Polydactyly and ectopic ZPA formation in Alx-4 mutant mice

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Andrews, N. C. and Faller, D. V (1991). A rapid micropreparation technique for the extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res 19, 2459-.

Chan, D. C., Laufer, E., Tabin, C. and Leder, P (1995). Polydactylous limbs in Strong's luxoid mice result from ectopic polarizing activity. Development 121, 1971-1978.[Abstract]

Chang, D. T., Lopez, A., Kessler, D. P., Chiang, C., Simandl, B. K., Zhao, R., Seldin, M. F., Fallon, J. F. and Beachy, P. A (1994). Products, genetic linkage, and limb patterning activity of a murine hedgehog gene. Development 120, 3339-3353.[Abstract]

Charite, J., Guaaff, W., Shen, S. and Deschamps, J (1994). Ectopic expression of HoxB-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures. Cell 78, 589-601.[Medline]

Chen, F. and Capecchi, M. ( (1997). Targeted mutations in Hoxa-9 and Hoxb-9 reveal synergistic interactions. Dev. Biol 181, 186-196.[Medline]

Cohn, M. J., Izpisua-Belmonte, J. C., Abud, H., Heath, J. K. and Tickle, C (1995). Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell 80, 739-746.[Medline]

Crossley, P. H., Minowada, G., MacArthur, C. A. and Martin, G. R. ( (1996). Roles for FGF8 in the induction, initiation, and maintenance of chick limb bud development. Cell 84, 127-136.[Medline]

Dolle, P., Dierich, A., LeMeur, M., Schimmang, T., Schubaur, B., Chambon, P. and Duboule, D (1993). Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75, 431-441.[Medline]

Echelard, Y., Epstein,D. J., St.-Jacques, B., Shen, L.,Mohler, J., McMahon, J. A. and McMahon, A. P (1993). Sonic Hedgehog, a member of a family of putative signaling molecules, is implicated in the the regulation of CNS polarity. Cell 75, 1417-1430.[Medline]

Fallon, J. F., Lopez, A., Ros, M. A., Savage, M. P., Olwin, B. B. and Simandl, B. K (1994). FGF-2 : Apical ectodermal ridge growth signal for chick limb development. Science 264, 104-107.[Abstract/Free Full Text]

Forsthoefel, P. F (1963). Responses to selection for plus and minus modifiers of some effects of Strong's luxoid gene on the mouse skeleton. Teratology 1, 339-352.

Goulding, M. D., Chelapakis, G., Deutsch, U., Erselius, J. R. and Gruss, P (1991). Pax-3, a novel murine DNA binding protein expressed during early myogenesis. EMBO J 10, 1135-1147.[Medline]

Goulding, M., Lumsden, A. and Paquette, A. J (1994). Regulation of Pax-3 expression in the dermomyotome and its role in muscle development. Development 120, 957-971.[Abstract]

Heikenheimo, M., Lawshe, A., Shackleford, G. M., Wilson, D. B. and MacArthur, C. A (1994). FGF-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system. Mech. Dev 48, 129-138.[Medline]

Hui, C. C. and Joyner, A. L (1993). A mouse model of Greig cephalopolysyndactyly syndrome: the extra toes mutation contains an intragenic deletion of the Gli3 gene. Nature Genet 3, 241-246.[Medline]

Izpisua-Belmonte, J.-C., Tickle, C., Dolle, P., Wolpert, L. and Duboule, D (1991). Expression of the homeobox Hox-4 genes and specification of position in chick wing development. Nature 350, 585-589.[Medline]

Johnson, R. L., Riddle, R. D. and Tabin, C. J (1994). Mechanisms of limb patterning. Curr. Opin. Genet. Dev 4, 535-542.[Medline]

Kern, M. J., Witte, D. P., Valerius, M. D., Aronow, B. J. and Potter, S. S (1992). A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy. Nuc. Acids Res 20, 5189-5195.[Abstract/Free Full Text]

Kuratani, S., Martin, J. F., Wawersik, S., Lilly, B., Eichele, G. and Olson, E. N (1994). The expression pattern of the chick homeobox gene gMHox suggests a role in patterning of the limbs and face and in compartmentalization of somites. Dev. Biol 161, 357-369.[Medline]

Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A. and Tabin, C. ( (1994). Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79, 993-1003.[Medline]

Marigo, V., Johnson, R. L., Vortkamp, A. and Tabin, C (1996). Sonic hedgehog differentially regulates expression of Gli and Gli3 during limb development. Dev. Biol 180, 273-283.[Medline]

Martin, J. F., Bradley, A. and Olson, E. N (1995). The paired-like homeobox gene MHox is required for early events of skeletogenesis in multiple lineages. Genes Dev 9, 1237-1249.[Abstract/Free Full Text]

Masuya, H., Sagai, T., Wakana, S., Moriwaki, K. and Shiroishi, T (1995). A duplicated zone of polarizing activity in polydactylous mouse mutants. Genes Dev 9, 1237-1249.

