In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE)

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Dupe, V.
	Articles by Rijli, F. M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Dupe, V.
	Articles by Rijli, F. M.

Ang, S. L., Conlon, R. A., Jin, O. and Rossant, J (1994). Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. Development 120, 2979-2989.[Abstract]

Baron, A., Featherstone, M. S., Hill, R. E., Hall, A., Galliot, B. and Duboule, D (1987). Hox-1. 6: a mouse homeo-box-containing gene member of the Hox-1 complex. EMBO J 6, 2977-2986.[Medline]

Birgbauer, E. and Fraser, S. E (1994). Violation of cell lineage restriction compartments in the chick hindbrain. Development 120, 1347-1356.[Abstract]

Birgbauer, E., Sechrist, J., Bronner-Fraser, M. and Fraser, S (1995). Rhombomeric origin and rostrocaudal reassortment of neural crest cells revealed by intravital microscopy. Development 121, 935-945.[Abstract]

Boshart, M., Weber, F., Jahn, G., Dorsch-Hasler, K., Fleckenstein, B. and Schaffner, W (1985). A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Cell 41, 521-530.[Medline]

Carpenter, E. M., Goddard, J. M., Chisaka, O., Manley, N. R. and Capecchi, M. R (1993). Loss of Hox-A1 (Hox-1. 6) function results in the reorganization of the murine hindbrain. Development 118, 1063-1075.[Abstract]

Chazaud, C., Oulad-Abdelghani, M., Bouillet, P., Decimo, D., Chambon, P. and Dolle, P (1996). AP2-2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesis. Mech. Dev 54, 83-94.[Medline]

Chen, Y., Huang, L., Russo, A. F. and Solursh, M (1992). Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo. Proc. Natl. Acad. Sci. USA 89, 10056-10059.[Abstract/Free Full Text]

Chen, Y., Huang, L. and Solursh, M (1994). A concentration gradient of retinoids in the early Xenopus laevis embryo. Dev. Biol 161, 70-76.[Medline]

Chisaka, O. and Capecchi, M. R (1991). Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1. 5. Nature 350, 473-479.[Medline]

Chisaka, O., Musci, T. S. and Capecchi, M. R (1992). Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1. 6. Nature 355, 516-520.[Medline]

Clarke, J. D. and Lumsden, A (1993). Segmental repetition of neuronal phenotype sets in the chick embryo hindbrain. Development 118, 151-162.[Abstract]

Conlon, R. A. and Rossant, J (1992). Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo. Development 116, 357-368.[Medline]

Conlon, R. A (1995). Retinoic acid and pattern formation in vertebrates. Trends Genet 11, 314-319.[Medline]

Dekker, E. J., Pannese, M., Houtzager, E., Boncinelli, E. and Durston, A (1993). Colinearity in the Xenopus laevis Hox-2 complex. Mech. Dev 40, 3-12.[Medline]

Deschamps, J. and Wijgerde, M (1993). Two phases in the establishment of HOX expression domains. Dev. Biol 156, 473-480.[Medline]

Dolle, P., Lufkin, T., Krumlauf, R., Mark, M., Duboule, D. and Chambon, P (1993). Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1. 6) mutant embryos. Proc. Natl. Acad. Sci. USA 90, 7666-7670.[Abstract/Free Full Text]

Duboule, D. and Dolle, P (1989). The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J 8, 1497-1505.[Medline]

Fraser, S., Keynes, R. and Lumsden, A (1990). Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions. Nature 344, 431-435.[Medline]

Frohman, M. A., Boyle, M. and Martin, G. R (1990). Isolation of the mouse Hox-2. 9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm. Development 110, 589-607.[Abstract/Free Full Text]

Gaunt, S. J. and Strachan, L (1994). Forward spreading in the establishment of a vertebrate Hox expression boundary: the expression domain separates into anterior and posterior zones, and the spread occurs across implanted glass barriers. Dev. Dyn 199, 229-240.[Medline]

Gendron-Maguire, M., Mallo, M., Zhang, M. and Gridley, T (1993). Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest. Cell 75, 1317-1331.[Medline]

Graham, A., Papalopulu, N. and Krumlauf, R (1989). The murine and Drosophila homeobox gene complexes have common features of organization and expression. Cell 57, 367-378.[Medline]

Grapin-Botton, A., Bonnin, M. A., McNaughton, L. A., Krumlauf, R. and Le Douarin, N. M (1995). Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications. Development 121, 2707-2721.[Abstract]

Gu, H., Zou, Y. R. and Rajewsky, K (1993). Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73, 1155-1164.[Medline]

