The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Sun, X.
	Articles by Artavanis-Tsakonas, S.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Sun, X.
	Articles by Artavanis-Tsakonas, S.

Artavanis-Tsakonas, S., Matsuno, K. and Fortini, M. E (1995). Notch signaling. Science 268, 225-232.[Abstract/Free Full Text]

Baker, N. E. and Zitron, A (1995). Drosophila eye development: Notch and Delta amplify a neurogenic pattern conferred on the morphogenetic furrow by scabrous. Mech. Dev 49, 173-189.[Medline]

Banerjee, U., Renfranz, P. J., Pollock, J. A. and Benzer, S (1987). Molecular characterization and expression of sevenless , a gene involved in neuronal pattern formation in the Drosophila eye. Cell 49, 281-291.[Medline]

Bang, A. G., Hartenstein, V. and Posakony, J. W (1991). Hairless is required for the development of adult sensory organ precursor cells in Drosophila. Development 111, 89-104.[Abstract]

Bang, A. G. and Posakony, J. W (1992). The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development. Genes Dev 6, 1752-1769.[Abstract/Free Full Text]

Basler, K., Siegrist, P. and Hafen, E (1989). The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements. EMBO J 8, 2381-2386.[Medline]

Bowtell, D. D. L., Kimmel, B. E., Simon, M. A. and Rubin, G. M (1989). Regulation of the complex pattern of sevenless expression in the developing Drosophila eye. Proc. Natl. Acad. Sci. USA 86, 6245-6249.[Abstract/Free Full Text]

Bowtell, D. D. L., Lila, T., Michael, W. M., Hackett, D. and Rubin, G. M (1991). Analysis of the enhancer element that controls expression of sevenless in the developing Drosophila eye. Proc. Natl. Acad. Sci. USA 88, 6853-6857.[Abstract/Free Full Text]

Brou, C., Logeat, F., Lecourtois, M., Vandekerckhove, J., Kourilsky, P., Schweisguth, F. and Isra\221l, A (1994). Inhibition of the DNA-binding activity of DrosophilaSuppresser of Hairless and of its human homolog, KBF2/RBP-Jk, by direct protein-protein interaction with Drosophila Hairless. Genes Dev 8, 2491-2503.[Abstract/Free Full Text]

Cagan, R. L. and Ready, D. F (1989). Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev 3, 1099-1112.[Abstract/Free Full Text]

Carthew, R. W. and Rubin, G. M (1990). seven in absentia , a gene required for specification of R7 cell fate in the Drosophila eye. Cell 63, 561-577.[Medline]

Chitnis, A., Henrique, D., Lewis, J., Ish-Horowicz, D. and Kintner, C (1995). Primary neurogenesis in Xenopus embryos regulated by a homolog of the Drosophila neurogenic gene Delta. Nature 375, 761-766.[Medline]

Coffman, C. R., Skoglund, P., Harris, W. A. and Kintner, C. R (1993). Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Cell 73, 659-671.[Medline]

Fehon, R. G., Johansen, K., Rebay, I. and Artavanis-Tsakonas, S (1991). Complex cellular and subcellular regulation of Notch expression during embryonic and imaginal development of Drosophila : implications for Notch function. J. Cell Biol 113, 657-669.[Abstract/Free Full Text]

Fehon, R. G., Kooh, P. J., Rebay, I., Regan, C. L., Xu, T., Muskavitch, M. A. and Artavanis-Tsakonas, S (1990). Molecular interactions between the protein products of the neurogenic loci Notch and Delta , two EGF-homologous genes in Drosophila. Cell 61, 523-534.[Medline]

Fitzgerald, K. and Greenwald, I (1995). Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo. Development 121, 4275-4282.[Abstract]

Fleming, R. J., Scottgale, T. M., Diederich, R. J. and Artavanis-Tsakonas, S (1990). The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev 4, 2188-2201.[Abstract/Free Full Text]

Fortini, M. E., Simon, M. A. and Rubin, G. M (1992). Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature 336, 559-561.

