Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning

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Barth, K. A. and Wilson, S (1995). Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain. Development 121, 1755-1768.[Abstract]

Basler, K. and Struhl, G (1994). Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208-214.[Medline]

Bitgood, M. J., Shen, L. and McMahon, A. P (1996). Sertoli cell signallingby desert hedgehog regulates the male germline. Current Biology 6, 298-304.[Medline]

Capdevila, J., Estrada, M. P., Sanchez-Herrero, E. and Guerrero, I (1994). The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J 13, 71-82.[Medline]

Capdevila, J. and Guerrero, I (1994). Targeted expression of the signalling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J 13, 4459-4468.[Medline]

Chang, D. T (1994). Products, genetic linkage and limb patterning activity of a murine hedgehog gene. Development 120, 3339-3353.[Abstract]

Diaz-Benjumea, F. J. and Cohen, S. M (1994). Cell-interaction between compartments establishes the proximal-distal axis of Drosophila legs. Nature 372, 175-179.[Medline]

Dietrich, S., Schubert, F. R. and Gruss, P (1993). Altered Pax gene expression in murine notochord mutants: The notochord is required to initiate and maintain ventral identity in the somite. Mech. Dev 44, 189-207.[Medline]

Echelard, Y., Epstein, D. J., St.-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P (1993). Sonic hedgehog , a member of a family of putative signalling molecules is implicated in the regulation of CNS and limb polarity. Cell 75, 1417-1430.[Medline]

Ekker, S.C., Ungar, A. R., Greenstein, P., von Kessler, D. P., Porter, J.A., Moon, R.T., and Beachy, P.A (1995). Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Current Biology 5, 944-955.[Medline]

Fan, C.-M. and Tessier-Lavigne, M (1994). Patterning of Mammalian Somites by the Surface Ectoderm and the Notochord: Evidence for Sclerotome Induction by Sonic hedgehog/Vhh-1. Cell 79, 1175-1186.[Medline]

Fan, C.-M., Porter, J. A., Chiang, C., Chang, D. T., Beachy, P. A. and Tessier-Lavigne, M (1995). Long-Range Induction of Sclerotome by Sonic hedgehog: A Direct Role for the Amino Terminal Product of Autoproteolytic Cleavage and Modulation by the Cyclic AMP Signalling Pathway. Cell 81, 457-465.[Medline]

Felsenfeld, A. L., Curry, M. and Kimmel, C. B (1991). The fub-1 mutation blocks initial myofibril formation in zebrafish muscle pioneer cells. Dev. Biol 148, 23-36.[Medline]

Fietz, M., Concordet, J.-P., Barbosa, R., Johnson, R., Krauss, S., McMahon, A. P., Tabin, C. and Ingham, P. W (1994). The hedgehog gene family in Drosophila and vertebrate development. Development 1994, 43-51.

Forbes, A. J., Nakano, Y., Taylor, A. M. and Ingham, P. W (1993). Genetic analysis of hedgehog signalling in the Drosophila embryo. Development 1993, 115-124.

Forbes, A.J., Lin, H., Ingham, P. W., and Spradling, A. C (1996). hedgehog is required for the proliferation and specification of somatic cells prior to egg chamber formation in Drosophila. Development 122, 1125-1135.[Abstract]

Goodrich, L. V., Johnson, R. L., Milenokovic, L., McMahon, J. A. and Scott, M. P (1996). Conservation of the hedgehog / patched signalling pathway from flies to mice: induction of a mouse patched gene by hedgehog. Genes and Development 10, 301-312.[Abstract/Free Full Text]

Goulding, M., Lumsden, A. and Paquette, A. J (1994). Regulation of pax-3 expression in the dermomyotome and its role in muscle development. Development 120, 957-971.[Abstract]

Halpern, M. E., Ho, R.K., Walker, C., and Kimmel, C (1993). Induction of Muscle Pioneers and Floor Plate is Distinguished by the zebrafish no tail mutation. Cell 75, 99-111.[Medline]

Halpern, M. E., Thisse, C., Ho, R. K., Thisse, B., Riggleman, B., Trevarrow, B., Weinberg, E. S., Postlethwait, J. H. and Kimmel, C. B (1995). Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants. Development 121, 4257-4264.[Abstract]

