A male-specific role for SOX9 in vertebrate sex determination

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Abbas, N. E., Toublanc, J. E., Boucekkine, C., Toublanc, M., Affara, N. A., Job, J.-C. and Fellous, M (1990). A possible common origin of \324Y-negative' human XX males and XX true hermaphrodites. Hum. Genet 84, 356-360.[Medline]

Baarends, W. M., van Helmond, M. J. L., Post, M., van der Schoot, P. J. C. M., Hoogerbrugge, J. W., de Winter, J. P., Uilenbroek, J. T. J., Karels, B., Wilming, L. G., Meijers, J. H. C., Themmen, A. P. N. and Grootegoed, J. A (1994). A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in the mesenchymal cells adjacent to the mullerian duct. Development 120, 189-197.[Abstract]

Bardoni, B., Zanaria, E., Guioli, S., Floridia, G., Worley, K. C., Tonini, G., Ferrante, E., Chiumello, G., McCabe, E. R. B., Fraccaro, M., Zuffardi, O. and Camerino, G (1994). A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal. Nature Genet 7, 497-501.[Medline]

Behringer, R. R., Cate, R. L., Froelick, G. J., Palmiter, R. D. and Brinster, R. L (1990). Abnormal sexual development in transgenic mice chronically expressing Mullerian inhibiting substance. Nature 345, 167-170.[Medline]

Behringer, R. R., Finegold, M. J. and Cate, R. L (1994). Mullerian-inhibiting substance function during mammalian sexual development. Cell 79, 415-425.[Medline]

Burgoyne, P. S., Buehr, M., Koopman, P., Rossant, J. and McLaren, A (1988). Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XXXY chimaeric mouse testes. Development 102, 443-450.[Abstract]

Cate, R. L., Mattaliano, R. J., Hession, C., Tizard, R., Farber, N. M., Cheung, A., Ninfa, E. G., Frey, A. Z., Gash, D. J., Chow, E. P., Fisher, R. A., Bertonis, J. M., Torres, G., Wallner, B. P., Ramachandran, K. L., Ragin, R. C., Manganaro, T. F., MacLaughlin, D. T. and Donahoe, P. K (1986). Isolation of the bovine and human genes for Mullerian inhibiting substance and expression of the human gene in animal cells. Cell 45, 685-698.[Medline]

Christiansen, J. H., Dennis, C. L., Wicking, C. A., Monkley, S. J., Wilkinson, D. G. and Wainwright, B. J (1995). Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development. Mech. Dev 51, 341-350.[Medline]

Connor, F., Wright, E., Denny, P., Koopman, P. and Ashworth, A (1995). The Sry -related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse. Nucl. Acids Res 23, 3365-3372.[Abstract/Free Full Text]

Coriat, A.-M., Mueller, U., Harry, J. L., Uwanogho, D. and Sharpe, P. T (1993). PCR amplification of SRY -related gene sequences reveals evolutionary conservation of the SRY -box motif. PCR Methods. Appl 2, 218-222.[Medline]

Denny, P., Swift, S., Connor, F. and Ashworth, A (1992). An SRY- related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein. EMBO J 11, 3705-3712.[Medline]

Denny, P., Swift, S., Brand, N., Dabhade, N., Barton, P. and Ashworth, A (1992). A conserved family of genes related to the testis determining gene, SRY. Nucl. Acids Res 20, 2887-.[Free Full Text]

Foster, J. W., Dominguez-Steglich, M. A., Guioli, S., Kwok, C., Weller, P. A., Weissenbach, J., Mansour, S., Young, I. D., Goodfellow, P. N., Brook, J. D. and Schafer, A. J (1994). Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY -related gene. Nature 372, 525-530.[Medline]

Goodfellow, P. N. and Lovell-Badge, R (1993). Sry and sex determination in mammals. Annu. Rev. Genet 27, 71-92.[Medline]

Griffiths, R (1991). The isolation of conserved DNA sequences related to the human sex-determining region Y gene from the lesser black-backed gull ( Larus fuscus ). Philos. Trans. R. Soc. Lond. Biol 244, 123-128.