Fortini, M. E., Rebay, I., Caron, L. A. and Artavanis-Tsakonas, S (1993). An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature 365, 555-557.[Medline]

Gaul, U., Mardon, G. and Rubin, G. M (1992). A putative Ras GTPase activating protein acts as a negative regulator of signalling by the sevenless receptor tyrosine kinase. Cell 68, 1007-1019.[Medline]

Gu, Y., Hukriede, N. A. and Fleming, R. J (1995). Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo. Development 121, 855-865.[Abstract]

Henderson, S. T., Gao, D., Lambie, E. J. and Kimble, J (1994). lag-2 may encode a signaling ligand for the Glp-1 and Lin-12 receptors of C. elegans. Development 120, 2913-2924.[Abstract]

Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J. and Ish-Horowicz, D (1995). Expression of a Delta homolog in prospective neurons in the chick. Nature 375, 787-790.[Medline]

Higashijima, S., Kojima, T., Michiue, T., Ishimaru, S., Emori, Y. and Saigo, K (1992). Dual Bar homeo box genes of Drosophila required in two photoreceptor cells, R1 and R6, and primary pigment cells for normal eye development. Genes Dev 6, 50-60.[Abstract/Free Full Text]

Jennings, B., Preiss, A., Delidakis, C. and Bray, S (1994). The Notch signaling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development 120, 3537-3548.[Abstract]

Jennings, B., de Celis, J., Delidakis, C., Preiss, A. and Bray, S (1995). Role of Notch and achaete-scute complex in the expression of Enhancer of split bHLH proteins. Development 121, 3745-3752.[Abstract]

Kimmel, B. E., Heberlein, U. and Rubin, G. M (1990). The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. Genes Dev 4, 712-727.[Abstract/Free Full Text]

Kooh, P. J., Fehon R. G. and Muskavitch, M. A. T (1993). Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development. Development 117, 493-507.[Abstract]

Kopczynski, C. C., Alton, A. K., Fechtel, K., Kooh, P. H. and Muskavitch, M. A (1988). Delta , a Drosophila neurogenic gene, is transcriptionallycomplex and encodes a protein related to blood coagulation factors and epidermal growth factors of vertebrates. Genes Dev 2, 1723-1735.[Abstract/Free Full Text]

Kreis, T. E (1986). Microinjected antibodies against the cytoplasmic domain of vesicular stomatitis virus glycoprotein block its transport to the cell surface. EMBO J 5, 931-941.[Medline]

Lindsell, C. E., Shawber, C. J., Boulter, J. and Weinmaster, G (1995). Jagged: a mammalian ligand that activates Notch1. Cell 80, 909-917.[Medline]

Matsuno, K., Diederich, R. J., Go, M. J., Blaumueller, C. M. and Artavanis-Tsakonas (1995). Deltex acts as a positive regulator of Notch signalling through interactions with the Notch ankyrin repeats. Development 121, 2633-2644.[Abstract]

Mello, C. C., Draper, B. W. and Priess, J. R (1994). The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo. Cell 77, 95-106.[Medline]

Moffat, K. G., Gould, J. H., Smith, H. K. and O'Kane, C. J (1992). Inducible cell ablation in Drosophila by cold-sensitive ricin A chain. Development 114, 681-687.[Abstract]

Muskavitch, M. A. T (1994). Delta-Notch signaling and Drosophila cell fate choice. Dev. Biol 166, 415-430.[Medline]

O'Toole, T. E., Katagiri, Y., Faull, R. J., Peter, K., Tamura, R., Quaranta, V., Loftus, J. D., Shattil, S. J. and Ginsburg, M. H (1994). Integrin cytoplasmic domains mediate inside-out signal transduction. J. Cell Biol 124, 1047-1059.[Abstract/Free Full Text]

Parks, A. L., Turner, F. R. and Muskavitch, M. A. T (1995). Relationships between complex Delta expression and the specification of retinal cell fates during Drosophila eye development. Mech. Dev 50, 201-216.[Medline]

