Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth

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Altabef, M., Clarke, J. D. W. and Tickle, C (1997). Dorso-ventralectodermal compartments and origin of apical ectodermal ridge in developing chick limb. Development 124, 4547-4556.[Abstract]

Araujo, M. and Nieto, M. A (1997). The expression of chick EphA7 during segmentation of the central and peripheral nervous system. Mech. Dev 68, 173-177.[Medline]

Bach, I., Carriere, C., Ostendorff, H. P., Andersen, B. and Rosenfeld, M. G (1997). A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev 11, 1370-1380.[Abstract/Free Full Text]

Bach, I., Rhodes, S. J., Pearse II, R. V., Heinzel, T., Gloss, B., Scully, K. M., Sawchenko, P. E. and Rosenfeld, M. G (1995). P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc. Nat. Acad. Sci. USA 92, 2720-2724.[Abstract/Free Full Text]

Beauchemin, M. and Savard, P (1992). Two Distal-less related homeobox-containing genes expressed in regeneration blastemas of the newt. Dev. Biol 154, 55-65.[Medline]

Blair, S. S., Brower, D. L., Thomas, J. B. and Zavortink, M (1994). The role of apterous in the control of dorso-ventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila. Development 120, 1805-1815.[Abstract]

Blair, S. S (1993). Mechanisms of compartment formation, Evidence that non-proliferating cells do not play a critical role in defining the D/V lineage restriction in the developing wing of Drosophila. Development 119, 339-351.[Abstract]

Brand, A. and Perrimon, N (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.[Abstract]

Bryant, P. J (1970). Cell lineage relationships in the imaginal wing disc of Drosophila melanogaster. Dev. Biol 22, 389-411.[Medline]

Bushdid, P. B., Brantley, D. M., Yull, F. E., Blaeuer, G. L., Hoffman, L. H., Niswander, L. and Kerr, L. D (1998). Inhibition of NF-kB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature 392, 615-618.[Medline]

Calleja, M., Moreno, E., Pelaz, S. and Morata, G (1996). Visualization of gene expression in living adult Drosophila. Science 274, 252-255.[Abstract/Free Full Text]

Capovilla, M., Brandt, M. and Botas, J (1994). Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis. Cell 76, 461-475.[Medline]

Cohen, B., McGuffin, M. E., Pfeifle, C., Segal, D. and Cohen, S. M (1992). apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins. Genes Dev 6, 715-729.[Abstract/Free Full Text]

Cohen, S. M (1990). Specification of limb development in the Drosophila embryo by positional cues from segmentation genes. Nature 343, 173-177.[Medline]

Cohen, S. M., Br\232nner, G., Kuttner, F., Jurgens, G. and J\212ckie, H (1989). Distal-less encodes a homeodomain protein required for limb development in Drosophila. Nature 338, 432-434.[Medline]

Cygan, J. A., Johnson, R. L. and McMahon, A. P (1997). Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development 124, 5021-5032.[Abstract]

De Celis, J. F., Garcia-Bellido, A. and Bray, S. J (1996). Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. Development 122, 359-369.[Abstract]

Dealy, C. N., Roth, A., Ferrari, D., Brown, A. M. C. and Kosher, R. A (1993). Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes. Mech. Dev 43, 175-186.[Medline]

Diaz-Benjumea, F. J. and Cohen, S. M (1993). Interaction between Dorsal and Ventral cells in the imaginal discs directs wing development in Drosophila. Cell 75, 741-752.[Medline]

Fallon, J. F., Frederick, J. M., Carrington, J. L., Lanser, M. E. and Simandl, B. K (1983). Studies on a limbless mutant in the chick embryo. Prog. Clin. Biol. Res 110, 33-43.

