Gli1 is a target of Sonic hedgehog that induces ventral neural tube development

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Alexandre, C., Jacinto, A. and Ingham, P. W (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by theCubitus interruptus protein, a member of the Gli family of zinc finger DNA-binding proteins. GenesDev 10, 2003-2013.[Abstract/Free Full Text]

Ang, S. L., Wierda, A., Wong, D., Stevens, K. A., Cascio, S., Rossant, J. and Zaret, K. S (1993). The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF-3/fork head proteins. Development 119, 1301-1315.[Abstract]

Barth, K. A. and Wilson, S. W (1995). Zebrafish Nkx2.2 is regulated by sonic hedgehog/vertebrte hedgehog-1 and demarcates a neurogenic zone in the embryonic forebrain. Development 121, 1755-1768.[Abstract]

Belloni, E., Muenke, M., Roessler, E., Traverso, G., Siegel-Bartelt, J., Frumkin, A., Mitchell, H. F., Donis-Keller, H., Helms, C., Hing, A. V., Heng, H. H. Q., Koop, B., Martindale, D., Rommens, J. M., Tsui, L.-C. and Scherer, S. W (1996). Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. NatureGenetics 14, 353-356.[Medline]

Campbell, M. E. M., Palfreyman, J. W. and Preston, C. M (1984). Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for the stimulation of immediate early trasncription. J. Mol. Biol 180, 1-19.[Medline]

Chang, D. T., Lopez, A., von Kessler, D. P., Chiang, C., Simandl, B. K., Zhao, R., Seldin, M. F., Fallon, J. F., and Beachy, P. A (1994). Products, genetic linkage, and limb patterning activity of a murine hedgehog gene. Development 120, 3339-3353.[Abstract]

Chen, Y. and Struhl, G (1996). Dual roles for patched in sequestering and transducing hedgehog. Cell 87, 553-563.[Medline]

Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A (1996). Cyclopia and defective axial patterning in mice lacking Sonichedgehog gene function. Nature 383, 407-413.[Medline]

Chitnis, A., Henrique, D., Lewis, J., Ish-Horowicz, D. and Kintner, C (1995). Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta. Nature 375, 761-766.[Medline]

Concordet, J.-P., Lewis, K.E., Moore, J.W., Goodrich, L.V., Johnson, R.L., Scott, M.P. and Ingham, P.W (1996). Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development 122, 2835-2846.[Abstract]

Conlon, R. A. and Herrmann, B. G (1993). Detection of messenger RNA by in situ hybridization to postimplantation embryo whole mounts. Methods in Enzymology 225, 373-383.[Medline]

Dale, L. and Slack, J. M. W (1987). Fate map for the 32-cell stage of Xenopus laevis. Development 99, 197-210.[Abstract]

Dale, L., Howes, G., Price, B. M. and Smith, J. C (1992). Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development. Development 115, 573-585.[Abstract]

Dirksen, M. L. and Jamrich, M (1992). A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain. Genes Dev 6, 599-608.[Abstract/Free Full Text]

Dom\222nguez, M., Brunner, M., Hafen, E. and Basler, K (1996). Sending and receiving the hedgehog signal: control by the Drosophila Gli protein cubitus interruptus. Science 272, 1621-1625.[Abstract]

Eaton, S. and Kornberg, T. B (1990). Repression of ci-D in posterior compartments of Drosophila by engrailed. Genes Dev 4, 1068-1077.[Abstract/Free Full Text]

Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P (1993). Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.[Medline]

Ekker, S. C., McGrew, L. L., Lai, C.-J., Lee, J. J., von Kessler, D. P., Moon, R. T. and Beachy, P. A (1995). Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis. Development 121, 2337-2347.[Abstract]

Epstein, D. J., Mart\222, E., Scott, M. P. and McMahon, A. P (1996). Antagonizing cAMP dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122, 2885-2894.[Abstract]

Ericson, J., Muhr, J., Placzek, M., Lints, T., Jessell, T. M. and Edlund, T (1995). Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube. Cell 81, 747-756.[Medline]

Ericson, J., Mortin, S., Kawakami, A., Roelink, H. and Jessell, T. M (1996). Two critical periods of sonic hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661-673.[Medline]

Fainsod, A., Steinbeisser, H. and De Robertis, E. M (1994). On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo. EMBO J 13, 5015-5025.[Medline]

Fan, C.-M. and Tessier-Lavigne, M (1994). Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell 79, 1175-1186.[Medline]

Fan, C.-M., Porter, J. A., Chiang, C., Chang, D. T., Beachy, P. A. and Tessier-Lavigne, M (1995). Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 81, 457-465.[Medline]

Forbes, A.J., Nakano, Y., Taylor, A. M. and Ingham, P. W (1993). Genetic analysis of hedgehog signalling in the Drosophila embryo. Development 1993, 115-124.

