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Artavanis-Tsakonas, S. Matsuno, K. and Fortini, M. E (1995). Notch signaling. Science 268, 225-232.[Abstract/Free Full Text]

Austin, J. and Kimble, J (1987). glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans. Cell 51, 589-599.[Medline]

Bishop, J (1991). Molecular themes in oncogenesis. Cell 64, 235-248.[Medline]

Bowerman, B (1995). Determinants of blastomere identity in the early C. elegans embryo. BioEssays 17, 404-414.

Brenner, S (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.[Abstract/Free Full Text]

Christensen, S., Kodoyianni, V., Bosenberg, M., Friedman, L. and Kimble, J (1996). lag-1 , a gene required for lin-12 and glp-1 signalling in Caenorhabditis elegans , is homologous to human CBF1 and Drosophila Su(H). Development 122, 1373-1383.[Abstract]

Crittenden, S. L., Troemel, E. R., Evans, T. C. and Kimble, J (1994). GLP-1 is localized to the mitotic region of the C. elegans germ line. Development 120, 2901-2911.[Abstract]

Ellis, R. E. and Kimble, J (1995). The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans. Genetics 139, 561-577.[Abstract]

Ellisen, L. W., Bird, J., West, D. C., Soreng, A. L., Reynolds, T. C., Smith, S. D. and Sklar, J (1991). TAN1, the human homolog of the DrosophilaNotch_Fb_GLP-1* ProliferationmRNA translation+ LigandWild-type-LigandGLP-1Meiotic Prophase No_Fb_mRNA translationGLP-1(gf)ProliferationmRNA translation*_Fb_(No Signalling)Fig. 8. Model for positive feedback of GLP-1 signalling on glp-1 expression in the hermaphrodite germ line. In wild type, germ-line proliferation is controlled by a localized source of ligand. Ligand binding activates (*) GLP-1, promoting receptor signalling and proliferation. GLP-1 signalling then initiates a positive feedback loop that promotes translation (as shown) or transcription (not shown; see text) of glp-1 mRNA, leading to increased GLP-1 expression. As germ cells move away from the source of ligand, signalling decreases and the positive feedback loop is down regulated leading to reduced GLP-1 levels. Eventually, germ cells enter the meiotic pathway and glp-1 translation ceases. In glp-1(oz112gf) mutants, the GLP-1 receptor is constitutively active; signalling is never down regulated and both proliferation and GLP-1 synthesis are maintained. GLP-1 immunolocalization data for wild type are consistent with the model (Crittenden et al., 1994), but did not establish whether the levels of membrane-associated GLP-1 begin to fall before or after germ cells enter the meiotic pathway. Although the syncytial nature of the germ line complicates interpretation of the glp-1 RNA/protein accumulation patterns, additional studies may resolve this question.gene, is broken by chromosomally translocations in T lymphoblastic neoplasms. Cell 66, 649-661.[Medline]

Evans, T. C., Crittenden, S. L., Kodoyianni, V. and Kimble, J (1994). Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo. Cell 77, 183-194.[Medline]

Fitzgerald, K., Wilkinson, H. and Greenwald, I (1993). glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans. Development 119, 1019-1027.[Abstract]

Fitzgerald, K. and Greenwald, I (1995). Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo. Development 121, 4275-4282.[Abstract]

Francis, R., Barton, M. K., Kimble, J. and Schedl, T (1995). gld-1 , a tumor suppressor gene required for oocyte development in Caenorhabditis elegans. Genetics 139, 579-606.[Abstract]

Francis, R., Maine, E. and Schedl, T (1995). Analysis of the multiple roles of gld-1 in germline development: interactions with the sex determination cascade and the glp-1 signaling pathway. Genetics 139, 607-630.[Abstract]

Greenwald, I. S., Sternberg, P. W. and Horvitz, H.R (1983). The lin-12 locus specifies cell fates in Caenorhabditis elegans. Cell 34, 435-444.[Medline]

Greenwald, I., and Seydoux, G (1990). Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans. Nature 346, 197-199.[Medline]

Greenwald, I. and Rubin, G (1992). Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells. Cell 68, 271-281.[Medline]

Greenwald, I (1994). Structure/function studies of LIN-12/Notch proteins. Current Opinion Genet. Dev 4, 556-562.[Medline]

Henderson, S. T., Gao, D., Lambie, E. J. and Kimble, J (1994). lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans. Development 120, 2913-2924.[Abstract]

Hodgkin, J. and Barnes, T (1991). More is not better: brood size and population growth in a self-fertilizing nematode. Proc. R. Soc. Lond. B 246, 19-24.[Medline]

Jhappan, C., Gallahan, D., Stahle, C., Chu, E., Smith, G. H., Merlino, G. and Callahan, R (1992). Expression of an activated Notch -related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev 6, 345-355.[Abstract/Free Full Text]

