Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Levitan, D.
	Articles by Greenwald, I.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Levitan, D.
	Articles by Greenwald, I.


Social Bookmarking

	What's this?

Aroian, R. V., Koga, M., Mendel, J. E., Ohshima, Y. and Sternberg, P. W (1990). The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature 348, 693-9.[Medline]

Bettinger, J. C., Lee, K., Rougvie, A. E (1996). Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development. Development 122, 2517-3527.[Abstract]

Blaumueller, C. M., Qui, H., Zagouras, P. and Artavanis-Tsakonas, S (1997). Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell 90, 281-291.[Medline]

Borchelt, D. et al (1996). Familial Alzheimer's disease-linked presenilin elevate A1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013.[Medline]

Brenner, S (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.[Abstract/Free Full Text]

Brown, M. S. and Goldstein, J. L (1997). The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331-340.[Medline]

Chalfie, M., Tu, Y., Euskirchen, G., Ward, W. W. and Prasher, D. C (1994). Green fluorescent protein as a marker for gene expression. Science 263, 802-804.[Abstract/Free Full Text]

Chartier-Harlin, M.-C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rossor, M., P., R. and Hardy, J (1991). Early-onset Alzheimer's disease caused by mutations at codon 717 of the-amyloid precursor protein gene. Nature 353, 844-846.[Medline]

De Strooper, B. et al (1997). Phosphorylation, subcellular localization andmembrane orientation of the Alzheimer's disease-associated presenilins. J. Biol. Chem 272, 3590-3598.[Abstract/Free Full Text]

DeStrooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K. and Van Leuven, F (1998). Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390.[Medline]

DeVore, D., Horvitz, H. R. and Stern, M (1995). An FGF receptor singaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites. Cell 83, 611-620.[Medline]

Duff, K. et al (1996). Increased amyloid-42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713.[Medline]

Estevez, M., Attisano, L., Wrana, J., Albert, P., Massague, J. and Riddle, D (1993). The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature 365, 644-649.[Medline]

Ferguson, E. L. and Horvitz, H. R (1985). Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics 110, 17-72.[Abstract/Free Full Text]

Georgi, L., Albert, P. and Riddle, D (1990). daf-1 , a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase. Cell 61, 635-645.[Medline]

Goate, A. et al (1991). Segregation of a missense mutation in the amyloid precursor protein gene family with Alzheimer's disease. Nature 349, 704-706.[Medline]

Greenwald, I. S., Sternberg, P. W. and Horvitz, H. R (1983). The lin-12 locus specifies cell fates in Caenorhabditis elegans. Cell 34, 435-444.[Medline]

Greenwald, I. and Seydoux, G (1990). Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans. Nature 346, 197-9.[Medline]

Haass, C., Schlossmacher, M., Hung, A., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B., Liebergurg, I., Koo, E., Schenk, D., Teplow, D. and Selkoe, D (1992). Amyloid-peptide is produced by cultured cells during nomal metabolism. Nature 359, 322-325.[Medline]

Henderson, S. T., Gao, D., Lambie, E. J. and Kimble, J (1994). lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans. Development 120, 2913-2924.[Abstract]

Hill, R. J. and Sternberg, P. W (1992). The gene lin-3 encodes an inductive signal for vulval development in C. elegans. Nature 358, 470-6.[Medline]

Hodgkin, J. and Doniach, T (1997). Natural variation and copulatory plug formation in Caenorhabditis elegans. Genetics 146, 149-164.[Abstract]

Huynh, D.P., Vinters, H.V., Ho, D.H., Ho, V.V. and Pulst, S.M (1997). Neuronal expression and intracellular localization of presenilins in normal and Alzheimer disease brains. J. Neuropathol. Exp. Neurol 56, 1009-1017.[Medline]

Ishii, N., Wadsworth, W., Stern, B., Culotti, J. and Hedgecock, E (1992). UNC-6, a laminin-related protein, guides cell and pioneer axons in C. elegans. Neuron 9, 873-881.[Medline]

Kimble, J (1981). Alteration in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans. Dev. Biol 87, 286-300.[Medline]

Levitan, D. and Greenwald, I (1995). Facilitation of lin-12 -mediated signalling by sel-12 , a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377, 351-354.[Medline]

Levitan, D., Doyle, T., Brousseau, D., Lee, M., Thinakaran, G., Slunt, H., Sisodia, S. and Greenwald, I (1996). Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 93, 1490-14944.

