Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family

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				S. Itoh, S. Kanno, Z. Gai, H. Suemoto, M. Kawakatsu, H. Tanishima, Y. Morimoto, K. Nishioka, I. Hatamura, M. Yoshida, et al. Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. Genes Cells, April 1, 2008; 13(4): 355 - 363. [Abstract] [Full Text] [PDF]

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				S. Provot, D. Zinyk, Y. Gunes, R. Kathri, Q. Le, H. M. Kronenberg, R. S. Johnson, M. T. Longaker, A. J. Giaccia, and E. Schipani Hif-1{alpha} regulates differentiation of limb bud mesenchyme and joint development J. Cell Biol., May 7, 2007; 177(3): 451 - 464. [Abstract] [Full Text] [PDF]

				D. Spater, T. P. Hill, R. J. O'Sullivan, M. Gruber, D. A. Conner, and C. Hartmann Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis Development, August 1, 2006; 133(15): 3039 - 3049. [Abstract] [Full Text] [PDF]

				X. Guo, T. F. Day, X. Jiang, L. Garrett-Beal, L. Topol, and Y. Yang Wnt/{beta}-catenin signaling is sufficient and necessary for synovial joint formation Genes & Dev., October 1, 2004; 18(19): 2404 - 2417. [Abstract] [Full Text] [PDF]

				A. Nifuji, O. Kellermann, and M. Noda Noggin Inhibits Chondrogenic But Not Osteogenic Differentiation in Mesodermal Stem Cell Line C1 and Skeletal Cells Endocrinology, July 1, 2004; 145(7): 3434 - 3442. [Abstract] [Full Text] [PDF]

				Y. Chen, V. Knezevic, V. Ervin, R. Hutson, Y. Ward, and S. Mackem Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh Development, May 15, 2004; 131(10): 2339 - 2347. [Abstract] [Full Text] [PDF]

				T. Takada, T. Katagiri, M. Ifuku, N. Morimura, M. Kobayashi, K. Hasegawa, A. Ogamo, and R. Kamijo Sulfated Polysaccharides Enhance the Biological Activities of Bone Morphogenetic Proteins J. Biol. Chem., October 31, 2003; 278(44): 43229 - 43235. [Abstract] [Full Text] [PDF]

				K. Lehmann, P. Seemann, S. Stricker, M. Sammar, B. Meyer, K. Suring, F. Majewski, S. Tinschert, K.-H. Grzeschik, D. Muller, et al. From the Cover: Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2 PNAS, October 14, 2003; 100(21): 12277 - 12282. [Abstract] [Full Text] [PDF]

				C. T. Miller, D. Yelon, D. Y. R. Stainier, and C. B. Kimmel Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint Development, April 1, 2003; 130(7): 1353 - 1365. [Abstract] [Full Text] [PDF]

				E. E. Storm, J. L. R. Rubenstein, and G. R. Martin Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain PNAS, February 18, 2003; 100(4): 1757 - 1762. [Abstract] [Full Text] [PDF]

				E. C. Delot, M. E. Bahamonde, M. Zhao, and K. M. Lyons BMP signaling is required for septation of the outflow tract of the mammalian heart Development, January 1, 2003; 130(1): 209 - 220. [Abstract] [Full Text] [PDF]

				H. Chang, C. W. Brown, and M. M. Matzuk Genetic Analysis of the Mammalian Transforming Growth Factor-{beta} Superfamily Endocr. Rev., December 1, 2002; 23(6): 787 - 823. [Abstract] [Full Text] [PDF]

				H. Akiyama, M.-C. Chaboissier, J. F. Martin, A. Schedl, and B. de Crombrugghe The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 Genes & Dev., November 1, 2002; 16(21): 2813 - 2828. [Abstract] [Full Text] [PDF]

				Q. Wang, R. P. Green, G. Zhao, and D. M. Ornitz Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains Development, October 1, 2001; 128(19): 3867 - 3876. [Abstract] [Full Text] [PDF]

