Text] [PDF]

				U. B. Kaiser Genetic Labeling: New Approaches to Creating a Gonadotroph "ID" Endocrinology, June 1, 2008; 149(6): 2699 - 2700. [Full Text] [PDF]

				P. Lamba, V. Khivansara, A. C. D'Alessio, M. M. Santos, and D. J. Bernard Paired-Like Homeodomain Transcription Factors 1 and 2 Regulate Follicle-Stimulating Hormone {beta}-Subunit Transcription through a Conserved cis-Element Endocrinology, June 1, 2008; 149(6): 3095 - 3108. [Abstract] [Full Text] [PDF]

				H. L Henderson, J. Townsend, and D. J Tortonese Direct effects of prolactin and dopamine on the gonadotroph response to GnRH J. Endocrinol., May 1, 2008; 197(2): 343 - 350. [Abstract] [Full Text] [PDF]

				V. G. Thackray and P. L. Mellon Synergistic Induction of Follicle-Stimulating Hormone {beta}-Subunit Gene Expression by Gonadal Steroid Hormone Receptors and Smad Proteins Endocrinology, March 1, 2008; 149(3): 1091 - 1102. [Abstract] [Full Text] [PDF]

				H. A Ferris, H. E Walsh, J. Stevens, P. C Fallest, and M. A Shupnik Luteinizing Hormone Beta Promoter Stimulation by Adenylyl Cyclase and Cooperation with Gonadotropin-Releasing Hormone 1 in Transgenic Mice and LBetaT2 Cells Biol Reprod, December 1, 2007; 77(6): 1073 - 1080. [Abstract] [Full Text] [PDF]

				K. K. Kim, S. B. Song, K. I. Kang, M. Rhee, and K. E. Kim Activation of the Thyroid-Stimulating Hormone {beta}-Subunit Gene by LIM Homeodomain Transcription Factor Lhx2 Endocrinology, July 1, 2007; 148(7): 3468 - 3476. [Abstract] [Full Text] [PDF]

				S. Lim, M. Luo, M. Koh, M. Yang, M. N. bin Abdul Kadir, J. H. Tan, Z. Ye, W. Wang, and P. Melamed Distinct Mechanisms Involving Diverse Histone Deacetylases Repress Expression of the Two Gonadotropin {beta}-Subunit Genes in Immature Gonadotropes, and Their Actions Are Overcome by Gonadotropin-Releasing Hormone Mol. Cell. Biol., June 1, 2007; 27(11): 4105 - 4120. [Abstract] [Full Text] [PDF]

				S. M. McGillivray, V. G. Thackray, D. Coss, and P. L. Mellon Activin and Glucocorticoids Synergistically Activate Follicle-Stimulating Hormone {beta}-Subunit Gene Expression in the Immortalized L{beta}T2 Gonadotrope Cell Line Endocrinology, February 1, 2007; 148(2): 762 - 773. [Abstract] [Full Text] [PDF]

				H. Zhang, J. S. Bailey, D. Coss, B. Lin, R. Tsutsumi, M. A. Lawson, P. L. Mellon, and N. J. G. Webster Activin Modulates the Transcriptional Response of L{beta}T2 Cells to Gonadotropin-Releasing Hormone and Alters Cellular Proliferation Mol. Endocrinol., November 1, 2006; 20(11): 2909 - 2930. [Abstract] [Full Text] [PDF]

				T. Sato, K. Kitahara, T. Susa, T. Kato, and Y. Kato Pituitary transcription factor Prop-1 stimulates porcine pituitary glycoprotein hormone {alpha} subunit gene expression. J. Mol. Endocrinol., October 1, 2006; 37(2): 341 - 352. [Abstract] [Full Text] [PDF]

				A. Granger, C. Bleux, M.-L. Kottler, S. J. Rhodes, R. Counis, and J.-N. Laverriere The LIM-Homeodomain Proteins Isl-1 and Lhx3 Act with Steroidogenic Factor 1 to Enhance Gonadotrope-Specific Activity of the Gonadotropin-Releasing Hormone Receptor Gene Promoter Mol. Endocrinol., September 1, 2006; 20(9): 2093 - 2108. [Abstract] [Full Text] [PDF]

				S. LARIVIERE, G. GARREL, M.-T. ROBIN, R. COUNIS, and J. COHEN-TANNOUDJI Differential Mechanisms for PACAP and GnRH cAMP Induction Contribute to Cross-talk between both Hormones in the Gonadotrope LbetaT2 Cell Line Ann. N.Y. Acad. Sci., July 1, 2006; 1070(1): 376 - 379. [Abstract] [Full Text] [PDF]

				V. Sharma, W. R. Hays, W. M. Wood, U. Pugazhenthi, D. L. St. Germain, A. C. Bianco, W. Krezel, P. Chambon, and B. R. Haugen Effects of Rexinoids on Thyrotrope Function and the Hypothalamic-Pituitary-Thyroid Axis Endocrinology, March 1, 2006; 147(3): 1438 - 1451. [Abstract] [Full Text] [PDF]

				B. C. Yaden, M. Garcia III, T. P. L. Smith, and S. J. Rhodes Two Promoters Mediate Transcription from the Human LHX3 Gene: Involvement of Nuclear Factor I and Specificity Protein 1 Endocrinology, January 1, 2006; 147(1): 324 - 337. [Abstract] [Full Text] [PDF]

				H. Kanasaki, G. Y. Bedecarrats, K.-Y. Kam, S. Xu, and U. B. Kaiser Gonadotropin-Releasing Hormone Pulse Frequency-Dependent Activation of Extracellular Signal-Regulated Kinase Pathways in Perifused L{beta}T2 Cells Endocrinology, December 1, 2005; 146(12): 5503 - 5513. [Abstract] [Full Text] [PDF]

