An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression

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Chien, K. R., Zhu, H., Knowlton, K.U., Miller-Hance, W., van-Bilsen, M., O'Brien, T.X. and Evans, S. M (1993). Transcriptional regulation during cardiac growth and development. Annu. Rev. Physiol 55, 77-95.[Medline]

Cserjesi, P. and Olson, E. N (1991). Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products. Mol. Cell. Biol 11, 4854-4862.[Abstract/Free Full Text]

Donoghue, M. J., Merlie, J. P., Rosenthal, N. and Sanes, J. R (1991). Rostrocaudal gradient of transgene expression in adult skeletal muscle. Proc. Natl. Acad. Sci. USA 88, 5847-5851.[Abstract/Free Full Text]

Engler, P., Haasch, D., Pinkert, C. A., Doglio, L., Glymour, M., Brinster, R. and Storb, U (1991). A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci. Cell 65, 939-947.[Medline]

Evans, S. M., Tai, L. J., Tan, V. P., Newton, C. B. and Chien, K. R (1994). Heterokaryons of cardiac myocytes and fibroblasts reveal the lack of dominance of the cardiac muscle phenotype. Mol. Cell Biol 14, 4269-4279.[Abstract/Free Full Text]

Grieshammer, U., Sassoon, D. and Rosenthal, N (1992). A transgene target for positional regulators marks early rostrocaudal specification of myogenic lineages. Cell 69, 79-93.[Medline]

Henderson, S. A., Spencer, M., Sen, A., Kumar, C., Siddiqui, M. A. and Chien, K. R (1989). Structure, organization, and expression of the rat cardiac myosin light chain-2 gene. Identification of a 250-base pair fragment which confers cardiac-specific expression. J. Biol. Chem 264, 18142-18148.[Abstract/Free Full Text]

Hoyle, C., Brown, N. A. and Wolpert, L (1992). Development of left/right handedness in the chick heart. Development 115, 1071-1078.[Abstract]

Hunter, J. J., Tanaka, N., Rockman, H. A., Ross, Jr. and Chien, K. R (1995). Ventricular expression of a MLC-2v- Ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice. J. Biol. Chem 270, 23173-23178.[Abstract/Free Full Text]

Kelly, R., Alonso, S., Tajbakhsh, S., Cossu, G. and Buckingham, M (1995). Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in transgenic mice. J. Cell Biol 129, 383-396.[Abstract/Free Full Text]

Lee, K. J., Ross, R. S., Rockman, H. A., Harris, A. N., O'Brien, T. X., van Bilsen, M., Shubeita, H. E., Kandolf, R., Brem, G., Price, J. and Chien, K. R (1992). Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory. J. Biol. Chem 267, 15875-15885.[Abstract/Free Full Text]

Lee, K. J., Hickey, R., Zhu, H. and Chien, K. R (1994). Positive regulatory elements (HF-1a and HF-1b) and a novel negative regulatory element (HF-3) mediate ventricular muscle-specific expression of myosin light-chain 2-luciferase fusion genes in transgenic mice. Mol. Cell Biol 14, 1220-1229.[Abstract/Free Full Text]

Levin, M., Johnson, R. L., Stern, C. D., Kuehn, M. and Tabin, C (1995). A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell 82, 803-814.[Medline]

Lilly, B., Zhao, B., Ranganayakulu, G., Paterson, B. M., Schulz, R. A., and Olson, E. N (1995). Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila. Science 267, 688-93.[Abstract/Free Full Text]

Lyons, G. E., Schiaffino, S., Sassoon, D., Barton, P. and Buckingham, M (1990). Developmental regulation of myosin gene expression in mouse cardiac muscle. J. Cell Biol 111, 2427-2436.[Abstract/Free Full Text]

Lyons, I., Parsons, L. M., Hartley, L., Li, R., Andrews, J. E., Robb, L. and Harvey, R. P (1995). Myogenic and morphogenic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev 9, 1654-1666.[Abstract/Free Full Text]

