Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos

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Ang, S. L. and Rossant, J. ( (1994). HNF-3is essential for node and notochord formation in mouse development. Cell 78, 561-574.[Medline]

Barton, S. C., Surani, M. A. H. and Norris, M. L (1984). Role of paternal and maternal genomes in mouse development. Nature 311, 374-376.[Medline]

Basheeruddin, K., Stein, P., Strickland, S. and Williams, D. L (1987). Expression of the murine apolipoprotein E gene is coupled to the differentiated state of F9 embryonal carcinoma cells. Proc. Natl. Acad. Sci. USA 84, 709-713.[Abstract/Free Full Text]

Brent, R. L., Beckman, D. A., Jensen, M. and Koszalka, T. R (1990). Experimental yolk sac dysfunction as a model for studying nutritional disturbances in the embryo during organogenesis. Teratology 41, 405-413.[Medline]

Carmeliet, P.Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Erberhardt,C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W. and Nagy, A (1996). Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435-439.[Medline]

Cereghini, S., Ott, M.-O., Power, S. and Maury, M (1992). Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles. Development 116, 783-797.[Abstract]

Chen, W. S., Manova, K., Weinstein, D. C., Duncan, S. A., Plump, A. S., Prezioso, V. R., Bachvarova, R. F. and Darnell, J. E., Jr (1994). Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev 8, 2466-2477.[Abstract/Free Full Text]

Coucouvanis, E. and Martin, G. R (1995). Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo. Cell 83, 279-287.[Medline]

Doetschman, T. C., Eistetter, H., Katz, M., Schmidt, W. and Kemler, R (1985). The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J. Embryol. Exp. Morphol 87, 27-45.[Medline]

Drewes, T., Senkel, S., Holewa, B. and Ryffel, G. U (1996). Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. Mol. Cell Biol 16, 925-931.[Abstract]

Duncan, S. A., Manova, K., Chen, W. S., Hoodless, P., Weinstein, D. C., Bachvarova, R. F. and Darnell, J. E., Jr (1994). Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc. Natl. Acad. Sci. USA 91, 7598-7602.[Abstract/Free Full Text]

Episkopou, V., Maeda, S., Nishiguchi, S., Kazunori, S., Gaitanaris, G. A., Gottesman, M. E. and Robertson, E. J (1993). Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone. Proc. Nat. Acad. Sci. USA 90, 2375-2379.[Abstract/Free Full Text]

Evans, M. J. and Kaufman, M. H (1981). Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154-156.[Medline]

Farese, R. V., Ruland, S. L., Flynn, L. M., Stokowski, R. P. and Young, S. G (1995). Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc. Natl. Acad. Sci. USA 92, 1774-1778.[Abstract/Free Full Text]

Gardner, R. L (1983). Origin and differentiation of extraembryonic endoderm in the mouse. J. Embryol. Exp. Morphol 80, 251-288.

Grover, A., Andrews, G. and Adamson, E. D (1983). Role of laminin in epithelium formation by F9 aggregates. J. Cell Biol 97, 137-144.[Abstract/Free Full Text]

Grover, A., Oshima, R. G. and Adamson, E. D (1983). Epithelial layer formation in differentiating aggregates of F9 embryonal carcinoma cells. J. Cell Biol 96, 1690-1696.[Abstract/Free Full Text]

Guillemot, F., Nagy, A., Auerbach, A. and Joyner, A. L (1994). Essential role of Mash-2 in extraembryonic development. Nature 371, 333-336.[Medline]

Harrison, S. M., Dunwoodie, S. L., Arkell, R. M., Lerach, H. and Beddington, R. S. P (1995). Isolation of novel tissue-specific genes from cDNA libraries representing the individual constituents of the gastrulating mouse embryo. Development 121, 2479-2489.[Abstract]

Heath, J. K. and Deller, M. J (1983). Serum-free culture of PC13 murine embryonal carcinoma cells. J. Cell. Physiol 115, 225-230.[Medline]

Hooper, M., Hardy, K., Handyside, A., Hunter, S. and Monk, M (1987). HPRT-deficient (Lesch-Nyan) mouse embryos derived from germline colonization by cultured cells. Nature 326, 292-295.[Medline]

Huang, L. S., Voyiaziakis, E., Markenson, D. F., Sokol, K. A., Hayek, T. and Breslow, J. L (1995). Apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and Apo A-I transport rates in heterozygotes. J. Clin. Invest 96, 2152-2161.

