Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis

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Chen, J., Kubalak, S. W., Minamisawa, S., Price, R. L., Becker, K. D.Hickey, R., Ross, J. and Chien, K. R (1998). Selective requirement of myosin light chain 2v in embryonic heart function. J. Biol. Chem 273, 1252-1256.[Abstract/Free Full Text]

Chien, K. R., Zhu, H., Knowlton, K. U., Miller, H. W., van, B. M., OBrien, T. X. and Evans, S. M (1993). Transcriptional regulation during cardiac growth and development. Annu. Rev. Physiol 55, 77-95.[Medline]

Dolle, P., Fraulob, V., Kastner, P. and Chambon, P (1994). Developmental expression of murine retinoid X receptor (RXR) genes. Mech. Dev 45, 91-104.[Medline]

Dyson, E., Sucov, H. M., Kubalak, S. W., Schmid-Schonbein, G. W., DeLano, F. A., Evans, R. M., Ross, J. and Chien, K. R (1995). Atrial-like phenotype is associated with embryonic ventricular failure in RXR-/-mice. Proc. Natn. Acad. Sci. USA 92, 7386-7390.[Abstract/Free Full Text]

Eisenberg L. M. and Markwald R. R (1995). Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circ. Res 77, 1-6.[Free Full Text]

Evans, R. M. ( (1988). The steroid and thyroid hormone receptor superfamily. Science 240, 889-95.[Abstract/Free Full Text]

Fishman, M. C. and Chien, K. R (1997). Fashioning the vertebrate heart: earliest embryonic decisions. Development 124, 2099-117.[Abstract]

Gruber, P. J., Kubalak, S. W., Pexieder, T., Sucov, H. M., Evans, R. M. and Chien, K. R (1996). RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. J. Clin. Invest 98, 1332-43.[Medline]

Gu, H., Marth, J. D., Orban, P. C., Mossmann, H. and Rajewsky, K (1994). Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265, 103-6.[Abstract/Free Full Text]

Harvey, R. P (1996). NK-2 homeobox genes and heart development. Dev. Biol 178, 203-16.[Medline]

Kastner, P., Grondona, J. M., Mark, M., Gansmuller, A., LeMeur, M., Decimo, D., Vonesch, J. L., Dolle, P. and Chambon, P (1994). Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell 78, 987-1003.[Medline]

Kastner, P., Mark, M. and Chambon, P. ( (1995). Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?. Cell 83, 859-69.[Medline]

Mangelsdorf, D. J., Borgmeyer, U., Heyman, R. A., Zhou, J. Y., Ong, E. S., Oro, A. E., Kakizuka, A. and Evans, R. M (1992). Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 6, 329-44.[Abstract/Free Full Text]

Marth, J. D (1996). Recent advances in gene mutagenesis by site-directed recombination. J. Clin. Invest 97, 1999-2002.[Medline]

O'Brien, T. X., Lee, K. J. and Chien, K. R (1993). Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube. Proc. Natl. Acad. Sci. USA 90, 5157-61.[Abstract/Free Full Text]

O'Gorman, S.,Dagenais, N. A., Qian, M. and Marchuuk, Y (1997). Protamine-cre recombinase transgenes efficiently recombine target sequences in the male germline of mice, but not in embryonic stem cells. Proc. Natl. Acad. Sci. USA 94, 14602-14607.[Abstract/Free Full Text]

Olson, E. N. and Srivastava, D (1996). Molecular pathways controlling heart development. Science 272, 671-6.[Abstract]

Rezaee, M., Isokawa, K., Halligan, N., Markwald, R. R. and Krug, E. L (1993). Identification of an extracellular 130-kDa protein involved in early cardiac morphogenesis. J. Biol. Chem 268, 14404-11.[Abstract/Free Full Text]

Ross, R. S., Navankasattusas, S., Harvey, R. P. and Chien, K. R (1996). An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression. Development 122, 1799-809.[Abstract]

Rossant, J (1996). Mouse mutants and cardiac development: new molecular insights into cardiogenesis. Circ. Res 78, 349-353.[Abstract/Free Full Text]

Soonpaa, M. H., Kim, K. K., Pajak, L., Franklin, M. and Field, L. J (1996). Cardiomyocyte DNA synthesis and binucleation during murine development. Amer. J. Physiol 271, 2183-89.