Molkentin, J. D., Brogan, R. S., Jobe, S. M. and Markham, B. E (1993). Expression of the alpha-myosin heavy chain gene in the heart is regulated in part by an E-box-dependent mechanism. J. Biol. Chem 268, 2602-2609.[Abstract/Free Full Text]

Navankasattusas, S., Zhu, H., Garcia, A. V., Evans, S. M. and Chien, K. R (1992). A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression. Mol. Cell. Biol 12, 1469-1479.[Abstract/Free Full Text]

Navankasattusas, S., Sawadogo, M., van Bilsen, M., Dang, C. V. and Chien, K. R (1994). The basic helix-loop-helix protein upstream stimulating factor regulates the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements. Mol. Cell Biol 14, 7331-7339.[Abstract/Free Full Text]

Nordeen, S. K (1988). Luciferase reporter gene vectors for analysis of promoters and enhancers. BioTechniques 6, 454-457.[Medline]

O'Brien, T. X., Lee, K. J. and Chien, K. R (1993). Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube. Proc. Natl. Acad. Sci. USA 90, 5157-5161.[Abstract/Free Full Text]

Ozer, J., Faber, M., Chalkley, R. and Sealy, L (1990). Isolation and characterization of a cDNA clone for the CCAAT transcription factor EFIA reveals a novel structural motif. J. Biol. Chem 265, 22143-22152.[Abstract/Free Full Text]

Sanes, J. R., Rubenstein, J. L. and Nicolas, J. F (1986). Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. EMBO J 5, 3133-3142.[Medline]

Shubeita, H. E., Thorburn, J. and Chien, K. R (1992). Microinjection of antibodies and expression vectors into living myocardial cells. Development of a novel approach to identify candidate genes that regulate cardiac growth and hypertrophy. Circulation 85, 2236-2246.[Abstract/Free Full Text]

Sucov, H. M., Dyson, E., Gumeringer, C. L., Price, J., Chien, K. R. and Evans, R. M (1994). RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev 8, 1007-1018.[Abstract/Free Full Text]

Yang, J. T., Rayburn, H. and Hynes, R. O (1995). Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development 121, 549-560.[Abstract]

Yu, Y. T., Breitbart, R. E., Smoot, L. B., Lee, Y., Mahdavi, V. and Nadal-Ginard, B (1992). Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev 6, 1783-1798.[Abstract/Free Full Text]

Zeller, R., Bloch, K. D., Williams, B. S., Arceci, R. J. and Seidman, C. E (1987). Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis. Genes Dev 1, 693-698.[Abstract/Free Full Text]

Zhu, H., Garcia, A. V., Ross, R. S., Evans, S. M. and Chien, K. R (1991). A conserved 28-base-pair element (HF-1) in the rat cardiac myosin light-chain-2 gene confers cardiac-specific and alpha-adrenergic-inducible expression in cultured neonatal rat myocardial cells. Mol. Cell. Biol 11, 2273-2281.[Abstract/Free Full Text]

Zou, Y. and Chien, K. R (1995). EFIA/YB-1 is a component of cardiac HF-1A binding activity and positively regulates transcription of the myosin light-chain 2v gene. Mol. Cell Biol 15, 2972-2982.[Abstract]

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				S. Zaffran, R. G. Kelly, S. M. Meilhac, M. E. Buckingham, and N. A. Brown Right Ventricular Myocardium Derives From the Anterior Heart Field Circ. Res., August 6, 2004; 95(3): 261 - 268. [Abstract] [Full Text] [PDF]

				K. Togi, T. Kawamoto, R. Yamauchi, Y. Yoshida, T. Kita, and M. Tanaka Role of Hand1/eHAND in the Dorso-Ventral Patterning and Interventricular Septum Formation in the Embryonic Heart Mol. Cell. Biol., June 1, 2004; 24(11): 4627 - 4635. [Abstract] [Full Text] [PDF]

