Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Greenwood, S.
	Articles by Struhl, G.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Greenwood, S.
	Articles by Struhl, G.


Social Bookmarking

	What's this?

Basler, K. and Struhl, G (1994). Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208-214.[Medline]

Brand, A. H. and Perrimon, N (1994). Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis. Genes Dev 8, 629-639.[Abstract/Free Full Text]

Br\232nner, G. and J\212ckle, H (1991). Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embyro. Mech. Dev 35, 205-211.[Medline]

Brook, W. J. and Cohen, S. M (1996). Antagonistic interactions between wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila Leg. Science 273, 1373-1377.[Abstract]

Brunner, D., Oellers, N., Szabad, J., Biggs, W. H., Zipursky, S. L. and Hafen, E (1994). A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 76, 875-888.[Medline]

Casanova, J (1990). Pattern formation under the control of the terminal system in the Drosophila embryo. Development 110, 621-628.[Abstract/Free Full Text]

Casanova, J., Furriols, M., McCormick, C. A. and Struhl, G (1995). Similarities between trunk and spatzle, putative extracellular ligands specifying body pattern in Drosophila. Genes Dev 9, 2539-2544.[Abstract/Free Full Text]

Casanova, J., Llimargas, M., Greenwood, S. and Struhl, G (1994). An oncogenic form of human raf can specify terminal body pattern in Drosophila. Mech. Dev 48, 59-64.[Medline]

Casanova, J. and Struhl, G (1989). Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila. Genes Dev 3, 2025-2938.[Abstract/Free Full Text]

Casanova, J. and Struhl, G (1993). The torso receptor localizes as well astransduces the spatial signal specifying terminal body pattern in Drosophila. Nature 362, 152-155.[Medline]

Clifford, R. J. and Schupbach, T (1989). Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene. Genetics 123, 771-787.[Abstract/Free Full Text]

Cowley, S., Paterson, H., Kemp, P. and Marshall, C. J (1994). Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77, 841-852.[Medline]

Diaz, R., Harbecke, R., Singer, J., Pignoni, F., Janning, W. and Lengyel, J (1996). Graded effect of tailless on posterior gut development: molecular basis of an alleleic series of a nuclear receptor gene. Mech Dev 54, 119-139.[Medline]

Duffy, J. B. and Perrimon, N (1994). The torso pathway in Drosophila: lessons on receptor tyrosine kinase signaling and pattern formation. Dev. Biol 166, 380-395.[Medline]

Fortini, M. E., Simon, M. A. and Rubin, G. M (1992). Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature 355, 559-561.[Medline]

Freeman, M (1996). Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87, 651-660.[Medline]

Furriols, M., Sprenger, F. and Casanova, J (1996). Variation in the number of activated torso receptors correlates with differential gene expression. Development 122, 2313-2317.[Abstract]

Gaul, U. and J\212ckle, H (1989). Analysis of maternal effect mutant combinations elucidates regulation and function of the overlap of hunchback and Kruppel gene expression in the Drosophila blastoderm embryo. Development 107, 651-662.[Abstract]

Gray, S. and Levine, M (1996). Transcriptional repression in development. Curr.Opin. Cell Biol 8, 358-364.[Medline]

Hulskamp, M., Schroder, C., Pfeifle, C., J\212ckle, H. and Tautz, D (1989). Posterior segmentation of the Drosophila embryo in the absence of a maternal posterior organizer gene. Nature 338, 629-632.[Medline]

Irish, V., Lehmann, R. and Akam, M (1989). The Drosophila posterior-group gene nanos functions by repressing hunchback activity. Nature 338, 646-648.[Medline]

Jiang, J., Kosman, D., Ip, Y. T. and Levine, M (1991). The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. Genes Dev 5, 1881-1891.[Abstract/Free Full Text]

Jiang, J. and Struhl, G (1996). Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development. Cell 86, 401-409.[Medline]

Katz, W. S., Hill, R. J., Clandinin, T. R. and Sternberg, P. W (1995). Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates. Cell 82, 297-307.[Medline]

Kayne, P. S. and Sternberg, P. W (1995). Ras pathways in Caenorhabditis elegans. Curr. Opin. Genet. Dev 5, 38-43.[Medline]

Kazlauskas, A (1994). Receptor tyrosine kinases and their targets. Curr. Opin. Genet. Dev 4, 5-14.[Medline]

Kispert, A., Herrmann, B. G., Leptin, M. and Reuter, R (1994). Homologs of the mouse Brachyury gene are involved in the specification of posterior terminal structures in Drosophila, Tribolium, and Locusta. Genes Dev 8, 2137-2150.[Abstract/Free Full Text]

Klingler, M., Erdelyi, M., Szabad, J. and Nusslein-Volhard, C (1988). Function of torso in determining the terminal anlagen of the Drosophila embryo. Nature 335, 275-277.[Medline]

Kongsuwan, K., Yu, Q., Vincent, A., Frisardi, M. C., Rosbash, M., Lengyel, J. A. and Merriam, J (1985). A Drosophila Minute gene encodes a ribosomal protein. Nature 317, 555-558.[Medline]

Liaw, G. J. and Lengyel, J. A (1992). Control of tailless expression by bicoid, dorsal and synergistically interacting terminal system regulatory elements. Mech. Dev 40, 47-61.