Hogan, B. L., Thaller, C. and Eichele, G (1992). Evidence that Hensen's node is a site of retinoic acid synthesis. Nature 359, 237-241.[Medline]

Hunt, P., Gulisano, M., Cook, M., Sham, M. H., Faiella, A., Wilkinson, D., Boncinelli, E. and Krumlauf, R (1991). A distinct Hox code for the branchial region of the vertebrate head. Nature 353, 861-864.[Medline]

Irving, C., Nieto, M. A., Das Gupta, R., Charnay, P. and Wilkinson, D. G (1996). Progressive spatial restriction of Sek-1 and Krox-20 gene expression during hindbrain segmentation. Dev. Biol 173, 26-38.[Medline]

Itasaki, N., Sharpe, J., Morrison, A. and Krumlauf, R (1996). Reprogramming Hox Expression in the Vertebrate Hindbrain: Influence of Paraxial Mesoderm and Rhombomere Transposition. Neuron 16, 487-500.[Medline]

Kastner, P., Mark, M. and Chambon, P (1995). Nonsteroid nuclear receptors: What are genetic studies telling us about their role in real life?. Cell 83, 859-869.[Medline]

Kessel, M (1993). Reversal of axonal pathways from rhombomere 3 correlates with extra Hox expression domains. Neuron 10, 379-393.[Medline]

Krumlauf, R (1993). Hox genes and pattern formation in the branchial region of the vertebrate head. Trends Genet 9, 106-112.[Medline]

Krumlauf, R (1994). Hox genes in vertebrate development. Cell 78, 191-201.[Medline]

Langston, A. W. and Gudas, L. J (1992). Identification of a retinoic acid responsive enhancer 3of the murine homeobox gene Hox-1. 6. Mech. Dev 38, 217-227.[Medline]

Langston, A. W. and Gudas, L. J (1994). Retinoic acid and homeobox gene regulation. Curr. Opin. Genet. Dev 4, 550-555.[Medline]

Lewis, E. B (1978). A gene complex controlling segmentation in Drosophila. Nature 276, 565-570.[Medline]

Lohnes, D., Kastner, P., Dierich, A., Mark, M., LeMeur, M. and Chambon, P (1993). Function of retinoic acid receptor gamma in the mouse. Cell 73, 643-658.[Medline]

Lohnes, D., Mark, M., Mendelsohn, C., Dolle, P., Dierich, A., Gorry, P. Gansmuller, A. and Chambon, P (1994). Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants. Development 120, 2723-2748.[Abstract]

Lufkin, T., Dierich, A., Le Meur, M., Mark, M. and Chambon, P (1991). Disruption of the Hox-1. 6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell 66, 1105-1119.[Medline]

Lumsden, A., Sprawson, N. and Graham, A (1991). Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo. Development 113, 1281-1291.[Abstract]

Mark, M., Lufkin, T., Vonesch, J. L., Ruberte, E., Olivo, J. C., Gorry, P., Lumsden, A. and Chambon, P (1993). Two rhombomeres are altered in Hoxa-1 mutant mice. Development 119, 319-338.[Abstract]

Marshall, H., Nonchev, S., Sham, M. H., Muchamore, I., Lumsden, A. and Krumlauf, R (1992). Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity. Nature 360, 737-741.[Medline]

Marshall, H., Studer, M., Popperl, H., Aparicio, S., Kuroiwa, A., Brenner, S. and Krumlauf, R (1994). A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1. Nature 370, 567-571.[Medline]

Metzger, D., Clifford, J., Chiba, H. and Chambon, P (1995). Conditional site-specific recombinaison in mammalian cells using a ligand-dependent chimeric Cre recombinase. Proc. Natl. Acad. Sci. USA 92, 6991-6995.[Abstract/Free Full Text]

Mitchell, P. J., Timmons, P. M., Hebert, J. M., Rigby, P. W. and Tjian, R (1991). Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes. Dev 5, 105-119.[Abstract/Free Full Text]

Morrison, A., Moroni, C. M., Ariza-McNaughton, L., Krumlauf, R. and Mavilio, F (1996). In vitro and transgenic analysis of a human HOXD4 retinoid-responsive enhancer. Development 122, 1895-1907.[Abstract]

Morriss-Kay, G. M., Murphy, P., Hill, R. E. and Davidson, D. R (1991). Effects of retinoic acid excess on expression of Hox-2. 9 and Krox-20 and on morphological segmentation in the hindbrain of mouse embryos. EMBO J 10, 2985-2995.[Medline]