				J. K. Takeuchi, M. Ohgi, K. Koshiba-Takeuchi, H. Shiratori, I. Sakaki, K. Ogura, Y. Saijoh, and T. Ogura Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis Development, December 15, 2003; 130(24): 5953 - 5964. [Abstract] [Full Text] [PDF]

				A. F. M. MOORMAN and V. M. CHRISTOFFELS Cardiac Chamber Formation: Development, Genes, and Evolution Physiol Rev, October 1, 2003; 83(4): 1223 - 1267. [Abstract] [Full Text] [PDF]

				P. E.M.H. Habets, A. F.M. Moorman, and V. M. Christoffels Regulatory modules in the developing heart Cardiovasc Res, May 1, 2003; 58(2): 246 - 263. [Abstract] [Full Text] [PDF]

				P. E.M.H. Habets, A. F.M. Moorman, D. E.W. Clout, M. A. van Roon, M. Lingbeek, M. van Lohuizen, M. Campione, and V. M. Christoffels Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation Genes & Dev., May 15, 2002; 16(10): 1234 - 1246. [Abstract] [Full Text] [PDF]

				E.M. SMALL and P.A. KRIEG Molecular Mechanisms of Chamber-specific Myocardial Gene Expression: Transgenic Analysis of the ANF Promoter Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 71 - 80. [Abstract] [PDF]

				Q. Zhou, P.-H. Chu, C. Huang, C.-F. Cheng, M. E. Martone, G. Knoll, G. D. Shelton, S. Evans, and J. Chen Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy J. Cell Biol., November 12, 2001; 155(4): 605 - 612. [Abstract] [Full Text] [PDF]

				Z. A. Quinn, C.-C. Yang, J. L. Wrana, and J. C. McDermott Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins Nucleic Acids Res., February 1, 2001; 29(3): 732 - 742. [Abstract] [Full Text] [PDF]

				Q. He, D. Wang, X.-P. Yang, O. A. Carretero, and M. C. LaPointe Inducible regulation of human brain natriuretic peptide promoter in transgenic mice Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H368 - H376. [Abstract] [Full Text] [PDF]

				T. Tsukui, J. Capdevila, K. Tamura, P. Ruiz-Lozano, C. Rodriguez-Esteban, S. Yonei-Tamura, J. Magallon, R. A. S. Chandraratna, K. Chien, B. Blumberg, et al. Multiple left-right asymmetry defects in Shh-/- mutant mice unveil a convergence of the Shh and retinoic acid pathways in the control of Lefty-1 PNAS, September 28, 1999; 96(20): 11376 - 11381. [Abstract] [Full Text] [PDF]

				Q. Qian, L. Kuo, Y.-T. Yu, and J. N. Rottman A Concise Promoter Region of the Heart Fatty Acid�Binding Protein Gene Dictates Tissue-Appropriate Expression Circ. Res., February 19, 1999; 84(3): 276 - 289. [Abstract] [Full Text] [PDF]

				H Kuo, J Chen, P Ruiz-Lozano, Y Zou, M Nemer, and K. Chien Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis Development, January 10, 1999; 126(19): 4223 - 4234. [Abstract] [PDF]

				J Xavier-Neto, C. Neville, M. Shapiro, L Houghton, G. Wang, W Nikovits, F. Stockdale, and N Rosenthal A retinoic acid-inducible transgenic marker of sino-atrial development in the mouse heart Development, January 6, 1999; 126(12): 2677 - 2687. [Abstract] [PDF]

				F. Naya, C Wu, J. Richardson, P Overbeek, and E. Olson Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene Development, January 5, 1999; 126(10): 2045 - 2052. [Abstract] [PDF]

				M Tanaka, S. Wechsler, I. Lee, N Yamasaki, J. Lawitts, and S Izumo Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5 Development, January 4, 1999; 126(7): 1439 - 1450. [Abstract] [PDF]