Fraser, R. A. and Abbott, U. K (1971). Studies on limb morphogenesis. VI. Experiments with early stages of the polydactylous mutant Eudiplopodia. J. Exp. Zool 176, 237-248.[Medline]

Garcia-Bellido, A., Ripoll, P. and Morata, G (1973). Developmental compartmentalisation of the wing disk of Drosophila. Nature New Biol 245, 251-253.[Medline]

Garcia-Bellido, A., Ripoll, P. and Morata, G (1976). Developmental compartmentalization in the dorsal mesothoracic disc of Drosophila. Dev. Biol 48, 132-147.[Medline]

German, M. S., Wang, J., Chadwick, and Rutter, W. J (1992). Synergistic activation of the insulin gene by a LIM-homeodomain protein and a basic helix-loop-helix protein, Building a functional insulin minienhancer complex. Genes Dev 6, 2165-2176.[Abstract/Free Full Text]

Goetinck, P (1964). Studies on limb morphogenesis II. Experiments with the polydactylous mutant eudiplopodia. Dev. Biol 10, 71-91.

Grieshammer, U., Minowada, G., Pisenti, J. M., Abbott, U. K. and Martin, G. A (1996). The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning, implications for the mechanism of apical ridge formation. Development 122, 3851-3861.[Abstract]

Irvine, K. D. and Wieschaus, E (1994). Fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell 79, 595-606.[Medline]

Izpis\234a Belmonte, J. C., De Robertis, E. M., Storey, K. G. and Stern, C (1993). The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm. Cell 74, 645-659.[Medline]

Izpis\234a Belmonte, J. C., Falkenstein, H., Dolle, P., Renucci, A. and Duboule, D (1991). Murine genes related to the Drosophila AbdB homeotic gene are sequentially expressed during development of the posterior part of the body. EMBO J 10, 2279-2289.[Medline]

Izpis\234a Belmonte, J. C., Tickle, C., Dolle, P., Wolpert, L. and Duboule, D (1991). Expression of the homeobox Hox-4 genes and the specification of position in chick wing development. Nature 350, 585-589.[Medline]

Kanegae, Y., Tavares, A. T., Izpis\234a Belmonte, J. C. and Verma, I. M (1998). The role of Rel/NF-kB during the outgrowth of the vertebrate limb. Nature 392, 611-614.[Medline]

Kengaku, M., Capdevila, J., Rodriguez Esteban, C., De La Pe\226a, J., Johnson, R. L., Izpis\234a Belmonte, J. C. and Tabin, C (1997). Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science 280, 1274-1277.[Abstract/Free Full Text]

Kim, J., Irvine, K. D. and Carroll, S. B (1995). Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing. Cell 82, 795-802.[Medline]

Kliewer, S. A., Umesono, K., Mangelsdorf, D. J. and Evans R. M (1992). Retinoic X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signaling. Nature 355, 446-449.[Medline]

Laufer, E., Dahn, R., Orozco, O. E., Yeo, C.-Y., Pisenti, J., Abbott, U. K., Fallon, J. F. and Tabin, C (1997). The Radical fringe expression boundary in the limb bud ectoderm regulates AER formation. Nature 386, 366-373.[Medline]

Lawrence, P. and Struhl, G (1996). Morphogens, compartments, and pattern, Lessons from Drosophila ?. Cell 85, 951-961.[Medline]

Logan, C., Hanks, M. C., Noble-Topham, S., Nallainathan, D., Provart, N. J. and Joyner, A. L (1992). Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions. Dev. Genet 13, 345-358.[Medline]

Loomis, C. A., Harris, E., Michaud, J., Wurst, W., Hanks, M. and Joyner, A. L (1996). The Engrailed-1 gene and ventral limb patterning. Nature 382, 360-363.[Medline]

Michaud, J. L., Lapointe, F. and Le Douarin, N. M (1997). The dorsoventral polarity of the presumptive limb is determined by signals produced by the somites and by the lateral somatopleure. Development 124, 1453-1463.[Abstract]

Morgan, B. A., Izpis\234a Belmonte, J. C., Duboule, D. and Tabin, C. J (1992). Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations. Nature 358, 236-239.[Medline]

Myat, A., Henrique, D., Ish-Horowicz, D. and Lewis, J (1996). A chick homologue of serrate and its relationship with notch and delta homologues during central neurogenesis. Dev. Biol 174, 233-247.[Medline]