Levitan, D. and Greenwald, I (1998). LIN-12 protein expression and localization during vulval development. Development 125, 3101-3109.[Abstract]

Levy-Lahad et al (1995). A Familial Alzheimer's disease locus on chromosome I. Science 269, 970-973.[Abstract/Free Full Text]

Levy-Lahad et al (1995). Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977.[Abstract/Free Full Text]

Li, X. and Greenwald, I (1996). Membrane topology of the C. elegans SEL-12 presenilin. Neuron 17, 1015-1021.[Medline]

Li, X. and Greenwald, I (1997). HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc. Natl. Acad. Sci. USA 94, 12204-12209.[Abstract/Free Full Text]

Li, J., Xu, M., Zhou, H., Ma, J. and Potter, H (1997). Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes, suggest a role in chromosome segregation. Cell 90, 917-927.[Medline]

Malone, E. and Thomas, J (1994). A screen for nonconditional dauer-constitutive mutations in Caenorhabditis elegans. Genetics 136, 879-886.[Abstract]

Mello, C. C., Kramer, J. M., Stinchcomb, D. and Ambros, V (1991). Efficient gene transfer in C. elegans , extrachromosomal maintenance and integration of transforming sequences. EMBO J 10, 3959-3970.[Medline]

Pan, D. and Rubin, G. M (1997). Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 90, 271-280.[Medline]

Priess, J. and Hirsh, D (1986). C. elegans morphogenesis: The role of the cytoskeleton in elongation of the embryo. Dev. Biol 117, 156-173.[Medline]

Ren, P., Lim, C.-S., Johnsen, R., Albert, P., Pilgrim, D. and Riddle, D (1996). Control of C. elegans larval development by neuronal expression of a TGF-homolog. Science 274, 1389-1391.[Abstract/Free Full Text]

Riddle, D., Swanson, M. and Albert, P (1981). Interacting genes in nematode dauer larva formation. Nature 290, 668-671.[Medline]

Rogaev, E. I. et al (1995). Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.[Medline]

Sawa, H., Lobel, L. and Horvitz, H. R (1996). The Caenorhabditis elegans gene lin-17 , which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila Frizzled protein. Genes Dev 10, 2189-2197.[Abstract/Free Full Text]

Schroeter, E.H., Kisslinger, J.A. and Kopan, R (1998). Notch1 signaling requires ligand-induced proteolytic release of the intracellular domain. Nature 393, 382-386.[Medline]

Selkoe, D (1994). Cell biology of the amyloid-protein precursor and the mechanism of Alzheimer's disease. Annual Review of Cell Biology 10, 373-403.

Seubert, P. et al (1992). Isolation and quantitation of soluble Alzheimer's-peptide from biological fluids. Nature 359, 325-327.[Medline]

Seydoux, G. and Greenwald, I (1989). Cell autonomy of lin-12 function in a cell fate decision in C. elegans. Cell 57, 1237-45.[Medline]

Shen, J., Bronson, R. T., Chen, D. F., Xia, W., Selkoe, D. J. and Tonegawa, S (1997). Skeletal and CNS defects in Presenilin-1 deficient mice. Cell 89, 629-639.[Medline]

Sherrington, R. et al (1995). Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.[Medline]

Sisodia, S., Koo, E., Beyreuther, K., Unterback, A. and Price, D (1990). Evidence that-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 248, 492-495.[Abstract/Free Full Text]

Sternberg, P. W. and Horvitz, H. R (1986). Pattern formation during vulval development in C. elegans. Cell 44, 761-772.[Medline]

Sternberg, P. W. and Horvitz, H. R (1988). lin-17 mutations of Caenorhabditis elegans disrupt certain asymmetric cell divisions. Dev. Biol 130, 67-73.[Medline]

Struhl, G. and Adachi, A (1998). Nuclear access and action of Notch in vivo. Cell 93, 649-660.[Medline]

Struhl, G., Fitzgerald, K. and Greenwald, I (1993). Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74, 331-45.[Medline]

Sulston, J. E. and White, J. G (1980). Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans. Dev. Biol 78, 577-597.[Medline]

