Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues

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Abbondanzo, S. J., Gadi, I. and Stewart, C. L (1993). Derivation of embryonic stem cell lines. MethodsEnzymol 225, 803-823.[Medline]

Acampora, D., Mazan, S., Lallemand, Y., Avantaggiato, V., Maury, M., Simeone, A. and Brulet, P (1995). Forebrain and midbrain regions are deleted in Oxt2/ mutants due to a defective anterior neuroectoderm specification during gastrulation. Development 121, 3279-3290.[Abstract]

Adamson, E. D (1982). The location and synthesis of transferrin in mouse embryos and teratocarcinoma cells. Dev. Biol 91, 227-234.[Medline]

Andrade, M. A. and Bork, P (1995). HEAT repeats in the Huntington's disease protein. Nature Genet 11, 115-116.[Medline]

Beck, F (1981). Induced cell injury and cell death as a cause of congenital malformations in rats. Histochem. J 13, 667-679.[Medline]

Beck, F., Erler, T., Russell, A. and James, R (1995). Expression of Cdx-2 in the mouse embryo and placenta: Possible role in patterning of the extraembryonic membranes. Dev. Dyn 204, 219-227.[Medline]

Becker, S., Wang, Z. J., Massey, H., Arauz, A., Labosky, P., Hammerschmidt, M., St-Jacques, B., Bumcrot, D., McMahon, A. and Grabel, L (1997). A role for Indian hedgehog in extraembryonic endoderm differentiation in F9 cells and the early mouse embryo. Dev. Biol 187, 298-310.[Medline]

Beckman, D. A., Lloyd, J. B. and Brent, R. L (1997). Investigations into mechanisms of amino acid supply to the rat embryo using whole-embryo culture. Int. J. Dev. Biol 41, 315-318.[Medline]

Beddington, R. S. P. and Robertson, E. J (1989). An assessment of the developmental potential of embryonic stem cells in the midgestation embryo. Development 105, 733-737.[Abstract/Free Full Text]

Chawengsaksophak, K., James, R., Hammond, V. E., K\232ntgen, F. and Beck, F (1997). Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 386, 84-87.[Medline]

Chen, W.S., Manova, K., Weinstein, D. C., Duncan, S. A., Plump, A. S., Prezioso, V. R., Bachvarova, R. F. and Darnell, J. E (1994). Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev 8, 2466-2477.[Abstract/Free Full Text]

Colomer, V., Engelender, S., Sharp, A. H., Duan, K., Cooper, J. K., Lanahan, A., Lyford, G., Worley, P. and Ross, C. A (1997). Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. Hum. Mol. Genet 6, 1519-1525.[Abstract/Free Full Text]

Coucouvanis, E. and Martin, G. R (1995). Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo. Cell 83, 279-287.[Medline]

Cross, J. C., Werb, Z. and Fisher, S. J (1994). Implantation and the placenta: key pieces of the developmental puzzle. Science 266, 1508-1518.[Abstract/Free Full Text]

Davies, S. W., Turmaine, M., Cozens, B. A., DiFiglia, M., Sharp, A. H., Ross, C. A., Scherzinger, E., Wanker, E. E., Mangiarini, L. and Bates, G. P (1997). Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90, 537-548.[Medline]

De Rooij, K. E., Dorsman, J. C., Smoor, M. A., Dunnen, J. T. D. and Van Ommen, G.-J. B (1996). Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation. Hum. Mol. Genet 5, 1093-1099.[Abstract/Free Full Text]

DiFiglia, M., Sapp, E., Chase, K., Schwarz, C., Meloni, A., Young, C., Martin, E., Vonsattel, J.-P., Carraway, R., Reeves, S. A., Boyce, F. M. and Aronin, N (1995). Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 14, 1075-1081.[Medline]

DiFiglia, M., Sapp, E., Chase, K. O., Davies, S. W., Bates, G. P., Vonsattel, J. P. and Aronin, N (1997). Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990-1993.[Abstract/Free Full Text]

Downs, K. M., Matrin, G. R. and Bishop, J. M (1989). Contrasting patterns of myc and N- myc expression during gastrulation of the mouse embryo. Genes Dev 3, 860-869.[Abstract/Free Full Text]

Drake, B. L. and Head, J. R (1990). Transferrin receptor expression in early postimplantation mouse trophoblast and associated tissues. Placenta 11, 535-547.[Medline]

Duncan, S. A., Manova, K., Chen, W. S., Hoodless, P., Weinstein, D. C., Bachvorova, R. F. and Darnell, J. E (1994). Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc. Natl. Acad. Sci. USA 91, 7598-7602.[Abstract/Free Full Text]