Hammerschmidt, H., Bitgood, M. J. and McMahon, A. P (1996). Protein kinase A is a common negative regulator of Hedgehog signalling in the vertebrate embryo. Genes Dev 10, 647-658.[Abstract/Free Full Text]

Hatta, K., Kimmel, C. B., Ho, R. K. and Walker, C (1991). The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system. Nature 350, 339-341.[Medline]

Heberlein, U., Singh, C. M., Luk, A. Y., and Donohoe, T. J (1995). Growth and differentiation in the Drosophila eye coordinated by hedgehog. Nature 373, 709-711.[Medline]

Henrique, D., Adam, J., A., Chitnis, A., Lewis, J. and Ish-Horowicz, D (1995). Expression of a Delta homologue in prospective neurons in the chick. Nature 375, 787-790.[Medline]

Hidalgo, A. and Ingham, P (1990). Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched. Development 110, 291-302.[Abstract]

Hooper, J. and Scott, M. P (1989). The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 59, 751-765.[Medline]

Hynes, M., Porter, J. A., Chiang, C., Chang, D., Tessier-Lavigne, M., Beachy, P. A. and Rosenthal, A (1995). Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron 15, 35-44.[Medline]

Ingham, P. W., Taylor, A. M. and Nakano, Y (1991). Role of the Drosophila patched gene in positional signalling. Nature 353, 184-187.[Medline]

Ingham, P. W (1993). Localised hedgehog activity controls spatially restricted transcription of wingless in the Drosophila embryo. Nature 366, 560-562.[Medline]

Ingham, P. W. and Hidalgo, A (1993). Regulation of wingless transcription in the Drosophila embryo. Development 117, 283-291.[Abstract]

Ingham, P (1995). Signalling by hedgehog family proteins in Drosophila and vertebrate development. Current Opinion In Genetics and Development 5, 492-498.[Medline]

Ingham, P. W. and Fietz, M. J (1995). Quantitative Effects of hedgehog and decapentaplegic Activity on the Patterning of the Drosophila Wing. Current Biology 5, 432-441.[Medline]

Jiang, J. and Struhl, G (1995). Protein kinase A and Hedgehog signalling in Drosophila limb development. Cell 80, 563-572.[Medline]

Johnson, R. L., Laufer, E., Riddle, R. D. and Tabin, C (1994). Ectopic expression of Sonic hedgehog Alters Dorsal-Ventral Patterning of Somites. Cell 79, 1165-1173.[Medline]

Jowett, T. and Lettice, L (1994). Whole-mount in-situ hybridizations on zebrafish embryos using a mixture of digoxigenin-labelled and fluorescein-labelled probes. Trends In Genetics 10, 73-74.[Medline]

Kalderon, D (1995). Responses to Hedgehog. Current Biology 5, 580-582.[Medline]

Klingensmith, J. and Nusse, R (1994). Signalling by wingless in Drosophila. Dev. Biol 166, 396-414.[Medline]

Koseki, H., Wallin, J., Wilting, J., Mizutani, Y., Kispert, A., Ebensperger, C., Herrmann, B. G., Christ, B. and Balling, R (1993). A role for pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebrae. Development 119, 649-660.[Abstract]

Krauss, S., Johansen, T., Korzh, V. and Fjose, A (1991). Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis. Development 113, 1193-1206.[Abstract]

Krauss, S., Concordet, J.-P. and Ingham, P. W (1993). A functionally conserved homolog of the Drosophila segment polarity gene hedgehog is expressed in tissues with polarising activity in zebrafish embryos. Cell 75, 1431-1444.[Medline]

Lee, J. J., von Kessler, D. P., Parks, S. and Beachy, P. A (1992). Secretion and localised transcription suggests a role in positional signalling for products of the segmentation gene hedgehog. Cell 70, 777-789.[Medline]

Lepage, T., Cohen S. M., Diaz-Benjumea, F. J. and Parkhurst, S. M (1995). Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373, 711-715.[Medline]

Li, W., J. Ohlmeyer, T., Lane, M. E. and Kalderon, D (1995). Function of protein kinase A in Hedgehog signal transduction and Drosophila imaginal disc development. Cell 80, 553-562.[Medline]

Ma, C., Zhou, Y., Beachy, P. A. and Moses, K (1993). The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell 75, 927-938.[Medline]