				C. Ueta, M. Iwamoto, N. Kanatani, C. Yoshida, Y. Liu, M. Enomoto-Iwamoto, T. Ohmori, H. Enomoto, K. Nakata, K. Takada, et al. Skeletal Malformations Caused by Overexpression of Cbfa1 or Its Dominant Negative Form in Chondrocytes J. Cell Biol., April 2, 2001; 153(1): 87 - 100. [Abstract] [Full Text] [PDF]

				A. H. Reddi Bone Morphogenetic Proteins: From Basic Science to Clinical Applications J. Bone Joint Surg. Am., April 1, 2001; 83(90010): S1 - 6. [Full Text] [PDF]

				L. A. van Grunsven, A. Schellens, D. Huylebroeck, and K. Verschueren SIP1 (Smad Interacting Protein 1) and {delta}EF1 ({delta}-Crystallin Enhancer Binding Factor) are Structurally Similar Transcriptional Repressors : A Current Survey of Their Functions and Mechanisms of Action in Transforming Growth Factor-{beta} Signalling J. Bone Joint Surg. Am., April 1, 2001; 83(90010): S40 - 47. [Abstract] [Full Text] [PDF]

				X. Yang, L. Chen, X. Xu, C. Li, C. Huang, and C.-X. Deng TGF-{beta}/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage J. Cell Biol., March 26, 2001; 153(1): 35 - 46. [Abstract] [Full Text] [PDF]

				R. D. Dahn and J. F. Fallon Interdigital Regulation of Digit Identity and Homeotic Transformation by Modulated BMP Signaling Science, July 21, 2000; 289(5478): 438 - 441. [Abstract] [Full Text]

				A. M. Ho, M. D. Johnson, and D. M. Kingsley Role of the Mouse ank Gene in Control of Tissue Calcification and Arthritis Science, July 14, 2000; 289(5477): 265 - 270. [Abstract] [Full Text]

				L. Gilboa, A. Nohe, T. Geissendörfer, W. Sebald, Y. I. Henis, and P. Knaus Bone Morphogenetic Protein Receptor Complexes on the Surface of Live Cells: A New Oligomerization Mode for Serine/Threonine Kinase Receptors Mol. Biol. Cell, March 1, 2000; 11(3): 1023 - 1035. [Abstract] [Full Text]

				C. Miller, T. Schilling, K Lee, J Parker, and C. Kimmel sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development Development, January 9, 2000; 127(17): 3815 - 3828. [Abstract] [PDF]

				B Schmid, M Furthauer, S. Connors, J Trout, B Thisse, C Thisse, and M. Mullins Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation Development, January 3, 2000; 127(5): 957 - 967. [Abstract] [PDF]

				S. Baur, J. Mai, and S. Dymecki Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity Development, January 2, 2000; 127(3): 605 - 619. [Abstract] [PDF]

				S. Yi, A Daluiski, R Pederson, V Rosen, and K. Lyons The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb Development, January 2, 2000; 127(3): 621 - 630. [Abstract] [PDF]

				A. J. Davidson, J. H. Postlethwait, Y.-L. Yan, D. R. Beier, C. van Doren, D. Foernzler, A. J. Celeste, K. E. Crosier, and P. S. Crosier Isolation of Zebrafish gdf7 and Comparative Genetic Mapping of Genes Belonging to the Growth/Differentiation Factor 5, 6,�7�Subgroup of the TGF-beta Superfamily Genome Res., February 1, 1999; 9(2): 121 - 129. [Abstract] [Full Text]

				N. Tsumaki, K. Tanaka, E. Arikawa-Hirasawa, T. Nakase, T. Kimura, J. T. Thomas, T. Ochi, F. P. Luyten, and Y. Yamada Role of CDMP-1 in Skeletal Morphogenesis: Promotion of Mesenchymal Cell Recruitment and Chondrocyte Differentiation J. Cell Biol., January 11, 1999; 144(1): 161 - 173. [Abstract] [Full Text] [PDF]