Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs

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Akita, K (1996). The effect of the ectoderm on the dorsoventral pattern of epidermis, muscles and joints in the developing chick leg: a new model. Anatomy & Embryology 193, 377-386.[Medline]

Altabef, M., Clarke, J. D. W. and Tickle, C (1997). Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb. Development 124, 4547-4556.[Abstract]

Bulfone, A., Kim, H. J., Puelles, L., Porteus, M. H., Grippo, J. F. andRubenstein, J. L (1993). The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos. Mech. Dev 40, 129-140.[Medline]

Chan, D. C., Laufer, E., Tabin, C. and Leder, P (1995). Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity. Development 121, 1971-1978.[Abstract]

Crossley, P. H. and Martin, G. R (1995). The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121, 439-451.[Abstract]

Crossley, P. H., Minowada, G., MacArthur, C. A. and Martin, G. R (1996). Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell 84, 127-136.[Medline]

Cygan, J. A., Johnson, R. L. and McMahon, A. P (1997). Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development 124, 5021-5032.[Abstract]

Davis, C. A., Holmyard, D. P., Millen, K. J. and Joyner, A. L (1991). Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum. Development 111, 287-298.[Abstract]

Gardner, C. A. and Barald, K. F (1992). Expression patterns of engrailed-like proteins in the chick embryo. Dev. Dynamics 193, 370-388.[Medline]

Geduspan, J. S. and MacCabe, J. A (1987). The ectodermal control of mesodermal patterns of differentiation in the developing chick wing. Dev. Biol 124, 398-408.[Medline]

Geduspan, J. S. and MacCabe, J. A (1989). Transfer of dorsoventral information from mesoderm to ectoderm at the onset of limb development. Anatomical Record 224, 79-87.[Medline]

Grieshammer, U., Minowada, G., Pisenti, J. M., Abbott, U. K. and Martin, G. R (1996). The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation. Development 122, 3851-3861.[Abstract]

Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A. B. and Joyner, A. L (1995). Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2 [see comments]. Science 269, 679-682.[Abstract/Free Full Text]

Haramis, A. G., Brown, J. M. and Zeller, R (1995). The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5HoxD genes during limb pattern formation. Development 121, 4237-4245.[Abstract]

Johnson, R. L., Riddle, R. D. and Tabin, C. J (1994). Mechanisms of limb patterning. Curr. Opin. Genet. Dev 4, 535-542.[Medline]

Jurand, A (1965). Ultrastructural aspects of early development of the fore-limb buds in the chick and the mouse. Proc. Royal Soc 162, 387-405.

Kelley, R. O. and Fallon, J. F (1983). A freeze-fracture and morphometric analysis of gap junctions of limb bud cells: initial studies on a possible mechanism for morphogenetic signalling during development. Progress in Clinical & Biological Research 110, 119-130.

Laufer, E., Dahn, R., Orozco, O. E., Yeo, C. Y., Pisenti, J., Henrique, D., Abbott, U. K., Fallon, J. F. and Tabin, C (1997). Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation [see comments]. Nature 386, 366-373.[Medline]

Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A. and Tabin, C (1994). Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79, 993-1003.[Medline]

Lindsell, C. E., Shawber, C. J., Boulter, J. and Weinmaster, G (1995). Jagged: a mammalian ligand that activates Notch1. Cell 80, 909-917.[Medline]

Logan, C., Hornbruch, A., Campbell, I. and Lumsden, A (1997). The role of Engrailed in establishing the dorsoventral axis of the chick limb. Development 124, 2317-2324.[Abstract]

Loomis, C. A., Harris, E., Michaud, J., Wurst, W., Hanks, M. and Joyner, A. L (1996). The mouse Engrailed-1 gene and ventral limb patterning. Nature 382, 360-363.[Medline]

Lyons, K. M., Pelton, R. W. and Hogan, B. L (1990). Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development 109, 833-844.[Abstract/Free Full Text]

MacCabe, J. A., Errick, J. and Saunders, J. W., Jr (1974). Ectodermal control of the dorsoventral axis in the leg bud of the chick embryo. Dev. Biol 39, 69-82.[Medline]

Mahmood, R., et al (1995). A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Current Biology 5, 797-806.[Medline]

Martin, G. R (1995). Why thumbs are up. Nature 374, 410-411.[Medline]

Matise, M. P. and Joyner, A. L (1997). Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons. J. Neurosci 17, 7805-7816.[Abstract/Free Full Text]

