Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin

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J. Biol. Chem., March 14, 2003; 278(12): 10094 - 10101.
[Abstract] [Full Text] [PDF]

M. E. Piedra and M. A. Ros
BMP signaling positively regulates Nodal expression during left right specification in the chick embryo
Development, March 9, 2003; 129(14): 3431 - 3440.
[Abstract] [Full Text] [PDF]

D. P. Norris, J. Brennan, E. K. Bikoff, and E. J. Robertson
The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo
Development, March 9, 2003; 129(14): 3455 - 3468.
[Abstract] [Full Text] [PDF]

H. Chang, C. W. Brown, and M. M. Matzuk
Genetic Analysis of the Mammalian Transforming Growth Factor-{beta} Superfamily
Endocr. Rev., December 1, 2002; 23(6): 787 - 823.
[Abstract] [Full Text] [PDF]

X. Zhu, A. Zhou, A. Dey, C. Norrbom, R. Carroll, C. Zhang, V. Laurent, I. Lindberg, R. Ugleholdt, J. J. Holst, et al.
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
PNAS, August 6, 2002; 99(16): 10293 - 10298.
[Abstract] [Full Text] [PDF]

T. Kang, Y.-G. Zhao, D. Pei, J. F. Sucic, and Q.-X. A. Sang
Intracellular Activation of Human Adamalysin 19/Disintegrin and Metalloproteinase 19 by Furin Occurs via One of the Two Consecutive Recognition Sites
J. Biol. Chem., July 5, 2002; 277(28): 25583 - 25591.
[Abstract] [Full Text] [PDF]

R. A. Zirngibl, Y. Senis, and P. A. Greer
Enhanced Endotoxin Sensitivity in Fps/Fes-Null Mice with Minimal Defects in Hematopoietic Homeostasis
Mol. Cell. Biol., April 15, 2002; 22(8): 2472 - 2486.
[Abstract] [Full Text] [PDF]

T. Kang, H. Nagase, and D. Pei
Activation of Membrane-type Matrix Metalloproteinase 3 Zymogen by the Proprotein Convertase Furin in the trans-Golgi Network
Cancer Res., February 1, 2002; 62(3): 675 - 681.
[Abstract] [Full Text] [PDF]

A. Tsuji, T. Ikoma, E. Hashimoto, and Y. Matsuda
Development of selectivity of {alpha}1-antitrypsin variant by mutagenesis in its reactive site loop against proprotein convertase. A crucial role of the P4 arginine in PACE4 inhibition
Protein Eng. Des. Sel., February 1, 2002; 15(2): 123 - 130.
[Abstract] [Full Text] [PDF]

J. Leitlein, S. Aulwurm, R. Waltereit, U. Naumann, B. Wagenknecht, W. Garten, M. Weller, and M. Platten
Processing of Immunosuppressive Pro-TGF-{{beta}}1,2 by Human Glioblastoma Cells Involves Cytoplasmic and Secreted Furin-Like Proteases
J. Immunol., June 15, 2001; 166(12): 7238 - 7243.
[Abstract] [Full Text] [PDF]

M. Negishi, D. Lu, Y.-Q. Zhang, Y. Sawada, T. Sasaki, T. Kayo, J. Ando, T. Izumi, M. Kurabayashi, I. Kojima, et al.
Upregulatory Expression of Furin and Transforming Growth Factor-{beta} by Fluid Shear Stress in Vascular Endothelial Cells
Arterioscler. Thromb. Vasc. Biol., May 1, 2001; 21(5): 785 - 790.
[Abstract] [Full Text] [PDF]

A. C.-K. Chung, D. Katz, F. A. Pereira, K. J. Jackson, F. J. DeMayo, A. J. Cooney, and B. W. O'Malley
Loss of Orphan Receptor Germ Cell Nuclear Factor Function Results in Ectopic Development of the Tail Bud and a Novel Posterior Truncation
Mol. Cell. Biol., January 15, 2001; 21(2): 663 - 677.
[Abstract] [Full Text]

C. M. Dubois, F. Blanchette, M.-H. Laprise, R. Leduc, F. Grondin, and N. G. Seidah
Evidence that Furin Is an Authentic Transforming Growth Factor-{beta}1-Converting Enzyme
Am. J. Pathol., January 1, 2001; 158(1): 305 - 316.
[Abstract] [Full Text] [PDF]

D. B. Constam and E. J. Robertson
SPC4/PACE4 regulates a TGFbeta signaling network during axis formation
Genes & Dev., May 1, 2000; 14(9): 1146 - 1155.
[Abstract] [Full Text]

R. D. Burdine and A. F. Schier
Conserved and divergent mechanisms in left-right axis formation
Genes & Dev., April 1, 2000; 14(7): 763 - 776.
[Full Text]

Y. Xiang, S. S. Molloy, L. Thomas, and G. Thomas
The PC6B Cytoplasmic Domain Contains Two Acidic Clusters That Direct Sorting to Distinct trans-Golgi Network/Endosomal Compartments
Mol. Biol. Cell, April 1, 2000; 11(4): 1257 - 1273.
[Abstract] [Full Text]