Gubbay, J., Collignon, J., Koopman, P., Capel, B., Economou, A., Munsterberg, A., Vivian, N., Goodfellow, P. and Lovell-Badge, R (1990). A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature 346, 245-250.[Medline]

Hacker, A., Capel, B., Goodfellow, P. and Lovell-Badge, R (1995). Expression of Sry , the mouse sex determining gene. Development 121, 1603-1614.[Abstract]

Haqq, C. M., King, C.-Y., Donahoe, P. K. and Weiss, M. A (1993). SRY recognizes conserved DNA sites in sex-specific promoters. Proc. Natl. Acad. Sci. USA 90, 1097-1101.[Abstract/Free Full Text]

Haqq, C. M., King, C.-Y., Ukiyama, E., Falsafi, S., Haqq, T. N., Donahoe, P. K. and Weiss, M. A (1994). Molecular basis of mammalian sex determination: Activation of Mullerian inhibiting substance gene expression by SRY. Science 266, 1494-1500.[Abstract/Free Full Text]

Harley, V. R., Jackson, D. I., Hextall, P. J., Hawkins, J. R., Berkovitz, G. D., Sockanathan, S., Lovell-Badge, R. and Goodfellow, P. N (1992). DNA binding activity of recombinant SRY from normal males and XY females. Science 255, 453-456.[Abstract/Free Full Text]

Hosking, B. M., Muscat, G. E. O., Koopman, P. A., Dowhan, D. H. and Dunn, T. L (1995). Trans -activation and DNA-binding properties of the transcription factor, Sox-18. Nucl. Acids Res 23, 2626-2628.[Abstract/Free Full Text]

Houston, C. S., Opitz, J. M., Spranger, J. W., Macpherson, R. I., Reed, M. H., Gilbert, E. F., Herrmann, J. and Schinzel, A (1983). The campomelic syndrome: review, report of 17 cases, and follow-up on the currently 17-year old boy first reported by Maroteaux et al. in 1971. Am. J. Med. Genet 15, 3-28.[Medline]

Jacobs, P. A. and Strong, J. A (1959). A case of human intersexuality having a possible XXY sex determining mechanism. Nature 183, 302-303.[Medline]

J\212ger, R. J., Anvret, M., Hall, K. and Scherer, G (1990). A human XY female with a frame shift mutation in the candidate testis-determining gene SRY. Nature 348, 452-454.[Medline]

Jeske, Y. W. A., Mishina, Y., Cohen, D. R., Behringer, R. R. and Koopman, P (1996). Analysis of the role of Amh and Fra1 in the Sry regulatory pathway. Mol. Reprod. Dev 44, 153-158.[Medline]

Kanai, Y., Kanai-Azuma, M., Noce, T., Saido, T. C., Shiroishi, T., Hayashi, Y. and Yazaki, K (1996). Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J. Cell Biol 96, 667-681.

Kato, G. J., Barrett, J., Villa-Garcia, M., and Dang, C.V (1990). An amino-terminal c-myc domain required for neoplastic transformation activates transcription. Mol. Cell. Biol 10, 5914-5920.[Abstract/Free Full Text]

Kodama, H., Saitoh, H., Tone, M., Kuhara, S., Sakaki, Y. and Mizuno, S (1987). Nucleotide sequences and unusual electrophoretic behavior of the W chromosome-specific repeating DNA units of the domestic fowl Gallus gallus domesticus. Chromosoma 96, 18-25.[Medline]

Koopman, P., Gubbay, J., Vivian, N., Goodfellow, P. and Lovell-Badge, R (1991). Male development of chromosomally female mice transgenic for Sry. Nature 351, 117-121.[Medline]

Koopman, P., Munsterberg, A., Capel, B., Vivian, N. and Lovell-Badge, R (1990). Expression of a candidate sex-determining gene during mouse testis differentiation. Nature 34, 8-.