Sucov, H. M., Dyson, E., Gumeringer, C. L., Price, J., Chien, K. R. and Evans, R. M (1994). RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev 8, 1007-18.[Abstract/Free Full Text]

Sucov, H. M., Murakami, K. K. and Evans, R. M (1990). Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene. Proc. Natl. Acad. Sci. USA 87, 5392-6.[Abstract/Free Full Text]

Tran, C. M. and Sucov, H. M (1998). The RXRgene function in a non-cell-autonomous manner during mouse cardiac morphogenesis. Development_Fb_125,._Fb_Wolska, B. M. and Solaro, R. J. 1996. Method for isolation of adult mouse cardiac myocytes for studies of contraction and microfluorimetry. Amer. J. Physiol 271, 1250-55.

Wunsch, A. M., Little, C. D. and Markwald, R. R (1994). Cardiac endothelial heterogeneity defines valvular development as demonstrated by the diverse expression of JB3, an antigen of the endocardial cushion tissue. Dev. Biol 165, 585-601.[Medline]

Zhou, M. D., Sucov, H. M., Evans, R. M. and Chien, K. R (1995). Retinoid-dependent pathways suppress myocardial cell hypertrophy. Proc. Natl. Acad. Sci. USA 92, 7391-5.[Abstract/Free Full Text]

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[Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text]

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[Abstract] [Full Text] [PDF]

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[Full Text] [PDF]

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Inactivation of erythropoietin leads to defects in cardiac morphogenesis
Development, January 8, 1999; 126(16): 3597 - 3605.
[Abstract] [PDF]

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Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos
Development, January 11, 1998; 125(22): 4427 - 4438.
[Abstract] [PDF]

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The RXRalpha gene functions in a non-cell-autonomous manner during mouse cardiac morphogenesis
Development, January 5, 1998; 125(10): 1951 - 1956.
[Abstract] [PDF]

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[Abstract] [Full Text] [PDF]

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Cardiac Myocyte-Specific Excision of the {beta}1 Integrin Gene Results in Myocardial Fibrosis and Cardiac Failure
Circ. Res., March 8, 2002; 90(4): 458 - 464.
[Abstract] [Full Text] [PDF]

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Articles by Chen, J.

Articles by Chien, K. R.

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				L. A. DiMichele, Z. S. Hakim, R. L. Sayers, M. Rojas, R. J. Schwartz, C. P. Mack, and J. M. Taylor Transient Expression of FRNK Reveals Stage-Specific Requirement for Focal Adhesion Kinase Activity in Cardiac Growth Circ. Res., May 22, 2009; 104(10): 1201 - 1208. [Abstract] [Full Text] [PDF]

				C. A. Risebro, R. G. Searles, A. A. D. Melville, E. Ehler, N. Jina, S. Shah, J. Pallas, M. Hubank, M. Dillard, N. L. Harvey, et al. Prox1 maintains muscle structure and growth in the developing heart Development, February 1, 2009; 136(3): 495 - 505. [Abstract] [Full Text] [PDF]

				A. Croquelois, A. A. Domenighetti, M. Nemir, M. Lepore, N. Rosenblatt-Velin, F. Radtke, and T. Pedrazzini Control of the adaptive response of the heart to stress via the Notch1 receptor pathway J. Exp. Med., December 22, 2008; 205(13): 3173 - 3185. [Abstract] [Full Text] [PDF]

				J. Krishnan, P. Ahuja, S. Bodenmann, D. Knapik, E. Perriard, W. Krek, and J.-C. Perriard Essential Role of Developmentally Activated Hypoxia-Inducible Factor 1{alpha} for Cardiac Morphogenesis and Function Circ. Res., November 7, 2008; 103(10): 1139 - 1146. [Abstract] [Full Text] [PDF]

				K. J. Lavine, F. Long, K. Choi, C. Smith, and D. M. Ornitz Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development Development, September 15, 2008; 135(18): 3161 - 3171. [Abstract] [Full Text] [PDF]

				K. Jepsen, A. S. Gleiberman, C. Shi, D. I. Simon, and M. G. Rosenfeld Cooperative regulation in development by SMRT and FOXP1 Genes & Dev., March 15, 2008; 22(6): 740 - 745. [Abstract] [Full Text] [PDF]