Sundaram, M. and Greenwald, M (1993). Genetic and phenotypic analysis of hypomorphic lin-12 mutants in Caenorhabditis elegans. Genetics 135, 755-763.[Abstract]

Tax, F. E., Yeargers, J. J. and Thomas, J. H (1994). Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila. Nature 368, 150-154.[Medline]

Weinmaster, G (1997). The ins and outs of Notch signaling. Molec. Cell. Neurosci 9, 91-102.[Medline]

Wilkinson, H. A., Fitzgerald, K. and Greenwald, I (1994). Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Cell 79, 1187-1198.[Medline]

Wilkinson, H. A. and Greenwald, I (1995). Spatial and temporal patterns of lin-12 expression during C. elegans hermaphrodite development. Genetics 141, 513-526.[Abstract]

Wong, P. C., Zheng, H., Chen, H., Becher, M. W., Sirinathsinghji, D. J. S., Trumbauer, M. W., Chen, H. Y., Price, D. L., Van der Ploeg, L. H. T. and Sisodia, S. S (1997). Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm. Nature 387, 288-292.[Medline]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

J. Ouellet, S. Li, and R. Roy
Notch signalling is required for both dauer maintenance and recovery in C. elegans
Development, August 1, 2008; 135(15): 2583 - 2592.
[Abstract] [Full Text] [PDF]

R. Wang, P. Tang, P. Wang, R. E. Boissy, and H. Zheng
Regulation of tyrosinase trafficking and processing by presenilins: Partial loss of function by familial Alzheimer's disease mutation
PNAS, January 10, 2006; 103(2): 353 - 358.
[Abstract] [Full Text] [PDF]

M. Wines-Samuelson and J. Shen
Presenilins in the Developing, Adult, and Aging Cerebral Cortex
Neuroscientist, October 1, 2005; 11(5): 441 - 451.
[Abstract] [PDF]

B. R. Ellerbrock, E. M. Coscarelli, M. E. Gurney, and T. G. Geary
Screening for Presenilin Inhibitors Using the Free-Living Nematode, Caenorhabditis elegans
J Biomol Screen, March 1, 2004; 9(2): 147 - 152.
[Abstract] [PDF]

J. Chen, X. Li, and I. Greenwald
sel-7, a Positive Regulator of lin-12 Activity, Encodes a Novel Nuclear Protein in Caenorhabditis elegans
Genetics, January 1, 2004; 166(1): 151 - 160.
[Abstract] [Full Text] [PDF]

B. E. Berechid, M. Kitzmann, D. R. Foltz, A. H. Roach, D. Seiffert, L. A. Thompson, R. E. Olson, A. Bernstein, D. B. Donoviel, and J. S. Nye
Identification and Characterization of Presenilin-independent Notch Signaling
J. Biol. Chem., March 1, 2002; 277(10): 8154 - 8165.
[Abstract] [Full Text] [PDF]

J. J. Palacino, M. P. Murphy, O. Murayama, K. Iwasaki, M. Fujiwara, A. Takashima, T. E. Golde, and B. Wolozin
Presenilin 1 Regulates beta -Catenin-mediated Transcription in a Glycogen Synthase Kinase-3-independent Fashion
J. Biol. Chem., October 12, 2001; 276(42): 38563 - 38569.
[Abstract] [Full Text] [PDF]

S. Zhou and S. D. Hayward
Nuclear Localization of CBF1 Is Regulated by Interactions with the SMRT Corepressor Complex
Mol. Cell. Biol., September 15, 2001; 21(18): 6222 - 6232.
[Abstract] [Full Text] [PDF]

S. Pichler, P. Gonczy, H. Schnabel, A. Pozniakowski, A. Ashford, R. Schnabel, and A. A. Hyman
OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P(1) blastomere of C. elegans embryos
Development, May 15, 2000; 127(10): 2063 - 2073.
[Abstract] [PDF]

W. Scheper, R. Zwart, P. van der Sluijs, W. Annaert, W.A. v. Gool, and F. Baas
Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor
Hum. Mol. Genet., January 22, 2000; 9(2): 303 - 310.
[Abstract] [Full Text] [PDF]

M Handler, X Yang, and J Shen
Presenilin-1 regulates neuronal differentiation during neurogenesis
Development, January 6, 2000; 127(12): 2593 - 2606.
[Abstract] [PDF]