Kost, T. A., Theodorakis, N. and Hughes, S. H (1983). The nucleotide sequence of the chick cytoplasmic beta-actin gene. Nucl. Acids Res 11, 8287-8301.[Abstract/Free Full Text]

Laemmli, U. K (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.[Medline]

Luo, X., Ikeda, Y. and Parker, K. L (1994). A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77, 481-490.[Medline]

Marshall Graves, J. A (1995). The origin and function of the mammalian Y chromosome and Y-borne genes \320 an evolving understanding. BioEssays 17, 311-321.[Medline]

McLaren, A., Simpson, E., Tomonari, K., Chandler, P. and Hogg, H (1984). Male sexual differentiation in mice lacking H-Y antigen. Nature 312, 552-555.[Medline]

Munsterberg, A. and Lovell-Badge, R (1991). Expression of the mouse anti-Mullerian hormone gene suggests a role in both female and male sexual differentiation. Development 113, 613-624.[Abstract]

Muscatelli, F., Strom, T. M., Walker, A. P., Zanaria, E., Recan, D., Meindi, A.,Bardoni, B., Guioli, S., Zehetner, G., Rabl, W., Schwarz, H. P., Kaplan, J.-C., Camerino, G., Meitinger, T. and Monaco, A. P (1994). Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Nature 372, 672-676.[Medline]

Nasrin, N., Buggs, C., Fu Kong, X., Carnazza, J., Goebl, M. and Alexander-Bridges, M (1991). DNA-binding properties of the product of the testis-determining gene and a related protein. Nature 354, 317-320.[Medline]

Ohno, S (1961). Sex chromosomes and microchromosomes of Gallus domesticus. Chromosoma 11, 484-498.

Palmer, S. J. and Burgoyne, P. S (1991). The Musmusculus domesticusTdy allele acts later than the Musmusculus musculus Tdy allele: a basis for XY sex reversal in C57BL/6-YPOSmice. Development 113, 709-714.[Abstract]

Pontiggia, A., Rimini, R., Harley, V. R., Goodfellow, P. N., Lovell-Badge, R. and Bianchi, M. E (1994). Sex-reversing mutations affect the architecture of SRY-DNA complexes. EMBO J 13, 6115-6124.[Medline]

Rossi, P., Dolci, S., Albanesi, C., Grimaldi, P. and Geremia, R (1993). Direct evidence that the mouse sex-determining gene Sry is expressed in the somatic cells of male fetal gonads and in the germ cell line in the adult testis. Mol. Reprod. Dev 34, 369-73.[Medline]

Shen, W.-H., Moore, C. C. D., Ikeda, Y., Parker, K. L. and Ingraham, H (1994). Nuclear receptor steriodogenic factor 1 regulates the Mullerian inhibiting substance gene: a link to the sex determination cascade. Cell 77, 651-661.[Medline]

Sinclair, A. H., Berta, P., Palmer, M. S., Hawkins, J. R., Griffiths, B. L., Smith, M. J.,Foster, J. W., Frischauf, A.-M., Lovell-Badge, R. and Goodfellow, P. N (1990). A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 346, 240-244.[Medline]

Stevanovic, M., Lovell-Badge, R., Collignon, J. and Goodfellow, P. N (1993). SOX3 is an X-linked gene related to SRY. Human Mol. Genet 3, 2013-2018.

Swain, A., Zanaria, E., Hacker, A., Lovell-Badge, R. and Camerino, G (1996). Mouse DAX1 expression is consistent with a role in sex determination as well as in adrenal hypothalamus function. Nature Genet 12, 404-409.[Medline]

Tommerup, N., Schempp, W., Mienecke, P., Pedersen, S., Bolund, L., Brandt, C., Goodpasture, C., Guldberg, P., Held, K. R., Reinwein, H., Saaugstad, O. D., Scherer, G., Skjeldal, O., Toder, R., Westvik, J., van der Hagen, C. B. and Wolf, U (1993). Assignment of an autosomal sex reversal locus (SRA1) and campomelic dysplasia (CMPD1) to 17q24.3-q25.1. Nature Genet 4, 170-174.[Medline]

