Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer

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Andree, B., Duprez D., Vorbusch B., Arnold H. H. and Brand T (1998). BMP-2 induces ectopic expression of cardiac lineage markers and interferes with somite formation in chicken embryos. Mech. Dev 70, 119-131.[Medline]

Arceci, R. J., King, A. A. J., Simon, M. C., Orkin, S. H. and Wilson, D. B (1993). Mouse GATA-4: A retinoic acid-inducible GATA-binding transcription factor expressed in endodermally-derived tissues and heart. Mol. Cell Biol 13, 2235-2246.[Abstract/Free Full Text]

Azpiazu, N. and Frasch, M (1993). tinman and bagpipe : Two homeobox genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev 7, 1325-1340.[Abstract/Free Full Text]

Biben, C. and Harvey, R. P (1997). Homeodomain factor Nkx2-5 controls left/right asymmetric expression of the bHLH gene eHAND during murine heart development. Genes Dev 11, 1357-1369.[Abstract/Free Full Text]

Biben, C., Hatzistavrou, T. and Harvey, R.P (1998). Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart. Mech. Dev 73, 125-127.[Medline]

Bodmer, R (1993). The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 118, 719-729.[Abstract]

Bodmer, R., Jan, L.Y., and Jan, Y. N (1990). A new homeobox-containing gene, msh-2 , is transiently expressed early during mesoderm formation in Drosophila. Development 110, 661-669.[Abstract/Free Full Text]

Brand, T., Andree, B., Schneider, A., Buchberger, A. and Arnold, H.-H (1997). Chicken Nkx2-8, a novel homeobox gene expressed during early heart and foregut development. Mech. Dev 64, 53-59.[Medline]

Brennan, T. J. and Olson, E. N (1990). Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization. Genes Dev 4, 582-595.[Abstract/Free Full Text]

Buchberger, A., Pabst, O., Brand, T., Seidl, K. and Arnold, H.-H (1996). Chick Nkx2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman : differential expression of cNKx2.3 and cNKx2-5 during heart and gut development. Mech. Dev 56, 151-163.[Medline]

Chen, J.-N. and Fishman, M. C (1996). Zebrafish tinman homologdemarcates the heart field and initiates myocardial differentiation. Development 122, 3809-3816.[Abstract]

Cheng, T. C., Wallace, M. C., Merlie, J. P. and Olson, E. N (1993). Separable regulatory elements governing myogenin transcription during mouse embryogenesis. Science 261, 215-218.[Abstract/Free Full Text]

Cleaver, O. B., Patterson, K. D. and Krieg, P. A (1996). Overexpression of the tinman-related genes XNkx2-5 and XNkx2-3 in Xenopus embryos results in myocardial hyperplasia. Development 122, 3549-3556.[Abstract]

Cserjesi, P., Brown, D., Lyons, G. E. and Olson, E. N (1995). Expression of the novel basic-helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev. Biol 170, 664-678.[Medline]

Durocher, D., Charron, F., Warren, R., Schwartz, R. J. and Nemer, M (1997). The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J 16, 5687-5696.[Medline]

Edmondson, D. G., Lyons, G. E., Martin, J. F. and Olson, E. N (1994). Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development 120, 1251-.[Abstract]

Evans, S. M., Yan, W., Murillo, P. M., Ponce, J. and Papalopulu, N (1995). tinman , a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrtaes: XNkx2.3, a second vertebrate homologue of tinman. Development 121, 3889-3899.[Abstract]

Firulli, A. B. and Olson, E. N (1997). Modular regulation of muscle gene transcription: A mechanism for muscle cell diversity. Trends Genet 13, 364-369.[Medline]

Firulli, A. B., McFadden, D. G., Lin, Q., Srivastava, D. and Olson, E. N (1998). Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand 1. Nat. Gen 18, 266-270.[Medline]

Fishman, M. C. and Chien K. R (1997). Fashioning the vertebrate heart: earliest embryonic decisions. Development 124, 2099-2117.[Abstract]

Fishman, M. C. and Olson, E. N (1997). Parsing the heart: genetic modules for organ assembly. Cell 91, 153-156.[Medline]

Frasch, M (1995). Induction of visceral and cardiac mesoderm by ectopic Dpp in the early Drosophila embryo. Nature 374, 464-467.[Medline]

Franco, D., Kelly, R., Lamers, W. H., Buckingham, M. and Moorman, A. F. M (1997). Regionalized transcriptional domains of myosin light chain 3f transgenes in the embryonic mouse heart: morphogenetic implications. Dev. Biol 188, 17-33.[Medline]

