BMP-2/-4 mediate programmed cell death in chicken limb buds

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Aono, H. and Ide, H (1988). A gradient of responsiveness to the growth-promoting activity of ZPA (zonre of polarizing activity) in the chick limb bud. Dev. Biol 128, 136-141.[Medline]

Behringer, R. R., Finegold, M. J. and Cate, R. L (1994). Mullerian-inhibiting substance function during mammalian sexual development. Cell 79, 415-25.[Medline]

Chen, R. H., Miettinen, P. J., Maruoka, E. M., Choy, L. and Derynck, R (1995). A WD-domain protein that is associated with and phosphorylated by the type II TGFbeta receptor. Nature 377, 548-552.[Medline]

Dono, R. and Zeller, R (1994). Cell-type-specific translocation of fibroblast growth factor-2 isoformes during chicken kidney and limb morphogenesis. Dev. Biol 163, 316-330.[Medline]

Fallon, J. F., Lopez, A., Ros, M. A., Savage, M. P., Olwin, B. B. and Simandl, B. K (1994). FGF-2: Apical ectodermal ridge growth signal for chick limb development. Science 264, 104-107.[Abstract/Free Full Text]

Gavrieli, Y., Sherman, Y. and Ben-Sasson, S. A (1992). Identification of programed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol 119, 493-501.[Abstract/Free Full Text]

Graff, J. M., Thies, R. S., Song, J. J., Celeste, A. J. and Melton, D. A (1994). Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell 79, 169-179.[Medline]

Graham, A., Francis-West, P., Brickell, P. and Lumsden, A (1994). The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest. Nature 372, 684-686.[Medline]

Hamburger, V. and Hamilton, H. L (1951). A series of normal stages in the development of the chick embryo. J. Morph 88, 49-92.

Hemmati-Brivanlou, A. and Melton, D (1992). A truncated activin receptorinhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature 359, 608-614.

Hurle, J. M. and Ganan, Y. G (1986). Interdigital tissure chondrogenesis induced by surgical removal of the ectoderm in the embryonic chick leg bud. J. Embryol. Exp. Morph 94, 231-244.[Medline]

Hurle, J. M. and Ganan, Y (1987). Formation of extra-digits induced by surgical removal of the apical ectodermal ridge of the chick embryo leg bud in the stages previous to the onset of interdigital cell death. Anat. Embryol 176, 393-399.[Medline]

Iba, H., Shindo, Y., Nishina, H. and Yoshida, T (1988). Transforming potential and growth stimulating activity of the v-fos and c-fos genes carried by avian retrovirus vectors. Oncogene Res 2, 121-133.[Medline]

Iba, H., Takeya, T., Cross, F. R., Hanafusa, T. and Hanafusa, H (1984). Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts. Proc. Natl. Acad. Sci. USA 81, 4424-4428.[Abstract/Free Full Text]

Kawabata, M., Imamura, T., Miyazono, K., Engel, M. E. and Moses, H. L (1995). Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha. J. Biol. Chem 270, 29628-29631.[Abstract/Free Full Text]

Kingsley, D. M (1994). The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev 8, 133-46.[Free Full Text]

Kingsley, D. M (1994). What do BMPs do in mammals? Clues from the mouse short-ear mutation. Trends Genet 10, 16-21.[Medline]

Koenig, B. B., Cook, J. S., Wolsing, D. H., Ting, J., Tiesman, J. P., Correa, P. E., Olson, C. A., Pecquet, A. L., Ventura, F., Grant, R. A., Chen, G.-X., Wrana, J. L., Massague, J. and Rosenbaum, J. S (1994). Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Mol. Cell. Biol 14, 5961-5974.[Abstract/Free Full Text]

Liu, F., Ventura, F., Doody, J. and Massague, J (1995). Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol. Cell. Biol 15, 3479-86.[Abstract]

Mishina, Y., Suzuki, A., Ueno, N. and Behringer, R. R (1995). Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev 9, 3027-3037.[Abstract/Free Full Text]

Niswander, L. and Martin, G. R (1992). Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development 114, 755-768.[Abstract]

Niswander, L. and Martin, G. R (1993). FGF-4 and BMP-2 have opposite effects on limb growth. Nature 361, 68-71.[Medline]

Pautou, M.-P (1975). Morphogenese de l autopode chez l embryon de poulet. J. Embryol. Exp. Morph 34, 511-529.[Medline]

Potts, W. M., Olsen, M., Boettiger, D. and Vogt, V (1987). Epitope mapping of monoclonal antibobies to gag protein p19 of avian sarcoma and leukemia viruses. J. Gen. Virol 68, 3177-3182.[Abstract/Free Full Text]

Ros, M. A., Macias, D., Fallon, J. F. and Hurle, J. M (1994). Formation of extra digits in the interdigital spaces of the chick leg bud is not preceded by changes in the expression of the Msx and Hoxd genes. Anat. Embryol 190, 375-382.[Medline]

Saitoh, M., Nishitoh, H., Amagasa, T., Miyazono, K., Takagi, M. and Ichijo, H (1996). Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta. J. Biol. Chem 271, 2769-2775.[Abstract/Free Full Text]

Saunders, J. W., Jr., Gasseling, M. T. and Saunders, L. C (1962). Cellular death in morphogenesis of the avian wing. Dev. Biol 5, 16-25.

