Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells

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beta -Cell Differentiation Factor Nkx6.1 Contains Distinct DNA Binding Interference and Transcriptional Repression Domains
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Regulation of the Pancreatic Islet-Specific Gene BETA2 (neuroD) by Neurogenin 3
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[Abstract] [Full Text]

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[Abstract] [Full Text]

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[Abstract] [Full Text] [PDF]

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Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
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[Abstract] [PDF]

V. Schwitzgebel, D. Scheel, J. Conners, J Kalamaras, J. Lee, D. Anderson, L Sussel, J. Johnson, and M. German
Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
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J. Wells and D. Melton
Early mouse endoderm is patterned by soluble factors from adjacent germ layers
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T. J. Kieffer and J. Francis Habener
The Glucagon-Like Peptides
Endocr. Rev., December 1, 1999; 20(6): 876 - 913.
[Abstract] [Full Text]

S. B. Smith, H. C. Ee, J. R. Conners, and M. S. German
Paired-Homeodomain Transcription Factor PAX4 Acts as a Transcriptional Repressor in Early Pancreatic Development
Mol. Cell. Biol., December 1, 1999; 19(12): 8272 - 8280.
[Abstract] [Full Text] [PDF]

C. Y. Choi, Y. M. Lee, Y. H. Kim, T. Park, B. H. Jeon, R. A. Schulz, and Y. Kim
The Homeodomain Transcription Factor NK-4 Acts as either a Transcriptional Activator or Repressor and Interacts with the p300 Coactivator and the Groucho Corepressor
J. Biol. Chem., October 29, 1999; 274(44): 31543 - 31552.
[Abstract] [Full Text] [PDF]

M. E. Hill, S. L. Asa, and D. J. Drucker
Essential Requirement for Pax6 in Control of Enteroendocrine Proglucagon Gene Transcription
Mol. Endocrinol., September 1, 1999; 13(9): 1474 - 1486.
[Abstract] [Full Text]

P. T. Schwartz, B. Perez-Villamil, A. Rivera, R. Moratalla, and M. Vallejo
Pancreatic Homeodomain Transcription Factor IDX1/IPF1 Expressed in Developing Brain Regulates Somatostatin Gene Transcription in Embryonic Neural Cells
J. Biol. Chem., June 16, 2000; 275(25): 19106 - 19114.
[Abstract] [Full Text] [PDF]

S. Herzig, L. Fuzesi, and W. Knepel
Heterodimeric Pbx-Prep1 Homeodomain Protein Binding to the Glucagon Gene Restricting Transcription in a Cell Type-dependent Manner
J. Biol. Chem., September 1, 2000; 275(36): 27989 - 27999.
[Abstract] [Full Text] [PDF]

H. Watada, R. G. Mirmira, J. Leung, and M. S. German
Transcriptional and Translational Regulation of beta -Cell Differentiation Factor Nkx6.1
J. Biol. Chem., October 27, 2000; 275(44): 34224 - 34230.
[Abstract] [Full Text] [PDF]

S. B. Smith, H. Watada, D. W. Scheel, C. Mrejen, and M. S. German
Autoregulation and Maturity Onset Diabetes of the Young Transcription Factors Control the Human PAX4 Promoter
J. Biol. Chem., November 17, 2000; 275(47): 36910 - 36919.
[Abstract] [Full Text] [PDF]

R. H. Harrington and A. Sharma
Transcription Factors Recognizing Overlapping C1-A2 Binding Sites Positively Regulate Insulin Gene Expression
J. Biol. Chem., January 5, 2001; 276(1): 104 - 113.
[Abstract] [Full Text] [PDF]

T.-a. Matsuoka, L. Zhao, and R. Stein
The DNA Binding Activity of the RIPE3b1 Transcription Factor of Insulin Appears to Be Influenced by Tyrosine Phosphorylation
J. Biol. Chem., June 15, 2001; 276(25): 22071 - 22076.
[Abstract] [Full Text] [PDF]

H. Wang, P. Maechler, B. Ritz-Laser, K. A. Hagenfeldt, H. Ishihara, J. Philippe, and C. B. Wollheim
Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation
J. Biol. Chem., June 29, 2001; 276(27): 25279 - 25286.
[Abstract] [Full Text] [PDF]

C. Missero, M. T. Pirro, S. Simeone, M. Pischetola, and R. Di Lauro
The DNA Glycosylase T:G Mismatch-specific Thymine DNA Glycosylase Represses Thyroid Transcription Factor-1-activated Transcription
J. Biol. Chem., August 31, 2001; 276(36): 33569 - 33575.
[Abstract] [Full Text] [PDF]

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