Macdonald, R., Barth, K. A., Xu, Q., Holder, N., Mikkola, I. and Wilson, S. W (1995). Midline signalling is required for Pax gene regulation and patterning of the eyes. Development 121, 3267-3278.[Abstract]

Marigo, V., Scott, M. P., Johnson, R. L., Goodrich, L. and Tabin, C. J (1996). Conservation in hedgehog signalling, Sonic hedgehog controls the expression of a chicken patched homolog in the developing limb. Development 122, 1225-1233.[Abstract]

Marti, E., Bumcrot, D. A., Takada, R. and McMahon, A. P (1995). Requirement of, 19kDalton form of Sonic hedgehog for induction of distinct ventral cell types in vertebrate CNS explants. Nature 375, 322-325.[Medline]

Mohler, J. and Vani, K (1992). Molecular organisation and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning in Drosophila. Development 115, 957-971.[Abstract]

Munsterberg, A., Kitajewski, J., Bumcrot, D. A., McMahon, A. P. and Lassar, A. B (1995). Combinatorial signalling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev 9, 2911-2922.[Abstract/Free Full Text]

Nakano, Y., Guerrero, I., Hidalgo, A., Taylor, A. M., Whittle, J. R. S. and Ingham, P. W (1989). The Drosophila segment polarity gene patched encodes a protein with multiple potential membrane spanning domains. Nature 341, 508-513.[Medline]

Orellana, S. A. and McKnight, G. S (1992). Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity. Proc. Natn. Acad. Sci. USA 89, 4726-30.[Abstract/Free Full Text]

Oxtoby, E. and Jowett, T (1993). Cloning of the zebrafish krox-20 gene ( krx-20 ) and its expression during hindbrain development. Nuc. Acids Res 21, 1087-1095.[Abstract/Free Full Text]

Pan, D. and Rubin, G. M (1995). cAMP-dependent Protein Kinase and hedgehog Act Antagonistically in Regulating decapentaplegic Transcription in Drosophila Imaginal Discs. Cell 80, 543-552.[Medline]

Placzek, M., Tessier-Lavigne, M., Yamada, T., Jessel, T. and Dodd, J (1990). Mesodermal control of neural cell identity: floor plate induction by the notochord. Science 250, 985-988.[Abstract/Free Full Text]

Placzek, M., Yamada, T., Tessier-Lavigne, M., Jessel, T. and Dodd, J (1991). Control of dorsoventral pattern in vertebrate neural development: induction and polarising properties of the floor plate. Development 1991, 105-122.

Pourquie, O., Coltey, M., Teillet, M. A., Ordahl, C. and Ledouarin, N. M (1993). Control of dorsoventral patterning of somitic derivatives by notochord and floor plate. Proc. Natn. Acad. Sci. USA 90, 11-.[Abstract/Free Full Text]

Riddle, R., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic Hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.[Medline]

Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V., Norlin, S., Ruiz i Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T. M. and Dodd, J (1994). Floor plate and motor neuron induction by vhh-1 , a vertebrate homolog of hedgehog expressed by the notochord. Cell 76, 761-775.[Medline]

Roelink, H., J. Porter, C. Chiang, Y. Tanabe, D. T. Chang, P. A. Beachy and Jessell, T. M (1995). Floor plate and motor neuron induction by different concentrations of the amino terminal cleavage product of Sonic Hedgehog autoproteolysis. Cell 81, 445-455.[Medline]

Ruiz i Altaba, A., Roelink, H. and Jessell, T. M (1995). Restrictions to floorplate induction by hedgehog and winged helix genes in the neural tube of frog embryos. Mol. Cell Neuroscience 6, 106-121.[Medline]

Seed, B (1987). An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2. Nature 329, 840-842.[Medline]

Strutt, D. I., Wiersdorff, V. and Mlodzik, M (1995). Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A. Nature 373, 705-709.[Medline]

Tabata, T., Eaton, S. and Kornberg, T. B (1992). The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev 6, 2635-2645.[Abstract/Free Full Text]

Tabata, T. and Kornberg, T. B (1994). Hedgehog is a signalling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89-102.[Medline]

Tabata, T., Schwartz, C., Gustavson, E., Ali, Z. and Kornberg, T (1995). Creating a Drosophila wing de-novo, the role of engrailed , and the compartment border hypothesis. Development 121, 3359-3369.[Abstract]

Talbot, W. S., Trevarrow, B., Halpern, M. E., Melby, A. E., Farr, G., Postlethwait, J. H., Jowett, T., Kimmel, C. B. and Kimelman, D (1995). A homeobox gene essential for zebrafish notochord development. Nature 378, 150-157.[Medline]

Taylor, A. M., Nakano, Y., Mohler, J. and Ingham, P. W (1993). Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo. Mech. Dev 43, 89-96.