D. Constam and E. Robertson
Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping
Development, January 1, 2000; 127(2): 245 - 254.
[Abstract] [PDF]

A. Zhou, G. Webb, X. Zhu, and D. F. Steiner
Proteolytic Processing in the Secretory Pathway
J. Biol. Chem., July 23, 1999; 274(30): 20745 - 20748.
[Full Text] [PDF]

M. Komada and P. Soriano
Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis
Genes & Dev., June 1, 1999; 13(11): 1475 - 1485.
[Abstract] [Full Text]

D. B. Constam and E. J. Robertson
Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases
J. Cell Biol., January 11, 1999; 144(1): 139 - 149.
[Abstract] [Full Text] [PDF]

				D. Szumska, G. Pieles, R. Essalmani, M. Bilski, D. Mesnard, K. Kaur, A. Franklyn, K. El Omari, J. Jefferis, J. Bentham, et al. VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5 Genes & Dev., June 1, 2008; 22(11): 1465 - 1477. [Abstract] [Full Text] [PDF]

				K. Nagao, Y. Taniyama, T. Kietzmann, T. Doi, I. Komuro, and R. Morishita HIF-1{alpha} Signaling Upstream of NKX2.5 Is Required for Cardiac Development in Xenopus J. Biol. Chem., April 25, 2008; 283(17): 11841 - 11849. [Abstract] [Full Text] [PDF]

				R. Essalmani, A. Zaid, J. Marcinkiewicz, A. Chamberland, A. Pasquato, N. G. Seidah, and A. Prat In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate PNAS, April 15, 2008; 105(15): 5750 - 5755. [Abstract] [Full Text] [PDF]

				N. Picard, D. Eladari, S. El Moghrabi, C. Planes, S. Bourgeois, P. Houillier, Q. Wang, M. Burnier, G. Deschenes, M. A. Knepper, et al. Defective ENaC Processing and Function in Tissue Kallikrein-deficient Mice J. Biol. Chem., February 22, 2008; 283(8): 4602 - 4611. [Abstract] [Full Text] [PDF]

				M. C. Jorgensen, J. Ahnfelt-Ronne, J. Hald, O. D. Madsen, P. Serup, and J. Hecksher-Sorensen An Illustrated Review of Early Pancreas Development in the Mouse Endocr. Rev., October 1, 2007; 28(6): 685 - 705. [Abstract] [Full Text] [PDF]

				T. Sakaguchi, Y. Kikuchi, A. Kuroiwa, H. Takeda, and D. Y. R. Stainier The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish Development, October 15, 2006; 133(20): 4063 - 4072. [Abstract] [Full Text] [PDF]

				N. Scamuffa, F. Calvo, M. Chretien, N. G. Seidah, and A.-M. Khatib Proprotein convertases: lessons from knockouts FASEB J, October 1, 2006; 20(12): 1954 - 1963. [Abstract] [Full Text] [PDF]

				A. S. Rakeman and K. V. Anderson Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching Development, August 15, 2006; 133(16): 3075 - 3083. [Abstract] [Full Text] [PDF]

				M. Pesu, L. Muul, Y. Kanno, and J. J. O'Shea Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma Blood, August 1, 2006; 108(3): 983 - 985. [Abstract] [Full Text] [PDF]

				D. Mesnard, M. Guzman-Ayala, and D. B. Constam Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning Development, July 1, 2006; 133(13): 2497 - 2505. [Abstract] [Full Text] [PDF]

				D. C. Goldman, R. Hackenmiller, T. Nakayama, S. Sopory, C. Wong, H. Kulessa, and J. L. Christian Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity Development, May 15, 2006; 133(10): 1933 - 1942. [Abstract] [Full Text] [PDF]

				R. Essalmani, J. Hamelin, J. Marcinkiewicz, A. Chamberland, M. Mbikay, M. Chretien, N. G. Seidah, and A. Prat Deletion of the Gene Encoding Proprotein Convertase 5/6 Causes Early Embryonic Lethality in the Mouse Mol. Cell. Biol., January 1, 2006; 26(1): 354 - 361. [Abstract] [Full Text] [PDF]

				M. Tang, A. Mikhailik, I. Pauli, L. C. Giudice, A. T. Fazelabas, S. Tulac, D. D. Carson, D. G. Kaufman, C. Barbier, J. W. M. Creemers, et al. Decidual Differentiation of Stromal Cells Promotes Proprotein Convertase 5/6 Expression and Lefty Processing Endocrinology, December 1, 2005; 146(12): 5313 - 5320. [Abstract] [Full Text] [PDF]

				T. Kunath, D. Arnaud, G. D. Uy, I. Okamoto, C. Chureau, Y. Yamanaka, E. Heard, R. L. Gardner, P. Avner, and J. Rossant Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts Development, April 1, 2005; 132(7): 1649 - 1661. [Abstract] [Full Text] [PDF]

