Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Warot, X.
	Articles by Dolle, P.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Warot, X.
	Articles by Dolle, P.


Social Bookmarking

	What's this?

Benson, G. V., Lim, H., Paria, B. C., Satokata I., Dey, S. K. and Maas R. L (1996). Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression. Development 122, 2687-2696.[Abstract]

Chen, Z., Friedrich, G. A. and Soriano, P (1994). Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev 8, 2293-2301.[Abstract/Free Full Text]

Chisaka, O. and Capecchi, M. R (1991). Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene Hox-1. 5. Nature 350, 473-479.[Medline]

Davis, A. P. and Capecchi, M. R (1996). A mutational analysis of the 5 HoxD genes: dissection of genetic interactions during limb development in the mouse. Development 122, 1175-1185.[Abstract]

Davis, A. P., Witte, D. P., Hsieh-Li, H. M., Potter, S. S. and Capecchi, M. R (1995). Absence of radius and ulna in mice lacking Hoxa-11 and Hoxd-11. Nature 375, 791-795.[Medline]

Dolle, P., Izpis\235a-Belmonte, J. C., Brown, J., Tickle, C. and Duboule, D (1991). Hox-4 genes and the morphogenesis of mammalian genitalia. Genes Dev 5, 1767-1776.[Abstract/Free Full Text]

Dolle, P., Izpis\235a-Belmonte, J., Boncinelli, E. and Duboule, D (1991). The Hox-4. 8 gene is localized at the 5extremity of the Hox-4 complex and is expressed in the posterior end of the body during development. Mech. Dev 36, 3-14.[Medline]

Dolle, P., Dierich, A., Le Meur, M., Schimmang, T., Schuhbaur, B., Chambon, P. and Duboule, D (1993). Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75, 431-441.[Medline]

Donnenfeld, A. E., Schrager, D. S. and Corson, S. L (1992). Update on a family with hand-foot-genital syndrome: hypospadias and urinary tract abnormalities in two boys from the fourth generation. Am. J. Med. Genet 44, 482-484.[Medline]

Fromental-Ramain, C., Warot, X., Messaddeq, N., LeMeur, M., Dolle, P. and Chambon, P (1996). Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod. Development 122, 2997-3011.[Abstract]

Fryns, J. P., Vogels, A., Decock, P. and Van den Berghe, H (1993). The hand-foot-genital syndrome: on the variable expression in affected males. Clin. Genet 43, 232-234.[Medline]

Gendron, R. L., Paradis, H., Hsieh-Li, H. M., Lee, D. W., Potter, S. S. and Markoff, E (1997). Abnormal uterine stromal and glandular function associated with maternal reproductive defects in Hoxa-11 null mice. Biol. Reprod 56, 1097-1105.[Abstract]

Giedion, A. and Prader, A (1975). Hand-Foot-Uterus (HFU) Syndrome with Hypospadias: The Hand-Foot-Genital (HFG) Syndrome. Pediat. Radiol 4, 96-102.

Goff, D. J. and Tabin, C. J (1997). Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth. Development 124, 627-636.[Abstract]

Gurtner, G. C., Davis, V., Li, H., McCoy, M. J., Sharpe, A. and Cybulsky, M. I (1995). Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes Dev 9, 1-14.[Abstract/Free Full Text]

Haack, H. and Gruss, P (1993). The establishment of murine Hox-1 expression domains during patterning of the limb. Dev. Biol 157, 410-422.[Medline]

Halal, F (1986). A new syndrome of severe upper limb hypoplasia and Mullerian duct anomalies. Am. J. Med. Genet 24, 119-126.[Medline]

Halal, F (1988). The Hand-Foot-Genital (Hand-Foot-Uterus) Syndrome: Family report and update. Am. J. Med. Genet 30, 793-803.[Medline]

Hsieh-Li, H. M., Witte, D. P., Weinstein, M., Branford, W., Li, H., Small, K. and Potter, S. S (1995). Hoxa-11 structure, extensive antisense transcription, and function in male and female fertility. Development 121, 1373-1385.[Abstract]