Masuya, H., Sagai, T., Morikawi, K. and Shiroishi, T (1997). Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse. Dev. Biol 182, 42-51.[Medline]

Mathers, P. H., Grinberg, A., Mahon, K. A. and Jamrich, M (1997). The Rx homeobox gene is essential for vertebrate eye development. Nature 387, 603-607.[Medline]

Niswander, L. and Martin, G (1992). FGF-4 expression during gastrulation, myogenesis, limb, and tooth development in the mouse. Development 114, 755-768.[Abstract]

Niswander, L., Tickle, C., Vogel, A., Booth, I. and Martin, G. R. ( (1993). FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell 75, 579-587.[Medline]

Niswander, L., Jeffrey, S., Martin, G. R. and Tickle, C (1994). Positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature 371, 609-612.[Medline]

Nohno, T., Noji, S., Koyama, E., Ohyama, K., Myokai, F., Kuroiwa, A., Saito T., and Taniguchi, S. ( (1991). Involvement of the Chox-4 genes indetermination of the anteroposterior axial polarity during limb development. Cell 64, 1197-1205.[Medline]

Opstelten, D.-J. E., Vogels, R., Robert, B., Kahlhoven, E., Zwartkruis, F., de Laaf, L., Destree, O. H., Lawson, K. and Meijlink, F (1991). The mouse homeobox gene S8 is expressed during development predominantly in mesenchyme. Mech. Dev 34, 29-42.[Medline]

Ordahl, C. and LeDouarin, N (1992). Two myogenic lineages within the developing somite. Development 114, 339-353.[Abstract]

Pourquie, O., Fan, C.-M., Cotley, M., Hirsinger, E., Watanabe, Y., Breant, C., Francis-West, P., Brickell, P., Tessier,-Lavigne, M. and LeDouarin, N (1996). Lateral and axial signals involved in avian somite patterning: a role for BMP-4. Cell 84, 461-471.[Medline]

Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1041-1416.

Riley, B. B., Savage, M. P., Simandl, B. K., Sasse, J., Olwin, B. B. and Fallon, J. F (1993). Retroviral expression of FGF-2 ( bFGF ) affects patterning in chick limb bud. Development 118, 95-104.[Abstract]

Rowe, L. B., Nadeau, J. H., Turner, R., Frankel, W. N., Letts, V. A., Eppis, J. T., Ko, M. S. H., Thurston, S. J. and Birkenmeier, E. H (1994). Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm. Genome 5, 253-274.[Medline]

Sasaki, H. and Hogan, B. L. M (1993). Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118, 47-59.[Abstract]

Savage, M. P., Hart, C. E., Riley, B. B., Sasse, J., Olwin, B. B. and Fallon, J. F (1993). Distribution of FGF-2 suggests it has a role in chick limb bud growth. Dev. Dyn 198, 159-170.[Medline]

Schimmang, T., Lemaistre, M., Vortkamp, A. and Ruther, U (1992). Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes ( Xt ). Development 116, 799-804.[Abstract]

Strong, L. C. and Hardy, L. B (1956). A new \324luxoid' mutant in mice. J. Hered 47, 277-284.[Free Full Text]

Tabin, C (1995). The initiation of the limb bud: growth factors, Hox genes and retinoids. Cell 80, 671-674.[Medline]

Tickle, C. and Eichele, G (1994). Vertebrate limb development. Ann. Rev. Cell. Biol 10, 121-152.

van der Hoeven, F., Zakany J. and Duboule, D (1996). Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls. Cell 85, 1025-1035.[Medline]

Van Allen, M. I., Curry, C., Walden, C. E., Gallagher, L. and Patten, R. M (1987). Limb-body wall complex: II. Limb and spine defects. Am. Jour. Med. Gen 28, 549-565.[Medline]

Vogel, A. and Tickle, C (1993). FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro. Development 119, 199-206.[Abstract]

Vogt, T. and Leder, P (1996). Polydactyly in the Strong's luxoid mouse is suppressed by limb deformity alleles. Developmental Genetics 19, 33-42.[Medline]