Rabinow, L. and Birchler, J. A (1990). Interactions of vestigial and scabrous with the Notch locus of Drosophila melanogaste r. Genetics 125, 41-50.[Abstract]

Rebay, I., Fehon, R. G. and Artavanis-Tsakonas, S (1993). Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell 74, 319-329.[Medline]

Rebay, I., Fleming, R. J., Fehon, R. G., Cherbas, L., Cherbas, P. and Artavanis-Tsakonas, S (1991). Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 67, 687-699.[Medline]

Struhl, G., Fitzgerald, K. and Greenwald, I (1993). Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74, 331-345.[Medline]

Tata, F. and Hartley, D. A (1995). Inhibition of cell fate in Drosophila by Enhancer of split genes. Mech. Dev 51, 305-315.[Medline]

Tax, F. E., Yeargers, J. J. and Thomas, J. H (1994). Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila. Nature 368, 150-154.[Medline]

Thomas, U., Speicher, S. A. and Knust, E (1991). The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs. Development 111, 749-761.[Abstract]

Tomlinson, A., Bowtell, D. D. L., Hafen, E. and Rubin, G. M (1987). Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila. Cell 51, 143-150.[Medline]

V\212ssin, H., Bremer, K. A., Knust, E. and Campos-Ortega, J. A (1987). The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats. EMBO J 6, 3433-3440.

Wharton, K. A., Johansen, K. M., Xu, T. and Artavanis-Tsakonas, S (1985). Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43, 567-581.[Medline]

Wilkinson, H., Fizgerald, K. and Greenwald, I (1994). Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Cell 79, 1187-1198.[Medline]

Xu, T. and Rubin, G. M (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.[Abstract]

Zabin, I (1982). -Galactosidase -complementation: a model of protein-protein interaction. Mol. Cell. Biochem 49, 87-96.[Medline]

Zervos, A. S., Gyuris, J. and Brent, R (1993). Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell 72, 223-232.[Medline]

Zipursky, S. L. and Rubin, G. M (1994). Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Annu. Rev. Neurosci 17, 373-397.[Medline]

This article has been cited by other articles:

U.-M. Fiuza and A. M. Arias
Cell and molecular biology of Notch
J. Endocrinol., September 1, 2007; 194(3): 459 - 474.
[Abstract] [Full Text] [PDF]

M. Nagao, M. Sugimori, and M. Nakafuku
Cross Talk between Notch and Growth Factor/Cytokine Signaling Pathways in Neural Stem Cells
Mol. Cell. Biol., June 1, 2007; 27(11): 3982 - 3994.
[Abstract] [Full Text] [PDF]

M. Grammont
Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis
J. Cell Biol., April 9, 2007; 177(1): 139 - 150.
[Abstract] [Full Text] [PDF]

M. Hiratochi, H. Nagase, Y. Kuramochi, C.-S. Koh, T. Ohkawara, and K. Nakayama
The Delta intracellular domain mediates TGF-{beta}/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway
Nucleic Acids Res., February 16, 2007; 35(3): 912 - 922.
[Abstract] [Full Text] [PDF]

A. L. Parks, J. R. Stout, S. B. Shepard, K. M. Klueg, A. A. Dos Santos, T. R. Parody, M. Vaskova, and M. A. T. Muskavitch
Structure-Function Analysis of Delta Trafficking, Receptor Binding and Signaling in Drosophila
Genetics, December 1, 2006; 174(4): 1947 - 1961.
[Abstract] [Full Text] [PDF]

E. Rottinger, J. Croce, G. Lhomond, L. Besnardeau, C. Gache, and T. Lepage
Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo
Development, November 1, 2006; 133(21): 4341 - 4353.
[Abstract] [Full Text] [PDF]

C. Hudson and H. Yasuo
A signalling relay involving Nodal and Delta ligands acts during secondary notochord induction in Ciona embryos
Development, August 1, 2006; 133(15): 2855 - 2864.
[Abstract] [Full Text] [PDF]