Liaw, G. J., Rudolph, K. M., Huang, J. D., Dubnicoff, T., Courey, A. J. and Lengyel, J. A (1995). The torso response element binds GAGA and NTF-1/Elf-1, and regulates tailless by relief of repression. Genes Dev 9, 3163-3176.[Abstract/Free Full Text]

Lu, X., Chou, T. B., Williams, N. G., Roberts, T. and Perrimon, N (1993). Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila. Genes Dev 7, 621-32.[Abstract/Free Full Text]

Marshall, C. J (1994). MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr. Opin. Genet. Dev 4, 82-89.[Medline]

Marshall, C. J (1995). Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185.[Medline]

Martin, J. R., Raibaud, A. and Ollo, R (1994). Terminal pattern elements in Drosophila embryo induced by the torso-like protein. Nature 367, 741-745.[Medline]

McCormick, F (1994). Activators and effectors of ras p21 proteins. Curr. Opin. Genet. Dev 4, 71-76.[Medline]

Nusslein-Volhard, C., Frohnh\232fer, H. G. and Lehmann, R (1987). Determination of anteroposterior polarity in Drosophila. Science 238, 1675-1681.[Abstract/Free Full Text]

O'Connell, P. O. and Rosbash, M (1984). Sequence, structure, and codon preference of the Drosophila ribosomal protein 49 gene. Nucl. Acids Res 12, 5495-5513.[Abstract/Free Full Text]

Penton, A. and Hoffmann, F. M (1996). Decapentaplegic restricts the domain of wingless during Drosophila limb patterning. Nature 382, 162-164.[Medline]

Perrimon, N (1993). The torso receptor protein-tyrosine kinase signaling pathway: an endless story. Cell 74, 219-222.[Medline]

Perrimon, N (1994). Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila. Curr. Opin. Cell Biol 6, 260-266.[Medline]

Pignoni, F., Baldarelli, R. M., Steingrimsson, E., Diaz, R. J., Patapoutian, A., Merriam, J. R. and Lengyel, J. A (1990). The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily. Cell 62, 151-163.[Medline]

Pignoni, F., Steingrimsson, E. and Lengyel, J. A (1992). bicoid and the terminal system activate tailless expression in the early Drosophila embryo. Development 115, 239-251.[Abstract]

Price, J. V., Clifford, R. J. and Schupbach, T (1989). The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog. Cell 56, 1085-1092.[Medline]

Rubin, G. M. and Spradling, A. C (1982). Genetic transformation of Drosophila with transposable element vectors. Science 218, 348-353.[Abstract/Free Full Text]

Savant-Bhonsale, S. and Montell, D. J (1993). torso-like encodes the localized determinant of Drosophila terminal pattern formation. Genes Dev 7, 2548-2555.[Abstract/Free Full Text]

Schweitzer, R., Shaharabany, M., Seger, R. and Shilo, B. Z (1995). Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev 9, 1518-1529.[Abstract/Free Full Text]

Singer, J.B., Harbecke, R., Kusch, T. Reuter, R., and Lengyel, J.A (1996). Drosophila brachyenteron regulates gene activity and morphogenesis in the gut. Development 122, 3707-3718.[Abstract]

Sprenger, F. and Nusslein-Volhard, C (1992). Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg. Cell 71, 987-1001.[Medline]

Sprenger, F., Stevens, L. M. and Nusslein-Volhard, C (1989). TheDrosophila gene torso encodes a putative receptor tyrosine kinase. Nature 338, 478-483.[Medline]

St. Johnston, D. and Nusslein-Volhard, C (1992). The origin of pattern and polarity in the Drosophila embryo. Cell 68, 201-219.[Medline]

Steingrimsson, E., Pignoni, F., Liaw, G. J. and Lengyel, J. A (1991). Dual role of the Drosophila pattern gene tailless in embryonic termini. Science 254, 418-421.[Abstract/Free Full Text]

Stevens, L. M., Frohnh\232fer, H. G., Klingler, M. and Nusslein-Volhard, C (1990). Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo. Nature 346, 660-663.[Medline]

Strahle, U., Blader, P., Adam, J. and Ingham, P. W (1994). A simple and efficient procedure for non-isotopic in situ hybridization to sectioned material. Trends Genet 10, 75-76.[Medline]

Strecker, T. R., Merriam, J. R. and Lengyel, J. A (1988). Graded requirement for the zygotic terminal gene, tailless , in the brain and tail region of the Drosophila embryo. Development 102, 721-734.[Abstract/Free Full Text]

Struhl, G (1984). Spiltting the bithorax complex in Drosophila. Nature 308, 454-457.