Jollie, W. P (1990). Development, morphology, and function of the yolk-sac placenta of laboratory rodents. Terat 41, 361-381.[Medline]

Kaufman, M. H., Barton, S. C. and Surani, A. A. H (1977). Normal postimplantation development of mouse parthenogenetic embryos to the forelimb bud stage. Nature 265, 53-55.[Medline]

Kubiak, J. C. and Tarkowski, A. K (1985). Electrofusion of mouse blastomeres. Exp. Cell. Res 157, 561-566.[Medline]

Kuo, C. J., Conley, P. B., Chen, L., Sladek, F. M., Darnell, J. E., Jr. and Crabtree, G. R (1992). A transcriptional hierarchy involved in mammalian cell-type specification. Nature 355, 458-460.

Lee, J. J., Radice, G., Perkins, C. P. and Constantini, F (1992). Identification and characterization of a novel, evolutionarily conserved gene disrupted bythe murine H\24758 embryonic lethal transgene insertion. Development 115, 277-288.[Abstract]

Martin, G. R (1981). Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci. USA 78, 7634-7638.[Abstract/Free Full Text]

McGrath, J. and Solter, D (1984). Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell 37, 179-183.[Medline]

Meehan, R. R., Barlow, D. P., Hill, R. E., Hogan, B. L. M. and Hastie, N. D (1984). Pattern of serum protein gene expression in the mouse visceral yolk sac and foetal liver. EMBO J 3, 1881-1885.[Medline]

Mortensen, R. M., Conner, D. A., Chao, S., Geisterfer-Lowrance, A. A. T. and Seidman, J. G (1992). Production of homozygous mutant ES cells with a single targeting construct. Mol. Cell. Biol 12, 2391-2395.[Abstract/Free Full Text]

Nagy, A., Gocza, E., Diaz, E. M., Prideaux, V. R., Ivanyi, E., Markkula, M. and Rossant, J (1990). Embryonic stem cells alone are able to support fetal development in the mouse. Development 110, 815-821.[Abstract/Free Full Text]

Plump, A. S., Smith, j. D., Hayek, T., Aalto-Setaa, K., Walsh, A., Verstuyft, J. G., Rubin, E. M. and Breslow, J. L (1992). Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71, 343-353.[Medline]

Pontoglio, M., Barra, J., Hadchouei, M., Doyen, A., Kress, C., Bach, J. P., Babinet, C. and Yaniv, M (1996). Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria and renal Fanconi syndrome. Cell 84, 575-585.[Medline]

Sato, M. and Muramatsu, T (1985). Reactivity of five N-acetylgalactosamine-recognizing lectins with preimplantation embryos, early postimplantation embryos, and teratocarcinoma cells of the mouse. Diff 29, 29-38.[Medline]

Sladek, F. M., Zhong, W., Lai, E. and Darnell, J. E., Jr (1990). Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev 4, 2353-2365.[Abstract/Free Full Text]

Soudais, C., Bielinska, M., Heikinheimo, M., MacArthur, C. A., Narita, N., Saffitz, J. E., Simon, M. C., Leiden, J. M. and Wilson, D. B (1995). Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development 121, 3877-3888.[Abstract]

Spyropoulos, D. D. and Capecchi, M. R (1994). Targeted disruption of the even-skipped gene, evx1 , causes early postimplantation lethality of the mouse conceptus. Genes Dev 8, 1949-1961.[Abstract/Free Full Text]

Sturm, K., Flannery, M. L. and Pederson, R. A (1994). Abnormal development of embryonic and extraembryonic cell lineages in parthenogenetic mouse embryos. Dev. Dyn 201, 11-28.[Medline]

Surani, M. A. H., Barton, S. C. and Norris, M. L (1984). Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis. Nature 308, 548-308.[Medline]

Taraviras, S., Monaghan, A. P., Schutz, G. and Kelsey, G (1994). Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis. Mech. Dev 48, 67-79.[Medline]

Tian, J. M. and Schibler, U (1991). Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4. Genes Dev 5, 2225-2234.[Abstract/Free Full Text]

Weinstein, D. C., Altaba, A. R. i., Chen, W. S., Hoodless, P., Prezioso, V. R., Jessell, T. M. and Darnell, J. E., Jr (1994). The winged-helix transcription factor HNF-3is required for notochord development in the mouse embryo. Cell 78, 575-588.[Medline]

Williamson, R., Lee, D., Hagaman, J. and Maeda, N (1992). Marked reduction in high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc. Natl. Acad. Sci. USA 89, 7134-7138.[Abstract/Free Full Text]

Wilson, P. A. and Melton, D. A (1994). Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr. Biol 4, 676-686.[Medline]