Franz, T (1994). Extra-Toes (Xt) Homozygous Mutant Mice Demonstrate a Role for the Gli-3 Gene in the Development of the Forebrain. Acta Anat 150, 38-44.[Medline]

Fu, X.-D. and Maniatis, T (1990). Factor required for mamalian spliceosome assembly is localized to discrete regions in the nucleus. Nature 343, 437-441.[Medline]

Goodrich, L. V., Johnson, R. L., Milenkovic, L., McMahon, J. A. and Scott, M. P (1996). Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Development 10, 301-312.[Abstract/Free Full Text]

Goulding, M., Lumsden, A. and Gruss, P (1993). Signals from the notochord and floor plate regulate the region-specific expression of two pax genes in the developing spinal cord. Development 117, 1001-1016.[Abstract]

Hahn, H., Wicking, C., Zaphiropoulous, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vorechovsky, I., Holmberg, E., Unden, A. B., Gillies, S., Negus, K., Smyth, I., Pressman, C., Leffell., D. J., Gerrard, B., Goldstein, A. M., Dean, M., Toftgard, R., Chenevix-Trench, G., Wainwrught, B. and Bale, A. E (1996). Mutations of the human homolog of Drosohila patched in the nevoid basal cell carcinoma syndrome. Cell 85, 841-951.[Medline]

Hammerschmidt, M., Bitgood, M. J. and McMahon, A. P (1996). Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev 10, 647-658.[Abstract/Free Full Text]

Harland, R. M (1991). In situ hybridization: an improved whole mount method for Xenopus embryos. Meth. Enzymol 36, 675-685.

Hemmati-Brivanlou, A. and Thomsen, G (1995). Ventral mesodermal patterning in Xenopus embros: expression patterns and activities of BMP-2 and BMP-4. Dev. Genetics 17, 78-89.[Medline]

Hui, C.-C. and Joyner, A. L (1993). A mouse model of Greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nature Genetics 3, 241-246.[Medline]

Hui, C.-C., Slusarski, D., Platt, K. A., Holmgren, R. and Joyner, A. L (1994). Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol 162, 402-413.[Medline]

Hynes, M., Porter, J. A., Chians, C., Chang, D., Tessier-Lavigne, M. and Beachy, P. A (1995). Induction of midbrain dopaminergic neurons by sonic hedgehog. Neuron 15, 35-44.[Medline]

Johnson, D. R (1967). Extra-toes: a new mutant gene causing multiple abnormalities in the mouse. J. Embryol. Exp. Morph 17, 543-581.[Medline]

Johnson, R. L., Rothman, A. L., Xie, J., Goodrich, L. V., Bare, J. W., Bonifas, J. M., Quinn, A. G., Myers, R. M., Cox, D.R., Epstein, E. H. Jr. and Scott, M. P (1996). Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272, 1668-1671.[Abstract]

Kelsey-Motzny, C. and Holmgren, R (1995). The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech. Dev 52, 137-150.[Medline]

Kintner, C. R. and Melton, D. A (1987). Expression of the Xenopus N-CAM RNA in ectoderm is an early response to neural induction. Development 99, 311-325.[Abstract]

Kinzler, K. W., Bigner, S. H., Bigner, D. D., Trent, J. M., Law, M. L., O'Brien, S. J., Wong, A. J. and Vogelstein, B (1987). Identification of an amplified, highly expressed gene in a human glioma. Science 236, 70-73.[Abstract/Free Full Text]

Kinzler, K. W., Ruppert, J. M., Bigner, S. H. and Vogelstein, B (1988). The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature 332, 371-74.[Medline]

Kinzler, K. W. and Vogelstein, B (1990). The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol. Cell Biol 10, 634-642.[Abstract/Free Full Text]

Kn\232chel, S., Lef, J., Clement, J., Klocke, B., Hille, S., Koster, M. and Kn\232chel, W (1992). Activin A-induced expression of a fork-head-related gene in posterior chordamesoderm (notochord) of Xenopus laevis embryos. Mech. Dev 38, 157-165.[Medline]

Krauss, S., Concordet, J.-P. and Ingham, P. W (1993). A functionallyconserved homolog of the Drosophila segment polarity gene hedgehog is expressed in tissues with polarizing activity in zebrafish embryos. Cell 75, 1431-1444.[Medline]

Larsson, S. H., Charlieu, J.-P., Miyagawa, K., Engelkamo, D., Rassoulzadegan, M., Ross, A., Cuzin, F., van Heyningen, V. and Hastie, N. D (1995). Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing. Cell 81, 391-401.[Medline]

Lazzaro, D., Price, M., De Felice, M. and Di Lauro, R (1991). The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development 113, 1093-1104.[Abstract]

Liem, K. F., Jr., Tremmel, G., Roelink, H. and Jessell, T. M (1995). Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 82, 969-979.[Medline]