E. Mizuhara, T. Nakatani, Y. Minaki, Y. Sakamoto, Y. Ono, and Y. Takai
MAGI1 Recruits Dll1 to Cadherin-based Adherens Junctions and Stabilizes It on the Cell Surface
J. Biol. Chem., July 15, 2005; 280(28): 26499 - 26507.
[Abstract] [Full Text] [PDF]

E. C. Lai, F. Roegiers, X. Qin, Y. N. Jan, and G. M. Rubin
The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
Development, May 15, 2005; 132(10): 2319 - 2332.
[Abstract] [Full Text] [PDF]

R. Le Borgne, A. Bardin, and F. Schweisguth
The roles of receptor and ligand endocytosis in regulating Notch signaling
Development, April 15, 2005; 132(8): 1751 - 1762.
[Abstract] [Full Text] [PDF]

E. M. Six, D. Ndiaye, G. Sauer, Y. Laabi, R. Athman, A. Cumano, C. Brou, A. Israel, and F. Logeat
The Notch Ligand Delta1 Recruits Dlg1 at Cell-Cell Contacts and Regulates Cell Migration
J. Biol. Chem., December 31, 2004; 279(53): 55818 - 55826.
[Abstract] [Full Text] [PDF]

X. Tian, D. Hansen, T. Schedl, and J. B. Skeath
Epsin potentiates Notch pathway activity in Drosophila and C. elegans
Development, December 1, 2004; 131(23): 5807 - 5815.
[Abstract] [Full Text] [PDF]

G. J. Wright, J. D. Leslie, L. Ariza-McNaughton, and J. Lewis
Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development
Development, November 15, 2004; 131(22): 5659 - 5669.
[Abstract] [Full Text] [PDF]

E. Overstreet, E. Fitch, and J. A. Fischer
Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells
Development, November 1, 2004; 131(21): 5355 - 5366.
[Abstract] [Full Text] [PDF]

W. Wang and G. Struhl
Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch
Development, November 1, 2004; 131(21): 5367 - 5380.
[Abstract] [Full Text] [PDF]

R. Trifonova, D. Small, D. Kacer, D. Kovalenko, V. Kolev, A. Mandinova, R. Soldi, L. Liaw, I. Prudovsky, and T. Maciag
The non-transmembrane form of Delta1 but not of jagged1 Induces normal migratory behavior accompanied by FGF receptor 1-dependent transformation
J. Biol. Chem., February 9, 2004; (2004) 300564200.
[Abstract] [PDF]

Y. Li, L. Li, K. D. Irvine, and N. E. Baker
Notch activity in neural cells triggered by a mutant allele with altered glycosylation
Development, July 1, 2003; 130(13): 2829 - 2840.
[Abstract] [Full Text] [PDF]

C. E. Bland, P. Kimberly, and M. D. Rand
Notch-induced Proteolysis and Nuclear Localization of the Delta Ligand
J. Biol. Chem., April 11, 2003; 278(16): 13607 - 13610.
[Abstract] [Full Text] [PDF]

J. M. Ascano, L. J. Beverly, and A. J. Capobianco
The C-terminal PDZ-Ligand of JAGGED1 Is Essential for Cellular Transformation
J. Biol. Chem., February 28, 2003; 278(10): 8771 - 8779.
[Abstract] [Full Text] [PDF]

K. Mishra-Gorur, M. D. Rand, B. Perez-Villamil, and S. Artavanis-Tsakonas
Down-regulation of Delta by proteolytic processing
J. Cell Biol., October 28, 2002; 159(2): 313 - 324.
[Abstract] [Full Text] [PDF]

J. J. Chern and K.-W. Choi
Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc
Development, September 1, 2002; 129(17): 4005 - 4013.
[Abstract] [Full Text] [PDF]

K. Sakamoto, S. Yamaguchi, R. Ando, A. Miyawaki, Y. Kabasawa, M. Takagi, C. L. Li, B. Perbal, and K.-i. Katsube
The Nephroblastoma Overexpressed Gene (NOV/ccn3) Protein Associates with Notch1 Extracellular Domain and Inhibits Myoblast Differentiation via Notch Signaling Pathway
J. Biol. Chem., August 9, 2002; 277(33): 29399 - 29405.
[Abstract] [Full Text] [PDF]