Wu, T.-C., Wan, Y.-J. and Damjanov, I (1983). Flourescein-conjugated Badeira simplicifolia lectin as a marker of endodermal, yolk sac and trophoblastic differentiaition in the mouse embryo. Diff 24, 55-59.[Medline]

Zhong, W., Sladek, F. M. and Darnell, J. E., Jr (1993). The expression pattern of a Drosophila homolog to the mouse transcription factor HNF-4 suggests a determinative role in gut formation. EMBO J 12, 537-544.[Medline]

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G. Gallicano, C Bauer, and E Fuchs
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Development, January 3, 2001; 128(6): 929 - 941.
[Abstract] [PDF]

G. Peiler, B. Böckmann, H. Nakhei, and G. U. Ryffel
Inhibitor of the Tissue-Specific Transcription Factor HNF4, a Potential Regulator in Early Xenopus Development
Mol. Cell. Biol., December 1, 2000; 20(23): 8676 - 8683.
[Abstract] [Full Text]

B. I. Ghanayem, Hongbing Wang, and S. Sumner
Using Cytochrome P-450 Gene Knock-Out Mice to Study Chemical Metabolism, Toxicity, and Carcinogenicity
Toxicol Pathol, November 1, 2000; 28(6): 839 - 850.
[Abstract] [PDF]

N. J. Sund, S.-L. Ang, S. D. Sackett, W. Shen, N. Daigle, M. A. Magnuson, and K. H. Kaestner
Hepatocyte Nuclear Factor 3beta (Foxa2) Is Dispensable for Maintaining the Differentiated State of the Adult Hepatocyte
Mol. Cell. Biol., July 15, 2000; 20(14): 5175 - 5183.
[Abstract] [Full Text]

M. D. Dabeva, P. M. Petkov, J. Sandhu, R. Oren, E. Laconi, E. Hurston, and D. A. Shafritz
Proliferation and Differentiation of Fetal Liver Epithelial Progenitor Cells after Transplantation into Adult Rat Liver
Am. J. Pathol., June 1, 2000; 156(6): 2017 - 2031.
[Abstract] [Full Text] [PDF]

J. Li, G. Ning, and S. A. Duncan
Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha
Genes & Dev., February 15, 2000; 14(4): 464 - 474.
[Abstract] [Full Text]

J. Lausen, H. Thomas, I. Lemm, M. Bulman, M. Borgschulze, A. Lingott, A. T. Hattersley, and G. U. Ryffel
Naturally occurring mutations in the human HNF4{alpha} gene impair the function of the transcription factor to a varying degree
Nucleic Acids Res., January 15, 2000; 28(2): 430 - 437.
[Abstract] [Full Text] [PDF]

				S. Wanderling, B. B. Simen, O. Ostrovsky, N. T. Ahmed, S. M. Vogen, T. Gidalevitz, and Y. Argon GRP94 Is Essential for Mesoderm Induction and Muscle Development Because It Regulates Insulin-like Growth Factor Secretion Mol. Biol. Cell, October 1, 2007; 18(10): 3764 - 3775. [Abstract] [Full Text] [PDF]

				G. Konopka, J. Tekiela, M. Iverson, C. Wells, and S. A. Duncan Junctional Adhesion Molecule-A Is Critical for the Formation of Pseudocanaliculi and Modulates E-cadherin Expression in Hepatic Cells J. Biol. Chem., September 21, 2007; 282(38): 28137 - 28148. [Abstract] [Full Text] [PDF]

				K. Sumi, T. Tanaka, A. Uchida, K. Magoori, Y. Urashima, R. Ohashi, H. Ohguchi, M. Okamura, H. Kudo, K. Daigo, et al. Cooperative Interaction between Hepatocyte Nuclear Factor 4{alpha} and GATA Transcription Factors Regulates ATP-Binding Cassette Sterol Transporters ABCG5 and ABCG8 Mol. Cell. Biol., June 15, 2007; 27(12): 4248 - 4260. [Abstract] [Full Text] [PDF]

				R. S. V. Chadalavada, J. E. Korkola, J. Houldsworth, A. B. Olshen, G. J. Bosl, L. Studer, and R. S. K. Chaganti Constitutive Gene Expression Predisposes Morphogen-Mediated Cell Fate Responses of NT2/D1 and 27X-1 Human Embryonal Carcinoma Cells Stem Cells, March 1, 2007; 25(3): 771 - 778. [Abstract] [Full Text] [PDF]

