Eph receptors and ephrins: effectors of morphogenesis

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A Genome-Wide Screen Reveals Functional Gene Clusters in the Cancer Genome and Identifies EphA2 as a Mitogen in Glioblastoma
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[Abstract] [Full Text] [PDF]

U. K. Sinha, K. Mazhar, S. B. Chinn, V. K. Dhillon, L. Liu, R. Masood, D. H. Rice, and P. S. Gill
The Association Between Elevated EphB4 Expression, Smoking Status, and Advanced-Stage Disease in Patients With Head and Neck Squamous Cell Carcinoma.
Arch Otolaryngol Head Neck Surg, October 1, 2006; 132(10): 1053 - 1059.
[Abstract] [Full Text] [PDF]

H. Guo, H. Miao, L. Gerber, J. Singh, M. F. Denning, A. C. Gilliam, and B. Wang
Disruption of EphA2 Receptor Tyrosine Kinase Leads to Increased Susceptibility to Carcinogenesis in Mouse Skin.
Cancer Res., July 15, 2006; 66(14): 7050 - 7058.
[Abstract] [Full Text] [PDF]

S. R. Kumar, J. Singh, G. Xia, V. Krasnoperov, L. Hassanieh, E. J. Ley, J. Scehnet, N. G. Kumar, D. Hawes, M. F. Press, et al.
Receptor Tyrosine Kinase EphB4 Is a Survival Factor in Breast Cancer
Am. J. Pathol., July 1, 2006; 169(1): 279 - 293.
[Abstract] [Full Text] [PDF]

M. Takano-Maruyama, K. Hase, H. Fukamachi, Y. Kato, H. Koseki, and H. Ohno
Foxl1-deficient mice exhibit aberrant epithelial cell positioning resulting from dysregulated EphB/EphrinB expression in the small intestine
Am J Physiol Gastrointest Liver Physiol, July 1, 2006; 291(1): G163 - G170.
[Abstract] [Full Text] [PDF]

S. Abraham, D. W. Knapp, L. Cheng, P. W. Snyder, S. K. Mittal, D. S. Bangari, M. Kinch, L. Wu, J. Dhariwal, and S. I. Mohammed
Expression of EphA2 and Ephrin A-1 in Carcinoma of the Urinary Bladder
Clin. Cancer Res., January 15, 2006; 12(2): 353 - 360.
[Abstract] [Full Text] [PDF]

M. Parri, F. Buricchi, M. L. Taddei, E. Giannoni, G. Raugei, G. Ramponi, and P. Chiarugi
EphrinA1 Repulsive Response Is Regulated by an EphA2 Tyrosine Phosphatase
J. Biol. Chem., October 7, 2005; 280(40): 34008 - 34018.
[Abstract] [Full Text] [PDF]

H. Matsuoka, H. Obama, M. L. Kelly, T. Matsui, and M. Nakamoto
Biphasic Functions of the Kinase-defective Ephb6 Receptor in Cell Adhesion and Migration
J. Biol. Chem., August 12, 2005; 280(32): 29355 - 29363.
[Abstract] [Full Text] [PDF]

G. Xia, S. R. Kumar, R. Masood, M. Koss, C. Templeman, D. Quinn, S. Zhu, R. Reddy, V. Krasnoperov, and P. S. Gill
Up-Regulation of EphB4 in Mesothelioma and Its Biological Significance
Clin. Cancer Res., June 15, 2005; 11(12): 4305 - 4315.
[Abstract] [Full Text] [PDF]

G. Xia, S. R. Kumar, R. Masood, S. Zhu, R. Reddy, V. Krasnoperov, D. I. Quinn, S. M. Henshall, R. L. Sutherland, J. K. Pinski, et al.
EphB4 Expression and Biological Significance in Prostate Cancer
Cancer Res., June 1, 2005; 65(11): 4623 - 4632.
[Abstract] [Full Text] [PDF]

X. Ran and J. Song
Structural Insight into the Binding Diversity between the Tyr-phosphorylated Human EphrinBs and Nck2 SH2 Domain
J. Biol. Chem., May 13, 2005; 280(19): 19205 - 19212.
[Abstract] [Full Text] [PDF]

H.-C. Aasheim, J. Delabie, and E. F. Finne
Ephrin-A1 binding to CD4+ T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2
Blood, April 1, 2005; 105(7): 2869 - 2876.
[Abstract] [Full Text] [PDF]

S. R. F. Twigg, R. Kan, C. Babbs, E. G. Bochukova, S. P. Robertson, S. A. Wall, G. M. Morriss-Kay, and A. O. M. Wilkie
Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome
PNAS, June 8, 2004; 101(23): 8652 - 8657.
[Abstract] [Full Text] [PDF]

B. R. Shepherd, H. Y.S. Chen, C. M. Smith, G. Gruionu, S. K. Williams, and J. B. Hoying
Rapid Perfusion and Network Remodeling in a Microvascular Construct After Implantation
Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 898 - 904.
[Abstract] [Full Text]

B. Fuss, F. Josten, M. Feix, and M. Hoch
Cell movements controlled by the Notch signalling cascade during foregut development in Drosophila
Development, April 1, 2004; 131(7): 1587 - 1595.
[Abstract] [Full Text] [PDF]

S. H. Wimmer-Kleikamp, P. W. Janes, A. Squire, P. I.H. Bastiaens, and M. Lackmann
Recruitment of Eph receptors into signaling clusters does not require ephrin contact
J. Cell Biol., March 1, 2004; 164(5): 661 - 666.
[Abstract] [Full Text] [PDF]