S. S. Nijjar, L. Wallace, H. A. Crosby, S. G. Hubscher, and A. J. Strain
Altered Notch Ligand Expression in Human Liver Disease : Further Evidence for a Role of the Notch Signaling Pathway in Hepatic Neovascularization and Biliary Ductular Defects
Am. J. Pathol., May 1, 2002; 160(5): 1695 - 1703.
[Abstract] [Full Text] [PDF]

A. Baonza and M. Freeman
Notch signalling and the initiation of neural development in the Drosophila eye
Development, October 15, 2001; 128(20): 3889 - 3898.
[Abstract] [Full Text] [PDF]

J. J.D. Morrissette, R. P. Colliton, and N. B. Spinner
Defective intracellular transport and processing of JAG1 missense mutations in Alagille syndrome
Hum. Mol. Genet., February 1, 2001; 10(4): 405 - 413.
[Abstract] [Full Text] [PDF]

A. Parks, K. Klueg, J. Stout, and M. Muskavitch
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
Development, January 4, 2000; 127(7): 1373 - 1385.
[Abstract] [PDF]

V. Papayannopoulos, A. Tomlinson, V. M. Panin, C. Rauskolb, and K. D. Irvine
Dorsal-Ventral Signaling in the Drosophila Eye
Science, September 25, 1998; 281(5385): 2031 - 2034.
[Abstract] [Full Text]

K. M. Klueg, T. R. Parody, and M. A.T. Muskavitch
Complex Proteolytic Processing Acts on Delta, a Transmembrane Ligand for Notch, during Drosophila Development
Mol. Biol. Cell, July 1, 1998; 9(7): 1709 - 1723.
[Abstract] [Full Text]

P Ligoxygakis, S. Yu, C Delidakis, and N. Baker
A subset of notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex
Development, January 8, 1998; 125(15): 2893 - 2900.
[Abstract] [PDF]

E. Sevrioukov, J. Walenta, A Sunio, M Phistry, and H Kramer
Oligomerization of the extracellular domain of Boss enhances its binding to the Sevenless receptor and its antagonistic effect on R7 induction
J. Cell Sci., January 3, 1998; 111(6): 737 - 747.
[Abstract] [PDF]

C Haddon, L Smithers, S Schneider-Maunoury, T Coche, D Henrique, and J Lewis
Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis
Development, January 2, 1998; 125(3): 359 - 370.
[Abstract] [PDF]

K Matsuno, M. Go, X Sun, D. Eastman, and S Artavanis-Tsakonas
Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements
Development, January 11, 1997; 124(21): 4265 - 4273.
[Abstract] [PDF]

N. Hukriede, Y Gu, and R. Fleming
A dominant-negative form of Serrate acts as a general antagonist of Notch activation
Development, January 9, 1997; 124(17): 3427 - 3437.
[Abstract] [PDF]

X Sun and S Artavanis-Tsakonas
Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila
Development, January 9, 1997; 124(17): 3439 - 3448.
[Abstract] [PDF]

C. Micchelli, E. Rulifson, and S. Blair
The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate
Development, January 4, 1997; 124(8): 1485 - 1495.
[Abstract] [PDF]

W. Jen, D Wettstein, D Turner, A Chitnis, and C Kintner
The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos
Development, January 3, 1997; 124(6): 1169 - 1178.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Sun, X.

Articles by Artavanis-Tsakonas, S.

Search for Related Content

PubMed

PubMed Citation

Articles by Sun, X.

Articles by Artavanis-Tsakonas, S.