Suzuki, A., Thies, R. S., Yamaji, N., Song, J. J., Wozney, J. M., Murakami, K. and Ueno, N (1994). A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopous embryo. Proc. Natl. Acad. Sci. USA 91, 10255-10259.[Abstract/Free Full Text]

Tone, S., Tanaka, S. and Kato, Y (1983). The inhibitory effect of 5-bromodeoxyuridine on the programmed cell death in the chick limb. Dev. Growth Differ 25, 381-391.

Vanio, S., Karavanova, I., Jowett, A. and Thesleff, I (1993). Identification of BMP-4 as a signal mediating secondary induction between epithelial mesenchymal tissues during early tooth development. Cell 75, 45-58.[Medline]

Wang, T., Danielson, P. D., Li, B., Shah, P. C., Kim, S. D. and Donahoe, P. K (1996). The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling. Science 271, 1120-1122.[Abstract]

White, K., Grether, M. E., Abrams, J. M., Young, L., Farrell, K. and Steller, H (1994). Genetic control of programmed cell death in Drosophila. Science 264, 677-683.[Abstract/Free Full Text]

Winnier, G., Blessing, M., Labosky, P. A. and Hogan, B. L (1995). Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 9, 2105-2116.[Abstract/Free Full Text]

Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J. and Greenberg, M. E (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.[Abstract/Free Full Text]

Yamaguchi, K., Shirakabe, K., Shibuya, H., Irie, K., Ohishi, I., Ueno, N., Taniguchi, T., Nishida, E. and Matsumoto, K (1995). identification of a member of the MAPKKK family as a potential mediator of TGA-signal transduction. Science 270, 2008-2011.[Abstract/Free Full Text]

Yamaji, N., Celeste, A. J., Thies, R. S., Song, J. J., Bernier, S. M., Goltzman, D., Lyons, K. M., Nove, J., Rosen, V. and Wozney, J. M (1994). A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun 205, 1944-1951.[Medline]

Yokouchi, Y., Nakazato, S., Yamamoto, M., Goto, Y., Kameda, T., Iba, H. and Kuroiwa, A (1995). Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb bud. Genes Dev 9, 2509-2522.[Abstract/Free Full Text]

Zou, H. and Niswander, L (1996). Requirement for BMP signaling in interdigital apoptosis and scale formation. Science 272, 738-741.[Abstract]

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				M. Yamashita, N. Mizusawa, M. Hojo, and T. Yabu Extensive apoptosis and abnormal morphogenesis in pro-caspase-3 transgenic zebrafish during development J. Exp. Biol., June 15, 2008; 211(12): 1874 - 1881. [Abstract] [Full Text] [PDF]

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				S. Pajni-Underwood, C. P. Wilson, C. Elder, Y. Mishina, and M. Lewandoski BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling Development, June 15, 2007; 134(12): 2359 - 2368. [Abstract] [Full Text] [PDF]

				J. Knobloch, J. D. Shaughnessy Jr., and U. Ruther Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway FASEB J, May 1, 2007; 21(7): 1410 - 1421. [Abstract] [Full Text] [PDF]

				S. D. Weatherbee, R. R. Behringer, J. J. Rasweiler IV, and L. A. Niswander Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification PNAS, October 10, 2006; 103(41): 15103 - 15107. [Abstract] [Full Text] [PDF]

				K. Teichert-Kuliszewska, M. J.B. Kutryk, M. A. Kuliszewski, G. Karoubi, D. W. Courtman, L. Zucco, J. Granton, and D. J. Stewart Bone Morphogenetic Protein Receptor-2 Signaling Promotes Pulmonary Arterial Endothelial Cell Survival: Implications for Loss-of-Function Mutations in the Pathogenesis of Pulmonary Hypertension Circ. Res., February 3, 2006; 98(2): 209 - 217. [Abstract] [Full Text] [PDF]

				P. Lu, G. Minowada, and G. R. Martin Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function Development, January 1, 2006; 133(1): 33 - 42. [Abstract] [Full Text] [PDF]

				Y. Lallemand, M.-A. Nicola, C. Ramos, A. Bach, C. S. Cloment, and B. Robert Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development Development, July 1, 2005; 132(13): 3003 - 3014. [Abstract] [Full Text] [PDF]

				W. M. Knosp, V. Scott, H. P. Bachinger, and H. S. Stadler HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis Development, September 15, 2004; 131(18): 4581 - 4592. [Abstract] [Full Text] [PDF]

				Y. Kida, Y. Maeda, T. Shiraishi, T. Suzuki, and T. Ogura Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis Development, September 1, 2004; 131(17): 4179 - 4187. [Abstract] [Full Text] [PDF]