				G. Benoit, A. Cooney, V. Giguere, H. Ingraham, M. Lazar, G. Muscat, T. Perlmann, J.-P. Renaud, J. Schwabe, F. Sladek, et al. International Union of Pharmacology. LXVI. Orphan Nuclear Receptors Pharmacol. Rev., December 1, 2006; 58(4): 798 - 836. [Abstract] [Full Text] [PDF]

				P. Hatzis, I. Kyrmizi, and I. Talianidis Mitogen-Activated Protein Kinase-Mediated Disruption of Enhancer-Promoter Communication Inhibits Hepatocyte Nuclear Factor 4{alpha} Expression. Mol. Cell. Biol., October 1, 2006; 26(19): 7017 - 7029. [Abstract] [Full Text] [PDF]

				L. E. Rufibach, S. A. Duncan, M. Battle, and S. S. Deeb Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter J. Lipid Res., July 1, 2006; 47(7): 1463 - 1477. [Abstract] [Full Text] [PDF]

				J. Rhee, H. Ge, W. Yang, M. Fan, C. Handschin, M. Cooper, J. Lin, C. Li, and B. M. Spiegelman Partnership of PGC-1{alpha} and HNF4{alpha} in the Regulation of Lipoprotein Metabolism J. Biol. Chem., May 26, 2006; 281(21): 14683 - 14690. [Abstract] [Full Text] [PDF]

				A. Archer, D. Sauvaget, V. Chauffeton, P.-E. Bouchet, J. Chambaz, M. Pincon-Raymond, P. Cardot, A. Ribeiro, and M. Lacasa Intestinal Apolipoprotein A-IV Gene Transcription Is Controlled by Two Hormone-Responsive Elements: A Role for Hepatic Nuclear Factor-4 Isoforms Mol. Endocrinol., September 1, 2005; 19(9): 2320 - 2334. [Abstract] [Full Text] [PDF]

				R. Hertz, B. Kalderon, T. Byk, I. Berman, G. Za'tara, R. Mayer, and J. Bar-Tana Thioesterase Activity and Acyl-CoA/Fatty Acid Cross-talk of Hepatocyte Nuclear Factor-4{alpha} J. Biol. Chem., July 1, 2005; 280(26): 24451 - 24461. [Abstract] [Full Text] [PDF]

				R. Zhao, A. J. Watt, J. Li, J. Luebke-Wheeler, E. E. Morrisey, and S. A. Duncan GATA6 Is Essential for Embryonic Development of the Liver but Dispensable for Early Heart Formation Mol. Cell. Biol., April 1, 2005; 25(7): 2622 - 2631. [Abstract] [Full Text] [PDF]

				K. Asahina, H. Fujimori, K. Shimizu-Saito, Y. Kumashiro, K. Okamura, Y. Tanaka, K. Teramoto, S. Arii, and H. Teraoka Expression of the liver-specific gene Cyp7a1 reveals hepatic differentiation in embryoid bodies derived from mouse embryonic stem cells Genes Cells, December 1, 2004; 9(12): 1297 - 1308. [Abstract] [Full Text] [PDF]

				M. A. Conti, S. Even-Ram, C. Liu, K. M. Yamada, and R. S. Adelstein Defects in Cell Adhesion and the Visceral Endoderm following Ablation of Nonmuscle Myosin Heavy Chain II-A in Mice J. Biol. Chem., October 1, 2004; 279(40): 41263 - 41266. [Abstract] [Full Text] [PDF]

				S. Strope, R. Rivi, T. Metzger, K. Manova, and E. Lacy Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules Development, October 1, 2004; 131(19): 4787 - 4795. [Abstract] [Full Text] [PDF]

				A. J. Watt, M. A. Battle, J. Li, and S. A. Duncan GATA4 is essential for formation of the proepicardium and regulates cardiogenesis PNAS, August 24, 2004; 101(34): 12573 - 12578. [Abstract] [Full Text] [PDF]

				N. Briancon, A. Bailly, F. Clotman, P. Jacquemin, F. P. Lemaigre, and M. C. Weiss Expression of the {alpha}7 Isoform of Hepatocyte Nuclear Factor (HNF) 4 Is Activated by HNF6/OC-2 and HNF1 and Repressed by HNF4{alpha}1 in the Liver J. Biol. Chem., August 6, 2004; 279(32): 33398 - 33408. [Abstract] [Full Text] [PDF]

				K. Duda, Y.-I. Chi, and S. E. Shoelson Structural Basis for HNF-4{alpha} Activation by Ligand and Coactivator Binding J. Biol. Chem., May 28, 2004; 279(22): 23311 - 23316. [Abstract] [Full Text] [PDF]