				M. Nagao, M. Sugimori, and M. Nakafuku Cross Talk between Notch and Growth Factor/Cytokine Signaling Pathways in Neural Stem Cells Mol. Cell. Biol., June 1, 2007; 27(11): 3982 - 3994. [Abstract] [Full Text] [PDF]

				M. Grammont Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis J. Cell Biol., April 9, 2007; 177(1): 139 - 150. [Abstract] [Full Text] [PDF]

				M. Hiratochi, H. Nagase, Y. Kuramochi, C.-S. Koh, T. Ohkawara, and K. Nakayama The Delta intracellular domain mediates TGF-{beta}/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway Nucleic Acids Res., February 16, 2007; 35(3): 912 - 922. [Abstract] [Full Text] [PDF]

				A. L. Parks, J. R. Stout, S. B. Shepard, K. M. Klueg, A. A. Dos Santos, T. R. Parody, M. Vaskova, and M. A. T. Muskavitch Structure-Function Analysis of Delta Trafficking, Receptor Binding and Signaling in Drosophila Genetics, December 1, 2006; 174(4): 1947 - 1961. [Abstract] [Full Text] [PDF]

				E. Rottinger, J. Croce, G. Lhomond, L. Besnardeau, C. Gache, and T. Lepage Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo Development, November 1, 2006; 133(21): 4341 - 4353. [Abstract] [Full Text] [PDF]

				C. Hudson and H. Yasuo A signalling relay involving Nodal and Delta ligands acts during secondary notochord induction in Ciona embryos Development, August 1, 2006; 133(15): 2855 - 2864. [Abstract] [Full Text] [PDF]

				E. Mizuhara, T. Nakatani, Y. Minaki, Y. Sakamoto, Y. Ono, and Y. Takai MAGI1 Recruits Dll1 to Cadherin-based Adherens Junctions and Stabilizes It on the Cell Surface J. Biol. Chem., July 15, 2005; 280(28): 26499 - 26507. [Abstract] [Full Text] [PDF]

				E. C. Lai, F. Roegiers, X. Qin, Y. N. Jan, and G. M. Rubin The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta Development, May 15, 2005; 132(10): 2319 - 2332. [Abstract] [Full Text] [PDF]

				R. Le Borgne, A. Bardin, and F. Schweisguth The roles of receptor and ligand endocytosis in regulating Notch signaling Development, April 15, 2005; 132(8): 1751 - 1762. [Abstract] [Full Text] [PDF]

				E. M. Six, D. Ndiaye, G. Sauer, Y. Laabi, R. Athman, A. Cumano, C. Brou, A. Israel, and F. Logeat The Notch Ligand Delta1 Recruits Dlg1 at Cell-Cell Contacts and Regulates Cell Migration J. Biol. Chem., December 31, 2004; 279(53): 55818 - 55826. [Abstract] [Full Text] [PDF]

				X. Tian, D. Hansen, T. Schedl, and J. B. Skeath Epsin potentiates Notch pathway activity in Drosophila and C. elegans Development, December 1, 2004; 131(23): 5807 - 5815. [Abstract] [Full Text] [PDF]

				G. J. Wright, J. D. Leslie, L. Ariza-McNaughton, and J. Lewis Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development Development, November 15, 2004; 131(22): 5659 - 5669. [Abstract] [Full Text] [PDF]

				E. Overstreet, E. Fitch, and J. A. Fischer Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells Development, November 1, 2004; 131(21): 5355 - 5366. [Abstract] [Full Text] [PDF]

				W. Wang and G. Struhl Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch Development, November 1, 2004; 131(21): 5367 - 5380. [Abstract] [Full Text] [PDF]

				R. Trifonova, D. Small, D. Kacer, D. Kovalenko, V. Kolev, A. Mandinova, R. Soldi, L. Liaw, I. Prudovsky, and T. Maciag The non-transmembrane form of Delta1 but not of jagged1 Induces normal migratory behavior accompanied by FGF receptor 1-dependent transformation J. Biol. Chem., February 9, 2004; (2004) 300564200. [Abstract] [PDF]

				Y. Li, L. Li, K. D. Irvine, and N. E. Baker Notch activity in neural cells triggered by a mutant allele with altered glycosylation Development, July 1, 2003; 130(13): 2829 - 2840. [Abstract] [Full Text] [PDF]