Uwanogho, D., Rex, M., Cartwright, E. J., Pearl, G., Healy, C., Scotting, P. and Sharpe, P. T (1994). Embryonic expression of the chicken Sox2 , Sox3 and Sox11 genes suggests an interactive role in neural development. Mech. Dev 49, 23-36.

van de Wetering, M., Oosterwegel, M., van Norren, K. and Clevers, H (1993). Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. EMBO J 12, 3847-3854.[Medline]

Wagner, T., Wirth, J., Meyer, J., Zabel, B., Held, M., Zimmer, J., Pasantes, J., Bricarelli, F. D., Keutel, J., Hustert, E., Wolf, U., Tommerup, N., Schempp, W. and Scherer, G (1994). Autosomal sex reversal andcampomelic dysplasia are caused by mutations in and around the SRY -related gene SOX9. Cell 79, 1111-1120.[Medline]

Welshons, W. J. and Russell, L. B (1959). The Y chromosome as the bearer of male determining factors in the mouse. Proc. Natl. Acad. Sci. USA 45, 560-566.[Free Full Text]

Wheatley, S. C., Isacke, C. M. and Crossley, P. H (1993). Restricted expression of the hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterning. Development 119, 295-306.[Abstract]

Wolff, E. and Wolff, E (1951). The effects of castration on bird embryos. J. Exp. Zool 116, 59-97.

Wright, E., Hargrave, M. R., Christiansen, J., Cooper, L., Kun, J., Evans, T., Gangadharan, U., Greenfield, A. and Koopman, P (1995). The Sry -related gene Sox-9 is expressed during chondrogenesis in mouse embryos. Nature Genet 9, 15-20.[Medline]

Wright, E. M., Snopek, B. and Koopman, P (1993). Seven new members of the Sox gene family expressed during mouse development. Nucl. Acids Res 21, 744-.[Free Full Text]

Zanaria, E., Muscatelli, F., Bardoni, B., Strom, T. M., Guioli, S., Guo, W., Lalli, E., Moser, C., Walker, A. P., McCabe, E. R. B., Meltinger, T., Monaco, A. P., Sassone-Corsi, P. and Camerino, G (1994). An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature_Fb_372 , 635-641.Since submitting this data, Sudbeck and colleagues (P. Sudbeck, M. L. Schmitz, P. A. Baeuerle and G. Scherer (1996). Sex reversal by loss of the C-terminal transactivation domain of human SOX9. Nature Genet 13, 230-232.

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[Abstract] [Full Text] [PDF]

C. A. Smith, M. Katz, and A. H. Sinclair
DMRT1 Is Upregulated in the Gonads During Female-to-Male Sex Reversal in ZW Chicken Embryos
Biol Reprod, February 1, 2003; 68(2): 560 - 570.
[Abstract] [Full Text] [PDF]

S. P. Scherrer, D. A. Rice, and L. L. Heckert
Expression of Steroidogenic Factor 1 in the Testis Requires an Interactive Array of Elements Within Its Proximal Promoter
Biol Reprod, November 1, 2002; 67(5): 1509 - 1521.
[Abstract] [Full Text] [PDF]

K. L. BRITT, J. KERR, L. O'DONNELL, M. E. E. JONES, A. E. DRUMMOND, S. R. DAVIS, E. R. SIMPSON, and J. K. FINDLAY
Estrogen regulates development of the somatic cell phenotype in the eutherian ovary
FASEB J, September 1, 2002; 16(11): 1389 - 1397.
[Abstract] [Full Text] [PDF]

R. Zhou, N. Bonneaud, C.-X. Yuan, P. de Santa Barbara, B. Boizet, S. Tibor, G. Scherer, R. G. Roeder, F. Poulat, and P. Berta
SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex
Nucleic Acids Res., July 15, 2002; 30(14): 3245 - 3252.
[Abstract] [Full Text] [PDF]

C. Hoyle, V. Narvaez, G. Alldus, R. Lovell-Badge, and A. Swain
Dax1 Expression Is Dependent on Steroidogenic Factor 1 in the Developing Gonad
Mol. Endocrinol., April 1, 2002; 16(4): 747 - 756.
[Abstract] [Full Text] [PDF]