Juillard, M. T (1972). Ultrastructure de l'epithelium vaginal de la souris au cours de sa differenciation. Arch. Anat. Microsc. Morphol. Exp 61, 33-46.[Medline]

Kastner, P., Grondona, J. M., Mark, M., Gansmuller, A., LeMeur, M., Decimo, D., Vonesch, J. L., Dolle, P. and Chambon, P (1994). Genetic analysis of RXRdevelopmental function: convergence of RXR and RAR signalling pathways in heart and eye morphogenesis. Cell 78, 987-1003.[Medline]

Kawabe, T., Muslin, A. J. and Korsmeyer, S. J (1997). HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. Nature 385, 454-458.[Medline]

Kondo, T., Dolle, P., Z\210k\210ny, J. and Duboule, D (1996). Function of posterior HoxD genes in the morphogenesis of the anal sphincter. Development 122, 2651-2659.[Abstract]

Kwee, L., Baldwin, H. S., Shen, H. M., Stewart, C. L., Buck, C., Buck, C. A. and Labow, M. A (1995). Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development 121, 489-503.[Abstract]

Mark, M., Lufkin, T., Vonesch, J. L., Ruberte, E., Olivo, J.-C., Dolle, P., Gorry, P., Lumdsen, A. and Chambon, P (1993). Two rhombomeres are altered in Hoxa-1 null mutant mice. Development 119, 319-338.[Abstract]

McGinnis, W. and Krumlauf, R (1992). Homeobox genes and axial patterning. Cell 68, 283-302.[Medline]

Mortlock, D. P. and Innis, J. W (1997). Mutation of HOXA13 in hand-foot-genital syndrome. Nature Genet 15, 179-180.[Medline]

Muragaki, Y., Mundlos, S., Upton, J. and Olsen, B. R (1996). Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13. Science 272, 548-551.[Abstract]

Oefelstein, M., Chin-Chance, C. and Bushman, W (1996). Expression of the homeotic gene Hoxd-13 in the developing and adult mouse prostate. J. Urol 155, 342-346.[Medline]

Peterson, R. L., Papenbrock, T., Davda, M. M. and Awgulevitsch, A (1994). The murine HOXC cluster contains five neighboring AbdB -related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions. Mech. Dev 47, 253-260.[Medline]

Pinsky, L. A (1973). A community of human malformation syndromes involving the Mullerian ducts, distal extremities, urinary tract, and ears. Teratol 9, 65-80.

Podlasek, C. A., Duboule, D. and Bushman, W (1997). Male accessory sex organ morphogenesis is altered by loss of function of Hoxd-13. Dev. Dyn 208, 454-465.[Medline]

Rijli, M. R., Mark, M., Lakkaraju, S., Dierich, A., Dolle, P. and Chambon, P (1993). A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2 , which acts as a selector gene. Cell 75, 1333-1349.[Medline]

Roberts, D. J., Johnson, R. L., Burke, A. C., Nelson, C. E., Morgan, B. A. and Tabin, C (1995). Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. Development 121, 3163-3174.[Abstract]

Satokata, I., Benson, G. and Maas, R (1995). Sexually dimorphic sterility phenotypes in Hoxa-10 deficient mice. Nature 374, 460-463.[Medline]

Scott, M (1992). Vertebrate homeobox gene nomenclature. Cell 71, 551-553.[Medline]

Sordino, P., van der Hoeven, F. and Duboule, D (1995). Hox gene expression in teleost fins and the origin of vertebrate digits. Nature 375, 678-681.[Medline]

Sordino, P., Duboule, D. and Kondo, T (1996). Zebrafish Hoxa and Evx-2 genes: cloning, developmental expression and implications for the functional evolution of posterior Hox genes. Mech. Dev 59, 165-175.[Medline]

Stern, A. M., Gall, J. C., Perry, B. L., Stimson, C. W., Weintkamp, L. R. and Poznanski, A. K (1970). The hand-foot-uterus syndrome. J. Pediatrics 77, 109-116.[Medline]

van der Hoeven, F., Sordino, P., Fraudeau, N., Izpis\235a-Belmonte, J. C. and Duboule, D (1996). Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex. Mech. Dev 54, 9-21.[Medline]