Marigo, V., Scott, M. P., Johnson, R. L., Goodrich, L. V. and Tabin, C. J (1996). Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development 122, 1225-1233.[Abstract]

Marigo, V. and Tabin, C. J (1996). Regulation of Patched by Sonic hedgehog in the developing neural tube. Proc. Natl. Acad. Sci. USA 93, 9346-9351.[Abstract/Free Full Text]

Marigo, V., Davey, R. A., Zuo, Y., Cunningham, J. M. and Tabin, C. J (1996). Biochemical evidence that patched is the hedgehog receptor. Nature 384, 176-179.[Medline]

Mart\222, E., Bumcrot, D. A., Takada, R. and McMahon, A. P (1995). Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature 375, 322-325.[Medline]

Mart\222, E., Takada, R., Bumcrot, D. A., Sasaki, H. and McMahon, A. P (1995). Distribution of sonic hedgehog peptides in the developing chick and mouse embryo. Development 121, 2537-2547.[Abstract]

Masuya, H., Sagai, T., Wakana, S., Moriwaki, K. and Shiroishi, T (1995). A duplicated zone of polarizing activity in polydactylous mouse mutants. Genes Dev 13, 1645-1653.

Monaghan, A. P., Kaestner, K. H., Grau, E. and Schutz, G (1993). Postimplanation expression patterns indicate a role for the mouse forkhead/HNF-3, andgenes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development 119, 567-578.[Abstract]

Nishimatsu, S., Suzuki, A., Shoda, A., Murakami, K. and Ueno, N (1992). Genes for bone morphogenetic proteins are differentiatlly transcribed in early amphibian embryos. Biochem. Biophys. Res. Com 186, 1487-1495.[Medline]

Orenic, T. V., Slusarski, D. C., Kroll, K. L. and Holmgren, R. A (1990). Cloning and characterization of the segment polarity gene cubitus interruptus dominant of Drosophila. Genes Dev 4, 1053-1067.[Abstract/Free Full Text]

Patel, N. H., Martin-Blanco, E., Coleman, K. G., Poole, S. J., Ellis, M. C., Kornberg, T. B. and Goodman, C. S (1989). Expression of engrailed proteins in arthropods, annelids and chordates. Cell 58, 955-968.[Medline]

Pavletich, N. P. and Pabo, C. O (1993). Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. Science 261, 1701-1707.[Abstract/Free Full Text]

Perrimon, N (1995). Hedgehog and beyond. Cell 80, 517-520.[Medline]

Placzek, M., Tessier-Lavigne, M., Yamada, T., Jessell, T. M. and Dodd, J (1990). Mesodermal control of neural cell identity: floor plate induction by the notochord. Science 250, 985-988.[Abstract/Free Full Text]

Placzek, M., Jessell, T. M. and Dodd, J (1993). Induction of floor plate differentiation by contact-dependent, homeogenetic signals. Development 117, 205-218.[Abstract]

Pourquie, O., Coltey, M., Breant, C. and Le Douarin, N. M (1995). Control of somite patterning by signals from the lateral plate. Proc. Natl. Acad. Sci. USA 92, 3219-3223.[Abstract/Free Full Text]

Pourquie, O., Fan, C.-M., Coltey, M., Hirsinger, E., Watanabe, Y, Breant, C., Francis-West, P., Brickell, P., Tessier-Lavigne, M. and Le Douarin, N. M (1996). Lateral and axial signals involved in somite patterning: a role for BMP-4. Cell 84, 461-471.[Medline]

Price, M., Lazzaro, D., Pohl, T., Mattei, M.-G., Ruther, U., Olivo, J.-C., Duboule, D. and Di Lauro, R (1992). Regional expression of the homeobox gene Nkx2.2 in the developing mammalian forebrain. Neuron 8, 241-255.[Medline]

Richter, K., Grunz, H. and Dawid, I. B (1988). Gene expression in the embryonic nervous system of Xenopus laevis. Proc. Natl. Acad. Sci. USA 85, 8086-8090.[Abstract/Free Full Text]

Riddle, R., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 751, 401-1418.