Nohno, T., Kawakami, Y., Wada, N., Ishikawa, T., Ohuchi., H. and Noji, S (1997). Differential expression of the two closely related LIM-class homeobox genes LH-2A and LH-2B during limb development. Biochem. Biophys. Res. Comm 238, 506-511.[Medline]

Noramly, S., Pisenti, J., Abbott, U. and Morgan, B (1996). Gene expression in the limbless mutant, polarized gene expression in the absence of Shh and an AER. Dev. Biol 179, 339-346.[Medline]

Ogura, T., Alvarez, I. S., Vogel, A., Rodriguez, C., Evans, and Izpis\234a Belmonte, J. C (1996). Evidence that Shh cooperates with a retinoic acid inducible co-factor to establish ZPA-like activity. Development 122, 537-542.[Abstract]

Ohuchi, H., Nakagawa, T., Yamamoto, A., Araga, A., Ohata, T., Ishimaru, Y., Yoshioka, H., Kuwana, T., Nohno, T., Yamasaki, M., Itoh, N. and Noji, S (1997). The mesenchymal factor, FGF-10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development 124, 2235-2244.[Abstract]

Parr, B. A. and McMahon, A. P (1995). Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374, 350-353.[Medline]

Popadic, A., Rusch, D., Peterson, M., Rogers, B. T. and Kaufman, T. C (1996). Origin of the arthropod mandible. Nature 380, 395-.

Porter, F. D., Drago, J., Xu, Y., Cheema, S. S., Wassif, C., Huang, S.-P., Lee, E., Grinberg, A., Massalas, J. S., Bodine, D., Alt, F. and Westphal, H (1997). Lhx2 , a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development 124, 2935-2944.[Abstract]

Prahlad, R. B., Skala, G., Jones, D. B. and Briles, W. S (1979). Limbless, A new genetic variant mutant in the chick. J. Exp. Zool 209, 427-434.[Medline]

Riddle, R., Ensini, M., Nelson, C., Tsuchida, T., Jessell, T. and Tabin, C (1995). Induction of the LIM Homeobox Gene Lmx-1 by Wnt7a establishes dorsoventral pattern in the vertebrate limb. Cell 83, 631-640.[Medline]

Robert, B., Sassoon, D., Jacq, B., Gehring., W. and Buckingham, M (1989). Expression of a novel Hox gene, Hox-7 , during mouse embryogenesis, is associated with morphogenetic phenomena. EMBO J 8, 91-100.[Medline]

Rodriguez-Esteban, C., Schwabe, J. W. R., De La Pe\226a, J., Foys, B., Eshelman, B. and Izpis\234a Belmonte, J. C (1997). Radical fringe positions the AER at the dorso-ventral boundary of the vertebrate limb and induces elaboration of the proximo-distal axis. Nature 386, 360-366.[Medline]

Ros, M. A., Lopez-Martinez, A., Simandl, B. K., Rodriguez, C., Izpis\234a Belmonte, J. C., Dahn, R. and Fallon, J (1996). The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions. Development 122, 2319-2330.[Abstract]

Rubin, G. M. and Spradling, A. C (1982). Genetic transformation of Drosophila with transposable element vectors. Science 218, 348-353.[Abstract/Free Full Text]

Shubin, N., Tabin., C. and Carroll, S (1997). Fossils, genes, and the evolution of animal limbs. Nature 388, 639-648.[Medline]

Summerbell, D., Lewis., J. and Wolpert, L (1973). Positional information in chick limb morphogenesis. Nature 244, 492-496.

Szeto, D. P., Ryan, A. K., O'Connell, S. M. and Rosenfeld, M. G (1996). P-OTX, A PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development. Proc. Nat. Acad. Sci. USA 93, 7706-7710.[Abstract/Free Full Text]

Tickle, C. and Eichele, G (1994). Vertebrate limb development. Ann. Rev. Cell Biol 10, 121-152.