Thisse, C., Thisse, B., Schilling, T. F. and Postlethwait, J. H (1993). Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos. Development 119, 1203-1215.[Abstract]

Thisse, C., Thisse, B., Halpern, M. E. and Postlethwait, J. H (1994). Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas. Dev. Biol 64, 420-429.

Turner, D L and Weintraub H (1994). Expression of achaete-scute homolog3in Xenopous embryos converts ectodermal cells to a neural fate. Genes Dev 8, 1434-1447.[Abstract/Free Full Text]

van Straaten, H. W. M., Hekking, J. W. M., Beursgens, J. P. W. M., Terwindt-Rouwenhorst, E. and Drukker, J (1989). Effect of the notochord on proliferation and differentiation in the neural tube of the chick embryo. Development 107, 793-803.[Abstract/Free Full Text]

Weinberg, E. S., Allende, M. L., Kelly, C. S., Abdelhamid, A., Murakami, T., Andermann, P., Doerre, O. G., Grunwald, D. J. and Riggleman, B (1996). Developmental regulation of zebrafish MyoD in wild type, no tail and spadetail embryos. Development 122, 271-280.[Abstract]

Wilson, R. et al., (1994). 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature 368, 32-38.[Medline]

Yamada, T., Placzek, M., Tanaka, H., Dodd, J. and Jessell, T. M (1991). Control of cell patterning in the developing nervous system: polarizing activity of the floor plate and notochord. Cell 64, 635-647.[Medline]

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Genes & Dev., August 1, 2000; 14(15): 1933 - 1944.
[Abstract] [Full Text]

M. J. Barresi, H. L. Stickney, and S. H. Devoto
The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity
Development, May 15, 2000; 127(10): 2189 - 2199.
[Abstract] [PDF]

F Muller, S Albert, P Blader, N Fischer, M Hallonet, and U Strahle
Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS
Development, January 9, 2000; 127(18): 3889 - 3897.
[Abstract] [PDF]

W Norris, C Neyt, P. Ingham, and P. Currie
Slow muscle induction by Hedgehog signalling in vitro
J. Cell Sci., January 8, 2000; 113(15): 2695 - 2703.
[Abstract] [PDF]

G Drossopoulou, K. Lewis, J. Sanz-Ezquerro, N Nikbakht, A. McMahon, C Hofmann, and C Tickle
A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling
Development, January 4, 2000; 127(7): 1337 - 1348.
[Abstract] [PDF]

J. Borjigin, J. Deng, M. M. Wang, X. Li, S. Blackshaw, and S. H. Snyder
Circadian Rhythm of Patched1 Transcription in the Pineal Regulated by Adrenergic Stimulation and cAMP
J. Biol. Chem., December 3, 1999; 274(49): 35012 - 35015.
[Abstract] [Full Text] [PDF]

R. O. Karlstrom, W. S. Talbot, and A. F. Schier
Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning
Genes & Dev., February 15, 1999; 13(4): 388 - 393.
[Abstract] [Full Text]

P. G. Zaphiropoulos, A. B. Unden, F. Rahnama, R. E. Hollingsworth, and R. Toftgard
PTCH2, a Novel Human Patched Gene, Undergoing Alternative Splicing andUp-regulated in Basal Cell Carcinomas
Cancer Res., February 1, 1999; 59(4): 787 - 792.
[Abstract] [Full Text] [PDF]

V. Wallace and M. Raff
A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve
Development, January 7, 1999; 126(13): 2901 - 2909.
[Abstract] [PDF]

D Arendt and K Nubler-Jung
Comparison of early nerve cord development in insects and vertebrates
Development, January 6, 1999; 126(11): 2309 - 2325.
[Abstract] [PDF]

K. Lewis, G Drossopoulou, I. Paton, D. Morrice, K. Robertson, D. Burt, P. Ingham, and C Tickle
Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway
Development, January 6, 1999; 126(11): 2397 - 2407.
[Abstract] [PDF]