Roberts, W. M., Douglass, E. C., Peiper, S. C., Houghton, P. J. and Look, A. T (1989). Amplification of the gli gene in childhood sarcomas. Cancer Research 49, 5407-5413.[Abstract/Free Full Text]

Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V., Norlin, S., Ruiz i Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T. M. and Dodd, J (1994). Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell 76, 761-775.[Medline]

Roelink, H., Porter, J. A., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A. and Jessell, T. M (1995). Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 81, 445-455.[Medline]

Roessler, E., Belloni, E., Gaudenz, K., Jay, P., Berta, P., Scherer, S. W., Tsui, L.-C. and Muenke, M (1996). Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nature Genetics 14, 357-360.[Medline]

Ruiz i Altaba, A (1992). Cooperation of Planar and Vertical Signals in the Induction and Patterning of the Xenopus Nervous System. Development 115, 67-80.[Abstract]

Ruiz i Altaba, A (1994). Pattern formation in the vertebrate neural plate. Trends Neurosci 17, 233-243.[Medline]

Ruiz i Altaba, A., and Jessell, T. M (1991). Retinoic acid modifies the pattern of cell differentiation in the central nervous system of neurula stage Xenopus embryos. Development 112, 945-958.[Abstract]

Ruiz i Altaba, A. and Jessell, T. M (1992). Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis. Development 116, 81-93.[Abstract]

Ruiz i Altaba, A., Prezioso, V. R., Darnell, J. E. and Jessell, T. M (1993). Sequential expression of HNF-3and HNF-3 by embryonic organizing centers: the dorsal lip/node, notochord and floor plate. Mech. Dev 44, 91-108.[Medline]

Ruiz i Altaba, A., Cox, C., Jessell, T. M. and Klar, A (1993). Ectopic neural expression of a floor plate marker in frog embryos injected with the midline transcription factor Pintallavis. Proc. Natl. Acad. Sci. USA 90, 8268-8272.[Abstract/Free Full Text]

Ruiz i Altaba, A., Jessell, T. M. and Roelink, H (1995). Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryos. Mol. Cell. Neurosci 6, 106-121.[Medline]

Ruiz i Altaba, A., Placzek, M., Baldassare, M., Dodd, J. and Jessell, T. M (1995). Early stages of notochord and floor plate differentiation defined by normal and induced expression of HNF-3in chick embryos. Dev. Biol 170, 299-313.[Medline]

Rupp, R. A. W., Snider, L. and Weintraub, H (1994). Xenopus embryos regulate the nuclear localization of XMyoD. Genes Dev 8, 1311-1323.[Abstract/Free Full Text]

Ruppert, J. M., Kinzler, K. W., Wong, A. J., Bigner, S. H., Kao, F. T., Law, M. L., Seuanez, H. N., O'Brien, S. J. and Vogelstein, B (1988). The GLI-Kruppel family of human genes. Mol. Cell. Biol 8, 3104-3113.[Abstract/Free Full Text]

Ruppert, J. M., Vogelstein, B., Arheden, K. and Kinzler, K.W (1990). GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol. Cell Biol 10, 5408-5415.[Abstract/Free Full Text]

Ruppert, J.M., Vogelstein, B. and Kinzler, K.W (1991). The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A. Mol. Cell Biol 11, 1724-1728.[Abstract/Free Full Text]

S\207nchez-Herrero, E., Couso, J. P., Capdevila, J. and Guerrero, I (1996). The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs. Mech. Dev 55, 159-170.[Medline]

Sasaki, H. and Hogan, B (1993). Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118, 47-59.[Abstract]

Sasaki, H. and Hogan, B (1994). HNF-3as a regulator of floor plate development. Cell 76, 103-115.[Medline]

Schimmang, T., Lemaistre, M., Vortkamp, A. and Ruther, U (1992). Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt). Development 116, 799-804.[Abstract]

Simon, H., Hornbruch, A. and Lumsden, A (1995). Independent assignment of antero-posterior and dorso-ventral positional values in the developing chick hindbrain. Current Biol 5, 205-214.[Medline]

Slusarski, D.C., Kelsey Motzny, C. and Holmgren, R (1995). Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster. Genetics 139, 229-240.[Abstract]

Stone, D. M., Hynes, M., Armanini, M., Swanson, T. A., Gu, Q, Johnson, R. L., Scott, M. P., Pennica, D., Goddard, A., Phillips, H., Noll, M., Hooper, J. E., de Sauvage, F. and Rosenthal, A (1996). The tumor suppressor genepatched encodes a candidate receptor for sonic hedgehog. Nature 384, 129-134.[Medline]

Str\212hle, U., Blader, P., Henrique, D. and Ingham, P. W (1993). Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos. Genes Dev 7, 1436-1446.[Abstract/Free Full Text]

Tanabe, Y., Roelink, H. and Jessell, T. M (1995). Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation. Current Biology 5, 651-658.[Medline]

Tanimura, A., Teshima, H., Fujisawa, J. and Yoshida, M (1993). A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins. J. Virology 67, 5375-5382.[Abstract/Free Full Text]

Triezenberg, S. J., Kingsbury, R. C. and McKnight, S. L (1988). Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. GenesDev 2, 718-729.[Abstract/Free Full Text]

Turner, D. L. and Weintraub, H (1994). Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. GenesDev 8, 1434-1447.[Abstract/Free Full Text]

van Mier, P., Joosten, H. W. J., van Rheden, R. and Ten Donkelaar, H. J (1986). The development of serotonergic raphespinal projections in Xenopus laevis. Int. J. Develop. Neurosci 24, 465-476.