Murphy, P. and Hill, R. E (1991). Expression of the mouse labial-like homeobox-containing genes, Hox 2. 9 and Hox 1. 6, during segmentation of the hindbrain. Development 111, 61-74.[Abstract]

Nonchev, S., Vesque, C., Maconochie, M., Seitanidou, T., Aiza-McNaughton, L., Frain, M., Marshall, H., Har Sham, M., Krumlauf, R. and Charnay, P (1996). Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20. Development 122, 543-554.[Abstract]

Popperl, H. and Featherstone, M. S (1993). Identification of a retinoic acid response element upstream of the murine Hox-4. 2 gene. Mol. Cell Biol 13, 257-265.[Abstract/Free Full Text]

Prince, V. and Lumsden, A (1994). Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest. Development 120, 911-923.[Abstract]

Rijli, F. M., Mark, M., Lakkaraju, S., Dierich, A., Dolle, P. and Chambon, P (1993). A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene. Cell 75, 1333-1349.[Medline]

Schorle, H., Meier, P., Buchert, M., Jaenisch, R. and Mitchell, P. J (1996). Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature 381, 235-238.[Medline]

Simeone, A., Acampora, D., Arcioni, L., Andrews, P. W., Boncinelli, E. and Mavilio, F (1990). Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. Nature 346, 763-766.[Medline]

Simeone, A., Acampora, D., Nigro, V., Faiella, A., D'Esposito, M., Stornaiuolo, A., Mavilio, F and Boncinelli, E (1991). Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells. Mech. Dev 33, 215-227.[Medline]

Simeone, A., Acampora, D., Mallamaci, A., Stornaiuolo, A., D'Apice, M. R, Nigro, V and Boncinelli, E (1993). A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcatesanterior neuroectoderm in the gastrulating mouse embryo. EMBO J 12, 2735-2747.[Medline]

Studer, M., Popperl, H., Marshall, H., Kuroiwa, A. and Krumlauf, R (1994). Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1. Science 265, 1728-1732.[Abstract/Free Full Text]

Sundin, O. and Eichele, G (1992). An early marker of axial pattern in the chick embryo and its respecification by retinoic acid. Development 114, 841-852.[Abstract]

Sundin, O. H., Busse, H. G., Rogers, M. B., Gudas, L. J. and Eichele, G (1990). Region-specific expression in early chick and mouse embryos of Ghox-lab and Hox 1. 6, vertebrate homeobox-containing genes related to Drosophila labial. Development 108, 47-58.[Abstract]

Wilkinson, D. G (1995). Genetic control of segmentation in the vertebrate hindbrain. Perspect. Dev. Neurobiol 3, 29-38.[Medline]

Wilkinson, D. G., Bhatt, S., Chavrier, P., Bravo, R. and Charnay, P (1989). Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse. Nature 337, 461-464.[Medline]

Wood, H., Pall, G. and Morriss-Kay, G (1994). Exposure to retinoic acid before or after the onset of somitogenesis reveals separate effects on rhombomeric segmentation and 3HoxB gene expression domains. Development 120, 2279-2285.[Abstract]

Zhang, M., Kim, H. J., Marshall, H., Gendron-Maguire, M., Lucas, D. A., Baron, A. and Gudas, L. J (1994). Ectopic Hoxa-1 induces rhombomere transformation in mouse hindbrain. Development 120, 2431-2442.[Abstract/Free Full Text]

Zhang, J., Hagopian-donaldson, S., Serbedzija, G., Elsemore, J., Plehn-dujowich, D., McMahon, A. P., Flavell, R. A. and Williams, T (1996). Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature 381, 238-241.[Medline]

This article has been cited by other articles:

A. Duchon, V. Besson, P. L. Pereira, L. Magnol, and Y. Herault
Inducing Segmental Aneuploid Mosaicism in the Mouse Through Targeted Asymmetric Sister Chromatid Event of Recombination
Genetics, September 1, 2008; 180(1): 51 - 59.
[Abstract] [Full Text] [PDF]

P. E. Lapinski, J. A. Oliver, L. A. Kamen, E. D. Hughes, T. L. Saunders, and P. D. King
Genetic Analysis of SH2D4A, a Novel Adapter Protein Related to T Cell-Specific Adapter and Adapter Protein in Lymphocytes of Unknown Function, Reveals a Redundant Function in T Cells
J. Immunol., August 1, 2008; 181(3): 2019 - 2027.
[Abstract] [Full Text] [PDF]