Verp, M. S (1989). Urinary tract abnormalities in Hand-Foot-Genital syndrome. Am. J. Med. Genetics 32, 555-.[Medline]

Yokouchi, Y., Sakiyama, J. and Kuroiwa, A (1995). Coordinated expression of Abd-B subfamily genes of the HoxA cluster in the developing digestive tract of chick embryo. Dev. Biol 169, 76-89.[Medline]

Yokouchi, Y., Nakazato, S., Yamamoto, M., Goto, Y., Kameda, T., Iba, H. and Kuroiwa, A (1995). Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes Dev 9, 2509-2522.[Abstract/Free Full Text]

Z\210k\210ny, J. and Duboule, D (1996). Synpolydactyly in mice with a targeted deficiency in the HoxD complex. Nature 384, 69-71.[Medline]

Zeltser, L., Desplan, C. and Heintz, N (1996). Hoxb-13 : a new Hox gene in a distant region of the HOXB cluster maintains colinearity. Development 122, 2475-2484.[Abstract]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

C. Lin, Y. Yin, G. M. Veith, A. V. Fisher, F. Long, and L. Ma
Temporal and spatial dissection of Shh signaling in genital tubercle development
Development, December 1, 2009; 136(23): 3959 - 3967.
[Abstract] [Full Text] [PDF]

O. Cocquempot, V. Brault, C. Babinet, and Y. Herault
Fork Stalling and Template Switching As a Mechanism for Polyalanine Tract Expansion Affecting the DYC Mutant of HOXD13, a New Murine Model of Synpolydactyly
Genetics, September 1, 2009; 183(1): 23 - 30.
[Abstract] [Full Text] [PDF]

R. Illig, H. Fritsch, and C. Schwarzer
Breaking the seals: Efficient mRNA detection from human archival paraffin-embedded tissue
RNA, August 1, 2009; 15(8): 1588 - 1596.
[Abstract] [Full Text] [PDF]

J. G. Bromer, J. Wu, Y. Zhou, and H. S. Taylor
Hypermethylation of Homeobox A10 by in Utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming
Endocrinology, July 1, 2009; 150(7): 3376 - 3382.
[Abstract] [Full Text] [PDF]

N. E. Freeman-Anderson, Y. Zheng, A. C. McCalla-Martin, L. M. Treanor, Y. D. Zhao, P. M. Garfin, T.-C. He, M. N. Mary, J. D. Thornton, C. Anderson, et al.
Expression of the Arf tumor suppressor gene is controlled by Tgf{beta}2 during development
Development, June 15, 2009; 136(12): 2081 - 2089.
[Abstract] [Full Text] [PDF]

C. Lin, Y. Yin, F. Long, and L. Ma
Tissue-specific requirements of {beta}-catenin in external genitalia development
Development, August 15, 2008; 135(16): 2815 - 2825.
[Abstract] [Full Text] [PDF]

A. Suzuki, H. Urushitani, T. Sato, T. Kobayashi, H. Watanabe, Y. Ohta, and T. Iguchi
Gene Expression Change in the Mullerian Duct of the Mouse Fetus Exposed to Diethylstilbestrol In Utero
Experimental Biology and Medicine, April 1, 2007; 232(4): 503 - 514.
[Abstract] [Full Text] [PDF]

L. Huang, Y. Pu, D. Hepps, D. Danielpour, and G. S. Prins
Posterior Hox Gene Expression and Differential Androgen Regulation in the Developing and Adult Rat Prostate Lobes
Endocrinology, March 1, 2007; 148(3): 1235 - 1245.
[Abstract] [Full Text] [PDF]

Y. Yin, C. Lin, and L. Ma
Msx2 Promotes Vaginal Epithelial Differentiation and Wolffian Duct Regression and Dampens the Vaginal Response to Diethylstilbestrol
Mol. Endocrinol., July 1, 2006; 20(7): 1535 - 1546.
[Abstract] [Full Text] [PDF]