van Straaten, H. W. M., Hekking, J. W. M., Wiertz-Hoessels, E. L., Thors,F. and Drukker, J (1988). Effect of the notochord on the differentiation of a floor plate area in the neural tube of the chick embryo. Anat. Embryol 177, 317-324.[Medline]

van Straaten, H. W. M. and Hekking, J. W. M (1991). Development of floor plate, neurons and axonal outgrowth pattern in the early spinal cord of the notochord-deficient chick embryo. Anat. Embryol 184, 55-63.[Medline]

Vortkamp, A., Gessler, M. and Grzeschik, K.-H (1991). GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families. Nature 352, 539-540.[Medline]

Walterhouse, D., Ahmed, M., Slusarski, D., Kalamaras, J., Boucher, D., Holmgren, R. and Iannaccone, P (1993). gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development. Dev. Dyn 196, 91-102.[Medline]

Yamada, T., Placzek, M., Tanaka, H., Dodd, J. and Jessell, T. M (1991). Control of cell pattern in the developing nervous system: polarizing activity of the floor plate notochord. Cell 64, 635-647.[Medline]

Zarkower, D. and Hodgkin, J (1992). Molecular Analysis of the C. elegans Sex-Determining Gene tra-1: A Gene Encoding Two Zinc Finger Proteins. Cell 70, 237-249.[Medline]

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H. Zhou, S. Kim, S. Ishii, and T. G. Boyer
Mediator Modulates Gli3-Dependent Sonic Hedgehog Signaling
Mol. Cell. Biol., December 1, 2006; 26(23): 8667 - 8682.
[Abstract] [Full Text] [PDF]

I. Sarkaria, P. O-charoenrat, S. G. Talbot, P. G. Reddy, I. Ngai, E. Maghami, K. N. Patel, B. Lee, Y. Yonekawa, M. Dudas, et al.
Squamous Cell Carcinoma Related Oncogene/DCUN1D1 Is Highly Conserved and Activated by Amplification in Squamous Cell Carcinomas
Cancer Res., October 1, 2006; 66(19): 9437 - 9444.
[Abstract] [Full Text] [PDF]

S. J. Hatsell and P. Cowin
Gli3-mediated repression of Hedgehog targets is required for normal mammary development
Development, September 15, 2006; 133(18): 3661 - 3670.
[Abstract] [Full Text] [PDF]

M. Zhao, M. Qiao, S. E. Harris, D. Chen, B. O. Oyajobi, and G. R. Mundy
The zinc finger transcription factor gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling.
Mol. Cell. Biol., August 1, 2006; 26(16): 6197 - 6208.
[Abstract] [Full Text] [PDF]

V. Dasari, M. Gallup, H. Lemjabbar, I. Maltseva, and N. McNamara
Epithelial-Mesenchymal Transition in Lung Cancer: Is Tobacco the "Smoking Gun"?
Am. J. Respir. Cell Mol. Biol., July 1, 2006; 35(1): 3 - 9.
[Full Text] [PDF]

T Akiyoshi, M Nakamura, K Koga, H Nakashima, T Yao, M Tsuneyoshi, M Tanaka, and M Katano
Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation
Gut, July 1, 2006; 55(7): 991 - 999.
[Abstract] [Full Text] [PDF]

Y. Pan, C. B. Bai, A. L. Joyner, and B. Wang
Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation.
Mol. Cell. Biol., May 1, 2006; 26(9): 3365 - 3377.
[Abstract] [Full Text] [PDF]

T. T. Turner, H. J. Bang, S. A. Attipoe, D. S. Johnston, and J. L. Tomsig
Sonic Hedgehog Pathway Inhibition Alters Epididymal Function as Assessed by the Development of Sperm Motility
J Androl, March 1, 2006; 27(2): 225 - 232.
[Abstract] [Full Text] [PDF]

V. Ribes, Z. Wang, P. Dolle, and K. Niederreither
Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling
Development, January 15, 2006; 133(2): 351 - 361.
[Abstract] [Full Text] [PDF]

D. Huangfu and K. V. Anderson
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
Development, January 1, 2006; 133(1): 3 - 14.
[Abstract] [Full Text] [PDF]

Q. Xu, C. P. Wonders, and S. A. Anderson
Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon
Development, November 15, 2005; 132(22): 4987 - 4998.
[Abstract] [Full Text] [PDF]

M. Wijgerde, M. Ooms, J. W. Hoogerbrugge, and J. A. Grootegoed
Hedgehog Signaling in Mouse Ovary: Indian Hedgehog and Desert Hedgehog from Granulosa Cells Induce Target Gene Expression in Developing Theca Cells
Endocrinology, August 1, 2005; 146(8): 3558 - 3566.
[Abstract] [Full Text] [PDF]