J. H.-C. Shen and H. A. Ingraham
Regulation of the Orphan Nuclear Receptor Steroidogenic Factor 1 by Sox Proteins
Mol. Endocrinol., March 1, 2002; 16(3): 529 - 540.
[Abstract] [Full Text] [PDF]

N. Lei and L. L. Heckert
Sp1 and Egr1 Regulate Transcription of the Dmrt1 Gene in Sertoli Cells
Biol Reprod, March 1, 2002; 66(3): 675 - 684.
[Abstract] [Full Text] [PDF]

S. G. Tevosian, K. H. Albrecht, J. D. Crispino, Y. Fujiwara, E. M. Eicher, and S. H. Orkin
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2
Development, January 10, 2002; 129(19): 4627 - 4634.
[Abstract] [Full Text] [PDF]

C. Tilmann and B. Capel
Cellular and Molecular Pathways Regulating Mammalian Sex Determination
Recent Prog. Horm. Res., January 1, 2002; 57(1): 1 - 18.
[Abstract] [Full Text] [PDF]

E. Sock, K. Schmidt, I. Hermanns-Borgmeyer, M. R. Bosl, and M. Wegner
Idiopathic Weight Reduction in Mice Deficient in the High-Mobility-Group Transcription Factor Sox8
Mol. Cell. Biol., October 15, 2001; 21(20): 6951 - 6959.
[Abstract] [Full Text] [PDF]

S. Liu, R. Guo, and L. D. Quarles
Cloning and Characterization of the Proximal Murine Phex Promoter
Endocrinology, September 1, 2001; 142(9): 3987 - 3995.
[Abstract] [Full Text] [PDF]

J. k. Chen and L. L. Heckert
Dmrt1 Expression Is Regulated by Follicle-Stimulating Hormone and Phorbol Esters in Postnatal Sertoli Cells
Endocrinology, March 1, 2001; 142(3): 1167 - 1178.
[Abstract] [Full Text] [PDF]

E. M. Perera, H. Martin, T. Seeherunvong, L. Kos, I. A. Hughes, J. R. Hawkins, and G. D. Berkovitz
Tescalcin, a Novel Gene Encoding a Putative EF-Hand Ca2+-Binding Protein, Col9a3, and Renin Are Expressed in the Mouse Testis during the Early Stages of Gonadal Differentiation
Endocrinology, January 1, 2001; 142(1): 455 - 46

				K. Piper Hanley, F. Oakley, S. Sugden, D. I. Wilson, D. A. Mann, and N. A. Hanley Ectopic SOX9 Mediates Extracellular Matrix Deposition Characteristic of Organ Fibrosis J. Biol. Chem., May 16, 2008; 283(20): 14063 - 14071. [Abstract] [Full Text] [PDF]

				H. Chang, F. Gao, F. Guillou, M. M. Taketo, V. Huff, and R. R. Behringer Wt1 negatively regulates {beta}-catenin signaling during testis development Development, May 15, 2008; 135(10): 1875 - 1885. [Abstract] [Full Text] [PDF]

				Y. Ishimaru, T. Komatsu, M. Kasahara, Y. Katoh-Fukui, H. Ogawa, Y. Toyama, M. Maekawa, K. Toshimori, R. A. S. Chandraratna, K.-i. Morohashi, et al. Mechanism of asymmetric ovarian development in chick embryos Development, February 15, 2008; 135(4): 677 - 685. [Abstract] [Full Text] [PDF]

				S. Ijiri, H. Kaneko, T. Kobayashi, D.-S. Wang, F. Sakai, B. Paul-Prasanth, M. Nakamura, and Y. Nagahama Sexual Dimorphic Expression of Genes in Gonads During Early Differentiation of a Teleost Fish, the Nile Tilapia Oreochromis niloticus Biol Reprod, February 1, 2008; 78(2): 333 - 341. [Abstract] [Full Text] [PDF]