R. Essalmani, A. Zaid, J. Marcinkiewicz, A. Chamberland, A. Pasquato, N. G. Seidah, and A. Prat
In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate
PNAS, April 15, 2008; 105(15): 5750 - 5755.
[Abstract] [Full Text] [PDF]

L. Ryckebusch, Z. Wang, N. Bertrand, S.-C. Lin, X. Chi, R. Schwartz, S. Zaffran, and K. Niederreither
Retinoic acid deficiency alters second heart field formation
PNAS, February 26, 2008; 105(8): 2913 - 2918.
[Abstract] [Full Text] [PDF]

G. MacLean, H. Li, D. Metzger, P. Chambon, and M. Petkovich
Apoptotic Extinction of Germ Cells in Testes of Cyp26b1 Knockout Mice
Endocrinology, October 1, 2007; 148(10): 4560 - 4567.
[Abstract] [Full Text] [PDF]

V. Besson, V. Brault, A. Duchon, D. Togbe, J.-C. Bizot, V. F.J. Quesniaux, B. Ryffel, and Y. Herault
Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses
Hum. Mol. Genet., September 1, 2007; 16(17): 2040 - 2052.
[Abstract] [Full Text] [PDF]

N. Pilon, K. Oh, J.-R. Sylvestre, J. G. A. Savory, and D. Lohnes
Wnt signaling is a key mediator of Cdx1 expression in vivo
Development, June 15, 2007; 134(12): 2315 - 2323.
[Abstract] [Full Text] [PDF]

A. Tarrade, C. Fassier, S. Courageot, D. Charvin, J. Vitte, L. Peris, A. Thorel, E. Mouisel, N. Fonknechten, N. Roblot, et al.
A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition
Hum. Mol. Genet., December 15, 2006; 15(24): 3544 - 3558.
[Abstract] [Full Text] [PDF]

P. Germain, P. Chambon, G. Eichele, R. M. Evans, M. A. Lazar, M. Leid, A. R. De Lera, R. Lotan, D. J. Mangelsdorf, and H. Gronemeyer
International Union of Pharmacology. LX. Retinoic Acid Receptors
Pharmacol. Rev., December 1, 2006; 58(4): 712 - 725.
[Abstract] [Full Text] [PDF]

L. Kobrossy, M. Rastegar, and M. Featherstone
Interplay between Chromatin and Trans-acting Factors Regulating the Hoxd4 Promoter during Neural Differentiation
J. Biol. Chem., September 8, 2006; 281(36): 25926 - 25939.
[Abstract] [Full Text] [PDF]

J.-P. Liu
The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord
Development, August 1, 2006; 133(15): 2865 - 2874.
[Abstract] [Full Text] [PDF]

Y.-S. Cho, E.-J. Kim, U.-H. Park, H.-S. Sin, and S.-J. Um
Additional Sex Comb-like 1 (ASXL1), in Cooperation with SRC-1, Acts as a Ligand-dependent Coactivator for Retinoic Acid Receptor
J. Biol. Chem., June 30, 2006; 281(26): 17588 - 17598.
[Abstract] [Full Text] [PDF]

Y. Tan, N. Dourdin, C. Wu, T. De Veyra, J. S. Elce, and P. A. Greer
Ubiquitous Calpains Promote Caspase-12 and JNK Activation during Endoplasmic Reticulum Stress-induced Apoptosis
J. Biol. Chem., June 9, 2006; 281(23): 16016 - 16024.
[Abstract] [Full Text] [PDF]

R. Essalmani, J. Hamelin, J. Marcinkiewicz, A. Chamberland, M. Mbikay, M. Chretien, N. G. Seidah, and A. Prat
Deletion of the Gene Encoding Proprotein Convertase 5/6 Causes Early Embryonic Lethality in the Mouse
Mol. Cell. Biol., January 1, 2006; 26(1): 354 - 361.
[Abstract] [Full Text] [PDF]

B. Monier, M. Astier, M. Semeriva, and L. Perrin
Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart
Development, December 1, 2005; 132(23): 5283 - 5293.
[Abstract] [Full Text] [PDF]

F. Santagati, M. Minoux, S.-Y. Ren, and F. M. Rijli
Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis
Development, November 15, 2005; 132(22): 4927 - 4936.
[Abstract] [Full Text] [PDF]

E. Martinez-Ceballos, P. Chambon, and L. J. Gudas
Differences in Gene Expression between Wild Type and Hoxa1 Knockout Embryonic Stem Cells after Retinoic Acid Treatment or Leukemia Inhibitory Factor (LIF) Removal
J. Biol. Chem., April 22, 2005; 280(16): 16484 - 16498.
[Abstract] [Full Text] [PDF]