V. Nguyen, A. L. Chokas, B. Stecca, and A. R. i Altaba
Cooperative requirement of the Gli proteins in neurogenesis
Development, July 15, 2005; 132(14): 3267 - 3279.
[Abstract] [Full Text] [PDF]

P. J. Gianakopoulos and I. S. Skerjanc
Hedgehog Signaling Induces Cardiomyogenesis in P19 Cells
J. Biol. Chem., June 3, 2005; 280(22): 21022 - 21028.
[Abstract] [Full Text] [PDF]

D. Stamataki, F. Ulloa, S. V. Tsoni, A. Mynett, and J. Briscoe
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
Genes & Dev., March 1, 2005; 19(5): 626 - 641.
[Abstract] [Full Text] [PDF]

S. L. Lopez, M. V. Rosato-Siri, P. G. Franco, A. R. Paganelli, and A. E. Carrasco
The Notch-target gene hairy2a impedes the involution of notochordal cells by promoting floor plate fates in Xenopus embryos
Development, March 1, 2005; 132(5): 1035 - 1046.
[Abstract] [Full Text] [PDF]

A. McDermott, M. Gustafsson, T. Elsam, C.-C. Hui, C. P. Emerson Jr, and A.-G. Borycki
Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation
Development, January 15, 2005; 132(2): 345 - 357.
[Abstract] [Full Text] [PDF]

A. R. Hallahan, J. I. Pritchard, S. Hansen, M. Benson, J. Stoeck, B. A. Hatton, T. L. Russell, R. G. Ellenbogen, I. D. Bernstein, P. A. Beachy, et al.
The SmoA1 Mouse Model Reveals That Notch Signaling Is Critical for the Growth and Survival of Sonic Hedgehog-Induced Medulloblastomas
Cancer Res., November 1, 2004; 64(21): 7794 - 7800.
[Abstract] [Full Text] [PDF]

P. Sanchez, A. M. Hernandez, B. Stecca, A. J. Kahler, A. M. DeGueme, A. Barrett, M. Beyna, M. W. Datta, S. Datta, and A. Ruiz i Altaba
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
PNAS, August 24, 2004; 101(34): 12561 - 12566.
[Abstract] [Full Text] [PDF]

Q. Lei, A. K. Zelman, E. Kuang, S. Li, and M. P. Matise
Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
Development, August 1, 2004; 131(15): 3593 - 3604.
[Abstract] [Full Text] [PDF]

M. T. Cobourne, I. Miletich, and P. T. Sharpe
Restriction of sonic hedgehog signalling during early tooth development
Development, June 15, 2004; 131(12): 2875 - 2885.
[Abstract] [Full Text] [PDF]

K. Sekimizu, N. Nishioka, H. Sasaki, H. Takeda, R. O. Karlstrom, and A. Kawakami
The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling
Development, June 1, 2004; 131(11): 2521 - 2532.
[Abstract] [Full Text] [PDF]

K. Lai, M. J. Robertson, and D. V. Schaffer
The Sonic Hedgehog Signaling System as a Bistable Genetic Switch
Biophys. J., May 1, 2004; 86(5): 2748 - 2757.
[Abstract] [Full Text] [PDF]

V. Palma and A. R. i Altaba
Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex
Development, January 15, 2004; 131(2): 337 - 345.
[Abstract] [Full Text] [PDF]

A. Moshiri and T. A. Reh
Persistent Progenitors at the Retinal Margin of ptc+/- Mice
J. Neurosci., January 7, 2004; 24(1): 229 - 237.
[Abstract] [Full Text] [PDF]

L. Buttitta, R. Mo, C.-C. Hui, and C.-M. Fan
Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction
Development, December 22, 2003; 130(25): 6233 - 6243.
[Abstract] [Full Text] [PDF]

G. C.M. Black, C. J. Mazerolle, Y. Wang, K. D. Campsall, D. Petrin, B. C. Leonard, K. F. Damji, D. G. Evans, D. McLeod, and V. A. Wallace
Abnormalities of the vitreoretinal interface caused by dysregulated Hedgehog signaling during retinal development
Hum. Mol. Genet., December 15, 2003; 12(24): 3269 - 3276.
[Abstract] [Full Text] [PDF]

E. Roessler, Y.-Z. Du, J. L. Mullor, E. Casas, W. P. Allen, G. Gillessen-Kaesbach, E. R. Roeder, J. E. Ming, A. R. i Altaba, and M. Muenke
Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features
PNAS, November 11, 2003; 100(23): 13424 - 13429.
[Abstract] [Full Text] [PDF]

H. Kawahira, N. H. Ma, E. S. Tzanakakis, A. P. McMahon, P.-T. Chuang, and M. Hebrok
Combined activities of hedgehog signaling inhibitors regulate pancreas development
Development, October 15, 2003; 130(20): 4871 - 4879.
[Abstract] [Full Text] [PDF]