				S. Shimasaki, R. K. Moore, F. Otsuka, and G. F. Erickson The Bone Morphogenetic Protein System In Mammalian Reproduction Endocr. Rev., February 1, 2004; 25(1): 72 - 101. [Abstract] [Full Text] [PDF]

				E. Hay, J. Lemonnier, O. Fromigue, H. Guenou, and P. J. Marie Bone Morphogenetic Protein Receptor IB Signaling Mediates Apoptosis Independently of Differentiation in Osteoblastic Cells J. Biol. Chem., January 16, 2004; 279(3): 1650 - 1658. [Abstract] [Full Text] [PDF]

				P. Sharma, N. Fatma, E. Kubo, T. Shinohara, L. T. Chylack Jr., and D. P. Singh Lens Epithelium-derived Growth Factor Relieves Transforming Growth Factor-{beta}1-induced Transcription Repression of Heat Shock Proteins in Human Lens Epithelial Cells J. Biol. Chem., May 23, 2003; 278(22): 20037 - 20046. [Abstract] [Full Text] [PDF]

				E. Canalis, A. N. Economides, and E. Gazzerro Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton Endocr. Rev., April 1, 2003; 24(2): 218 - 235. [Abstract] [Full Text] [PDF]

				J.-i. Sakiyama, A. Yamagishi, and A. Kuroiwa Tbx4-Fgf10 system controls lung bud formation during chicken embryonic development Development, April 1, 2003; 130(7): 1225 - 1234. [Abstract] [Full Text] [PDF]

				T. Schlange, H.-H. Arnold, and T. Brand BMP2 is a positive regulator of Nodal signaling during left-right axis formation in the chicken embryo Development, March 9, 2003; 129(14): 3421 - 3429. [Abstract] [Full Text] [PDF]

				S. Pizette, C. Abate-Shen, and L. Niswander BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb Development, November 15, 2001; 128(22): 4463 - 4474. [Abstract] [Full Text] [PDF]

				J. A. Montero, Y. Ganan, D. Macias, J. Rodriguez-Leon, J. J. Sanz-Ezquerro, R. Merino, J. Chimal-Monroy, M. A. Nieto, and J. M. Hurle Role of FGFs in the control of programmed cell death during limb development Development, June 1, 2001; 128(11): 2075 - 2084. [Abstract] [Full Text] [PDF]

				C. Kawamura, M. Kizaki, K. Yamato, H. Uchida, Y. Fukuchi, Y. Hattori, T. Koseki, T. Nishihara, and Y. Ikeda Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3 Blood, September 15, 2000; 96(6): 2005 - 2011. [Abstract] [Full Text] [PDF]

				J. R. Mathura Jr, N. Jafari, J. T. Chang, S. F. Hackett, K. J. Wahlin, N. G. Della, N. Okamoto, D. J. Zack, and P. A. Campochiaro Bone Morphogenetic Proteins-2 and -4: Negative Growth Regulators in Adult Retinal Pigmented Epithelium Invest. Ophthalmol. Vis. Sci., February 1, 2000; 41(2): 592 - 600. [Abstract] [Full Text]

				D. Ellies, V Church, P Francis-West, and A Lumsden The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain Development, January 12, 2000; 127(24): 5285 - 5295. [Abstract] [PDF]

				A. Nguyen and J. Pollard Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution Development, January 7, 2000; 127(14): 3107 - 3118. [Abstract] [PDF]

				T Narita, K Saitoh, T Kameda, A Kuroiwa, M Mizutani, C Koike, H Iba, and S Yasugi BMPs are necessary for stomach gland formation in the chicken embryo: a study using virally induced BMP-2 and Noggin expression Development, January 3, 2000; 127(5): 981 - 988. [Abstract] [PDF]

				S. Baur, J. Mai, and S. Dymecki Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity Development, January 2, 2000; 127(3): 605 - 619. [Abstract] [PDF]

				A.S. Tucker and P.T. Sharpe Molecular Genetics of Tooth Morphogenesis and Patterning: The Right Shape in the Right Place Journal of Dental Research, April 1, 1999; 78(4): 826 - 834. [Abstract] [PDF]

				R Merino, J Rodriguez-Leon, D Macias, Y Ganan, A. Economides, and J. Hurle The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb Development, January 12, 1999; 126(23): 5515 - 5522. [Abstract] [PDF]

				R Merino, D Macias, Y Ganan, J Rodriguez-Leon, A. Economides, C Rodriguez-Esteban, J. Izpisua-Belmonte, and J. Hurle Control of digit formation by activin signalling Development, January 5, 1999; 126(10): 2161 - 2170. [Abstract] [PDF]

				E Coucouvanis and G. Martin BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo Development, January 2, 1999; 126(3): 535 - 546. [Abstract] [PDF]

				S Pizette and L Niswander BMPs negatively regulate structure and function of the limb apical ectodermal ridge Development, January 2, 1999; 126(5): 883 - 894. [Abstract] [PDF]

				S. Cheifetz BMP Receptors in Limb and Tooth Formation Critical Reviews in Oral Biology & Medicine, January 1, 1999; 10(2): 182 - 198. [Abstract] [Full Text] [PDF]