S. Tabaries, J. Lapointe, T. Besch, M. Carter, J. Woollard, C. K. Tuggle, and L. Jeannotte
Cdx Protein Interaction with Hoxa5 Regulatory Sequences Contributes to Hoxa5 Regional Expression along the Axial Skeleton
Mol. Cell. Biol., February 15, 2005; 25(4): 1389 - 1401.
[Abstract] [Full Text] [PDF]

P. Serpente, S. Tumpel, N. B. Ghyselinck, K. Niederreither, L. M. Wiedemann, P. Dolle, P. Chambon, R. Krumlauf, and A. P. Gould
Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation
Development, February 1, 2005; 132(3): 503 - 513.
[Abstract] [Full Text] [PDF]

G. Mellitzer, M. Martin, M. Sidhoum-Jenny, C. Orvain, J. Barths, P. A. Seymour, M. Sander, and G. Gradwohl
Pancreatic Islet Progenitor Cells in Neurogenin 3-Yellow Fluorescent Protein Knock-Add-On Mice
Mol. Endocrinol., November 1, 2004; 18(11): 2765 - 2776.
[Abstract] [Full Text] [PDF]

M. Rastegar, L. Kobrossy, E. N. Kovacs, I. Rambaldi, and M. Featherstone
Sequential Histone Modifications at Hoxd4 Regulatory Regions Distinguish Anterior from Posterior Embryonic Compartments
Mol. Cell. Biol., September 15, 2004; 24(18): 8090 - 8103.
[Abstract] [Full Text] [PDF]

R. E. Hernandez, H. A. Rikhof, R. Bachmann, and C. B. Moens
vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafish
Development, September 15, 2004; 131(18): 4511 - 4520.
[Abstract] [Full Text] [PDF]

J. Shiotsugu, Y. Katsuyama, K. Arima, A. Baxter, T. Koide, J. Song, R. A. S. Chandraratna, and B. Blumberg
Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation
Development, June 1, 2004; 131(11): 2653 - 2667.
[Abstract] [Full Text] [PDF]

M. Houle, J.-R. Sylvestre, and D. Lohnes
Retinoic acid regulates a subset of Cdx1 function in vivo
Development, December 29, 2003; 130(26): 6555 - 6567.
[Abstract] [Full Text] [PDF]

A. Gavalas, C. Ruhrberg, J. Livet, C. E. Henderson, and R. Krumlauf
Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes
Development, December 1, 2003; 130(23): 5663 - 5679.
[Abstract] [Full Text] [PDF]

V. Dupe, N. Matt, J.-M. Garnier, P. Chambon, M. Mark, and N. B. Ghyselinck
A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment
PNAS, November 25, 2003; 100(24): 14036 - 14041.
[Abstract] [Full Text] [PDF]

A. H. Juan and F. H. Ruddle
Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer
Development, October 15, 2003; 130(20): 4823 - 4834.
[Abstract] [Full Text] [PDF]

W. S. Mohan II, E. Scheer, O. Wendling, D. Metzger, and L. Tora
TAF10 (TAFII30) Is Necessary for TFIID Stability and Early Embryogenesis in Mice
Mol. Cell. Biol., June 15, 2003; 23(12): 4307 - 4318.
[Abstract] [Full Text] [PDF]

S. Bel-Vialar, N. Itasaki, and R. Krumlauf
Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups
Development, March 13, 2003; 129(22): 5103 - 5115.
[Abstract] [Full Text] [PDF]

P. Weber, F. Cammas, C. Gerard, D. Metzger, P. Chambon, R. Losson, and M. Mark
Germ cell expression of the transcriptional co-repressor TIF1{beta} is required for the maintenance of spermatogenesis in the mouse
Development, March 7, 2003; 129(10): 2329 - 2337.
[Abstract] [Full Text] [PDF]

J. M. McClintock, M. A. Kheirbek, and V. E. Prince
Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention
Development, March 7, 2003; 129(10): 2339 - 2354.
[Abstract] [Full Text] [PDF]

P. Weber, M. Schuler, C. Gerard, M. Mark, D. Metzger, and P. Chambon
Temporally Controlled Site-Specific Mutagenesis in the Germ Cell Lineage of the Mouse Testis
Biol Reprod, February 1, 2003; 68(2): 553 - 559.
[Abstract] [Full Text] [PDF]