Y. Jeong and D. J. Epstein
Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node
Development, August 15, 2003; 130(16): 3891 - 3902.
[Abstract] [Full Text] [PDF]

C. T. Miller, S. Aggarwal, T. K. Lin, S. L. Dagenais, J. I. Contreras, M. B. Orringer, T. W. Glover, D. G. Beer, and L. Lin
Amplification and Overexpression of the Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 2 (DYRK2) Gene in Esophageal and Lung Adenocarcinomas
Cancer Res., July 15, 2003; 63(14): 4136 - 4143.
[Abstract] [Full Text] [PDF]

				I. Matera, D. E. Watkins-Chow, S. K. Loftus, L. Hou, A. Incao, D. L. Silver, C. Rivas, E. C. Elliott, L. L. Baxter, and W. J. Pavan A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy Hum. Mol. Genet., July 15, 2008; 17(14): 2118 - 2131. [Abstract] [Full Text] [PDF]

				M. Tada, F. Kanai, Y. Tanaka, K. Tateishi, M. Ohta, Y. Asaoka, M. Seto, R. Muroyama, K. Fukai, F. Imazeki, et al. Down-Regulation of Hedgehog-Interacting Protein through Genetic and Epigenetic Alterations in Human Hepatocellular Carcinoma Clin. Cancer Res., June 15, 2008; 14(12): 3768 - 3776. [Abstract] [Full Text] [PDF]

				C. Fontaine, W. Cousin, M. Plaisant, C. Dani, and P. Peraldi Hedgehog Signaling Alters Adipocyte Maturation of Human Mesenchymal Stem Cells Stem Cells, April 1, 2008; 26(4): 1037 - 1046. [Abstract] [Full Text] [PDF]

				K. E. Galvin, H. Ye, D. J. Erstad, R. Feddersen, and C. Wetmore Gli1 Induces G2/M Arrest and Apoptosis in Hippocampal but Not Tumor-Derived Neural Stem Cells Stem Cells, April 1, 2008; 26(4): 1027 - 1036. [Abstract] [Full Text] [PDF]

				F. Balordi and G. Fishell Mosaic Removal of Hedgehog Signaling in the Adult SVZ Reveals That the Residual Wild-Type Stem Cells Have a Limited Capacity for Self-Renewal J. Neurosci., December 26, 2007; 27(52): 14248 - 14259. [Abstract] [Full Text] [PDF]

				M. Fiaschi, B. Rozell, A. Bergstrom, R. Toftgard, and M. I. Kleman Targeted Expression of GLI1 in the Mammary Gland Disrupts Pregnancy-induced Maturation and Causes Lactation Failure J. Biol. Chem., December 7, 2007; 282(49): 36090 - 36101. [Abstract] [Full Text] [PDF]

				V. A. Ruzhynsky, K. A. McClellan, J. L. Vanderluit, Y. Jeong, M. Furimsky, D. S. Park, D. J. Epstein, V. A. Wallace, and R. S. Slack Cell Cycle Regulator E2F4 Is Essential for the Development of the Ventral Telencephalon J. Neurosci., May 30, 2007; 27(22): 5926 - 5935. [Abstract] [Full Text] [PDF]

				F. Balordi and G. Fishell Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons J. Neurosci., May 30, 2007; 27(22): 5936 - 5947. [Abstract] [Full Text] [PDF]

				C. Vaillant, O. Michos, S. Orolicki, F. Brellier, S. Taieb, E. Moreno, H. Te, R. Zeller, and D. Monard Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar development Development, May 1, 2007; 134(9): 1745 - 1754. [Abstract] [Full Text] [PDF]

				H. Zhou, S. Kim, S. Ishii, and T. G. Boyer Mediator Modulates Gli3-Dependent Sonic Hedgehog Signaling Mol. Cell. Biol., December 1, 2006; 26(23): 8667 - 8682. [Abstract] [Full Text] [PDF]

				I. Sarkaria, P. O-charoenrat, S. G. Talbot, P. G. Reddy, I. Ngai, E. Maghami, K. N. Patel, B. Lee, Y. Yonekawa, M. Dudas, et al. Squamous Cell Carcinoma Related Oncogene/DCUN1D1 Is Highly Conserved and Activated by Amplification in Squamous Cell Carcinomas Cancer Res., October 1, 2006; 66(19): 9437 - 9444. [Abstract] [Full Text] [PDF]

				S. J. Hatsell and P. Cowin Gli3-mediated repression of Hedgehog targets is required for normal mammary development Development, September 15, 2006; 133(18): 3661 - 3670. [Abstract] [Full Text] [PDF]

				M. Zhao, M. Qiao, S. E. Harris, D. Chen, B. O. Oyajobi, and G. R. Mundy The zinc finger transcription factor gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol. Cell. Biol., August 1, 2006; 26(16): 6197 - 6208. [Abstract] [Full Text] [PDF]