				Y. Kim, N. Bingham, R. Sekido, K. L. Parker, R. Lovell-Badge, and B. Capel Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination PNAS, October 16, 2007; 104(42): 16558 - 16563. [Abstract] [Full Text] [PDF]

				P. Val, J.-P. Martinez-Barbera, and A. Swain Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage Development, June 15, 2007; 134(12): 2349 - 2358. [Abstract] [Full Text] [PDF]

				E. Sumi, N. Iehara, H. Akiyama, T. Matsubara, A. Mima, H. Kanamori, A. Fukatsu, D. J. Salant, T. Kita, H. Arai, et al. SRY-Related HMG Box 9 Regulates the Expression of Col4a2 through Transactivating Its Enhancer Element in Mesangial Cells Am. J. Pathol., June 1, 2007; 170(6): 1854 - 1864. [Abstract] [Full Text] [PDF]

				T. Svingen, A. Beverdam, P. Bernard, P. McClive, V. R Harley, A. H Sinclair, and P. Koopman Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation Reproduction, May 1, 2007; 133(5): 983 - 989. [Abstract] [Full Text] [PDF]

				D. Wilhelm, R. Hiramatsu, H. Mizusaki, L. Widjaja, A. N. Combes, Y. Kanai, and P. Koopman SOX9 Regulates Prostaglandin D Synthase Gene Transcription in Vivo to Ensure Testis Development J. Biol. Chem., April 6, 2007; 282(14): 10553 - 10560. [Abstract] [Full Text] [PDF]

				F. Gao, S. Maiti, N. Alam, Z. Zhang, J. M. Deng, R. R. Behringer, C. Lecureuil, F. Guillou, and V. Huff The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis PNAS, August 8, 2006; 103(32): 11987 - 11992. [Abstract] [Full Text] [PDF]

				S. Rajender, V. Rajani, N. J. Gupta, B. Chakravarty, L. Singh, and K. Thangaraj SRY-negative 46,XX male with normal genitals, complete masculinization and infertility Mol. Hum. Reprod., May 1, 2006; 12(5): 341 - 346. [Abstract] [Full Text] [PDF]

				A. Beverdam and P. Koopman Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes Hum. Mol. Genet., February 1, 2006; 15(3): 417 - 431. [Abstract] [Full Text] [PDF]

				F. Barrionuevo, S. Bagheri-Fam, J. Klattig, R. Kist, M. M. Taketo, C. Englert, and G. Scherer Homozygous Inactivation of Sox9 Causes Complete XY Sex Reversal in Mice Biol Reprod, January 1, 2006; 74(1): 195 - 201. [Abstract] [Full Text] [PDF]

				X. Huang, Y. Guo, Y. Shui, S. Gao, H. Yu, H. Cheng, and R. Zhou Multiple Alternative Splicing and Differential Expression of dmrt1 During Gonad Transformation of the Rice Field Eel Biol Reprod, November 1, 2005; 73(5): 1017 - 1024. [Abstract] [Full Text] [PDF]

				A. Jeanes, D. Wilhelm, M. J Wilson, J. Bowles, P. J McClive, A. H Sinclair, and P. Koopman Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis Reproduction, October 1, 2005; 130(4): 509 - 516. [Abstract] [Full Text] [PDF]

				Y. Kanai, R. Hiramatsu, S. Matoba, and T. Kidokoro From SRY to SOX9: Mammalian Testis Differentiation J. Biochem., July 1, 2005; 138(1): 13 - 19. [Abstract] [Full Text] [PDF]

				C. J. Guigon, N. Coudouel, S. Mazaud-Guittot, M. G. Forest, and S. Magre Follicular Cells Acquire Sertoli Cell Characteristics after Oocyte Loss Endocrinology, July 1, 2005; 146(7): 2992 - 3004. [Abstract] [Full Text] [PDF]

				S. Matoba, Y. Kanai, T. Kidokoro, M. Kanai-Azuma, H. Kawakami, Y. Hayashi, and M. Kurohmaru A novel Sry-downstream cellular event which preserves the readily available energy source of glycogen in mouse sex differentiation J. Cell Sci., April 1, 2005; 118(7): 1449 - 1459. [Abstract] [Full Text] [PDF]