				H. M. Phillips, V. Hildreth, J. D. Peat, J. N. Murdoch, K. Kobayashi, B. Chaudhry, and D. J. Henderson Non-Cell-Autonomous Roles for the Planar Cell Polarity Gene Vangl2 in Development of the Coronary Circulation Circ. Res., March 14, 2008; 102(5): 615 - 623. [Abstract] [Full Text] [PDF]

				D. D'Andrea, G. L. Liguori, J. A. Le Good, E. Lonardo, O. Andersson, D. B. Constam, M. G. Persico, and G. Minchiotti Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction J. Cell Biol., February 6, 2008; 180(3): 597 - 605. [Abstract] [Full Text] [PDF]

				B. C. Lin, R. Sullivan, Y. Lee, S. Moran, E. Glover, and C. A. Bradfield Deletion of the Aryl Hydrocarbon Receptor-associated Protein 9 Leads to Cardiac Malformation and Embryonic Lethality J. Biol. Chem., December 7, 2007; 282(49): 35924 - 35932. [Abstract] [Full Text] [PDF]

				T. Yajima, H. Yasukawa, E.-S. Jeon, D. Xiong, A. Dorner, M. Iwatate, M. Nara, H. Zhou, D. Summers-Torres, M. Hoshijima, et al. Innate Defense Mechanism Against Virus Infection Within the Cardiac Myocyte Requiring gp130-STAT3 Signaling Circulation, November 28, 2006; 114(22): 2364 - 2373. [Abstract] [Full Text] [PDF]

				M. Ricote, C. S. Snyder, H.-Y. Leung, J. Chen, K. R. Chien, and C. K. Glass Normal hematopoiesis after conditional targeting of RXR{alpha} in murine hematopoietic stem/progenitor cells J. Leukoc. Biol., October 1, 2006; 80(4): 850 - 861. [Abstract] [Full Text] [PDF]

				L. A. DiMichele, J. T. Doherty, M. Rojas, H. E. Beggs, L. F. Reichardt, C. P. Mack, and J. M. Taylor Myocyte-Restricted Focal Adhesion Kinase Deletion Attenuates Pressure Overload-Induced Hypertrophy Circ. Res., September 15, 2006; 99(6): 636 - 645. [Abstract] [Full Text] [PDF]

				F. Sheikh, Y. Chen, X. Liang, A. Hirschy, A. E. Stenbit, Y. Gu, N. D. Dalton, T. Yajima, Y. Lu, K. U. Knowlton, et al. {alpha}-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction, Resulting in Cardiomyopathy and Susceptibility to Wall Rupture Circulation, September 5, 2006; 114(10): 1046 - 1055. [Abstract] [Full Text] [PDF]

				S. Liu, F. Liu, A. E. Schneider, T. St. Amand, J. A. Epstein, and D. E. Gutstein Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube Development, May 15, 2006; 133(10): 2063 - 2073. [Abstract] [Full Text] [PDF]

				E. Merki, M. Zamora, A. Raya, Y. Kawakami, J. Wang, X. Zhang, J. Burch, S. W. Kubalak, P. Kaliman, J. C. I. Belmonte, et al. From the Cover: Epicardial retinoid X receptor {alpha} is required for myocardial growth and coronary artery formation PNAS, December 20, 2005; 102(51): 18455 - 18460. [Abstract] [Full Text] [PDF]

				Genetically Modified Animals in Endocrinology Endocr. Rev., December 1, 2005; 26(7): 985 - 993. [Abstract] [Full Text] [PDF]

				J. Andrade, J. T. Lam, M. Zamora, C. Huang, D. Franco, N. Sevilla, P. J. Gruber, J. T. Lu, and P. Ruiz-Lozano Predominant fusion of bone marrow-derived cardiomyocytes Cardiovasc Res, December 1, 2005; 68(3): 387 - 393. [Abstract] [Full Text] [PDF]

				J. Jung, T.-g. Kim, G. E. Lyons, H.-R. C. Kim, and Y. Lee Jumonji Regulates Cardiomyocyte Proliferation via Interaction with Retinoblastoma Protein J. Biol. Chem., September 2, 2005; 280(35): 30916 - 30923. [Abstract] [Full Text] [PDF]