				S. Scholpp, I. Foucher, N. Staudt, D. Peukert, A. Lumsden, and C. Houart Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon Development, September 1, 2007; 134(17): 3167 - 3176. [Abstract] [Full Text] [PDF]

				C. R. Morales, J. Zeng, M. El Alfy, J. L. Barth, M. R. Chintalapudi, R. A. McCarthy, J. P. Incardona, and W. S. Argraves Epithelial Trafficking of Sonic Hedgehog By Megalin J. Histochem. Cytochem., October 1, 2006; 54(10): 1115 - 1127. [Abstract] [Full Text] [PDF]

				J. Xu, B. P. Srinivas, S. Y. Tay, A. Mak, X. Yu, S. G. P. Lee, H. Yang, K. R. Govindarajan, B. Leong, G. Bourque, et al. Genomewide Expression Profiling in the Zebrafish Embryo Identifies Target Genes Regulated by Hedgehog Signaling During Vertebrate Development Genetics, October 1, 2006; 174(2): 735 - 752. [Abstract] [Full Text] [PDF]

				G. Peng and M. Westerfield Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists Development, August 15, 2006; 133(16): 3191 - 3200. [Abstract] [Full Text] [PDF]

				S. Scholpp, O. Wolf, M. Brand, and A. Lumsden Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon Development, March 1, 2006; 133(5): 855 - 864. [Abstract] [Full Text] [PDF]

				M. A. Price CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling. Genes & Dev., February 15, 2006; 20(4): 399 - 410. [Abstract] [Full Text] [PDF]

				J. Pietsch, J.-M. Delalande, B. Jakaitis, J. D. Stensby, S. Dohle, W. S. Talbot, D. W. Raible, and I. T. Shepherd lessen encodes a zebrafish trap100 required for enteric nervous system development Development, February 1, 2006; 133(3): 395 - 406. [Abstract] [Full Text] [PDF]

				D. Huangfu and K. V. Anderson Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates Development, January 1, 2006; 133(1): 3 - 14. [Abstract] [Full Text] [PDF]

				S. Ellingsen, M. A. Laplante, M. Konig, H. Kikuta, T. Furmanek, E. A. Hoivik, and T. S. Becker Large-scale enhancer detection in the zebrafish genome Development, September 1, 2005; 132(17): 3799 - 3811. [Abstract] [Full Text] [PDF]

				N. Wada, Y. Javidan, S. Nelson, T. J. Carney, R. N. Kelsh, and T. F. Schilling Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull Development, September 1, 2005; 132(17): 3977 - 3988. [Abstract] [Full Text] [PDF]

				M. J. F. Barresi, L. D. Hutson, C.-B. Chien, and R. O. Karlstrom Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain Development, August 15, 2005; 132(16): 3643 - 3656. [Abstract] [Full Text] [PDF]

				I. Masai, M. Yamaguchi, N. Tonou-Fujimori, A. Komori, and H. Okamoto The hedgehog-PKA pathway regulates two distinct steps of the differentiation of retinal ganglion cells: the cell-cycle exit of retinoblasts and their neuronal maturation Development, April 1, 2005; 132(7): 1539 - 1553. [Abstract] [Full Text] [PDF]

				S. Y. Tay, P. W. Ingham, and S. Roy A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo Development, February 15, 2005; 132(4): 625 - 634. [Abstract] [Full Text] [PDF]

				T. P. Wilm and L. Solnica-Krezel Essential roles of a zebrafish prdm1/blimp1 homolog in embryo patterning and organogenesis Development, January 15, 2005; 132(2): 393 - 404. [Abstract] [Full Text] [PDF]

				C. Zhang, E. H. Williams, Y. Guo, L. Lum, and P. A. Beachy Inaugural Article: Extensive phosphorylation of Smoothened in Hedgehog pathway activation PNAS, December 28, 2004; 101(52): 17900 - 17907. [Abstract] [Full Text] [PDF]

				A. M. Wilbanks, G. B. Fralish, M. L. Kirby, L. S. Barak, Y.-X. Li, and M. G. Caron {beta}-Arrestin 2 Regulates Zebrafish Development Through the Hedgehog Signaling Pathway Science, December 24, 2004; 306(5705): 2264 - 2267. [Abstract] [Full Text] [PDF]