Gajewski, K., Kim, Y., Lee, Y. M., Olson, E. N. and Schulz, R. A (1997). D-Mef2: A target for tinman activation during Drosophila heart development. EMBO J 16, 515-522.[Medline]

Grepin, C., Nemer, G. and Nemer, M (1997). Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. Development 124, 2387-2395.[Abstract]

Harvey, R. P (1996). NK-2 homeobox genes and heart development. Dev. Biol 178, 203-216.[Medline]

Ip, H. S., Wilson, D. B., Heikinheimo, M., Tang, Z., Ting, C. N., Simon, M. C., Leiden, J. M. and Parmacek, M. S (1994). The GATA4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in non-muscle cells. Mol. Cell. Biol 14, 7517-5126.[Abstract/Free Full Text]

Jiang, Y. and Evans T (1996). The Xenopus GATA4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Dev. Biol 174, 258-270.[Medline]

Kasahara, H., Bartunkova, S., Martina, M., Tanaka, M. and Izumo, S (1997). Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein. Circ Res 82, 936-946.

Kelly, R., Alonso, S., Tajbakhsh, S., Cossu, G. and Buckingham, M (1995). Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in transgenic mice. J. Cell Biol 129, 383-396.[Abstract/Free Full Text]

Ko, L. J. and Engel, J. D (1993). DNA-binding specificities of the GATA transcription factor family. Mol. Cell Biol 13, 4011-4022.[Abstract/Free Full Text]

Komuro, I. and Izumo, S (1993). Csx : A murine homeobox-containing gene specifically expressed in the developing heart. Proc. Natl Acad. Sci. USA 90, 8145-8149.[Abstract/Free Full Text]

Kothary, R., Clapoff, S., Darling, S., Perry, M. D., Moran, L. A. and Rossant, J (1989). Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice. Development 105, 707-714.[Abstract/Free Full Text]

Kuisk, I. R. Li, H., Tran, D. and Capetanaki, Y (1996). A single MEF2 sitegoverns desmin transcription in both heart and skeletal muscle during mouse embryogenesis. Dev. Biol 174, 1-13.[Medline]

Kuo, C. T., Morrisey, E. E., Anandappa, R., Sigrist, K., Lu, M. M., Parmacek, M. S., Soudais, C. and Leiden, J. M (1997). GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev 11, 1048-1060.[Abstract/Free Full Text]

Laverriere, A. C., NacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B. E. and Evans, T (1994). GATA-4/5/6: A subfamily of three transcription factors expressed in developing heart and gut. J Biol. Chem 269, 23-.

Lee, K. H, Xu, Q. and Breitbart R. E (1996). A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Dev. Biol 180, 722-731.[Medline]

Lee, Y. M., Park, T., Schulz, R. A. and Kim, Y (1997). Twist-mediated activation of the NK-4 homeobox gene in the visceral mesoderm of Drosophila requires two distinct clusters of E-box regulatory elements. J. Biol. Chem 272, 17531-17541.[Abstract/Free Full Text]

Li, L., Miano, J. M., Mercer B. and Olson, E. N (1996). Expression of the SM22-promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells. J. Cell Biol 132, 849-859.[Abstract/Free Full Text]

Lin, Q., Schwarz, J., Bucana, C. and Olson, E. N (1997). Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276, 1404-1407.[Abstract/Free Full Text]

Lints, T. J., Parsons, L. M., Hartley, L., Lyons, I. and Harvey, R. P (1993). Nkx2-5 : A novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119, 419-431.[Abstract]

Lough, J. M., Barron, M., Brogley, M., Sugi, Y., Bolender, D. L. and Zhu, X. L (1996). Combined BMP-2 and FGF-4, but neither factor alone, induces cardiogenesis in non-precardiac embryonic mesoderm. Dev. Biol 178, 198-202.[Medline]

Lyons, I., Parsons, L. M., Hartley, L., Li, R., Andrews, J. E., Robb, L. and Harvey, R. P (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2-5. Genes Dev 9, 1654-1666.[Abstract/Free Full Text]

Merika, M. and Orkin, S. H (1993). DNA-binding specificity GATA family transcription factors. Mol. Cell Biol 13, 3999-4010.[Abstract/Free Full Text]

Moller, W. and Moller, G (1994). Chemical dehydration for rapid paraffin embedding. Biotechnic & Histochemistry 69, 289-290.[Medline]