Jones, A. and Schedl, T (1995). Mutations in gld-1 , a female germ cell-specific tumor suppressor gene in Caenorhabditis elegans , affect a conserved domain also found in Src-associated protein Sam68. Genes Dev 9, 1491-1504.[Abstract/Free Full Text]

Kimble, J. and Hirsh, D (1979). Postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. Dev. Biol 70, 396-417.[Medline]

Kimble, J (1981). Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans. Dev. Biol 87, 286-300.[Medline]

Kimble, J. E. and White, J. G (1981). On the control of germ cell development in Caenorhabditis elegans. Dev. Biol 81, 208-219.[Medline]

Kodoyianni, V., Maine, E. and Kimble, J (1992). Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans. Mol. Biol. Cell 3, 1199-1213.[Abstract]

Lambie, E. J. and Kimble, J (1991). Genetic control of cell interactions in nematode development. Annu. Rev. Genet 25, 411-436.[Medline]

Lambie, E. J. and Kimble, J (1991). Two homologous regulatory genes, lin-12 and glp-1 , have overlapping functions. Development 112, 231-240.[Abstract]

Lissemore, J., Currie, P., Turk, C. and Maine, E (1993). Intragenic dominantsuppressors of glp-1 , a gene essential for cell-signaling in Caenorhabditis elegans , support a role for cdc10/SWI6/ankyrin motifs in GLP-1 function. Genetics 135, 1023-1034.[Abstract]

Lyman, D. and Young, M (1993). Further evidence for function of the Drosophila Notch protein as a transmembrane receptor. Proc. Natl. Acad. Sci. USA 90, 10395-10399.[Abstract/Free Full Text]

Maine, E. M., Lissemore, J. L. and Starmer, W. T (1995). A phylogenetic analysis of vertebrate and invertebrate Notch -related genes. Molecular Phylogenetics and Evolution 4, 139-155.[Medline]

Mango, S. E., Maine, E. M. and Kimble, J (1991). Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans. Nature 352, 811-815.[Medline]

Mello, C. C., Kramer, J. M., Stinchcomb, D. and Ambros, V (1991). Efficient gene transfer in C. elegans : extrachromosomal maintenance and integration of transforming sequences. EMBO J 10, 3959-3970.[Medline]

Robbins, J., Blondel, B. J., Gallahan, D. and Callahan, R (1992). Mouse mammary tumor gene int-3 : a member of the notch gene family transforms mammary epithelial cells. J. Virol 66, 2594-2599.[Abstract/Free Full Text]

Roehl, H. and Kimble, J (1993). Control of cell fate in C. elegans by a glp-1 peptide consisting primarily of ankyrin repeats. Nature 364, 632-635.[Medline]

Rosenbluth, R. E., Cuddeford, C. and Baillie, D. L (1983). Mutagenesis in Caenorhabditis elegans . I. A rapid eukaryotic mutagen test system using the reciprocal translocation eT1(III,V). Mutat. Res 110, 39-48.

Sawyers, C., Denny, C. and Witte, O (1991). Leukemia and the disruption of normal hematopoiesis. Cell 64, 337-350.[Medline]

Seydoux, G., Schedl, T. and Greenwald, I (1990). Cell-cell interactions prevent a potential inductive interaction between soma and germ line in Caenorhabditis elegans. Cell 61, 939-951.[Medline]

Skakkebaek, N., Berthelsen, J., Giwercman, A. and Muller, J (1987). Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumors except spermatocytoma. Internat. J. Androl 10, 19-28.[Medline]

Sternberg, P. W. and Horvitz, H.R (1986). Pattern formation during vulval development in C. elegans. Cell 44, 761-772.[Medline]

Sulston, J. E. and Horvitz, H. R (1977). Post-embryonic cell lineages of the nematode Caenorhabditis elegans. Dev. Biol 56, 110-156.[Medline]

Surti, I., Hoffner, L., Chakravarti, A. and Ferrell, R (1990). Genetics and Biology of human ovarian teratomas. I. Cytogenetic analysis of mechanism of origin. Am. J. Hum. Genet 47, 635-643.[Medline]

Tax, F. E., Yeargers, J. J. and Thomas, J. H (1994). Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila. Nature 368, 150-154.[Medline]

Wilkinson, H. A., Fitzgerald, K. and Greenwald, I (1994). Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Cell 79, 1187-1196.[Medline]

Williams, B. D., Schrank, B., Huynh, C., Schownkeen, R. and Waterston, R. H (1992). A genetic mapping system in Caenorhabditis elegans based on polymorphic sequence-tagged sites. Genetics 131, 609-624.[Abstract]

Yochem, J. and Greenwald, I (1989). glp-1 and lin-12 , genes implicated in distinct cell-cell interactions in C. elegans , encode similar transmembrane proteins. Cell 58, 553-563.[Medline]




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