M. Gehin, M. Mark, C. Dennefeld, A. Dierich, H. Gronemeyer, and P. Chambon
The Function of TIF2/GRIP1 in Mouse Reproduction Is Distinct from Those of SRC-1 and p/CIP
Mol. Cell. Biol., August 15, 2002; 22(16): 5923 - 5937.
[Abstract] [Full Text] [PDF]

M. Kmita, B. Tarchini, D. Duboule, and Y. Herault
Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells
Development, January 12, 2002; 129(23): 5521 - 5528.
[Abstract] [Full Text] [PDF]

J. E. Pitera, V. V. Smith, A. S. Woolf, and P. J. Milla
Embryonic Gut Anomalies in a Mouse Model of Retinoic Acid-Induced Caudal Regression Syndrome : Delayed Gut Looping, Rudimentary Cecum, and Anorectal Anomalies
Am. J. Pathol., December 1, 2001; 159(6): 2321 - 2329.
[Abstract] [Full Text] [PDF]

M. Manzanares, S. Bel-Vialar, L. Ariza-McNaughton, E. Ferretti, H. Marshall, M. M. Maconochie, F. Blasi, and R. Krumlauf
Independent regulation of initiation and maintenance phases of Hoxa3 expression in the vertebrate hindbrain involve auto- and cross-regulatory mechanisms
Development, September 15, 2001; 128(18): 3595 - 3607.
[Abstract] [Full Text] [PDF]

G. Begemann, T. F. Schilling, G.-J. Rauch, R. Geisler, and P. W. Ingham
The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain
Development, August 15, 2001; 128(16): 3081 - 3094.
[Abstract] [Full Text] [PDF]

V. Dupe and A. Lumsden
Hindbrain patterning involves graded responses to retinoic acid signalling
Development, June 15, 2001; 128(12): 2199 - 2208.
[Abstract] [Full Text] [PDF]

S. Abu-Abed, P. Dollé, D. Metzger, B. Beckett, P. Chambon, and M. Petkovich
The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures
Genes & Dev., January 15, 2001; 15(2): 226 - 240.
[Abstract] [Full Text]

M Li, H Chiba, X Warot, N Messaddeq, C Gerard, P Chambon, and D Metzger
RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations
Development, January 3, 2001; 128(5): 675 - 688.
[Abstract] [PDF]

M. Houle, P. Prinos, A. Iulianella, N. Bouchard, and D. Lohnes
Retinoic Acid Regulation of Cdx1: an Indirect Mechanism for Retinoids and Vertebral Specification
Mol. Cell. Biol., September 1, 2000; 20(17): 6579 - 6586.
[Abstract] [Full Text]

T. Frugier, F. D. Tiziano, C. Cifuentes-Diaz, P. Miniou, N. Roblot, A. Dierich, M. Le Meur, and J. Melki
Nuclear targeting defect of SMN lacking the C-terminus in a mouse model of spinal muscular atrophy
Hum. Mol. Genet., March 22, 2000; 9(5): 849 - 858.
[Abstract] [Full Text] [PDF]

M. Kmita, F. van der Hoeven, J. Zákány, R. Krumlauf, and D. Duboule
Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex
Genes & Dev., January 15, 2000; 14(2): 198 - 211.
[Abstract] [Full Text]

S Dupont, A Krust, A Gansmuller, A Dierich, P Chambon, and M Mark
Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
Development, January 10, 2000; 127(19): 4277 - 4291.
[Abstract] [PDF]

F Cammas, M Mark, P Dolle, A Dierich, P Chambon, and R Losson
Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development
Development, January 7, 2000; 127(13): 2955 - 2963.
[Abstract] [PDF]

O Wendling, C Dennefeld, P Chambon, and M Mark
Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches
Development, January 4, 2000; 127(8): 1553 - 1562.
[Abstract] [PDF]

E Ferretti, H Marshall, H Popperl, M Maconochie, R Krumlauf, and F Blasi
Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins
Development, January 1, 2000; 127(1): 155 - 166.
[Abstract] [PDF]

C Irving and I Mason
Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression
Development, January 1, 2000; 127(1): 177 - 186.
[Abstract] [PDF]

M Manzanares, S Cordes, L Ariza-McNaughton, V Sadl, K Maruthainar, G Barsh, and R Krumlauf
Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes
Development, January 2, 1999; 126(4): 759 - 769.
[Abstract] [PDF]

J. C. White, V. N. Shankar, M. Highland, M. L. Epstein, H. F. DeLuca, and M. Clagett-Dame
Defects in embryonic hindbrain development and fetal resorption resulting from vitamin A deficiency in the rat are prevented by feeding pharmacological levels of all-trans-retinoic acid
PNAS, November 10, 1998; 95(23): 13459 - 13464.
[Abstract] [Full Text] [PDF]

