Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic mice

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Ang, S. L. and Rossant, J (1994). HNF-3 beta is essential for node and notochord formation in mouse development. Cell 78, 561-74.[Medline]

Asano, M. and Gruss, P (1992). Pax5 is expressed at the midbrain-hindbrain boundary during mouse development. Mech. Dev 39, 29-39.[Medline]

Auerbach, R (1954). Analysis of the developmental effects of a lethal mutation in the house mouse. J. Exp. Zool 127, 305-329.

Beddington, R. S. P (1994). Induction of a second neural axis by the mouse node. Development 120, 613-620.[Abstract]

Bober, E., Franz, T., Arnold, H. H., Gruss, P. and Tremblay, P (1994). Pax3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development 120, 603-612.[Abstract]

Bovolenta, P. and Dodd, J (1991). Perturbation of neuronal differentiation and axon guidance in the spinal cord of mouse embryos lacking a floor plate: analysis of Danforth\307s short-tail mutation. Development 113, 625-639.[Abstract]

Cohen, M. M (1982). An update on the holoprosencephalic disorders. J. Pediatr 101, 865-869.[Medline]

Dickinson, M. E., Krumlauf, R. and McMahon, A. P (1994). Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development 120, 1453-1471.[Abstract]

Dickinson, M. E., Selleck, M. A. J., McMahon, A. P. and Bronner-Fraser, M (1995). Dorsalization of the neural tube by the non-neural ectoderm. Development 121, 2099-2106.[Abstract]

Dietrich, S., Schubert, F. R. and Gruss, P (1993). Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite. Mech. Dev 44, 189-207.[Medline]

Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., Mc Mahon, J. A. and Mc Mahon, A (1993). Sonic hedgehog , a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.[Medline]

Epstein, D. J., Vogan, K. J., Trasler, D. G. and Gros, P (1993). A mutation within the intron 3 of Pax3 gene produced aberrantly spliced mRNA transcripts in the Splotch ( Sp ) mutant. Proc. Natl. Acad. Sci. USA 90, 532-536.[Abstract/Free Full Text]

Franz, T (1989). Persistent truncus arteriosus in the Splotch mutant mouse. Anat. Embryol 180, 457-464.[Medline]

Franz, T (1990). Defective ensheathment of motoric nerves in the Splotch mutant mouse. Acta Anat 138, 246-253.[Medline]

Goulding, M. D., Chalepakis, G., Deutsch, U., Erselius, J. R. and Gruss P (1991). Pax-3 , a novel murine DNA binding protein expressed during early neurogenesis. EMBO J 10, 1135-1147.[Medline]

Goulding, M. D., Lumsden, A. and Gruss P (1993). Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord. Development 117, 1001-1016.[Abstract]

Goulding, M., Lumsden, A. and Paquette A. J (1994). Regulation of Pax-3 expression in the dermomyotome and its role in muscle development. Development 120, 957-71.[Abstract]

Goulding, M., Sterrer, S., Fleming, J., Balling, R., Nadeau, J., Moore, K. J., Brown, A. D. M., Steel, K. P. and Gruss, P (1993). Analysis of the Pax3 mutant Splotch. Genomics 17, 355-363.[Medline]

Jostes, B., Walther, C. and Gruss, P (1991). The murine paired box gene, Pax-7 , is expressed specifically during the development of the nervous and muscular systems. Mech. Dev 33, 27-38.

Karamitopoulou, E., Perentes, E., Diamantis, I. and Maraziotis, T (1994). Ki-67 immunoreactivity in human central nervous system tunors: a study MIB1 monoclonal antibody on arhival material. Acta Neuropathol 87, 47-54.[Medline]

Karlsson, O., Thor, S., Norbert, T., Ohlsson, H. and Edlund, T (1990). Insulin gene enhancer protein Isl-1 is a member of a novel class of proteins containing both an homeo and a Cys-His domain. Nature 344, 879-882.[Medline]

Krauss, S., Concordet, J.-P. and Ingham P. W (1993). A functionally conserved homolog of the drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 75, 1431-1444.[Medline]

Leech, R. W. and Shuman, R. M (1986). Holoprosencephaly and related midline cerebral anomalies: A review. J. Child Neurol 1, 3-18.[Abstract/Free Full Text]

Liem, K. F., Jr., Tremml, G., Roelink, H. and Jessell, T.M (1995). Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 82, 969-979.[Medline]

Lurie, I. W. and Wulfsberg E. A (1993). \324Holoprosencephaly-Polydactyly' (Pseudotrisomy 13) syndrome: Expansion of the phenotypic spectrum. Am. J. Med. Genet 47, 405-409.[Medline]

Marti, E., Bumcrot, D. A., Takada, R. and McMahon, A (1995). Requirement of the 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature 375, 322-325.[Medline]