				A. K. Hett, C. Pitra, I. Jenneckens, and A. Ludwig Characterization of Sox9 in European Atlantic Sturgeon (Acipenser sturio) J. Hered., March 1, 2005; 96(2): 150 - 154. [Abstract] [Full Text] [PDF]

				M. J. Wilson, P. Jeyasuria, K. L. Parker, and P. Koopman The Transcription Factors Steroidogenic Factor-1 and SOX9 Regulate Expression of Vanin-1 during Mouse Testis Development J. Biol. Chem., February 18, 2005; 280(7): 5917 - 5923. [Abstract] [Full Text] [PDF]

				C. Poirier, Y. Qin, C. P. Adams, Y. Anaya, J. B. Singer, A. E. Hill, E. S. Lander, J. H. Nadeau, and C. E. Bishop A Complex Interaction of Imprinted and Maternal-Effect Genes Modifies Sex Determination in Odd Sex (Ods) Mice Genetics, November 1, 2004; 168(3): 1557 - 1562. [Abstract] [Full Text] [PDF]

				J. Schmahl, Y. Kim, J. S. Colvin, D. M. Ornitz, and B. Capel Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination Development, August 1, 2004; 131(15): 3627 - 3636. [Abstract] [Full Text] [PDF]

				P. Blache, M. van de Wetering, I. Duluc, C. Domon, P. Berta, J.-N. Freund, H. Clevers, and P. Jay SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes J. Cell Biol., July 5, 2004; 166(1): 37 - 47. [Abstract] [Full Text] [PDF]

				J. E. Shima, D. J. McLean, J. R. McCarrey, and M. D. Griswold The Murine Testicular Transcriptome: Characterizing Gene Expression in the Testis During the Progression of Spermatogenesis Biol Reprod, July 1, 2004; 71(1): 319 - 330. [Abstract] [Full Text] [PDF]

				Y. Qin, L.-k. Kong, C. Poirier, C. Truong, P. A. Overbeek, and C. E. Bishop Long-range activation of Sox9 in Odd Sex (Ods) mice Hum. Mol. Genet., June 15, 2004; 13(12): 1213 - 1218. [Abstract] [Full Text] [PDF]

				M.-C. Chaboissier, A. Kobayashi, V. I. P. Vidal, S. Lutzkendorf, H. J. G. van de Kant, M. Wegner, D. G. de Rooij, R. R. Behringer, and A. Schedl Functional analysis of Sox8 and Sox9 during sex determination in the mouse Development, May 1, 2004; 131(9): 1891 - 1901. [Abstract] [Full Text] [PDF]

				H. Akiyama, M.-C. Chaboissier, R. R. Behringer, D. H. Rowitch, A. Schedl, J. A. Epstein, and B. de Crombrugghe Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa PNAS, April 27, 2004; 101(17): 6502 - 6507. [Abstract] [Full Text] [PDF]

				R Pop, C Conz, K S Lindenberg, S Blesson, B Schmalenberger, S Briault, D Pfeifer, and G Scherer Screening of the 1 Mb SOX9 5' control region by array CGH identifies a large deletion in a case of campomelic dysplasia with XY sex reversal J. Med. Genet., April 1, 2004; 41(4): e47 - e47. [Full Text] [PDF]

				N. Moreno-Mendoza, L. Torres-Maldonado, J. Chimal-Monroy, V. Harley, and H. Merchant-Larios Disturbed Expression of Sox9 in Pre-Sertoli Cells Underlies Sex-Reversal in Mice B6.Ytir Biol Reprod, January 1, 2004; 70(1): 114 - 122. [Abstract] [Full Text] [PDF]

				P. G. Buxton, B. Hall, C. W. Archer, and P. Francis-West Secondary chondrocyte-derived Ihh stimulates proliferation of periosteal cells during chick development Development, October 1, 2003; 130(19): 4729 - 4739. [Abstract] [Full Text] [PDF]