W. J. Ray, M. Yao, J. Mumm, E. H. Schroeter, P. Saftig, M. Wolfe, D. J. Selkoe, R. Kopan, and A. M. Goate
Cell Surface Presenilin-1 Participates in the gamma -Secretase-like Proteolysis of Notch
J. Biol. Chem., December 17, 1999; 274(51): 36801 - 36807.
[Abstract] [Full Text] [PDF]

Y. Guo, I. Livne-Bar, L. Zhou, and G. L. Boulianne
Drosophila presenilin Is Required for Neuronal Differentiation and Affects Notch Subcellular Localization and Signaling
J. Neurosci., October 1, 1999; 19(19): 8435 - 8442.
[Abstract] [Full Text] [PDF]

Y. Ye and M. E. Fortini
Apoptotic Activities of Wild-Type and Alzheimer's Disease-Related Mutant Presenilins in Drosophila melanogaster
J. Cell Biol., September 20, 1999; 146(6): 1351 - 1364.
[Abstract] [Full Text] [PDF]

C. Wen and I. Greenwald
p24 Proteins and Quality Control of LIN-12 and GLP-1 Trafficking in Caenorhabditis elegans
J. Cell Biol., June 14, 1999; 145(6): 1165 - 1175.
[Abstract] [Full Text] [PDF]

W. J. Ray, M. Yao, P. Nowotny, J. Mumm, W. Zhang, J. Y. Wu, R. Kopan, and A. M. Goate
Evidence for a physical interaction between presenilin and Notch
PNAS, March 16, 1999; 96(6): 3263 - 3268.
[Abstract] [Full Text] [PDF]

B. Westlund, D. Parry, R. Clover, M. Basson, and C. D. Johnson
Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling
PNAS, March 2, 1999; 96(5): 2497 - 2502.
[Abstract] [Full Text] [PDF]

J Schlondorff and C. Blobel
Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding
J. Cell Sci., January 11, 1999; 112(21): 3603 - 3617.
[Abstract] [PDF]

G. Wu, E. J. A. Hubbard, J. K. Kitajewski, and I. Greenwald
Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin
PNAS, December 22, 1998; 95(26): 15787 - 15791.
[Abstract] [Full Text] [PDF]

M. Okochi, S. Eimer, A. Bottcher, R. Baumeister, H. Romig, J. Walter, A. Capell, H. Steiner, and C. Haass
A Loss of Function Mutant of the Presenilin Homologue SEL-12 Undergoes Aberrant Endoproteolysis in Caenorhabditis elegans and Increases Abeta 42 Generation in Human Cells
J. Biol. Chem., December 22, 2000; 275(52): 40925 - 40932.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Levitan, D.

Articles by Greenwald, I.

Search for Related Content

PubMed

PubMed Citation

Articles by Levitan, D.

Articles by Greenwald, I.

Social Bookmarking

What's this?

				R. Wang, P. Tang, P. Wang, R. E. Boissy, and H. Zheng Regulation of tyrosinase trafficking and processing by presenilins: Partial loss of function by familial Alzheimer's disease mutation PNAS, January 10, 2006; 103(2): 353 - 358. [Abstract] [Full Text] [PDF]

				M. Wines-Samuelson and J. Shen Presenilins in the Developing, Adult, and Aging Cerebral Cortex Neuroscientist, October 1, 2005; 11(5): 441 - 451. [Abstract] [PDF]

				B. R. Ellerbrock, E. M. Coscarelli, M. E. Gurney, and T. G. Geary Screening for Presenilin Inhibitors Using the Free-Living Nematode, Caenorhabditis elegans J Biomol Screen, March 1, 2004; 9(2): 147 - 152. [Abstract] [PDF]

				J. Chen, X. Li, and I. Greenwald sel-7, a Positive Regulator of lin-12 Activity, Encodes a Novel Nuclear Protein in Caenorhabditis elegans Genetics, January 1, 2004; 166(1): 151 - 160. [Abstract] [Full Text] [PDF]

				B. E. Berechid, M. Kitzmann, D. R. Foltz, A. H. Roach, D. Seiffert, L. A. Thompson, R. E. Olson, A. Bernstein, D. B. Donoviel, and J. S. Nye Identification and Characterization of Presenilin-independent Notch Signaling J. Biol. Chem., March 1, 2002; 277(10): 8154 - 8165. [Abstract] [Full Text] [PDF]