Meinhardt, H (1983). Cell determination boundaries as organizing regions for secondary embryonic fields. Dev. Biol 96, 375-385.[Medline]

Michaud, J. L., Lapointe, F. and Le Douarin, N. M (1997). The dorsoventral polarity of the presumptive limb is determined by signals produced by the somites and by the lateral somatopleure. Development 124, 1453-1463.[Abstract]

Morasso, M. I., Mahon, K. A. and Sargent, T. D (1995). A Xenopus distal-less gene in transgenic mice: conserved regulation in distal limb epidermis and other sites of epithelial-mesenchymal interaction. Proc. Natl. Acad. Sci. USA 92, 3968-3972.[Abstract/Free Full Text]

Niswander, L (1996). Growth factor interactions in limb development. Ann. N.Y. Acad. Sci 785, 23-26.[Medline]

Niswander, L., Jeffrey, S., Martin, G. R. and Tickle, C (1994). A positive feedback loop coordinates growth and patterning in the vertebrate limb [see comments]. Nature 371, 609-612.[Medline]

Niswander, L. and Martin, G. R (1992). Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development 114, 755-768.[Abstract]

Niswander, L. and Martin, G. R (1993). FGF-4 regulates expression of Evx-1 in the developing mouse limb. Development 119, 287-294.[Abstract]

Niswander, L., Tickle, C., Vogel, A., Booth, I. and Martin, G. R (1993). FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell 75, 579-587.[Medline]

Niswander, L., Tickle, C., Vogel, A. and Martin, G (1994). Function of FGF-4 in limb development. [Review]. Mol. Reprod. Dev 39, 83-88.[Medline]

Noramly, S., Pisenti, J., Abbott, U. and Morgan, B (1996). Gene expression in the limbless mutant: polarized gene expression in the absence of Shh and an AER. Dev. Biol 179, 339-346.[Medline]

Ohuchi, H., Shibusawa, M., Nakagawa, T., Ohata, T., Yoshioka, H., Hirai, Y., Nohno, T., Noji, S. and Kondo, N (1997). A chick wingless mutation causes abnormality in maintenance of Fgf8 expression in the wing apical ridge, resulting in loss of the dorsoventral boundary. Mech. Dev 62, 3-13.[Medline]

Ohuchi, H., Yoshioka, H., Tanaka, A., Kawakami, Y., Nohno, T. and Noji, S (1994). Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesis. Biochem. Biophys. Res. Comm 204, 882-888.[Medline]

Parr, B. A. and McMahon, A. P (1995). Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374, 350-353.[Medline]

Parr, B. A., Shea, M. J., Vassileva, G. and McMahon, A. P (1993). Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development 119, 247-261.[Abstract]

Pautou, M. P. and Kieny, M (1973). Interaction ec-mesodermique dans l'establissement de la polarite dorso-ventrale du pied de l'embryon de poulet. C.r. hebd Seanc. Acad. Sci., Paris_Fb_D277._Fb_Prahlad, K. V., Skala, G., Jones, D. G. and Briles, W. E. (1979). Limbless: a new genetic mutant in the chick. J. Exp. Zool 209, 427-434.

Riddle, R. D., Ensini, M., Nelson, C., Tsuchida, T., Jessell, T. M. and Tabin, C (1995). Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell 83, 631-640.[Medline]

Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.[Medline]

Robinson, G. W. and Mahon, K. A (1994). Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development. Mech. Dev 48, 199-215.[Medline]

Rodriguez-Esteban, C., Schwabe, J. W., De La Pena, J., Foys, B., Eshelman, B. and Belmonte, J. C (1997). Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb [see comments]. Nature 386, 360-366.[Medline]

Ros, M. A., Lopez-Martinez, A., Simandl, B. K., Rodriguez, C., Izpisua Belmonte, J. C., Dahn, R. and Fallon, J. F (1996). The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions. Development 122, 2319-2330.[Abstract]

Saunders, J. W., Jr (1948). The proximo-distal sequence of the origin of the parts of the chick wing and the role of th ectoderm. J. Exp. Zool 108, 363-404.

