Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos

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Tissue-specific deletion of Foxa2 in pancreatic {beta} cells results in hyperinsulinemic hypoglycemia
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Tissue-restricted expression of thrombomodulin in the placenta rescues thrombomodulin-deficient mice from early lethality and reveals a secondary developmental block
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G. Gallicano, C Bauer, and E Fuchs
Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature
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Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha
Genes & Dev., February 15, 2000; 14(4): 464 - 474.
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Naturally occurring mutations in the human HNF4{alpha} gene impair the function of the transcription factor to a varying degree
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Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation
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E Barbacci, M Reber, M. Ott, C Breillat, F Huetz, and S Cereghini
Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification
Development, January 11, 1999; 126(21): 4795 - 4805.
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Z Gu, E. Reynolds, J Song, H Lei, A Feijen, L Yu, W He, D. MacLaughlin, J van den Eijnden-van Raaij, P. Donahoe, et al.
The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo
Development, January 6, 1999; 126(11): 2551 - 2561.
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J Rathjen, J. Lake, M. Bettess, J. Washington, G Chapman, and P. Rathjen
Formation of a primitive ectoderm like cell population, EPL cells, from ES cells in response to biologically derived factors
J. Cell Sci., January 3, 1999; 112(5): 601 - 612.
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E Coucouvanis and G. Martin
BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo
Development, January 2, 1999; 126(3): 535 - 546.
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G. I. Gallicano, P. Kouklis, C. Bauer, M. Yin, V. Vasioukhin, L. Degenstein, and E. Fuchs
Desmoplakin Is Required Early in Development for Assembly of Desmosomes and Cytoskeletal Linkage
J. Cell Biol., December 28, 1998; 143(7): 2009 - 2022.
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E. T. Morgan, M. B. Sewer, H. Iber, F. J. Gonzalez, Y.-H. Lee, R. H. Tukey, S. Okino, T. Vu, Y.-H. Chen, J. S. Sidhu, et al.
Physiological and Pathophysiological Regulation of Cytochrome P450
Drug Metab. Dispos., December 1, 1998; 26(12): 1232 - 1240.
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E. E. Morrisey, Z. Tang, K. Sigrist, M. M. Lu, F. Jiang, H. S. Ip, and M. S. Parmacek
GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo
Genes & Dev., November 15, 1998; 12(22): 3579 - 3590.
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S. A. Duncan, M. A. Navas, D. Dufort, J. Rossant, and M. Stoffel
Regulation of a Transcription Factor Network Required for Differentiation and Metabolism
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H. Yamamoto, M. L. Flannery, S. Kupriyanov, J. Pearce, S. R. McKercher, G. W. Henkel, R. A. Maki, Z. Werb, and R. G. Oshima
Defective trophoblast function in mice with a targeted mutation of�Ets2
Genes & Dev., May 1, 1998; 12(9): 1315 - 1326.
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E. Arman, R. Haffner-Krausz, Y. Chen, J. K. Heath, and P. Lonai
Targeted disruption of fibroblast growth factor (FGF) receptor 2�suggests a role for FGF signaling in pregastrulation mammalian development
PNAS, April 28, 1998; 95(9): 5082 - 5087.
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G. F. Spath and M. C. Weiss
Hepatocyte Nuclear Factor 4 Provokes Expression of Epithelial Marker Genes, Acting As a Morphogen in Dedifferentiated Hepatoma Cells
J. Cell Biol., February 23, 1998; 140(4): 935 - 946.
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A Bailly, G Spath, V Bender, and M. Weiss
Phenotypic effects of the forced expression of HNF4 and HNF1alpha are conditioned by properties of the recipient cell
J. Cell Sci., January 8, 1998; 111(16): 2411 - 2421.
[Abstract] [PDF]

I Dragatsis, A Efstratiadis, and S Zeitlin
Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues
Development, January 4, 1998; 125(8): 1529 - 1539.
[Abstract] [PDF]

M Rhinn, A Dierich, W Shawlot, R. Behringer, M Le Meur, and S. Ang
Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification
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C. Sirard, J. L. de la Pompa, A. Elia, A. Itie, C. Mirtsos, A. Cheung, S. Hahn, A. Wakeham, L. Schwartz, S. E. Kern, et al.
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse�embryo
Genes & Dev., January 1, 1998; 12(1): 107 - 119.
[Abstract] [Full Text]

M. Stoffel and S. A. Duncan
The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and�metabolism
PNAS, November 25, 1997; 94(24): 13209 - 13214.
[Abstract] [Full Text] [PDF]

J D Molkentin, Q Lin, S A Duncan, and E N Olson
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
Genes & Dev., April 15, 1997; 11(8): 1061 - 1072.
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