Molkentin, J. D., Kalvakolanu, D. V. and Markham, B. E (1994). Transcription factor GATA4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Mol. Cell Biol 14, 4947-4957.[Abstract/Free Full Text]

Molkentin, J. D., Lin, Q., Duncan, S. A. and Olson, E. N (1997). Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev 11, 1061-1072.[Abstract/Free Full Text]

Morrisey, E. E., Ip, H. S., Lu, M. M. and Parmacek, M. S (1996). GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev. Biol 177, 309-322.[Medline]

Morissey, E. E., Ip, H. S., Tang, Z., Lu, M. M. and Parmacek, M. S (1997). GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev. Biol 182, 21-36.[Medline]

Murphy, A. M., Thompson, W. R., Peng, L. F. and Jones, L. 2nd ( (1997). Regulation of the rat cardiac troponin I gene by the transcription factor GATA-4. Biochem. J 322, 393-401.[Medline]

Olson, E. N and Srivastava, D (1996). Molecular pathways controlling heart development. Science 272, 671-676.[Abstract]

Park, M., Wu, X., Golden, K., Axelrod, J. D. and Bodmer, R (1996). The wingless signaling pathway is directly involved in Drosophila heart development. Dev. Biol 177, 104-116.[Medline]

Ranganayakulu, G., Elliott, D., Harvey, R. and Olson, E (1998). Divergent roles for Nk-2 class homeobox genes in cardiogenesis in flies and mice. Development 125, 3037-3048.[Abstract]

Reecy, J.M., Yamada, M., Cummings, K., Sosic, D., Chen, C.Y., Eichle, G., Olson, E. N. and Schwartz, R.J (1997). Chicken Nkx2-8: A novel homeobox gene expressed in early heart progenitor cells and pharyngeal pouch-2 and-3 endoderm. Dev. Biol 188, 295-311.[Medline]

Ross, R. S., Navankasattusas, S., Harvey, R. P. and Chien, K. R (1996). An HF-1a/HF-1b/MEF combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression. Development 122, 1799-1809.[Abstract]

Schultheiss, T. M., Burch, J. B. E. and Lassar, A. B (1996). A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev 11, 451-462.

Schultheiss, T. M., Xydas, S. and Lassar, A. B (1995). Induction of avian cardiac myogenesis by anterior endoderm. Development 121, 4203-4214.[Abstract]

Searcy, R. D., Vincent, E. B., Liberatore, C. M. and Yutzey, K. E (1998). A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice. Development 125, 4461-4470.[Abstract]

Srivastava, D., Cserjesi, P. and Olson, E. N (1995). New subclass of bHLHproteins required for cardiac morphogenesis. Science 270, 1995-1999.[Abstract/Free Full Text]

Staehling-Hampton, K., Laughon, A. and Hoffmann, F (1995). A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signalling. Development 121, 3393-3403.[Abstract]

Sugi, Y., and Lough, J (1995). Activin-A and FGF-2 mimic the inductive effects of anterior endoderm on terminal cardiac myogenesis. in vitro. Dev. Biol 169, 567-574.

Thuerauf, D. J., Hanford, D. S. and Glembotski, C. C (1994). Regulation of rat brain natriuretic peptide transcription. A potential role for GATA-related transcription factors in myocardial cell gene expression. J. Biol. Chem 269, 17772-17775.[Abstract/Free Full Text]

Yin, Z. and Frasch, M (1998). Regulation and function of tinman during dorsal mesoderm induction and heart specification in Drosophila. Dev. Genet 22, 187-200.[Medline]

Yin, Z., Xu, X.-L. and Frasch, M (1997). Regulation of the Twist target gene tinman by modular cis-regulatory elements during early mesoderm development. Development 124, 4871-4982.

Xu, X., Yin, Z., Hudson, J. B., Ferguson, E. L. and Frasch, M (1998). Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev 12, 2354-2370.[Abstract/Free Full Text]

Wu, X., Golden K. and Bodmer R (1995). Heart development in Drosophila requires the segment polarity gene wingless. Dev. Biol 169, 619-628.[Medline]

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Articles by Lien, C. L.

Articles by Olson, E. N.