				A. J. M. Roebroek, N. A. Taylor, E. Louagie, I. Pauli, L. Smeijers, A. Snellinx, A. Lauwers, W. J. M. Van de Ven, D. Hartmann, and J. W. M. Creemers Limited Redundancy of the Proprotein Convertase Furin in Mouse Liver J. Biol. Chem., December 17, 2004; 279(51): 53442 - 53450. [Abstract] [Full Text] [PDF]

				S. Benjannet, D. Rhainds, R. Essalmani, J. Mayne, L. Wickham, W. Jin, M.-C. Asselin, J. Hamelin, M. Varret, D. Allard, et al. NARC-1/PCSK9 and Its Natural Mutants: ZYMOGEN CLEAVAGE AND EFFECTS ON THE LOW DENSITY LIPOPROTEIN (LDL) RECEPTOR AND LDL CHOLESTEROL J. Biol. Chem., November 19, 2004; 279(47): 48865 - 48875. [Abstract] [Full Text] [PDF]

				M. Guzman-Ayala, N. Ben-Haim, S. Beck, and D. B. Constam Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment PNAS, November 2, 2004; 101(44): 15656 - 15660. [Abstract] [Full Text] [PDF]

				S. Li, D. Zhou, M. M. Lu, and E. E. Morrisey Advanced Cardiac Morphogenesis Does Not Require Heart Tube Fusion Science, September 10, 2004; 305(5690): 1619 - 1622. [Abstract] [Full Text] [PDF]

				M. M. Kacprzak, J. R. Peinado, M. E. Than, J. Appel, S. Henrich, G. Lipkind, R. A. Houghten, W. Bode, and I. Lindberg Inhibition of Furin by Polyarginine-containing Peptides: NANOMOLAR INHIBITION BY NONA-D-ARGININE J. Biol. Chem., August 27, 2004; 279(35): 36788 - 36794. [Abstract] [Full Text] [PDF]

				L. Rozan, D. J. Krysan, N. C. Rockwell, and R. S. Fuller Plasticity of Extended Subsites Facilitates Divergent Substrate Recognition by Kex2 and Furin J. Biol. Chem., August 20, 2004; 279(34): 35656 - 35663. [Abstract] [Full Text] [PDF]

				P. Stawowy, C. Margeta, H. Kallisch, N. G Seidah, M. Chretien, E. Fleck, and K. Graf Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-{beta}1 involves furin-convertase Cardiovasc Res, July 1, 2004; 63(1): 87 - 97. [Abstract] [Full Text] [PDF]

				S. Srinivasan, D. O. Bunch, Y. Feng, R. M. Rodriguiz, M. Li, R. L. Ravenell, G. X. Luo, A. Arimura, L. D. Fricker, E. M. Eddy, et al. Deficits in Reproduction and Pro-Gonadotropin-Releasing Hormone Processing in Male Cpefat Mice Endocrinology, April 1, 2004; 145(4): 2023 - 2034. [Abstract] [Full Text] [PDF]

				T. Komiyama, B. VanderLugt, M. Fugere, R. Day, R. J. Kaufman, and R. S. Fuller Optimization of protease-inhibitor interactions by randomizing adventitious contacts PNAS, July 8, 2003; 100(14): 8205 - 8210. [Abstract] [Full Text] [PDF]

				N. A. TAYLOR, W. J. M. VAN DE VEN, and J. W. M. CREEMERS Curbing activation: proprotein convertases in homeostasis and pathology FASEB J, July 1, 2003; 17(10): 1215 - 1227. [Abstract] [Full Text] [PDF]

				Y. Fu, E. J. Campbell, T. G. Shepherd, and M. W. Nachtigal Epigenetic Regulation of Proprotein Convertase PACE4 Gene Expression in Human Ovarian Cancer Cells Mol. Cancer Res., June 1, 2003; 1(8): 569 - 576. [Abstract] [Full Text] [PDF]

				G. Mayer, G. Boileau, and M. Bendayan Furin interacts with proMT1-MMP and integrin {alpha}V at specialized domains of renal cell plasma membrane J. Cell Sci., May 1, 2003; 116(9): 1763 - 1773. [Abstract] [Full Text] [PDF]

				S. Artigiani, D. Barberis, P. Fazzari, P. Longati, P. Angelini, J.-W. van de Loo, P. M. Comoglio, and L. Tamagnone Functional Regulation of Semaphorin Receptors by Proprotein Convertases J. Biol. Chem., March 14, 2003; 278(12): 10094 - 10101. [Abstract] [Full Text] [PDF]

				M. E. Piedra and M. A. Ros BMP signaling positively regulates Nodal expression during left right specification in the chick embryo Development, March 9, 2003; 129(14): 3431 - 3440. [Abstract] [Full Text] [PDF]

				D. P. Norris, J. Brennan, E. K. Bikoff, and E. J. Robertson The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo Development, March 9, 2003; 129(14): 3455 - 3468. [Abstract] [Full Text] [PDF]

				H. Chang, C. W. Brown, and M. M. Matzuk Genetic Analysis of the Mammalian Transforming Growth Factor-{beta} Superfamily Endocr. Rev., December 1, 2002; 23(6): 787 - 823. [Abstract] [Full Text] [PDF]