Marti, E., Takada, R., Bumcrot, D. A., Sasaki, H. and McMahon A. P (1995). Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development 121, 2537-2547.[Abstract]

Moase, C. E. and Trasler, D. G (1989). Spinal ganglia reduction in the Splotch-delayed mouse neural tube defect mutant. Teratology 40, 67-75.[Medline]

Morell, R., Friedman, T. B., Moeljopawiro, S., Hartono, S. and Asher, J. H (1992). A frameshift mutation in HuP2 paired domain of the probable human homolog of murine Pax-3 is responsible for Waardenburg syndrome type 1 in an Indonesian family. Hum. Mol. Genetics 4, 243-247.[Abstract/Free Full Text]

Moury, J. D. and Jacobson, A. G (1989). Neural fold formation at newly created boundaries between neural plate and epidermis in the axolotl. Dev. Biol 133, 44-57.[Medline]

Parr, B. A., Shea, M. J., Vassileva, G. and Mc Mahon, A. P (1993). MouseWnt genes exhibit discrete domains of expression in the early embryonic CNS and limb bud. Development 119, 247-261.[Abstract]

Pituello, F., Yamada, G. and Gruss, P (1995). Activin A inhibits Pax-6 expression and perturbs cell differentiation in the developing spinal cord in vitro. Proc. Natl. Acad. Sci. USA 92, 6952-6956.[Abstract/Free Full Text]

Placzek, M (1995). The role of the notochord and floor plate in inductive interactions. Current Opinion in Genetics and Development 5, 499-506.[Medline]

Placzek, M., Jessel, T. M. and Dodd, J (1993). Induction of floor plate differentiation by contact-dependent, homeogenetic signals. Development 117, 205-218.[Abstract]

Placzek, M., Tessier-Lavigne, M., Yamada, T., Jessel, T. M. and Dodd, J (1990). Mesodermal control of neural cell identity: floor plate induction by the notochord. Science 250, 985-988.[Abstract/Free Full Text]

Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.[Medline]

Robert, B., Sassoon, D., Jacq, B., Gehring, W. and Buckingham, M (1989). Hox-7 , a mouse homeobox gene with a novel pattern of expression during embryogenesis. EMBO J 8, 91-100.[Medline]

Roelink, H. and Nusse, R (1991). Expression of two members of the Wnt family during mouse development-restricted temporal and spatial pattern in the developing neural tube. Genes Dev 5, 381-388.[Abstract/Free Full Text]

Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V., Norlin, S., Ruiz i Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T. and Dodd, J (1994). Floor plate and motor neuron induction by vhh-1 , a vertebrate homolog of hedgehog expressed by the notochord. Cell 76, 761-775.[Medline]

Roelink, H., Porter, J. A., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A. and Jessell, T. M (1995). Floor plate and motor neuron induction by concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81, 445-455.[Medline]

Ruiz i Altaba, A., Cox, C., Jessell, T. M. and Klar, A (1993). Ectopic neural expression of a floor plate marker in frog embryos injected with the midline transcription factor Pintallavis. Proc. Natl. Acad. Sci. USA 90, 8268-8272.[Abstract/Free Full Text]

Ruiz i Altaba, A., Jessell, T. M. and Roelink, H (1995). Restrictions to floor plate induction by hedgehog and Winged-Helix genes in the neural tube of frog embryos. Mol. Cell. Neurosci 6, 106-121.[Medline]

Ruiz i Altaba, A., Placzek, M., Baldassare, M., Dodd, J. and Jessell, T. M (1995). Early stages of notochord and floor plate development in the chick embryo defined by normal and induced expression of HNF-3. Dev. Biol 170, 299-313.[Medline]

Sasaki, H. and Hogan, B. L. M (1993). Differential expression of multiple forkhead regulated genes during gastrulation and axial patterning formation in the mouse embryo. Development 118, 47-59.[Abstract]

Sasaki, H. and Hogan, B. L. M (1994). HNF-3 as a regulator of floor plate development. Cell 76, 103-115.[Medline]

Schoenwolf, G.C. and Sheard, P (1990). Fate mapping the avian epiblast with focal injections of a fluorescent-histochemical marker: ectodermal derivatives. J. Exp. Zool 255, 323-339.[Medline]

Schubert, F. R., Fainsod, A., Gruenbaum, Y. and Gruss, P (1995). Expression of the novel murine homeobox gene Sax-1 in the developing nervous system. Mech. Dev 51, 99-114.[Medline]

Selleck, M. and Bronner-Fraser, M (1995). Origin of the avian neural crest: the role of neural plate epidermal interactions. Development 121, 525-538.[Abstract]

Sibilia, M. and Wagner, E. F (1995). Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269, 234-238.[Abstract/Free Full Text]