Struhl, G (1989). Differing strategies for organizing anterior and posterior body pattern in Drosophila embryos. Nature 338, 741-744.[Medline]

Struhl, G. and Basler, K (1993). Organizing activity of wingless protein in Drosophila. Cell 72, 527-540.[Medline]

Struhl, G., Johnston, P. and Lawrence, P. A (1992). Control of Drosophila body pattern by the hunchback morphogen gradient. Cell 69, 237-249.[Medline]

Struhl, G., Struhl, K. and Macdonald, P. M (1989). The gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell 57, 1259-1273.[Medline]

Theurkauf, W. E., Baum, H., Bo, J. and Wensink, P. C (1986). Tissue-specific and constitutive alpha-tubulin genes of Drosophila melanogaster code for structurally distinct proteins. Proceedings of the National Academy of Sciences of the United States of America 83, 8477-8481.[Abstract/Free Full Text]

Tomlinson, A. and Ready, D. F (1987). Cell fate in the Drosophila ommatidium. Dev. Biol 120, 366-376.[Medline]

Trahey, M. and McCormick, F (1987). A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238, 542-545.[Abstract/Free Full Text]

Tsuda, L., Inoue, Y. H., et al (1993). A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila. Cell 72, 407-414.[Medline]

Weigel, D., Jurgens, G., Klingler, M. and J\212ckle, H (1990). Two gap genes mediate maternal terminal pattern information in Drosophila. Science 248, 495-498.[Abstract/Free Full Text]

Wharton, R. P. and Struhl, G (1991). RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos. Cell 67, 955-967.[Medline]

Xu, T. and Rubin, G. M (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.[Abstract]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

M. Zecca and G. Struhl
Recruitment of cells into the Drosophila wing primordium by a feed-forward circuit of vestigial autoregulation
Development, August 15, 2007; 134(16): 3001 - 3010.
[Abstract] [Full Text] [PDF]

M. Zecca and G. Struhl
Control of Drosophila wing growth by the vestigial quadrant enhancer
Development, August 15, 2007; 134(16): 3011 - 3020.
[Abstract] [Full Text] [PDF]

M. V. Sundaram
The love-hate relationship between Ras and Notch
Genes & Dev., August 15, 2005; 19(16): 1825 - 1839.
[Abstract] [Full Text] [PDF]

J. Li and W. X. Li
Drosophila Gain-of-Function Mutant RTK Torso Triggers Ectopic Dpp and STAT Signaling
Genetics, May 1, 2003; 164(1): 247 - 258.
[Abstract] [Full Text] [PDF]

W. X. Li, H. Agaisse, B. Mathey-Prevot, and N. Perrimon
Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila
Development, March 11, 2003; 129(18): 4241 - 4248.
[Abstract] [Full Text] [PDF]

A. Stathopoulos and M. Levine
Linear signaling in the Toll-Dorsal pathway of Drosophila: activated Pelle kinase specifies all threshold outputs of gene expression while the bHLH protein Twist specifies a subset
Development, March 9, 2003; 129(14): 3411 - 3419.
[Abstract] [Full Text] [PDF]

D. del Alamo, J. Terriente, and F. J. Diaz-Benjumea
Spitz/EGFr signalling via the Ras/MAPK pathway mediates the induction of bract cells in Drosophila legs
Development, March 6, 2003; 129(8): 1975 - 1982.
[Abstract] [Full Text] [PDF]

C. Dossenbach, S. Rock, and M. Affolter
Specificity of FGF signaling in cell migration in Drosophila
Development, November 15, 2001; 128(22): 4563 - 4572.
[Abstract] [Full Text] [PDF]

K. Radke, K. Johnson, R. Guo, A. Davidson, and L. Ambrosio
Drosophila-Raf Acts to Elaborate Dorsoventral Pattern in the Ectoderm of Developing Embryos
Genetics, November 1, 2001; 159(3): 1031 - 1044.
[Abstract] [Full Text] [PDF]