T. M. Williams, M. E. Williams, J. H. Heaton, T. D. Gelehrter, and J. W. Innis
Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability
Nucleic Acids Res., August 8, 2005; 33(14): 4475 - 4484.
[Abstract] [Full Text] [PDF]

X. Fei, H. Chung, and H. S. Taylor
Methoxychlor Disrupts Uterine Hoxa10 Gene Expression
Endocrinology, August 1, 2005; 146(8): 3445 - 3451.
[Abstract] [Full Text] [PDF]

J. Cobb and D. Duboule
Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia
Development, July 1, 2005; 132(13): 3055 - 3067.
[Abstract] [Full Text] [PDF]

V. Scott, E. A. Morgan, and H. S. Stadler
Genitourinary Functions of Hoxa13 and Hoxd13
J. Biochem., June 1, 2005; 137(6): 671 - 676.
[Abstract] [Full Text] [PDF]

Y. Yin and L. Ma
Development of the Mammalian Female Reproductive Tract
J. Biochem., June 1, 2005; 137(6): 677 - 683.
[Abstract] [Full Text] [PDF]

F. M. Poulet, R. Veneziale, P. M. Vancutsem, P. Losco, K. Treinen, and R. E. Morrissey
Ziracin-Induced Congenital Urogenital Malformations in Female Rats
Toxicol Pathol, April 1, 2005; 33(3): 320 - 328.
[Abstract] [Full Text] [PDF]

C. Jung, R.-S. Kim, H.-J. Zhang, S.-J. Lee, and M.-H. Jeng
HOXB13 Induces Growth Suppression of Prostate Cancer Cells as a Repressor of Hormone-Activated Androgen Receptor Signaling
Cancer Res., December 15, 2004; 64(24): 9185 - 9192.
[Abstract] [Full Text] [PDF]

J. W. Innis, D. Mortlock, Z. Chen, M. Ludwig, M. E. Williams, T. M. Williams, C. D. Doyle, Z. Shao, M. Glynn, D. Mikulic, et al.
Polyalanine expansion in HOXA13: three new affected families and the molecular consequences in a mouse model
Hum. Mol. Genet., November 15, 2004; 13(22): 2841 - 2851.
[Abstract] [Full Text] [PDF]

C. Jung, R.-S. Kim, S.-J. Lee, C. Wang, and M.-H. Jeng
HOXB13 Homeodomain Protein Suppresses the Growth of Prostate Cancer Cells by the Negative Regulation of T-Cell Factor 4
Cancer Res., May 1, 2004; 64(9): 3046 - 3051.
[Abstract] [Full Text] [PDF]

L. Huang, Y. Pu, S. Alam, L. Birch, and G. S. Prins
Estrogenic Regulation of Signaling Pathways and Homeobox Genes During Rat Prostate Development
J Androl, May 1, 2004; 25(3): 330 - 337.
[Full Text] [PDF]

M. Mericskay, J. Kitajewski, and D. Sassoon
Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus
Development, May 1, 2004; 131(9): 2061 - 2072.
[Abstract] [Full Text] [PDF]

K. H. H. Wong, H. D. Wintch, and M. R. Capecchi
Hoxa11 Regulates Stromal Cell Death and Proliferation during Neonatal Uterine Development
Mol. Endocrinol., January 1, 2004; 18(1): 184 - 193.
[Abstract] [Full Text] [PDF]

E. A. Morgan, S. B. Nguyen, V. Scott, and H. S. Stadler
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
Development, July 15, 2003; 130(14): 3095 - 3109.
[Abstract] [Full Text] [PDF]

K. D. Economides and M. R. Capecchi
Hoxb13 is required for normal differentiation and secretory function of the ventral prostate
Development, May 15, 2003; 130(10): 2061 - 2069.
[Abstract] [Full Text] [PDF]

G. S. Prins, W. Y. Chang, Y. Wang, and R. B. van Breemen
Retinoic Acid Receptors and Retinoids Are Up-Regulated in the Developing and Adult Rat Prostate by Neonatal Estrogen Exposure
Endocrinology, September 1, 2002; 143(9): 3628 - 3640.
[Abstract] [Full Text] [PDF]