				V. Dasari, M. Gallup, H. Lemjabbar, I. Maltseva, and N. McNamara Epithelial-Mesenchymal Transition in Lung Cancer: Is Tobacco the "Smoking Gun"? Am. J. Respir. Cell Mol. Biol., July 1, 2006; 35(1): 3 - 9. [Full Text] [PDF]

				T Akiyoshi, M Nakamura, K Koga, H Nakashima, T Yao, M Tsuneyoshi, M Tanaka, and M Katano Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation Gut, July 1, 2006; 55(7): 991 - 999. [Abstract] [Full Text] [PDF]

				Y. Pan, C. B. Bai, A. L. Joyner, and B. Wang Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation. Mol. Cell. Biol., May 1, 2006; 26(9): 3365 - 3377. [Abstract] [Full Text] [PDF]

				T. T. Turner, H. J. Bang, S. A. Attipoe, D. S. Johnston, and J. L. Tomsig Sonic Hedgehog Pathway Inhibition Alters Epididymal Function as Assessed by the Development of Sperm Motility J Androl, March 1, 2006; 27(2): 225 - 232. [Abstract] [Full Text] [PDF]

				V. Ribes, Z. Wang, P. Dolle, and K. Niederreither Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling Development, January 15, 2006; 133(2): 351 - 361. [Abstract] [Full Text] [PDF]

				D. Huangfu and K. V. Anderson Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates Development, January 1, 2006; 133(1): 3 - 14. [Abstract] [Full Text] [PDF]

				Q. Xu, C. P. Wonders, and S. A. Anderson Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon Development, November 15, 2005; 132(22): 4987 - 4998. [Abstract] [Full Text] [PDF]

				M. Wijgerde, M. Ooms, J. W. Hoogerbrugge, and J. A. Grootegoed Hedgehog Signaling in Mouse Ovary: Indian Hedgehog and Desert Hedgehog from Granulosa Cells Induce Target Gene Expression in Developing Theca Cells Endocrinology, August 1, 2005; 146(8): 3558 - 3566. [Abstract] [Full Text] [PDF]

				V. Nguyen, A. L. Chokas, B. Stecca, and A. R. i Altaba Cooperative requirement of the Gli proteins in neurogenesis Development, July 15, 2005; 132(14): 3267 - 3279. [Abstract] [Full Text] [PDF]

				P. J. Gianakopoulos and I. S. Skerjanc Hedgehog Signaling Induces Cardiomyogenesis in P19 Cells J. Biol. Chem., June 3, 2005; 280(22): 21022 - 21028. [Abstract] [Full Text] [PDF]

				D. Stamataki, F. Ulloa, S. V. Tsoni, A. Mynett, and J. Briscoe A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube Genes & Dev., March 1, 2005; 19(5): 626 - 641. [Abstract] [Full Text] [PDF]

				S. L. Lopez, M. V. Rosato-Siri, P. G. Franco, A. R. Paganelli, and A. E. Carrasco The Notch-target gene hairy2a impedes the involution of notochordal cells by promoting floor plate fates in Xenopus embryos Development, March 1, 2005; 132(5): 1035 - 1046. [Abstract] [Full Text] [PDF]

				A. McDermott, M. Gustafsson, T. Elsam, C.-C. Hui, C. P. Emerson Jr, and A.-G. Borycki Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation Development, January 15, 2005; 132(2): 345 - 357. [Abstract] [Full Text] [PDF]

				A. R. Hallahan, J. I. Pritchard, S. Hansen, M. Benson, J. Stoeck, B. A. Hatton, T. L. Russell, R. G. Ellenbogen, I. D. Bernstein, P. A. Beachy, et al. The SmoA1 Mouse Model Reveals That Notch Signaling Is Critical for the Growth and Survival of Sonic Hedgehog-Induced Medulloblastomas Cancer Res., November 1, 2004; 64(21): 7794 - 7800. [Abstract] [Full Text] [PDF]

				P. Sanchez, A. M. Hernandez, B. Stecca, A. J. Kahler, A. M. DeGueme, A. Barrett, M. Beyna, M. W. Datta, S. Datta, and A. Ruiz i Altaba Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling PNAS, August 24, 2004; 101(34): 12561 - 12566. [Abstract] [Full Text] [PDF]

				Q. Lei, A. K. Zelman, E. Kuang, S. Li, and M. P. Matise Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord Development, August 1, 2004; 131(15): 3593 - 3604. [Abstract] [Full Text] [PDF]

				M. T. Cobourne, I. Miletich, and P. T. Sharpe Restriction of sonic hedgehog signalling during early tooth development Development, June 15, 2004; 131(12): 2875 - 2885. [Abstract] [Full Text] [PDF]