Wilson, D., Sheng, G., Lecuit, T., Dostatni, N. and Desplan, C (1993). Cooperative dimerization of paired class homeodomains on DNA. Genes Dev 7, 2120-2134.[Abstract/Free Full Text]

Wilson, D., Guenther, B., Desplan, C. and Kuriyan, J (1995). High resolution crystal structure of a paired (pax) class cooperative homeodomain dimer on DNA. Cell 82, 709-719.[Medline]

Winnier, G., Blessing, M., Labosky, P. A. and Hogan, B. L. M (1995). Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 9, 2105-2116.[Abstract/Free Full Text]

Zhao, G.-Q., Eberspaecher, H., Seldin, M. and deCrombrugghe, B (1994). The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development. Mech. Dev 48, 245-254.[Medline]

Zhao, G.-Q., Zhou, X, Eberspaecher, H., Solursh, M. and deCrombrugghe, M (1993). Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes. Proc. Natl. Acad. Sci. USA 90, 8633-8637.[Abstract/Free Full Text]

Zhao, Q., Behringer, R. R. and deCrombrugghe, B (1996). Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene. Nature Genetics 13, 275-283.[Medline]

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				L. A. Naiche and V. E. Papaioannou Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowth Development, January 1, 2007; 134(1): 93 - 103. [Abstract] [Full Text] [PDF]

				M. Mirasierra and M. Vallejo The Homeoprotein Alx3 Expressed in Pancreatic {beta}-Cells Regulates Insulin Gene Transcription by Interacting with the Basic Helix-Loop-Helix Protein E47 Mol. Endocrinol., November 1, 2006; 20(11): 2876 - 2889. [Abstract] [Full Text] [PDF]

				P. Lu, G. Minowada, and G. R. Martin Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function Development, January 1, 2006; 133(1): 33 - 42. [Abstract] [Full Text] [PDF]

				F. Santagati, M. Minoux, S.-Y. Ren, and F. M. Rijli Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis Development, November 15, 2005; 132(22): 4927 - 4936. [Abstract] [Full Text] [PDF]

				B. Perez-Villamil, M. Mirasierra, and M. Vallejo The Homeoprotein Alx3 Contains Discrete Functional Domains and Exhibits Cell-specific and Selective Monomeric Binding and Transactivation J. Biol. Chem., September 3, 2004; 279(36): 38062 - 38071. [Abstract] [Full Text] [PDF]

				J. I. Pueyo and J. P. Couso Chip-mediated partnerships of the homeodomain proteins Bar and Aristaless with the LIM-HOM proteins Apterous and Lim1 regulate distal leg development Development, July 1, 2004; 131(13): 3107 - 3120. [Abstract] [Full Text] [PDF]

				O. Krebs, C. M. Schreiner, W. J. Scott Jr, S. M. Bell, D. J. Robbins, J. A. Goetz, H. Alt, N. Hawes, E. Wolf, and J. Favor Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud Development, December 15, 2003; 130(24): 6037 - 6047. [Abstract] [Full Text] [PDF]

				L. A. Lettice, S. J.H. Heaney, L. A. Purdie, L. Li, P. de Beer, B. A. Oostra, D. Goode, G. Elgar, R. E. Hill, and E. de Graaff A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly Hum. Mol. Genet., July 15, 2003; 12(14): 1725 - 1735. [Abstract] [Full Text] [PDF]

				A. J. M. LUIJSTERBURG, G. J. SONNEVELD, CHR. VERMEIJ-KEERS, and S. E. R. HOVIUS Recording Congenital Differences of the Upper Limb J Hand Surg Eur Vol., June 1, 2003; 28(3): 205 - 214. [Abstract] [Full Text] [PDF]

				S. Ruiz, C. Segrelles, A. Bravo, M. Santos, P. Perez, H. Leis, J. L. Jorcano, and J. M. Paramio Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130 Development, June 1, 2003; 130(11): 2341 - 2353. [Abstract] [Full Text] [PDF]

				M. P. Hoffman, B. L. Kidder, Z. L. Steinberg, S. Lakhani, S. Ho, H. K. Kleinman, and M. Larsen Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms Development, March 14, 2003; 129(24): 5767 - 5778. [Abstract] [Full Text] [PDF]

				Y. Liu, C. Liu, Y. Yamada, and C.-M. Fan growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb Development, March 13, 2003; 129(22): 5289 - 5300. [Abstract] [Full Text] [PDF]