Duncan, S. A., Nagy, A. and Chan, W (1997). Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4/ embryos. Development 124, 279-287.[Abstract]

Duyao, M. P., Auerbach, A. B., Ryan, A., Persichetti, F., Barnes, G. T., McNeil, S. M., Ge, P., Vonsattel, J.-P., Gusella, J. F., Joyner, A. L. and MacDonald, M. E (1995). Inactivation of the mouse Huntington's disease gene homolog Hdh. Science 269, 407-410.[Abstract/Free Full Text]

Dziadek, M. and Adamson, E (1978). Localization and synthesis of alphafoetoprotein in post-implantation mouse embryos. J. Embryol. Exp. Morph 43, 289-313.[Medline]

Dziadek, M. A. and Andrews, G. K (1983). Tissue specificity of alpha-fetoprotein messenger RNA expression during mouse embryogenesis. EMBO J 2, 549-554.[Medline]

Engelender, S., Sharp, A. H., Colomer, V., Tokito, M. K., Lanahan, A., Worley, P., Holzbaur, E. L. F. and Ross, C. A (1997). Huntingtin-associated protein 1 (HAP1) interacts with the p150 Glued subunit of dynactin. Hum. Mol. Genet 6, 2205-2212.[Abstract/Free Full Text]

Friedrich, G. and Soriano, P (1991). Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5, 1513-1523.[Abstract/Free Full Text]

Guillemot, F., Nagy, A., Auerbach, A., Rossant, J. and Joyner, A. L (1994). Essential role of Mash-2 in extraembryonic development. Nature 371, 333-336.[Medline]

Gutekunst, C.-A., Levey, A. I., Heilman, C. J., Whaley, W. L., Yi, H., Nash, N. R., Rees, H. D., Madden, J.J. and Hersch, S. M (1995). Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. Proc. Natl. Acad. Sci. USA 92, 8710-8714.[Abstract/Free Full Text]

Jones, A. L., Wood, J. D. and Harper, P. S (1997). Huntington disease: advances in molecular and cell biology. J. Inher. Metab. Dis 20, 125-138.[Medline]

Kadokawa, Y., Kato, Y. and Eguchi, G (1987). Cell lineage analysis of the primitive and visceral endoderm of mouse embryos cultured in vitro. Cell Differ 21, 69-76.[Medline]

Kalchman, M. A., Koide, H. B., McCutcheon, K., Graham, R. K., Nichol, K., Nishiyama, K., Kazemi-Esfarjani, P., Lynn, F. C., Wellington, C., Metzler, M., et al., (1997). HIP1 , a human homologue of S. cerevisiae Sla2p , interacts with membrane-associated huntingtin in the brain. Nature Genet 16, 44-53.[Medline]

Kuo, C. T., Morrisey, E. E., Anadappa, R., Sigrist, K., Lu, M. M., Parmacek, M. S., Soudais, C. and Leiden, J. M (1997). GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev 11, 1048-1960.[Abstract/Free Full Text]

Larue, L., Ohsugi, M., Hirchenhain, J. and Kempler, R (1994). E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc. Natl. Acad. Sci. USA 91, 8263-8267.[Abstract/Free Full Text]

Li, X.-J., Li, S.-H., Sharp, A. H., Nucifora, F. C., Schilling, G., Lanahan, A., Worley, P., Snyder, S. H. and Ross, C. A (1995). A huntingtin-associated protein enriched in brain with implications for pathology. Nature 378, 398-402.[Medline]

Lin, T. P., Labosky, P. A., Grabel., L. B., Kozak, C. A., Pitman, J. L., Kleeman, J., MacLeod, C. L (1994). The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development. Dev. Biol 166, 170-179.[Medline]

Lloyd, J. B (1990). Cell physiology of the rat visceral yolk sac: a study of pinocytosis and lysosome function. Teratology 41, 383-393.[Medline]

Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., Hetherington, C., Lawton, M., Trottier, Y., Lehrach, H., Davis, S. W. and Bates, G. P (1996). Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87, 493-506.[Medline]

McCann, R. O. and Craig, S. W (1997). The I/LWEQ module: a conserved sequence that signifies F-actin binding in functionally diverse proteins from yeast to mammals. Proc. Natl. Acad. Sci. USA 94, 5679-5684.[Abstract/Free Full Text]

McClatchey, A. I., Saotome, I., Ramesh, V., Gusella, J. F. and Jacks, T (1997). The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes Dev 11, 1253-1265.[Abstract/Free Full Text]