J. Aubin, U. Dery, M. Lemieux, P. Chailler, and L. Jeannotte
Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling
Development, September 1, 2002; 129(17): 4075 - 4087.
[Abstract] [Full Text] [PDF]

Y. M. Chau, S. Pando, and H. S. Taylor
HOXA11 Silencing and Endogenous HOXA11 Antisense Ribonucleic Acid in the Uterine Endometrium
J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2674 - 2680.
[Abstract] [Full Text] [PDF]

E. van den Akker, S. Forlani, K. Chawengsaksophak, W. de Graaff, F. Beck, B. I. Meyer, and J. Deschamps
Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation
Development, January 5, 2002; 129(9): 2181 - 2193.
[Abstract] [Full Text] [PDF]

P. de Santa Barbara and D. J. Roberts
Tail gut endoderm and gut/genitourinary/tail development: a new tissue-specific role for Hoxa13
Development, January 2, 2002; 129(3): 551 - 561.
[Abstract] [Full Text] [PDF]

J. E. Pitera, V. V. Smith, A. S. Woolf, and P. J. Milla
Embryonic Gut Anomalies in a Mouse Model of Retinoic Acid-Induced Caudal Regression Syndrome : Delayed Gut Looping, Rudimentary Cecum, and Anorectal Anomalies
Am. J. Pathol., December 1, 2001; 159(6): 2321 - 2329.
[Abstract] [Full Text] [PDF]

H. S. Stadler, K. M. Higgins, and M. R. Capecchi
Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs
Development, November 1, 2001; 128(21): 4177 - 4188.
[Abstract] [Full Text] [PDF]

K. BLOCK, A. KARDANA, P. IGARASHI, and H. S. TAYLOR
In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system
FASEB J, June 1, 2000; 14(9): 1101 - 1108.
[Abstract] [Full Text]

R Haraguchi, K Suzuki, R Murakami, M Sakai, M Kamikawa, M Kengaku, K Sekine, H Kawano, S Kato, N Ueno, et al.
Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation
Development, January 6, 2000; 127(11): 2471 - 2479.
[Abstract] [PDF]

S. Baur, J. Mai, and S. Dymecki
Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity
Development, January 2, 2000; 127(3): 605 - 619.
[Abstract] [PDF]

L. C. Post and J. W. Innis
Infertility in Adult Hypodactyly Mice Is Associated with Hypoplasia of Distal Reproductive Structures
Biol Reprod, December 1, 1999; 61(6): 1402 - 1408.
[Abstract] [Full Text]

J. Aubin, P. Chailler, D. Menard, and L. Jeannotte
Loss of Hoxa5 gene function in mice perturbs intestinal maturation
Am J Physiol Cell Physiol, November 1, 1999; 277(5): C965 - C973.
[Abstract] [Full Text] [PDF]

F. Chen and M. R. Capecchi
Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy
PNAS, January 19, 1999; 96(2): 541 - 546.
[Abstract] [Full Text] [PDF]

D. Roberts, D. Smith, D. Goff, and C. Tabin
Epithelial-mesenchymal signaling during the regionalization of the chick gut
Development, January 8, 1998; 125(15): 2791 - 2801.
[Abstract] [PDF]

D. Duboule
Hox is in the hair: a break in�colinearity?
Genes & Dev., January 1, 1998; 12(1): 1 - 4.
[Full Text]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Warot, X.

Articles by Dolle, P.

Search for Related Content

PubMed

PubMed Citation

Articles by Warot, X.

Articles by Dolle, P.

Social Bookmarking

What's this?