				J. Reecy, X Li, M Yamada, F. DeMayo, C. Newman, R. Harvey, and R. Schwartz Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5 Development, January 2, 1999; 126(4): 839 - 849. [Abstract] [PDF]

				C. Lien, C Wu, B Mercer, R Webb, J. Richardson, and E. Olson Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer Development, January 1, 1999; 126(1): 75 - 84. [Abstract] [PDF]

				G. F. Wang, W. Nikovits Jr., M. Schleinitz, and F. E. Stockdale A Positive GATA Element and a Negative Vitamin D Receptor-Like Element Control Atrial Chamber-Specific Expression of a Slow Myosin Heavy-Chain Gene during Cardiac Morphogenesis Mol. Cell. Biol., October 1, 1998; 18(10): 6023 - 6034. [Abstract] [Full Text]

				R. Di Lisi, C. Millino, E. Calabria, F. Altruda, S. Schiaffino, and S. Ausoni Combinatorial cis-Acting Elements Control Tissue-specific Activation of the Cardiac Troponin I Gene in Vitro and in Vivo J. Biol. Chem., September 25, 1998; 273(39): 25371 - 25380. [Abstract] [Full Text] [PDF]

				D. J. Henderson and A. J. Copp Versican Expression Is Associated With Chamber Specification, Septation, and Valvulogenesis in the Developing Mouse Heart Circ. Res., September 7, 1998; 83(5): 523 - 532. [Abstract] [Full Text] [PDF]

				Y. Lee, T. Shioi, H. Kasahara, S. M. Jobe, R. J. Wiese, B. E. Markham, and S. Izumo The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression Mol. Cell. Biol., June 1, 1998; 18(6): 3120 - 3129. [Abstract] [Full Text]

				P. A. Doevendans, P. Ruiz-Lozano, and M. van Bilsen Hunting down nucleic acid binding factors in the cardiovascular system Cardiovasc Res, May 1, 1998; 38(2): 301 - 315. [Abstract] [Full Text] [PDF]

				D. Franco, W. H Lamers, and A. F.M Moorman Patterns of expression in the developing myocardium: towards a morphologically integrated transcriptional model Cardiovasc Res, April 1, 1998; 38(1): 25 - 53. [Full Text] [PDF]

				T. Scheller, A. Kraev, S. Skinner, and E. Carafoli Cloning of the Multipartite Promoter of the Sodium-Calcium Exchanger Gene NCX1 and Characterization of Its Activity in Vascular Smooth Muscle Cells J. Biol. Chem., March 27, 1998; 273(13): 7643 - 7649. [Abstract] [Full Text] [PDF]

				R. Searcy, E. Vincent, C. Liberatore, and K. Yutzey A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice Development, January 11, 1998; 125(22): 4461 - 4470. [Abstract] [PDF]

				J. Chen, S. W. Kubalak, S. Minamisawa, R. L. Price, K. D. Becker, R. Hickey, J. Ross Jr., and K. R. Chien Selective Requirement of Myosin Light Chain 2v in Embryonic Heart Function J. Biol. Chem., January 9, 1998; 273(2): 1252 - 1256. [Abstract] [Full Text] [PDF]

				J Chen, S. Kubalak, and K. Chien Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis Development, January 5, 1998; 125(10): 1943 - 1949. [Abstract] [PDF]

				C. Tran and H. Sucov The RXRalpha gene functions in a non-cell-autonomous manner during mouse cardiac morphogenesis Development, January 5, 1998; 125(10): 1951 - 1956. [Abstract] [PDF]

				C.-Z. He and J. B.�E. Burch The Chicken GATA-6 Locus Contains Multiple Control Regions That Confer Distinct Patterns of Heart Region-specific Expression in Transgenic Mouse Embryos J. Biol. Chem., November 7, 1997; 272(45): 28550 - 28556. [Abstract] [Full Text] [PDF]