				P. E. Lapinski, J. A. Oliver, L. A. Kamen, E. D. Hughes, T. L. Saunders, and P. D. King Genetic Analysis of SH2D4A, a Novel Adapter Protein Related to T Cell-Specific Adapter and Adapter Protein in Lymphocytes of Unknown Function, Reveals a Redundant Function in T Cells J. Immunol., August 1, 2008; 181(3): 2019 - 2027. [Abstract] [Full Text] [PDF]

				R. Essalmani, A. Zaid, J. Marcinkiewicz, A. Chamberland, A. Pasquato, N. G. Seidah, and A. Prat In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate PNAS, April 15, 2008; 105(15): 5750 - 5755. [Abstract] [Full Text] [PDF]

				L. Ryckebusch, Z. Wang, N. Bertrand, S.-C. Lin, X. Chi, R. Schwartz, S. Zaffran, and K. Niederreither Retinoic acid deficiency alters second heart field formation PNAS, February 26, 2008; 105(8): 2913 - 2918. [Abstract] [Full Text] [PDF]

				G. MacLean, H. Li, D. Metzger, P. Chambon, and M. Petkovich Apoptotic Extinction of Germ Cells in Testes of Cyp26b1 Knockout Mice Endocrinology, October 1, 2007; 148(10): 4560 - 4567. [Abstract] [Full Text] [PDF]

				V. Besson, V. Brault, A. Duchon, D. Togbe, J.-C. Bizot, V. F.J. Quesniaux, B. Ryffel, and Y. Herault Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses Hum. Mol. Genet., September 1, 2007; 16(17): 2040 - 2052. [Abstract] [Full Text] [PDF]

				N. Pilon, K. Oh, J.-R. Sylvestre, J. G. A. Savory, and D. Lohnes Wnt signaling is a key mediator of Cdx1 expression in vivo Development, June 15, 2007; 134(12): 2315 - 2323. [Abstract] [Full Text] [PDF]

				A. Tarrade, C. Fassier, S. Courageot, D. Charvin, J. Vitte, L. Peris, A. Thorel, E. Mouisel, N. Fonknechten, N. Roblot, et al. A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition Hum. Mol. Genet., December 15, 2006; 15(24): 3544 - 3558. [Abstract] [Full Text] [PDF]

				P. Germain, P. Chambon, G. Eichele, R. M. Evans, M. A. Lazar, M. Leid, A. R. De Lera, R. Lotan, D. J. Mangelsdorf, and H. Gronemeyer International Union of Pharmacology. LX. Retinoic Acid Receptors Pharmacol. Rev., December 1, 2006; 58(4): 712 - 725. [Abstract] [Full Text] [PDF]

				L. Kobrossy, M. Rastegar, and M. Featherstone Interplay between Chromatin and Trans-acting Factors Regulating the Hoxd4 Promoter during Neural Differentiation J. Biol. Chem., September 8, 2006; 281(36): 25926 - 25939. [Abstract] [Full Text] [PDF]

				J.-P. Liu The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord Development, August 1, 2006; 133(15): 2865 - 2874. [Abstract] [Full Text] [PDF]

				Y.-S. Cho, E.-J. Kim, U.-H. Park, H.-S. Sin, and S.-J. Um Additional Sex Comb-like 1 (ASXL1), in Cooperation with SRC-1, Acts as a Ligand-dependent Coactivator for Retinoic Acid Receptor J. Biol. Chem., June 30, 2006; 281(26): 17588 - 17598. [Abstract] [Full Text] [PDF]

				Y. Tan, N. Dourdin, C. Wu, T. De Veyra, J. S. Elce, and P. A. Greer Ubiquitous Calpains Promote Caspase-12 and JNK Activation during Endoplasmic Reticulum Stress-induced Apoptosis J. Biol. Chem., June 9, 2006; 281(23): 16016 - 16024. [Abstract] [Full Text] [PDF]

				R. Essalmani, J. Hamelin, J. Marcinkiewicz, A. Chamberland, M. Mbikay, M. Chretien, N. G. Seidah, and A. Prat Deletion of the Gene Encoding Proprotein Convertase 5/6 Causes Early Embryonic Lethality in the Mouse Mol. Cell. Biol., January 1, 2006; 26(1): 354 - 361. [Abstract] [Full Text] [PDF]

				B. Monier, M. Astier, M. Semeriva, and L. Perrin Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart Development, December 1, 2005; 132(23): 5283 - 5293. [Abstract] [Full Text] [PDF]