Smith, J. L., Gesteland, K. M. and Schoenwolf, G. C (1994). Prospective fate map of the mouse primitive streak at 7.5 days of gestation. Developmental Dynamics 201, 279-289.[Medline]

Stoykova, A. and Gruss, P (1994). Roles of Pax genes in developing and adult brain as suggested by expression pattern. J. Neurosci 14, 1395-1412.[Abstract]

Sulik, K., Dehart, D. B., Inagaki, T., Carson, J. L., Vrablic, T., Gesteland, K. and Schoenwolf, G. C (1994). Morphogenesis of the murine node and notochordal plate. Developmental Dynamics 201, 260-278.[Medline]

Tanabe, Y., Roelink, H. and Jessell, T. M (1995). Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation. Current Biology 5, 651-658.[Medline]

Tassabehji, M., Read, A. P., Newton, V. E., Harris, R., Balling, R., Gruss, P. and Strachan, T (1992). Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature 355, 635-638.[Medline]

Tessier-Lavigne, M., Placzek, M., Lumsden, A. G. S., Dodd, J. and Jessell, T. M (1988). Chemotropic guidance of developing axons in the mammalian central nervous system. Nature 336, 775-778.[Medline]

hreadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., et al (1995). Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science 269, 230-4.[Abstract/Free Full Text]

Tremblay, P. and Gruss, P (1994). Pax: genes for mice and men. Pharmac. Ther 61, 205-226.

Tremblay, P., Kessel, M and Gruss, P (1995). A transgenic neuroanatomical marker identifies cranial neural crest deficiencies associated with the Pax3 mutant Splotch. Dev. Biol 171, 317-329.[Medline]

Tsuchida, T., Ensini, M., Morton, S. B., Baldassare, M., Edlund, T., Jessell, T. M. and Pfaff, S. L (1994). Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79, 957-970.[Medline]

van Straaten, H. M. W., Hekking, J. W. M., Wiertz-Hoessels, E. L., Thors, F. and Drukker J (1988). Effect of the notochord on the differentiation of a floor plate area in the neural tube of the chick embryo. Anat. Embryol 177, 317-324.[Medline]

van Straaten, H. W. M. and Hekking, J. W. M (1991). Development of floor plate, neurons and axonal outgrowth pattern in the early spinal cord of the notochord-deficient chick embryo. Anat. Embryol 184, 55-63.[Medline]

Walther, C. and Gruss, P (1991). Pax-6 , a murine paired box gene is expressed in the developing CNS. Development 113, 1435-1449.[Abstract]

Whiting, J., Marshall, H., Cook, M., Krumlauf, R., Rigby, P. W. J., Stott, D. and Allemann, R. K (1991). Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Genes Dev 5, 2048-2059.[Abstract/Free Full Text]

Yamada, T., Pfaff, S. L., Edlund, T. and Jessell, T. M (1993). Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate. Cell 73, 673-686.[Medline]

Yamada, T., Placzek, M., Tanaka, H., Dodd, J. and Jessell, T. M (1991). Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord. Cell 64, 635-647.[Medline]

Zhadanov, A. B., Bertuzzi, S., Taira, M., Dawid, I. B. and Westphal, H (1995). Expression pattern of the murine Lim class homeobox gene Lhx-3 in subsets of neural and neuroendocrine tissues. Developmental Dynamics 202, 354-364.[Medline]

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				E. Matsunaga, I. Araki, and H. Nakamura Role of Pax3/7 in the tectum regionalization Development, October 15, 2001; 128(20): 4069 - 4077. [Abstract] [Full Text] [PDF]

				J. C. Glover Development of Specific Connectivity Between Premotor Neurons and Motoneurons in the Brain Stem and Spinal Cord Physiol Rev, April 1, 2000; 80(2): 615 - 647. [Abstract] [Full Text] [PDF]

				D Arendt and K Nubler-Jung Comparison of early nerve cord development in insects and vertebrates Development, January 6, 1999; 126(11): 2309 - 2325. [Abstract] [PDF]

				J Li, K. Liu, F Jin, M. Lu, and J. Epstein Transgenic rescue of congenital heart disease and spina bifida in Splotch mice Development, January 6, 1999; 126(11): 2495 - 2503. [Abstract] [PDF]

				F Pituello, F Medevielle, F Foulquier, and A. Duprat Activation of Pax6 depends on somitogenesis in the chick embryo cervical spinal cord Development, January 2, 1999; 126(3): 587 - 596. [Abstract] [PDF]

				Q Ding, J Motoyama, S Gasca, R Mo, H Sasaki, J Rossant, and C. Hui Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice Development, January 7, 1998; 125(14): 2533 - 2543. [Abstract] [PDF]

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				A. Bang, N Papalopulu, C Kintner, and M. Goulding Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm Development, January 5, 1997; 124(10): 2075 - 2085. [Abstract] [PDF]