				J.-F. Pare, D. Malenfant, C. Courtemanche, M. Jacob-Wagner, S. Roy, D. Allard, and L. Belanger The Fetoprotein Transcription Factor (FTF) Gene Is Essential to Embryogenesis and Cholesterol Homeostasis and Is Regulated by a DR4 Element J. Biol. Chem., May 14, 2004; 279(20): 21206 - 21216. [Abstract] [Full Text] [PDF]

				F. Gao, H. Y. Shi, C. Daughty, N. Cella, and M. Zhang Maspin plays an essential role in early embryonic development Development, April 1, 2004; 131(7): 1479 - 1489. [Abstract] [Full Text] [PDF]

				P. P. L. Tam and J. Rossant Mouse embryonic chimeras: tools for studying mammalian development Development, December 22, 2003; 130(25): 6155 - 6163. [Abstract] [Full Text] [PDF]

				A. K. Man, L. J. T. Young, J. A. Tynan, J. Lesperance, M. Egeblad, Z. Werb, C. A. Hauser, W. J. Muller, R. D. Cardiff, and R. G. Oshima Ets2-Dependent Stromal Regulation of Mouse Mammary Tumors Mol. Cell. Biol., December 1, 2003; 23(23): 8614 - 8625. [Abstract] [Full Text] [PDF]

				J. Rathjen, J. M. Washington, M. D. Bettess, and P. D. Rathjen Identification of a Biological Activity That Supports Maintenance and Proliferation of Pluripotent Cells from the Primitive Ectoderm of the Mouse Biol Reprod, December 1, 2003; 69(6): 1863 - 1871. [Abstract] [Full Text] [PDF]

				J. Eeckhoute, B. Oxombre, P. Formstecher, P. Lefebvre, and B. Laine Critical role of charged residues in helix 7 of the ligand binding domain in Hepatocyte Nuclear Factor 4{alpha} dimerisation and transcriptional activity Nucleic Acids Res., November 15, 2003; 31(22): 6640 - 6650. [Abstract] [Full Text] [PDF]

				C. Haumaitre, M. Reber, and S. Cereghini Functions of HNF1 Family Members in Differentiation of the Visceral Endoderm Cell Lineage J. Biol. Chem., October 17, 2003; 278(42): 40933 - 40942. [Abstract] [Full Text] [PDF]

				S. Ghoshal, S. Pasham, D. P. Odom, H. C. Furr, and M. M. McGrane Vitamin A Depletion Is Associated with Low Phosphoenolpyruvate Carboxykinase mRNA Levels during Late Fetal Development and at Birth in Mice J. Nutr., July 1, 2003; 133(7): 2131 - 2136. [Abstract] [Full Text] [PDF]

				R. Hertz, N. Ben-Haim, A. D. Petrescu, B. Kalderon, I. Berman, N. Eldad, F. Schroeder, and J. Bar-Tana Rescue of MODY-1 by Agonist Ligands of Hepatocyte Nuclear Factor-4{alpha} J. Biol. Chem., June 13, 2003; 278(25): 22578 - 22585. [Abstract] [Full Text] [PDF]

				Y.-H. Lee, M. A. Magnuson, V. Muppala, and S.-S. Chen Liver-Specific Reactivation of the Inactivated Hnf-1{alpha} Gene: Elimination of Liver Dysfunction To Establish a Mouse MODY3 Model Mol. Cell. Biol., February 1, 2003; 23(3): 923 - 932. [Abstract] [Full Text]

				C. S. Lee, N. J. Sund, M. Z. Vatamaniuk, F. M. Matschinsky, D. A. Stoffers, and K. H. Kaestner Foxa2 Controls Pdx1 Gene Expression in Pancreatic {beta}-Cells In Vivo Diabetes, August 1, 2002; 51(8): 2546 - 2551. [Abstract] [Full Text] [PDF]

				Y. Inoue, G. P. Hayhurst, J. Inoue, M. Mori, and F. J. Gonzalez Defective Ureagenesis in Mice Carrying a Liver-specific Disruption of Hepatocyte Nuclear Factor 4alpha (HNF4alpha ). HNF4alpha REGULATES ORNITHINE TRANSCARBAMYLASE IN VIVO J. Biol. Chem., July 5, 2002; 277(28): 25257 - 25265. [Abstract] [Full Text] [PDF]

				C. S. Lee, N. Perreault, J. E. Brestelli, and K. H. Kaestner Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity Genes & Dev., June 15, 2002; 16(12): 1488 - 1497. [Abstract] [Full Text] [PDF]