				J. J. Palacino, M. P. Murphy, O. Murayama, K. Iwasaki, M. Fujiwara, A. Takashima, T. E. Golde, and B. Wolozin Presenilin 1 Regulates beta -Catenin-mediated Transcription in a Glycogen Synthase Kinase-3-independent Fashion J. Biol. Chem., October 12, 2001; 276(42): 38563 - 38569. [Abstract] [Full Text] [PDF]

				S. Zhou and S. D. Hayward Nuclear Localization of CBF1 Is Regulated by Interactions with the SMRT Corepressor Complex Mol. Cell. Biol., September 15, 2001; 21(18): 6222 - 6232. [Abstract] [Full Text] [PDF]

				S. Pichler, P. Gonczy, H. Schnabel, A. Pozniakowski, A. Ashford, R. Schnabel, and A. A. Hyman OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P(1) blastomere of C. elegans embryos Development, May 15, 2000; 127(10): 2063 - 2073. [Abstract] [PDF]

				W. Scheper, R. Zwart, P. van der Sluijs, W. Annaert, W.A. v. Gool, and F. Baas Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor Hum. Mol. Genet., January 22, 2000; 9(2): 303 - 310. [Abstract] [Full Text] [PDF]

				M Handler, X Yang, and J Shen Presenilin-1 regulates neuronal differentiation during neurogenesis Development, January 6, 2000; 127(12): 2593 - 2606. [Abstract] [PDF]

				W. J. Ray, M. Yao, J. Mumm, E. H. Schroeter, P. Saftig, M. Wolfe, D. J. Selkoe, R. Kopan, and A. M. Goate Cell Surface Presenilin-1 Participates in the gamma -Secretase-like Proteolysis of Notch J. Biol. Chem., December 17, 1999; 274(51): 36801 - 36807. [Abstract] [Full Text] [PDF]

				Y. Guo, I. Livne-Bar, L. Zhou, and G. L. Boulianne Drosophila presenilin Is Required for Neuronal Differentiation and Affects Notch Subcellular Localization and Signaling J. Neurosci., October 1, 1999; 19(19): 8435 - 8442. [Abstract] [Full Text] [PDF]

				Y. Ye and M. E. Fortini Apoptotic Activities of Wild-Type and Alzheimer's Disease-Related Mutant Presenilins in Drosophila melanogaster J. Cell Biol., September 20, 1999; 146(6): 1351 - 1364. [Abstract] [Full Text] [PDF]

				C. Wen and I. Greenwald p24 Proteins and Quality Control of LIN-12 and GLP-1 Trafficking in Caenorhabditis elegans J. Cell Biol., June 14, 1999; 145(6): 1165 - 1175. [Abstract] [Full Text] [PDF]

				W. J. Ray, M. Yao, P. Nowotny, J. Mumm, W. Zhang, J. Y. Wu, R. Kopan, and A. M. Goate Evidence for a physical interaction between presenilin and Notch PNAS, March 16, 1999; 96(6): 3263 - 3268. [Abstract] [Full Text] [PDF]

				B. Westlund, D. Parry, R. Clover, M. Basson, and C. D. Johnson Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling PNAS, March 2, 1999; 96(5): 2497 - 2502. [Abstract] [Full Text] [PDF]

				J Schlondorff and C. Blobel Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding J. Cell Sci., January 11, 1999; 112(21): 3603 - 3617. [Abstract] [PDF]

				G. Wu, E. J. A. Hubbard, J. K. Kitajewski, and I. Greenwald Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin PNAS, December 22, 1998; 95(26): 15787 - 15791. [Abstract] [Full Text] [PDF]

				M. Okochi, S. Eimer, A. Bottcher, R. Baumeister, H. Romig, J. Walter, A. Capell, H. Steiner, and C. Haass A Loss of Function Mutant of the Presenilin Homologue SEL-12 Undergoes Aberrant Endoproteolysis in Caenorhabditis elegans and Increases Abeta 42 Generation in Human Cells J. Biol. Chem., December 22, 2000; 275(52): 40925 - 40932. [Abstract] [Full Text] [PDF]