				H. Garcia-Rivello, J. Taranda, M. Said, P. Cabeza-Meckert, M. Vila-Petroff, J. Scaglione, S. Ghio, J. Chen, C. Lai, R. P. Laguens, et al. Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1153 - H1160. [Abstract] [Full Text] [PDF]

				X. Liang, Q. Zhou, X. Li, Y. Sun, M. Lu, N. Dalton, J. Ross Jr., and J. Chen PINCH1 Plays an Essential Role in Early Murine Embryonic Development but Is Dispensable in Ventricular Cardiomyocytes Mol. Cell. Biol., April 15, 2005; 25(8): 3056 - 3062. [Abstract] [Full Text] [PDF]

				L. Meikle, J. R. McMullen, M. C. Sherwood, A. S. Lader, V. Walker, J. A. Chan, and D. J. Kwiatkowski A mouse model of cardiac rhabdomyoma generated by loss of Tsc1 in ventricular myocytes Hum. Mol. Genet., February 1, 2005; 14(3): 429 - 435. [Abstract] [Full Text] [PDF]

				K. Nishida, O. Yamaguchi, S. Hirotani, S. Hikoso, Y. Higuchi, T. Watanabe, T. Takeda, S. Osuka, T. Morita, G. Kondoh, et al. p38{alpha} Mitogen-Activated Protein Kinase Plays a Critical Role in Cardiomyocyte Survival but Not in Cardiac Hypertrophic Growth in Response to Pressure Overload Mol. Cell. Biol., December 15, 2004; 24(24): 10611 - 10620. [Abstract] [Full Text] [PDF]

				M. Conrad, C. Jakupoglu, S. G. Moreno, S. Lippl, A. Banjac, M. Schneider, H. Beck, A. K. Hatzopoulos, U. Just, F. Sinowatz, et al. Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function Mol. Cell. Biol., November 1, 2004; 24(21): 9414 - 9423. [Abstract] [Full Text] [PDF]

				D. Fraidenraich, E. Stillwell, E. Romero, D. Wilkes, K. Manova, C. T. Basson, and R. Benezra Rescue of Cardiac Defects in Id Knockout Embryos by Injection of Embryonic Stem Cells Science, October 8, 2004; 306(5694): 247 - 252. [Abstract] [Full Text] [PDF]

				S. A. Henderson, J. I. Goldhaber, J. M. So, T. Han, C. Motter, A. Ngo, C. Chantawansri, M. R. Ritter, M. Friedlander, D. A. Nicoll, et al. Functional Adult Myocardium in the Absence of Na+-Ca2+ Exchange: Cardiac-Specific Knockout of NCX1 Circ. Res., September 17, 2004; 95(6): 604 - 611. [Abstract] [Full Text] [PDF]

				R. M. Smith, N. Suleman, L. Lacerda, L. H. Opie, S. Akira, K. R. Chien, and M. N. Sack Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning Cardiovasc Res, September 1, 2004; 63(4): 611 - 616. [Abstract] [Full Text] [PDF]

				M. H. Zile Vitamin A Requirement for Early Cardiovascular Morphogenesis Specification in the Vertebrate Embryo: Insights from the Avian Embryo Experimental Biology and Medicine, July 1, 2004; 229(7): 598 - 606. [Abstract] [Full Text] [PDF]

				Y. Wu, X. Zhang, F. Bardag-Gorce, R. C. V. Robel, J. Aguilo, L. Chen, Y. Zeng, K. Hwang, S. W. French, S. C. Lu, et al. Retinoid X Receptor {alpha} Regulates Glutathione Homeostasis and Xenobiotic Detoxification Processes in Mouse Liver Mol. Pharmacol., March 1, 2004; 65(3): 550 - 557. [Abstract] [Full Text] [PDF]

				P. J. Gruber and J. A. Epstein Development Gone Awry: Congenital Heart Disease Circ. Res., February 20, 2004; 94(3): 273 - 283. [Abstract] [Full Text] [PDF]

				A. F. M. MOORMAN and V. M. CHRISTOFFELS Cardiac Chamber Formation: Development, Genes, and Evolution Physiol Rev, October 1, 2003; 83(4): 1223 - 1267. [Abstract] [Full Text] [PDF]