Sidow, A., et al (1997). Serrate2 is disrupted in the mouse limb-development mutant syndactylism. Nature 389, 722-725.[Medline]

Tanaka, M., Tamura, K., Noji, S., Nohno, T. and Ide, H (1997). Induction of additional limb at the dorsal-ventral boundary of a chick embryo. Dev. Biol 182, 191-203.[Medline]

Tickle, C (1995). Vertebrate limb development. Curr. Opin. Genet. Dev 5, 478-484.[Medline]

Vogel, A., Rodriguez, C. and Izpisua-Belmonte, J. C (1996). Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development 122, 1737-1750.[Abstract]

Vogel, A., Rodriguez, C., Warnken, W. and Izpisua Belmonte, J. C (1995). Dorsal cell fate specified by chick Lmx1 during vertebrate limb development. Nature 378, 716-720.[Medline]

Wanek, N., Muneoka, K., Holler-Dinsmore, G., Burton, R. and Bryant, S. V (1989). A staging system for mouse limb development. J. Exp. Zool 249, 41-49.[Medline]

Wurst, W., Auerbach, A. B. and Joyner, A. L (1994). Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 120, 2065-2075.[Abstract]

Yang, Y. and Niswander, L (1995). Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning. Cell 80, 939-947.[Medline]

Zeller, R. and Duboule, D (1997). Dorso-ventral limb polarity and origin of the ridge: on the fringe of independence?. BioEssays 19, 541-546.[Medline]

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				S. M. Bell, C. M. Schreiner, R. R. Waclaw, K. Campbell, S. S. Potter, and W. J. Scott From the Cover: Sp8 is crucial for limb outgrowth and neuropore closure PNAS, October 14, 2003; 100(21): 12195 - 12200. [Abstract] [Full Text] [PDF]

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				J. R. Barrow, K. R. Thomas, O. Boussadia-Zahui, R. Moore, R. Kemler, M. R. Capecchi, and A. P. McMahon Ectodermal Wnt3/beta -catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge Genes & Dev., February 1, 2003; 17(3): 394 - 409. [Abstract] [Full Text] [PDF]

				A. Marcil, E. Dumontier, M. Chamberland, S. A. Camper, and J. Drouin Pitx1 and Pitx2 are required for development of hindlimb buds Development, January 1, 2003; 130(1): 45 - 55. [Abstract] [Full Text] [PDF]

				K. Ahn, Y. Mishina, M. C. Hanks, R. R. Behringer, and E. B. Crenshaw III BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb Development, November 15, 2001; 128(22): 4449 - 4461. [Abstract] [Full Text] [PDF]

				S. Pizette, C. Abate-Shen, and L. Niswander BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb Development, November 15, 2001; 128(22): 4463 - 4474. [Abstract] [Full Text] [PDF]

				R. A. Kimmel, D. H. Turnbull, V. Blanquet, W. Wurst, C. A. Loomis, and A. L. Joyner Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation Genes & Dev., June 1, 2000; 14(11): 1377 - 1389. [Abstract] [Full Text]

				M. Fernandez-Teran, M. E. Piedra, I. S. Kathiriya, D. Srivastava, J. C. Rodriguez-Rey, and M. A. Ros Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway Development, May 15, 2000; 127(10): 2133 - 2142. [Abstract] [PDF]

				B. L. Maria, R. G. Quisling, L. C. Rosainz, A. T. Yachnis, J. Gitten, D. Dede, and E. Fennell Molar Tooth Sign in Joubert Syndrome: Clinical, Radiologic, and Pathologic Significance J Child Neurol, June 1, 1999; 14(6): 368 - 376. [Abstract] [PDF]

				J. Galceran, I. Fariñas, M. J. Depew, H. Clevers, and R. Grosschedl Wnt3a-/--like phenotype and limb deficiency in Lef1-/-Tcf1-/- mice Genes & Dev., March 15, 1999; 13(6): 709 - 717. [Abstract] [Full Text]

				R. Widelitz, T. Jiang, C. Chen, N. Stott, and C. Chuong Wnt-7a in feather morphogenesis: involvement of anterior-posterior asymmetry and proximal-distal elongation demonstrated with an in vitro reconstitution model Development, January 6, 1999; 126(12): 2577 - 2587. [Abstract] [PDF]

				G. R. Martin The roles of FGFs in the early development of vertebrate�limbs Genes & Dev., June 1, 1998; 12(11): 1571 - 1586. [Full Text]

				M Araujo, M. Piedra, M. Herrera, M. Ros, and M. Nieto The expression and regulation of chick EphA7 suggests roles in limb patterning and innervation Development, January 11, 1998; 125(21): 4195 - 4204. [Abstract] [PDF]

				M. Hanks, C. Loomis, E Harris, C. Tong, L Anson-Cartwright, A Auerbach, and A Joyner Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development Development, January 11, 1998; 125(22): 4521 - 4530. [Abstract] [PDF]

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