Molkentin, J. D., Lin, Q., Duncan, S. A. and Olson, E. N (1997). Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev 11, 1061-1072.[Abstract/Free Full Text]

Morris, C. M., Candy, J. M., Oakley, A. E., Bloxham, C. A. and Edwardson, J. A (1992). Histochemical distribution of non-haem iron in the human brain. Acta Anat 144, 235-257.[Medline]

Narita, N., Bielinska, M. and Wilson, D. B (1997). Wild-type endoderm abrogates the ventral developmental defects associated with GATA-4 deficiency in the mouse. Dev. Biol 189, 270-274.[Medline]

Nasir, J., Floresco, S. B., O'Kusky, J. R., Diewert, V. M., Richman, J. M., Zeisler, J., Borowski, A., Marth, J. D., Phillips, A. G. and Hayden, M. R (1995). Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell 81, 811-823.[Medline]

Persichetti, F., Ambrose, C. M., Ge, P., McNeil, S. M., Srinidhi, J., Anderson, M. A., Jenkins, B., Barnes, G. T., Duyao, M. P., Kanaley, N., et al., (1995). Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat. Mol. Med 1, 374-383.[Medline]

Pettersson, K., Svensson, K., Mattson, R., Carlsson, B., Ohlsson, R. and Berkenstam, A (1996). Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech. Dev 54, 211-223.[Medline]

Poelmann, R. E (1980). Differential mitosis and degeneration patterns in relation to the alterations in the shape of the embryonic ectoderm of early post-implantation mouse embryos. J. Embryol. Exp. Morph 55, 33-51.[Medline]

Poirier, F., Timmons, P. M., Chan, C. T., Guenet, J. L. and Rigby, P. W (1992). Expression of the L14 lectin during mouse embryogenesis suggests multiple roles during pre-and post-implantation development. Development 115, 143-155.[Abstract]

Reuss, B., Hellmann, P., Traub, O., Butterweck, A. and Winterhager E (1997). Expression of connexin31 and connexin43 genes in early rat embryos. Dev. Genet 21, 82-90.[Medline]

Riethmacher, D., Brinkmann, V. and Birchmeier, C (1995). A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development. Proc. Natl. Acad. Sci. USA 92, 855-859.[Abstract/Free Full Text]

Sapp, E., Schwarz, C., Chase, K., Bhide, P. G., Young, A. B., Penney, J., Vonsattel, J.-P., Aronin, N. and DiFiglia, M (1997). Huntingtin localization in brains of normal and Huntington's disease patients. Ann. Neurol 42, 604-612.[Medline]

Schluter, G (1980). A mechanism of teratogenesis: experiments and ultrastructural investigations on the yolk sac placenta of the mouse. Norm. Pathol. Anat 38, 1-83.[Medline]

Sharp, A. H., Loev, S. J., Schilling, G., Li, S.-H., Li, X.-J., Bao, J., Wagster, M. V., Kotsuk, J. A., Steiner, J. P., Lo, A., et al., (1995). Widespread expression of Huntington's disease gene (IT15) protein product. Neuron 14, 1065-1074.[Medline]

Shi, W.-K. and Heath, J. K (1984). Apolipoprotein expression by murine visceral endoderm. J. Embryol. Exp. Morphol 81, 143-152.[Medline]

Soudais, C., Bielinska, M., Heikinheimo, M., MacArthur, C. A., Narita, N., Saffitz, J. E., Simon, M. C., Leiden, J. M.,and Wilson, D. B (1995). Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development 121, 3877-3888.[Abstract]

Tam, P. P. L. and Beddington, R. S. P (1992). Establishment andorganization of germ layers in the gastrulating mouse embryo. In Postimplanation Development in the Mouse. Ciba Found. Symp 165, 27-49.[Medline]

Taraviras, S., Monaghan, A. P., Schutz, G. and Kelsey, G (1994). Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis. Mech. Dev 48, 67-79.[Medline]

Thomas, P. and Beddington, R (1996). Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo. Curr. Biol 6, 1487-1496.[Medline]

Torres, M., Stoykova, A., Huber, O., Chowdhury, K., Bonaldo, P., Mansouri, A., Butz, S., Kemler, R. and Gruss, P (1997). An -E-catenin gene trap mutation defines its function in preimplantation development. Proc. Natl. Acad. Sci. USA 94, 901-906.[Abstract/Free Full Text]

Tyner, A. L., Godbout, R., Compton, R. S. and Tilghman. S. M (1990). The ontogeny of-fetoprotein gene expression in the mouse gastrointestinal tract. J. Cell Biol 110, 915-927.[Abstract/Free Full Text]