				F. Santagati, M. Minoux, S.-Y. Ren, and F. M. Rijli Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis Development, November 15, 2005; 132(22): 4927 - 4936. [Abstract] [Full Text] [PDF]

				E. Martinez-Ceballos, P. Chambon, and L. J. Gudas Differences in Gene Expression between Wild Type and Hoxa1 Knockout Embryonic Stem Cells after Retinoic Acid Treatment or Leukemia Inhibitory Factor (LIF) Removal J. Biol. Chem., April 22, 2005; 280(16): 16484 - 16498. [Abstract] [Full Text] [PDF]

				S. Tabaries, J. Lapointe, T. Besch, M. Carter, J. Woollard, C. K. Tuggle, and L. Jeannotte Cdx Protein Interaction with Hoxa5 Regulatory Sequences Contributes to Hoxa5 Regional Expression along the Axial Skeleton Mol. Cell. Biol., February 15, 2005; 25(4): 1389 - 1401. [Abstract] [Full Text] [PDF]

				P. Serpente, S. Tumpel, N. B. Ghyselinck, K. Niederreither, L. M. Wiedemann, P. Dolle, P. Chambon, R. Krumlauf, and A. P. Gould Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation Development, February 1, 2005; 132(3): 503 - 513. [Abstract] [Full Text] [PDF]

				G. Mellitzer, M. Martin, M. Sidhoum-Jenny, C. Orvain, J. Barths, P. A. Seymour, M. Sander, and G. Gradwohl Pancreatic Islet Progenitor Cells in Neurogenin 3-Yellow Fluorescent Protein Knock-Add-On Mice Mol. Endocrinol., November 1, 2004; 18(11): 2765 - 2776. [Abstract] [Full Text] [PDF]

				M. Rastegar, L. Kobrossy, E. N. Kovacs, I. Rambaldi, and M. Featherstone Sequential Histone Modifications at Hoxd4 Regulatory Regions Distinguish Anterior from Posterior Embryonic Compartments Mol. Cell. Biol., September 15, 2004; 24(18): 8090 - 8103. [Abstract] [Full Text] [PDF]

				R. E. Hernandez, H. A. Rikhof, R. Bachmann, and C. B. Moens vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafish Development, September 15, 2004; 131(18): 4511 - 4520. [Abstract] [Full Text] [PDF]

				J. Shiotsugu, Y. Katsuyama, K. Arima, A. Baxter, T. Koide, J. Song, R. A. S. Chandraratna, and B. Blumberg Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation Development, June 1, 2004; 131(11): 2653 - 2667. [Abstract] [Full Text] [PDF]

				M. Houle, J.-R. Sylvestre, and D. Lohnes Retinoic acid regulates a subset of Cdx1 function in vivo Development, December 29, 2003; 130(26): 6555 - 6567. [Abstract] [Full Text] [PDF]

				A. Gavalas, C. Ruhrberg, J. Livet, C. E. Henderson, and R. Krumlauf Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes Development, December 1, 2003; 130(23): 5663 - 5679. [Abstract] [Full Text] [PDF]

				V. Dupe, N. Matt, J.-M. Garnier, P. Chambon, M. Mark, and N. B. Ghyselinck A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment PNAS, November 25, 2003; 100(24): 14036 - 14041. [Abstract] [Full Text] [PDF]

				A. H. Juan and F. H. Ruddle Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer Development, October 15, 2003; 130(20): 4823 - 4834. [Abstract] [Full Text] [PDF]

				W. S. Mohan II, E. Scheer, O. Wendling, D. Metzger, and L. Tora TAF10 (TAFII30) Is Necessary for TFIID Stability and Early Embryogenesis in Mice Mol. Cell. Biol., June 15, 2003; 23(12): 4307 - 4318. [Abstract] [Full Text] [PDF]

				S. Bel-Vialar, N. Itasaki, and R. Krumlauf Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups Development, March 13, 2003; 129(22): 5103 - 5115. [Abstract] [Full Text] [PDF]

				P. Weber, F. Cammas, C. Gerard, D. Metzger, P. Chambon, R. Losson, and M. Mark Germ cell expression of the transcriptional co-repressor TIF1{beta} is required for the maintenance of spermatogenesis in the mouse Development, March 7, 2003; 129(10): 2329 - 2337. [Abstract] [Full Text] [PDF]

				J. M. McClintock, M. A. Kheirbek, and V. E. Prince Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention Development, March 7, 2003; 129(10): 2339 - 2354. [Abstract] [Full Text] [PDF]