				O. Cocquempot, V. Brault, C. Babinet, and Y. Herault Fork Stalling and Template Switching As a Mechanism for Polyalanine Tract Expansion Affecting the DYC Mutant of HOXD13, a New Murine Model of Synpolydactyly Genetics, September 1, 2009; 183(1): 23 - 30. [Abstract] [Full Text] [PDF]

				R. Illig, H. Fritsch, and C. Schwarzer Breaking the seals: Efficient mRNA detection from human archival paraffin-embedded tissue RNA, August 1, 2009; 15(8): 1588 - 1596. [Abstract] [Full Text] [PDF]

				J. G. Bromer, J. Wu, Y. Zhou, and H. S. Taylor Hypermethylation of Homeobox A10 by in Utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming Endocrinology, July 1, 2009; 150(7): 3376 - 3382. [Abstract] [Full Text] [PDF]

				N. E. Freeman-Anderson, Y. Zheng, A. C. McCalla-Martin, L. M. Treanor, Y. D. Zhao, P. M. Garfin, T.-C. He, M. N. Mary, J. D. Thornton, C. Anderson, et al. Expression of the Arf tumor suppressor gene is controlled by Tgf{beta}2 during development Development, June 15, 2009; 136(12): 2081 - 2089. [Abstract] [Full Text] [PDF]

				C. Lin, Y. Yin, F. Long, and L. Ma Tissue-specific requirements of {beta}-catenin in external genitalia development Development, August 15, 2008; 135(16): 2815 - 2825. [Abstract] [Full Text] [PDF]

				A. Suzuki, H. Urushitani, T. Sato, T. Kobayashi, H. Watanabe, Y. Ohta, and T. Iguchi Gene Expression Change in the Mullerian Duct of the Mouse Fetus Exposed to Diethylstilbestrol In Utero Experimental Biology and Medicine, April 1, 2007; 232(4): 503 - 514. [Abstract] [Full Text] [PDF]

				L. Huang, Y. Pu, D. Hepps, D. Danielpour, and G. S. Prins Posterior Hox Gene Expression and Differential Androgen Regulation in the Developing and Adult Rat Prostate Lobes Endocrinology, March 1, 2007; 148(3): 1235 - 1245. [Abstract] [Full Text] [PDF]

				Y. Yin, C. Lin, and L. Ma Msx2 Promotes Vaginal Epithelial Differentiation and Wolffian Duct Regression and Dampens the Vaginal Response to Diethylstilbestrol Mol. Endocrinol., July 1, 2006; 20(7): 1535 - 1546. [Abstract] [Full Text] [PDF]

				T. M. Williams, M. E. Williams, J. H. Heaton, T. D. Gelehrter, and J. W. Innis Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability Nucleic Acids Res., August 8, 2005; 33(14): 4475 - 4484. [Abstract] [Full Text] [PDF]

				X. Fei, H. Chung, and H. S. Taylor Methoxychlor Disrupts Uterine Hoxa10 Gene Expression Endocrinology, August 1, 2005; 146(8): 3445 - 3451. [Abstract] [Full Text] [PDF]

				J. Cobb and D. Duboule Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia Development, July 1, 2005; 132(13): 3055 - 3067. [Abstract] [Full Text] [PDF]

				V. Scott, E. A. Morgan, and H. S. Stadler Genitourinary Functions of Hoxa13 and Hoxd13 J. Biochem., June 1, 2005; 137(6): 671 - 676. [Abstract] [Full Text] [PDF]

				Y. Yin and L. Ma Development of the Mammalian Female Reproductive Tract J. Biochem., June 1, 2005; 137(6): 677 - 683. [Abstract] [Full Text] [PDF]

				F. M. Poulet, R. Veneziale, P. M. Vancutsem, P. Losco, K. Treinen, and R. E. Morrissey Ziracin-Induced Congenital Urogenital Malformations in Female Rats Toxicol Pathol, April 1, 2005; 33(3): 320 - 328. [Abstract] [Full Text] [PDF]

				C. Jung, R.-S. Kim, H.-J. Zhang, S.-J. Lee, and M.-H. Jeng HOXB13 Induces Growth Suppression of Prostate Cancer Cells as a Repressor of Hormone-Activated Androgen Receptor Signaling Cancer Res., December 15, 2004; 64(24): 9185 - 9192. [Abstract] [Full Text] [PDF]