K Halfar, C Rommel, H Stocker, and E Hafen
Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity
Development, January 5, 2001; 128(9): 1687 - 1696.
[Abstract] [PDF]

A. Tang, T. Neufeld, G. Rubin, and H. Muller
Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian
Development, January 3, 2001; 128(5): 801 - 813.
[Abstract] [PDF]

U. Gayko, V. Cleghon, T. Copeland, D. K. Morrison, and N. Perrimon
Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase
PNAS, January 19, 1999; 96(2): 523 - 528.
[Abstract] [Full Text] [PDF]

J. Kumar, M Tio, F Hsiung, S Akopyan, L Gabay, R Seger, B. Shilo, and K Moses
Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation
Development, January 10, 1998; 125(19): 3875 - 3885.
[Abstract] [PDF]

E Buff, A Carmena, S Gisselbrecht, F Jimenez, and A. Michelson
Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors
Development, January 6, 1998; 125(11): 2075 - 2086.
[Abstract] [PDF]

R. Schroder, C. Eckert, C. Wolff, and D. Tautz
Conserved and divergent aspects of terminal patterning in the beetle Tribolium castaneum
PNAS, June 6, 2000; 97(12): 6591 - 6596.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Greenwood, S.

Articles by Struhl, G.

Search for Related Content

PubMed

PubMed Citation

Articles by Greenwood, S.

Articles by Struhl, G.

Social Bookmarking

What's this?

				M. Zecca and G. Struhl Control of Drosophila wing growth by the vestigial quadrant enhancer Development, August 15, 2007; 134(16): 3011 - 3020. [Abstract] [Full Text] [PDF]

				M. V. Sundaram The love-hate relationship between Ras and Notch Genes & Dev., August 15, 2005; 19(16): 1825 - 1839. [Abstract] [Full Text] [PDF]

				J. Li and W. X. Li Drosophila Gain-of-Function Mutant RTK Torso Triggers Ectopic Dpp and STAT Signaling Genetics, May 1, 2003; 164(1): 247 - 258. [Abstract] [Full Text] [PDF]

				W. X. Li, H. Agaisse, B. Mathey-Prevot, and N. Perrimon Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila Development, March 11, 2003; 129(18): 4241 - 4248. [Abstract] [Full Text] [PDF]

				A. Stathopoulos and M. Levine Linear signaling in the Toll-Dorsal pathway of Drosophila: activated Pelle kinase specifies all threshold outputs of gene expression while the bHLH protein Twist specifies a subset Development, March 9, 2003; 129(14): 3411 - 3419. [Abstract] [Full Text] [PDF]

				D. del Alamo, J. Terriente, and F. J. Diaz-Benjumea Spitz/EGFr signalling via the Ras/MAPK pathway mediates the induction of bract cells in Drosophila legs Development, March 6, 2003; 129(8): 1975 - 1982. [Abstract] [Full Text] [PDF]

				C. Dossenbach, S. Rock, and M. Affolter Specificity of FGF signaling in cell migration in Drosophila Development, November 15, 2001; 128(22): 4563 - 4572. [Abstract] [Full Text] [PDF]

				K. Radke, K. Johnson, R. Guo, A. Davidson, and L. Ambrosio Drosophila-Raf Acts to Elaborate Dorsoventral Pattern in the Ectoderm of Developing Embryos Genetics, November 1, 2001; 159(3): 1031 - 1044. [Abstract] [Full Text] [PDF]

				K Halfar, C Rommel, H Stocker, and E Hafen Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity Development, January 5, 2001; 128(9): 1687 - 1696. [Abstract] [PDF]

				A. Tang, T. Neufeld, G. Rubin, and H. Muller Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian Development, January 3, 2001; 128(5): 801 - 813. [Abstract] [PDF]

				U. Gayko, V. Cleghon, T. Copeland, D. K. Morrison, and N. Perrimon Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase PNAS, January 19, 1999; 96(2): 523 - 528. [Abstract] [Full Text] [PDF]

				J. Kumar, M Tio, F Hsiung, S Akopyan, L Gabay, R Seger, B. Shilo, and K Moses Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation Development, January 10, 1998; 125(19): 3875 - 3885. [Abstract] [PDF]

				E Buff, A Carmena, S Gisselbrecht, F Jimenez, and A. Michelson Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors Development, January 6, 1998; 125(11): 2075 - 2086. [Abstract] [PDF]

				R. Schroder, C. Eckert, C. Wolff, and D. Tautz Conserved and divergent aspects of terminal patterning in the beetle Tribolium castaneum PNAS, June 6, 2000; 97(12): 6591 - 6596. [Abstract] [Full Text] [PDF]