				C. E. Bland, P. Kimberly, and M. D. Rand Notch-induced Proteolysis and Nuclear Localization of the Delta Ligand J. Biol. Chem., April 11, 2003; 278(16): 13607 - 13610. [Abstract] [Full Text] [PDF]

				J. M. Ascano, L. J. Beverly, and A. J. Capobianco The C-terminal PDZ-Ligand of JAGGED1 Is Essential for Cellular Transformation J. Biol. Chem., February 28, 2003; 278(10): 8771 - 8779. [Abstract] [Full Text] [PDF]

				K. Mishra-Gorur, M. D. Rand, B. Perez-Villamil, and S. Artavanis-Tsakonas Down-regulation of Delta by proteolytic processing J. Cell Biol., October 28, 2002; 159(2): 313 - 324. [Abstract] [Full Text] [PDF]

				J. J. Chern and K.-W. Choi Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc Development, September 1, 2002; 129(17): 4005 - 4013. [Abstract] [Full Text] [PDF]

				K. Sakamoto, S. Yamaguchi, R. Ando, A. Miyawaki, Y. Kabasawa, M. Takagi, C. L. Li, B. Perbal, and K.-i. Katsube The Nephroblastoma Overexpressed Gene (NOV/ccn3) Protein Associates with Notch1 Extracellular Domain and Inhibits Myoblast Differentiation via Notch Signaling Pathway J. Biol. Chem., August 9, 2002; 277(33): 29399 - 29405. [Abstract] [Full Text] [PDF]

				S. S. Nijjar, L. Wallace, H. A. Crosby, S. G. Hubscher, and A. J. Strain Altered Notch Ligand Expression in Human Liver Disease : Further Evidence for a Role of the Notch Signaling Pathway in Hepatic Neovascularization and Biliary Ductular Defects Am. J. Pathol., May 1, 2002; 160(5): 1695 - 1703. [Abstract] [Full Text] [PDF]

				A. Baonza and M. Freeman Notch signalling and the initiation of neural development in the Drosophila eye Development, October 15, 2001; 128(20): 3889 - 3898. [Abstract] [Full Text] [PDF]

				J. J.D. Morrissette, R. P. Colliton, and N. B. Spinner Defective intracellular transport and processing of JAG1 missense mutations in Alagille syndrome Hum. Mol. Genet., February 1, 2001; 10(4): 405 - 413. [Abstract] [Full Text] [PDF]

				A. Parks, K. Klueg, J. Stout, and M. Muskavitch Ligand endocytosis drives receptor dissociation and activation in the Notch pathway Development, January 4, 2000; 127(7): 1373 - 1385. [Abstract] [PDF]

				V. Papayannopoulos, A. Tomlinson, V. M. Panin, C. Rauskolb, and K. D. Irvine Dorsal-Ventral Signaling in the Drosophila Eye Science, September 25, 1998; 281(5385): 2031 - 2034. [Abstract] [Full Text]

				K. M. Klueg, T. R. Parody, and M. A.T. Muskavitch Complex Proteolytic Processing Acts on Delta, a Transmembrane Ligand for Notch, during Drosophila Development Mol. Biol. Cell, July 1, 1998; 9(7): 1709 - 1723. [Abstract] [Full Text]

				P Ligoxygakis, S. Yu, C Delidakis, and N. Baker A subset of notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex Development, January 8, 1998; 125(15): 2893 - 2900. [Abstract] [PDF]

				E. Sevrioukov, J. Walenta, A Sunio, M Phistry, and H Kramer Oligomerization of the extracellular domain of Boss enhances its binding to the Sevenless receptor and its antagonistic effect on R7 induction J. Cell Sci., January 3, 1998; 111(6): 737 - 747. [Abstract] [PDF]

				C Haddon, L Smithers, S Schneider-Maunoury, T Coche, D Henrique, and J Lewis Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis Development, January 2, 1998; 125(3): 359 - 370. [Abstract] [PDF]