Todt, W. and Fallon, J. F (1984). Development of the apical ectodermal ridge in the chick wing bud. J. Embryol. Exp. Morph 80, 21-41.[Medline]

Vogel, A., Rodriguez, C. and Izpis\234a Belmonte, J. C (1996). Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development 122, 1737-1750.[Abstract]

Vogel, A., C. Rodriguez, C., Warnken, W. and Izpis\234a Belmonte, J. C (1995). Dorsal cell fate specified by chick Lmx1 during vertebrate limb development. Nature 378, 716-720.[Medline]

Wang, M. and Drucker, D. J (1995). The LIM domain homeobox gene isl-l is a positive regulator of islet cell specific proglucagon gene transcription. J. Biol. Chem 270, 12646-12652.[Abstract/Free Full Text]

Williams, J. A., Paddock, S. W. and Carroll, S. B (1993). Pattern formation in a secondary field, A hirarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions. Development 117, 571-584.[Abstract]

Xu, Y., Baldassare, M., Fisher, P., Rathbun, G., Oltz, E. M., Yancopoulos, G. D., Jessell, T. M. and Alt, F. W (1993). LH-2, a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proc. Nat. Acad. Sci. USA 90, 227-231.[Abstract/Free Full Text]

Yang, Y. Z. and Niswander, L (1995). Interaction between the signaling molecules Wnt7a and shh during vertebrate limb development-dorsal signals regulated anteroposterior patterning. Cell 80, 939-947.[Medline]

Zeller, R. and Duboule, D (1997). Dorso-ventral limb polarity and origin of the ridge, independence day?. BioEssays 19, 541-546.[Medline]

Chen, H., Lun, Y., Ovchinnikov, D., Kokubo, H., Oberg, K. C., Pepicelli, C. V., Gan, L., Lee, B., and Johnson, R. L (1998). Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat. Genet 19, 51-55.[Medline]

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Articles by Rodriguez-Esteban, C.

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				J. I. Pueyo and J. P. Couso Chip-mediated partnerships of the homeodomain proteins Bar and Aristaless with the LIM-HOM proteins Apterous and Lim1 regulate distal leg development Development, July 1, 2004; 131(13): 3107 - 3120. [Abstract] [Full Text] [PDF]

				B. P. Gupta, M. Wang, and P. W. Sternberg The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development Development, June 15, 2003; 130(12): 2589 - 2601. [Abstract] [Full Text] [PDF]

				A. Vogel-Hopker and H. Rohrer The specification of noradrenergic locus coeruleus (LC) neurones depends on bone morphogenetic proteins (BMPs) Development, March 4, 2003; 129(4): 983 - 991. [Abstract] [Full Text] [PDF]

				M. Milan, U. Weihe, S. Tiong, W. Bender, and S. M. Cohen msh specifies dorsal cell fate in the Drosophila wing Development, September 1, 2001; 128(17): 3263 - 3268. [Abstract] [Full Text] [PDF]

				S.-H. Wang, A. Simcox, and G. Campbell Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development Genes & Dev., September 15, 2000; 14(18): 2271 - 2276. [Abstract] [Full Text]

				J. Pueyo, M. Galindo, S. Bishop, and J. Couso Proximal-distal leg development in Drosophila requires the apterous gene and the Lim1 homologue dlim1 Development, January 12, 2000; 127(24): 5391 - 5402. [Abstract] [PDF]

				E. Arman, R. Haffner-Krausz, M. Gorivodsky, and P. Lonai Fgfr2 is required for limb outgrowth and lung-branching morphogenesis PNAS, October 12, 1999; 96(21): 11895 - 11899. [Abstract] [Full Text] [PDF]

				D. E. Rincon-Limas, C.-H. Lu, I. Canal, M. Calleja, C. Rodriguez-Esteban, J. C. Izpisua-Belmonte, and J. Botas Conservation of the expression and function of apterous orthologs in Drosophila and mammals PNAS, March 2, 1999; 96(5): 2165 - 2170. [Abstract] [Full Text] [PDF]

				F Cavodeassi, R Diez Del Corral, S Campuzano, and M Dominguez Compartments and organising boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins Development, January 11, 1999; 126(22): 4933 - 4942. [Abstract] [PDF]