				C. Wolff, S. Roy, K. E. Lewis, H. Schauerte, G. Joerg-Rauch, A. Kirn, C. Weiler, R. Geisler, P. Haffter, and P. W. Ingham iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo Genes & Dev., July 1, 2004; 18(13): 1565 - 1576. [Abstract] [Full Text] [PDF]

				K. Sekimizu, N. Nishioka, H. Sasaki, H. Takeda, R. O. Karlstrom, and A. Kawakami The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling Development, June 1, 2004; 131(11): 2521 - 2532. [Abstract] [Full Text] [PDF]

				K. E. Lewis and J. S. Eisen Paraxial mesoderm specifies zebrafish primary motoneuron subtype identity Development, February 15, 2004; 131(4): 891 - 902. [Abstract] [Full Text] [PDF]

				K. Schlombs, T. Wagner, and J. Scheel Site-1 protease is required for cartilage development in zebrafish PNAS, November 25, 2003; 100(24): 14024 - 14029. [Abstract] [Full Text] [PDF]

				J. M. Ungos, R. O. Karlstrom, and D. W. Raible Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons Development, November 15, 2003; 130(22): 5351 - 5362. [Abstract] [Full Text] [PDF]

				R. J. Bink, H. Habuchi, Z. Lele, E. Dolk, J. Joore, G.-J. Rauch, R. Geisler, S. W. Wilson, J. den Hertog, K. Kimata, et al. Heparan Sulfate 6-O-Sulfotransferase Is Essential for Muscle Development in Zebrafish J. Biol. Chem., August 15, 2003; 278(33): 31118 - 31127. [Abstract] [Full Text] [PDF]

				L. D. Sacks, G. M. Cann, W. Nikovits Jr, S. Conlon, N. R. Espinoza, and F. E. Stockdale Regulation of myosin expression during myotome formation Development, August 1, 2003; 130(15): 3391 - 3402. [Abstract] [Full Text] [PDF]

				R. O. Karlstrom, O. V. Tyurina, A. Kawakami, N. Nishioka, W. S. Talbot, H. Sasaki, and A. F. Schier Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development Development, April 15, 2003; 130(8): 1549 - 1564. [Abstract] [Full Text] [PDF]

				K. L. Hammond, H. E. Loynes, A. A. Folarin, J. Smith, and T. T. Whitfield Hedgehog signalling is required for correct anteroposterior patterning of the zebrafish otic vesicle Development, April 1, 2003; 130(7): 1403 - 1417. [Abstract] [Full Text] [PDF]

				E. C. Bailey, L. Milenkovic, M. P. Scott, J. F. Collawn, and R. L. Johnson Several PATCHED1 Missense Mutations Display Activity in patched1-Deficient Fibroblasts J. Biol. Chem., September 6, 2002; 277(37): 33632 - 33640. [Abstract] [Full Text] [PDF]

				P. S. Amieux, D. G. Howe, H. Knickerbocker, D. C. Lee, T. Su, G. S. Laszlo, R. L. Idzerda, and G. S. McKnight Increased Basal cAMP-dependent Protein Kinase Activity Inhibits the Formation of Mesoderm-derived Structures in the Developing Mouse Embryo J. Biol. Chem., July 19, 2002; 277(30): 27294 - 27304. [Abstract] [Full Text] [PDF]

				E. Quint, A. Smith, F. Avaron, L. Laforest, J. Miles, W. Gaffield, and M.-A. Akimenko From the Cover: Bone patterning is altered in the regenerating zebrafish caudal fin after ectopic expression of sonic hedgehog and bmp2b or exposure to cyclopamine PNAS, June 25, 2002; 99(13): 8713 - 8718. [Abstract] [Full Text] [PDF]

				J. Mathieu, A. Barth, F. M. Rosa, S. W. Wilson, and N. Peyrieras Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development Development, January 7, 2002; 129(13): 3055 - 3065. [Abstract] [Full Text] [PDF]

				M. J. Parsons, S. M. Pollard, L. Saude, B. Feldman, P. Coutinho, E. M. A. Hirst, and D. L. Stemple Zebrafish mutants identify an essential role for laminins in notochord formation Development, January 7, 2002; 129(13): 3137 - 3146. [Abstract] [Full Text] [PDF]