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				A. Rojas, S. W. Kong, P. Agarwal, B. Gilliss, W. T. Pu, and B. L. Black GATA4 Is a Direct Transcriptional Activator of Cyclin D2 and Cdk4 and Is Required for Cardiomyocyte Proliferation in Anterior Heart Field-Derived Myocardium Mol. Cell. Biol., September 1, 2008; 28(17): 5420 - 5431. [Abstract] [Full Text] [PDF]

				K. Nagao, Y. Taniyama, T. Kietzmann, T. Doi, I. Komuro, and R. Morishita HIF-1{alpha} Signaling Upstream of NKX2.5 Is Required for Cardiac Development in Xenopus J. Biol. Chem., April 25, 2008; 283(17): 11841 - 11849. [Abstract] [Full Text] [PDF]

				P. F. van Loo, E. A. F. Mahtab, L. J. Wisse, J. Hou, F. Grosveld, G. Suske, S. Philipsen, and A. C. Gittenberger-de Groot Transcription Factor Sp3 Knockout Mice Display Serious Cardiac Malformations Mol. Cell. Biol., December 15, 2007; 27(24): 8571 - 8582. [Abstract] [Full Text] [PDF]

				Y. Zhang, N. Rath, S. Hannenhalli, Z. Wang, T. Cappola, S. Kimura, E. Atochina-Vasserman, M. M. Lu, M. F. Beers, and E. E. Morrisey GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo Development, January 1, 2007; 134(1): 189 - 198. [Abstract] [Full Text] [PDF]

				E. E. Creemers, L. B. Sutherland, J. McAnally, J. A. Richardson, and E. N. Olson Myocardin is a direct transcriptional target of Mef2, Tead and Foxo proteins during cardiovascular development Development, November 1, 2006; 133(21): 4245 - 4256. [Abstract] [Full Text] [PDF]

				C. Karamboulas, G. D. Dakubo, J. Liu, Y. De Repentigny, K. Yutzey, V. A. Wallace, R. Kothary, and I. S. Skerjanc Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis J. Cell Sci., October 15, 2006; 119(20): 4315 - 4321. [Abstract] [Full Text] [PDF]

				M. Xin, C. A. Davis, J. D. Molkentin, C.-L. Lien, S. A. Duncan, J. A. Richardson, and E. N. Olson A threshold of GATA4 and GATA6 expression is required for cardiovascular development PNAS, July 25, 2006; 103(30): 11189 - 11194. [Abstract] [Full Text] [PDF]

				X. Chi, P. K. Chatterjee, W. Wilson III, S.-X. Zhang, F. J. DeMayo, and R. J. Schwartz Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modules PNAS, September 20, 2005; 102(38): 13490 - 13495. [Abstract] [Full Text] [PDF]

				A. Rojas, S. De Val, A. B. Heidt, S.-M. Xu, J. Bristow, and B. L. Black Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element Development, August 1, 2005; 132(15): 3405 - 3417. [Abstract] [Full Text] [PDF]

				D. Phan, T. L. Rasmussen, O. Nakagawa, J. McAnally, P. D. Gottlieb, P. W. Tucker, J. A. Richardson, R. Bassel-Duby, and E. N. Olson BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart Development, June 1, 2005; 132(11): 2669 - 2678. [Abstract] [Full Text] [PDF]

				J. K. Takeuchi, M. Mileikovskaia, K. Koshiba-Takeuchi, A. B. Heidt, A. D. Mori, E. P. Arruda, M. Gertsenstein, R. Georges, L. Davidson, R. Mo, et al. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development Development, May 15, 2005; 132(10): 2463 - 2474. [Abstract] [Full Text] [PDF]

				D. G. McFadden, A. C. Barbosa, J. A. Richardson, M. D. Schneider, D. Srivastava, and E. N. Olson The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner Development, January 1, 2005; 132(1): 189 - 201. [Abstract] [Full Text] [PDF]

				I. S. Kathiriya, I. N. King, M. Murakami, M. Nakagawa, J. M. Astle, K. A. Gardner, R. D. Gerard, E. N. Olson, D. Srivastava, and O. Nakagawa Hairy-related Transcription Factors Inhibit GATA-dependent Cardiac Gene Expression through a Signal-responsive Mechanism J. Biol. Chem., December 24, 2004; 279(52): 54937 - 54943. [Abstract] [Full Text] [PDF]

				J. Oh, Z. Wang, D.-Z. Wang, C.-L. Lien, W. Xing, and E. N. Olson Target Gene-Specific Modulation of Myocardin Activity by GATA Transcription Factors Mol. Cell. Biol., October 1, 2004; 24(19): 8519 - 8528. [Abstract] [Full Text] [PDF]

				K.-H. Lee, S. Evans, T. Y. Ruan, and A. B. Lassar SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer Development, October 1, 2004; 131(19): 4709 - 4723. [Abstract] [Full Text] [PDF]