Wanker, E. E., Rovira, C., Scherzinger, E., Hasenbank, R., W\212lter, S., Tait, D., Colicelli, J. and Lehrach, H (1997). HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system. Hum. Mol. Genet 6, 487-495.[Abstract/Free Full Text]

Wellington, C. L. and Hayden, M. R (1997). Of molecular interactions, mice and mechanisms: new insights into Huntington's disease. Curr. Opin. Neurol 10, 291-298.[Medline]

Wood, J. D., MacMillan, J. C., Harper, P. S., Lowenstein, P. R. and Jones, A. L (1996). Partial characterization of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain. Hum. Mol. Genet 5, 481-487.[Abstract/Free Full Text]

Young, D., Klemm, A. R., Beckman, D. A., Brent, R. L. and Lloyd, J. B (1997). Uptake and processing of 59Fe-labelled and 125I-labelled rat transferrin by early organogenesis rat conceptuses in vitro. Placenta 18, 553-562.[Medline]

Zambrowicz, B. P., Imamoto, A., Fiering, S., Herzenberg, L. A., Kerr, W. G. and Soriano, P (1997). Disruption of overlapping transcripts in the ROSAgeo 26 gene trap strain leads to widespread expression of -galactosidase in mouse embryos and hemotopoietic cells. Proc. Natl. Acad. Sci. USA 94, 3789-3794.[Abstract/Free Full Text]

Zeitlin, S., Liu, J.-P., Chapman, D. L., Papaioannou, V. E. and Efstratiadis, A (1995). Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nature Genet 11, 155-163.[Medline]

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Articles by Dragatsis, I.

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				S. V. Bradley, T. S. Hyun, K. I. Oravecz-Wilson, L. Li, E. I. Waldorff, A. N. Ermilov, S. A. Goldstein, C. X. Zhang, D. G. Drubin, K. Varela, et al. Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1 Hum. Mol. Genet., June 1, 2007; 16(11): 1279 - 1292. [Abstract] [Full Text] [PDF]

				A. N.T. Strehlow, J. Z. Li, and R. M. Myers Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space Hum. Mol. Genet., February 15, 2007; 16(4): 391 - 409. [Abstract] [Full Text] [PDF]

				I. Dragatsis, S. Zeitlin, and P. Dietrich Huntingtin-associated protein 1 (Hap1) mutant mice bypassing the early postnatal lethality are neuroanatomically normal and fertile but display growth retardation Hum. Mol. Genet., December 15, 2004; 13(24): 3115 - 3125. [Abstract] [Full Text] [PDF]

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				H. J. Auman, T. Nottoli, O. Lakiza, Q. Winger, S. Donaldson, and T. Williams Transcription factor AP-2{gamma} is essential in the extra-embryonic lineages for early postimplantation development Development, January 6, 2002; 129(11): 2733 - 2747. [Abstract] [Full Text] [PDF]

				D. S. Rao, J. C. Chang, P. D. Kumar, I. Mizukami, G. M. Smithson, S. V. Bradley, A. F. Parlow, and T. S. Ross Huntingtin Interacting Protein 1 Is a Clathrin Coat Binding Protein Required for Differentiation of late Spermatogenic Progenitors Mol. Cell. Biol., November 15, 2001; 21(22): 7796 - 7806. [Abstract] [Full Text] [PDF]

				A. Reiner, N. Del Mar, C. A. Meade, H. Yang, I. Dragatsis, S. Zeitlin, and D. Goldowitz Neurons Lacking Huntingtin Differentially Colonize Brain and Survive in Chimeric Mice J. Neurosci., October 1, 2001; 21(19): 7608 - 7619. [Abstract] [Full Text] [PDF]

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				M. Metzler, C. D. Helgason, I. Dragatsis, T. Zhang, L. Gan, N. Pineault, S. O. Zeitlin, R. K. Humphries, and M. R. Hayden Huntingtin is required for normal hematopoiesis Hum. Mol. Genet., February 12, 2000; 9(3): 387 - 394. [Abstract] [Full Text] [PDF]

				T. Yamashita, R. Wada, T. Sasaki, C. Deng, U. Bierfreund, K. Sandhoff, and R. L. Proia A vital role for glycosphingolipid synthesis during development and differentiation PNAS, August 3, 1999; 96(16): 9142 - 9147. [Abstract] [Full Text] [PDF]

				S. Tanaka, T. Kunath, A. Hadjantonakis, A. Nagy, and J. Rossant Promotion of Trophoblast Stem Cell Proliferation by FGF4 Science, December 11, 1998; 282(5396): 2072 - 2075. [Abstract] [Full Text]