				S. M. McGillivray, J. S. Bailey, R. Ramezani, B. J. Kirkwood, and P. L. Mellon Mouse GnRH Receptor Gene Expression Is Mediated by the LHX3 Homeodomain Protein Endocrinology, May 1, 2005; 146(5): 2180 - 2185. [Abstract] [Full Text] [PDF]

				A. Rose, P. Froment, V. Perrot, M. J. Quon, D. LeRoith, and J. Dupont The Luteinizing Hormone-releasing Hormone Inhibits the Anti-apoptotic Activity of Insulin-like Growth Factor-1 in Pituitary {alpha}T3 Cells by Protein Kinase C{alpha}-mediated Negative Regulation of Akt J. Biol. Chem., December 10, 2004; 279(50): 52500 - 52516. [Abstract] [Full Text] [PDF]

				J. C. Wu, P. Su, N. W. Safwat, J. Sebastian, and W. L. Miller Rapid, Efficient Isolation of Murine Gonadotropes and Their Use in Revealing Control of Follicle-Stimulating Hormone by Paracrine Pituitary Factors Endocrinology, December 1, 2004; 145(12): 5832 - 5839. [Abstract] [Full Text] [PDF]

				B. E. West, G. E. Parker, J. J. Savage, P. Kiratipranon, K. S. Toomey, L. R. Beach, S. C. Colvin, K. W. Sloop, and S. J. Rhodes Regulation of the Follicle-Stimulating Hormone {beta} Gene by the LHX3 LIM-Homeodomain Transcription Factor Endocrinology, November 1, 2004; 145(11): 4866 - 4879. [Abstract] [Full Text] [PDF]

				J. S. Jorgensen, C. C. Quirk, and J. H. Nilson Multiple and Overlapping Combinatorial Codes Orchestrate Hormonal Responsiveness and Dictate Cell-Specific Expression of the Genes Encoding Luteinizing Hormone Endocr. Rev., August 1, 2004; 25(4): 521 - 542. [Abstract] [Full Text] [PDF]

				K. A. Nguyen, S. J. Santos, M. K. Kreidel, A. L. Diaz, R. Rey, and M. A. Lawson Acute Regulation of Translation Initiation by Gonadotropin-Releasing Hormone in the Gonadotrope Cell Line L{beta}T2 Mol. Endocrinol., May 1, 2004; 18(5): 1301 - 1312. [Abstract] [Full Text] [PDF]

				D. J. Bernard Both SMAD2 and SMAD3 Mediate Activin-Stimulated Expression of the Follicle-Stimulating Hormone {beta} Subunit in Mouse Gonadotrope Cells Mol. Endocrinol., March 1, 2004; 18(3): 606 - 623. [Abstract] [Full Text] [PDF]

				J.-F. Mouillet, C. Sonnenberg-Hirche, X. Yan, and Y. Sadovsky p300 Regulates the Synergy of Steroidogenic Factor-1 and Early Growth Response-1 in Activating Luteinizing Hormone-{beta} Subunit Gene J. Biol. Chem., February 27, 2004; 279(9): 7832 - 7839. [Abstract] [Full Text] [PDF]

				D. Coss, S. B. R. Jacobs, C. E. Bender, and P. L. Mellon A Novel AP-1 Site Is Critical for Maximal Induction of the Follicle-stimulating Hormone {beta} Gene by Gonadotropin-releasing Hormone J. Biol. Chem., January 2, 2004; 279(1): 152 - 162. [Abstract] [Full Text] [PDF]

				L. E. C. Miles, A. C. Hanyaloglu, J. R. Dromey, K. D. G. Pfleger, and K. A. Eidne Gonadotropin-Releasing Hormone Receptor-Mediated Growth Suppression of Immortalized L{beta}T2 Gonadotrope and Stable HEK293 Cell Lines Endocrinology, January 1, 2004; 145(1): 194 - 204. [Abstract] [Full Text] [PDF]

				F. Liu, D. A. Austin, and N. J. G. Webster Gonadotropin-Releasing Hormone-Desensitized L{beta}T2 Gonadotrope Cells Are Refractory to Acute Protein Kinase C, Cyclic AMP, and Calcium-Dependent Signaling Endocrinology, October 1, 2003; 144(10): 4354 - 4365. [Abstract] [Full Text] [PDF]

				S. L. Mellor, E. M. A. Ball, A. E. O'Connor, J.-F. Ethier, M. Cranfield, J. F. Schmitt, D. J. Phillips, N. P. Groome, and G. P. Risbridger Activin {beta}C-Subunit Heterodimers Provide a New Mechanism of Regulating Activin Levels in the Prostate Endocrinology, October 1, 2003; 144(10): 4410 - 4419. [Abstract] [Full Text] [PDF]

				L. K. Bachir, G. Garrel, A. Lozach, J.-N. Laverriere, and R. Counis The Rat Pituitary Promoter of the Neuronal Nitric Oxide Synthase Gene Contains an Sp1-, LIM Homeodomain-Dependent Enhancer and a Distinct Bipartite Gonadotropin-Releasing Hormone-Responsive Region Endocrinology, September 1, 2003; 144(9): 3995 - 4007. [Abstract] [Full Text] [PDF]

				G. Y. Bedecarrats, F. H. O'Neill, E. R. Norwitz, U. B. Kaiser, and J. Teixeira Regulation of gonadotropin gene expression by Mullerian inhibiting substance PNAS, August 5, 2003; 100(16): 9348 - 9353. [Abstract] [Full Text] [PDF]