				E. Dodou, M. P. Verzi, J. P. Anderson, S.-M. Xu, and B. L. Black Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development Development, August 15, 2004; 131(16): 3931 - 3942. [Abstract] [Full Text] [PDF]

				S. Pikkarainen, H. Tokola, R. Kerkela, and H. Ruskoaho GATA transcription factors in the developing and adult heart Cardiovasc Res, August 1, 2004; 63(2): 196 - 207. [Abstract] [Full Text] [PDF]

				C. O. Brown III, X. Chi, E. Garcia-Gras, M. Shirai, X.-H. Feng, and R. J. Schwartz The Cardiac Determination Factor, Nkx2-5, Is Activated by Mutual Cofactors GATA-4 and Smad1/4 via a Novel Upstream Enhancer J. Biol. Chem., March 12, 2004; 279(11): 10659 - 10669. [Abstract] [Full Text] [PDF]

				E. N. Olson and M. D. Schneider Sizing up the heart: development redux in disease Genes & Dev., August 15, 2003; 17(16): 1937 - 1956. [Full Text] [PDF]

				P. E.M.H. Habets, A. F.M. Moorman, and V. M. Christoffels Regulatory modules in the developing heart Cardiovasc Res, May 1, 2003; 58(2): 246 - 263. [Abstract] [Full Text] [PDF]

				M. J. Solloway and R. P. Harvey Molecular pathways in myocardial development: a stem cell perspective Cardiovasc Res, May 1, 2003; 58(2): 264 - 277. [Abstract] [Full Text] [PDF]

				I. I. Rybkin, D. W. Markham, Z. Yan, R. Bassel-Duby, R. S. Williams, and E. N. Olson Conditional Expression of SV40 T-antigen in Mouse Cardiomyocytes Facilitates an Inducible Switch from Proliferation to Differentiation J. Biol. Chem., April 25, 2003; 278(18): 15927 - 15934. [Abstract] [Full Text] [PDF]

				M. L. Clabby, T. A. Robison, H. F. Quigley, D. B. Wilson, and D. P. Kelly Retinoid X Receptor alpha Represses GATA-4-mediated Transcription via a Retinoid-dependent Interaction with the Cardiac-enriched Repressor FOG-2 J. Biol. Chem., February 14, 2003; 278(8): 5760 - 5767. [Abstract] [Full Text] [PDF]

				S. Zaffran and M. Frasch Early Signals in Cardiac Development Circ. Res., September 20, 2002; 91(6): 457 - 469. [Abstract] [Full Text] [PDF]

				N. Bodyak, P. M. Kang, M. Hiromura, I. Sulijoadikusumo, N. Horikoshi, K. Khrapko, and A. Usheva Gene expression profiling of the aging mouse cardiac myocytes Nucleic Acids Res., September 1, 2002; 30(17): 3788 - 3794. [Abstract] [Full Text] [PDF]

				Y.-S. Dai, P. Cserjesi, B. E. Markham, and J. D. Molkentin The Transcription Factors GATA4 and dHAND Physically Interact to Synergistically Activate Cardiac Gene Expression through a p300-dependent Mechanism J. Biol. Chem., June 28, 2002; 277(27): 24390 - 24398. [Abstract] [Full Text] [PDF]

				D.-Z. Wang, M. R. Valdez, J. McAnally, J. Richardson, and E. N. Olson The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development Development, November 15, 2001; 128(22): 4623 - 4633. [Abstract] [Full Text] [PDF]

				M. Jamali, P. J. Rogerson, S. Wilton, and I. S. Skerjanc Nkx2-5 Activity Is Essential for Cardiomyogenesis J. Biol. Chem., November 2, 2001; 276(45): 42252 - 42258. [Abstract] [Full Text] [PDF]

				Y. Kong, J. M. Shelton, B. Rothermel, X. Li, J. A. Richardson, R. Bassel-Duby, and R. S. Williams Cardiac-Specific LIM Protein FHL2 Modifies the Hypertrophic Response to {beta}-Adrenergic Stimulation Circulation, June 5, 2001; 103(22): 2731 - 2738. [Abstract] [Full Text] [PDF]

				S. Bekri, G. Kispal, H. Lange, E. Fitzsimons, J. Tolmie, R. Lill, and D. F. Bishop Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation Blood, November 1, 2000; 96(9): 3256 - 3264. [Abstract] [Full Text] [PDF]