				J. W. Innis, D. Mortlock, Z. Chen, M. Ludwig, M. E. Williams, T. M. Williams, C. D. Doyle, Z. Shao, M. Glynn, D. Mikulic, et al. Polyalanine expansion in HOXA13: three new affected families and the molecular consequences in a mouse model Hum. Mol. Genet., November 15, 2004; 13(22): 2841 - 2851. [Abstract] [Full Text] [PDF]

				C. Jung, R.-S. Kim, S.-J. Lee, C. Wang, and M.-H. Jeng HOXB13 Homeodomain Protein Suppresses the Growth of Prostate Cancer Cells by the Negative Regulation of T-Cell Factor 4 Cancer Res., May 1, 2004; 64(9): 3046 - 3051. [Abstract] [Full Text] [PDF]

				L. Huang, Y. Pu, S. Alam, L. Birch, and G. S. Prins Estrogenic Regulation of Signaling Pathways and Homeobox Genes During Rat Prostate Development J Androl, May 1, 2004; 25(3): 330 - 337. [Full Text] [PDF]

				M. Mericskay, J. Kitajewski, and D. Sassoon Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus Development, May 1, 2004; 131(9): 2061 - 2072. [Abstract] [Full Text] [PDF]

				K. H. H. Wong, H. D. Wintch, and M. R. Capecchi Hoxa11 Regulates Stromal Cell Death and Proliferation during Neonatal Uterine Development Mol. Endocrinol., January 1, 2004; 18(1): 184 - 193. [Abstract] [Full Text] [PDF]

				E. A. Morgan, S. B. Nguyen, V. Scott, and H. S. Stadler Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia Development, July 15, 2003; 130(14): 3095 - 3109. [Abstract] [Full Text] [PDF]

				K. D. Economides and M. R. Capecchi Hoxb13 is required for normal differentiation and secretory function of the ventral prostate Development, May 15, 2003; 130(10): 2061 - 2069. [Abstract] [Full Text] [PDF]

				G. S. Prins, W. Y. Chang, Y. Wang, and R. B. van Breemen Retinoic Acid Receptors and Retinoids Are Up-Regulated in the Developing and Adult Rat Prostate by Neonatal Estrogen Exposure Endocrinology, September 1, 2002; 143(9): 3628 - 3640. [Abstract] [Full Text] [PDF]

				J. Aubin, U. Dery, M. Lemieux, P. Chailler, and L. Jeannotte Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling Development, September 1, 2002; 129(17): 4075 - 4087. [Abstract] [Full Text] [PDF]

				Y. M. Chau, S. Pando, and H. S. Taylor HOXA11 Silencing and Endogenous HOXA11 Antisense Ribonucleic Acid in the Uterine Endometrium J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2674 - 2680. [Abstract] [Full Text] [PDF]

				E. van den Akker, S. Forlani, K. Chawengsaksophak, W. de Graaff, F. Beck, B. I. Meyer, and J. Deschamps Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation Development, January 5, 2002; 129(9): 2181 - 2193. [Abstract] [Full Text] [PDF]

				P. de Santa Barbara and D. J. Roberts Tail gut endoderm and gut/genitourinary/tail development: a new tissue-specific role for Hoxa13 Development, January 2, 2002; 129(3): 551 - 561. [Abstract] [Full Text] [PDF]

				J. E. Pitera, V. V. Smith, A. S. Woolf, and P. J. Milla Embryonic Gut Anomalies in a Mouse Model of Retinoic Acid-Induced Caudal Regression Syndrome : Delayed Gut Looping, Rudimentary Cecum, and Anorectal Anomalies Am. J. Pathol., December 1, 2001; 159(6): 2321 - 2329. [Abstract] [Full Text] [PDF]

				H. S. Stadler, K. M. Higgins, and M. R. Capecchi Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs Development, November 1, 2001; 128(21): 4177 - 4188. [Abstract] [Full Text] [PDF]

				K. BLOCK, A. KARDANA, P. IGARASHI, and H. S. TAYLOR In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system FASEB J, June 1, 2000; 14(9): 1101 - 1108. [Abstract] [Full Text]