				M. A. Ros, R. D. Dahn, M. Fernandez-Teran, K. Rashka, N. C. Caruccio, S. M. Hasso, J. J. Bitgood, J. J. Lancman, and J. F. Fallon The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb Development, February 1, 2003; 130(3): 527 - 537. [Abstract] [Full Text] [PDF]

				P. te Welscher, M. Fernandez-Teran, M. A. Ros, and R. Zeller Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling Genes & Dev., February 15, 2002; 16(4): 421 - 426. [Abstract] [Full Text] [PDF]

				A. Beverdam, A. Brouwer, M. Reijnen, J. Korving, and F. Meijlink Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice Development, October 15, 2001; 128(20): 3975 - 3986. [Abstract] [Full Text] [PDF]

				M. D. Layne, S.-F. Yet, K. Maemura, C.-M. Hsieh, M. Bernfield, M. A. Perrella, and M.-E. Lee Impaired Abdominal Wall Development and Deficient Wound Healing in Mice Lacking Aortic Carboxypeptidase-Like Protein Mol. Cell. Biol., August 1, 2001; 21(15): 5256 - 5261. [Abstract] [Full Text] [PDF]

				W. Wuyts, E. Cleiren, T. Homfray, A. Rasore-Quartino, F. Vanhoenacker, and W. Van Hul The ALX4 homeobox gene is mutated in patients with ossification defects of the skull (foramina parietalia permagna, OMIM 168500) J. Med. Genet., December 1, 2000; 37(12): 916 - 920. [Abstract] [Full Text]

				M. Fernandez-Teran, M. E. Piedra, I. S. Kathiriya, D. Srivastava, J. C. Rodriguez-Rey, and M. A. Ros Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway Development, May 15, 2000; 127(10): 2133 - 2142. [Abstract] [PDF]

				J Charite, D. McFadden, and E. Olson The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development Development, January 6, 2000; 127(11): 2461 - 2470. [Abstract] [PDF]

				G Drossopoulou, K. Lewis, J. Sanz-Ezquerro, N Nikbakht, A. McMahon, C Hofmann, and C Tickle A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling Development, January 4, 2000; 127(7): 1337 - 1348. [Abstract] [PDF]

				S. C. Tucker and R. Wisdom Site-specific Heterodimerization by Paired Class Homeodomain Proteins Mediates Selective Transcriptional Responses J. Biol. Chem., November 5, 1999; 274(45): 32325 - 32332. [Abstract] [Full Text] [PDF]

				L Lettice, J Hecksher-Sorensen, and R. Hill The dominant hemimelia mutation uncouples epithelial-mesenchymal interactions and disrupts anterior mesenchyme formation in mouse hindlimbs Development, January 11, 1999; 126(21): 4729 - 4736. [Abstract] [PDF]

				K. Lewis, G Drossopoulou, I. Paton, D. Morrice, K. Robertson, D. Burt, P. Ingham, and C Tickle Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway Development, January 6, 1999; 126(11): 2397 - 2407. [Abstract] [PDF]

				A Zuniga and R Zeller Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity Development, January 1, 1999; 126(1): 13 - 21. [Abstract] [PDF]

				S Qu, S. Tucker, Q Zhao, B deCrombrugghe, and R Wisdom Physical and genetic interactions between Alx4 and Cart1 Development, January 1, 1999; 126(2): 359 - 369. [Abstract] [PDF]

				G. R. Martin The roles of FGFs in the early development of vertebrate�limbs Genes & Dev., June 1, 1998; 12(11): 1571 - 1586. [Full Text]

				M Takahashi, K Tamura, D Buscher, H Masuya, S Yonei-Tamura, K Matsumoto, M Naitoh-Matsuo, J Takeuchi, K Ogura, T Shiroishi, et al. The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development Development, January 11, 1998; 125(22): 4417 - 4425. [Abstract] [PDF]

				D ten Berge, A Brouwer, J Korving, J. Martin, and F Meijlink Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs Development, January 10, 1998; 125(19): 3831 - 3842. [Abstract] [PDF]

				Y Yang, P Guillot, Y Boyd, M. Lyon, and A. McMahon Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling Development, January 8, 1998; 125(16): 3123 - 3132. [Abstract] [PDF]

				S Qu, S. Tucker, J. Ehrlich, J. Levorse, L. Flaherty, R Wisdom, and T. Vogt Mutations in mouse Aristaless-like4 cause Strong's luxoid polydactyly Development, January 7, 1998; 125(14): 2711 - 2721. [Abstract] [PDF]