W. Mao, E. Luis, S. Ross, J. Silva, C. Tan, C. Crowley, C. Chui, G. Franz, P. Senter, H. Koeppen, et al.
EphB2 as a Therapeutic Antibody Drug Target for the Treatment of Colorectal Cancer
Cancer Res., February 1, 2004; 64(3): 781 - 788.
[Abstract] [Full Text] [PDF]

J. G. Wohlfahrt, C. Karagiannidis, S. Kunzmann, M. M. Epstein, W. Kempf, K. Blaser, and C. B. Schmidt-Weber
Ephrin-A1 Suppresses Th2 Cell Activation and Provides a Regulatory Link to Lung Epithelial Cells
J. Immunol., January 15, 2004; 172(2): 843 - 850.
[Abstract] [Full Text] [PDF]

M. Kaneko and A. Nighorn
Interaxonal Eph-Ephrin Signaling May Mediate Sorting of Olfactory Sensory Axons in Manduca sexta
J. Neurosci., December 17, 2003; 23(37): 11523 - 11538.
[Abstract] [Full Text] [PDF]

P. M. S. Alves, O. Faure, S. Graff-Dubois, D.-A. Gross, S. Cornet, S. Chouaib, I. Miconnet, F. A. Lemonnier, and K. Kosmatopoulos
EphA2 as Target of Anticancer Immunotherapy: Identification of HLA-A*0201-Restricted Epitopes
Cancer Res., December 1, 2003; 63(23): 8476 - 8480.
[Abstract] [Full Text] [PDF]

A. P. SOMLYO and A. V. SOMLYO
Ca2+ Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase
Physiol Rev, October 1, 2003; 83(4): 1325 - 1358.
[Abstract] [Full Text] [PDF]

H. Miao, C. H. Nickel, L. G. Cantley, L. A. Bruggeman, L. N. Bennardo, and B. Wang
EphA kinase activation regulates HGF-induced epithelial branching morphogenesis
J. Cell Biol., September 29, 2003; 162(7): 1281 - 1292.
[Abstract] [Full Text] [PDF]

M. Egawa, S. Yoshioka, T. Higuchi, Y. Sato, K. Tatsumi, H. Fujiwara, and S. Fujii
Ephrin B1 Is Expressed on Human Luteinizing Granulosa Cells in Corpora Lutea of the Early Luteal Phase: The Possible Involvement of the B Class Eph-Ephrin System during Corpus Luteum Formation
J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4384 - 4392.
[Abstract] [Full Text] [PDF]

J. Song
Tyrosine Phosphorylation of the Well Packed EphrinB Cytoplasmic {beta}-Hairpin for Reverse Signaling: STRUCTURAL CONSEQUENCES AND BINDING PROPERTIES
J. Biol. Chem., June 27, 2003; 278(27): 24714 - 24720.
[Abstract] [Full Text] [PDF]

D. W. Houston and C. Wylie
The Xenopus LIM-homeodomain protein Xlim5 regulates the differential adhesion properties of early ectoderm cells
Development, June 15, 2003; 130(12): 2695 - 2704.
[Abstract] [Full Text] [PDF]

A. Palmer and R. Klein
Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function
Genes & Dev., June 15, 2003; 17(12): 1429 - 1450.
[Full Text] [PDF]

C. R. COFFMAN
Cell Migration and Programmed Cell Death of Drosophila Germ Cells
Ann. N.Y. Acad. Sci., May 1, 2003; 995(1): 117 - 126.
[Abstract] [Full Text] [PDF]

C. Deroanne, V. Vouret-Craviari, B. Wang, and J. Pouyssegur
EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway
J. Cell Sci., April 1, 2003; 116(7): 1367 - 1376.
[Abstract] [Full Text] [PDF]

A. Sakakibara, Y. Ohba, K. Kurokawa, M. Matsuda, and S. Hattori
Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation
J. Cell Sci., March 14, 2003; 115(24): 4915 - 4924.
[Abstract] [Full Text] [PDF]

T. Bossing and A. H. Brand
Dephrin, a transmembrane ephrin with a unique structure, prevents interneuronal axons from exiting the Drosophila embryonic CNS
Development, March 11, 2003; 129(18): 4205 - 4218.
[Abstract] [Full Text] [PDF]

J. Ghislain, C. Desmarquet-Trin-Dinh, P. Gilardi-Hebenstreit, P. Charnay, and M. Frain
Neural crest patterning: autoregulatory and crest-specific elements co-operate for Krox20 transcriptional control
Development, March 1, 2003; 130(5): 941 - 953.
[Abstract] [Full Text] [PDF]

A. Sakakibara, S. Hattori, S. Nakamura, and T. Katagiri
A Novel Hematopoietic Adaptor Protein, Chat-H, Positively Regulates T Cell Receptor-mediated Interleukin-2 Production by Jurkat Cells
J. Biol. Chem., February 14, 2003; 278(8): 6012 - 6017.
[Abstract] [Full Text] [PDF]

G. Berclaz, E. Karamitopoulou, L. Mazzucchelli, V. Rohrbach, E. Dreher, A. Ziemiecki, and A.-C. Andres
Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma
Ann. Onc., February 1, 2003; 14(2): 220 - 226.
[Abstract] [Full Text] [PDF]

K. Hamada, Y. Oike, Y. Ito, H. Maekawa, K. Miyata, T. Shimomura, and T. Suda
Distinct Roles of Ephrin-B2 Forward and EphB4 Reverse Signaling in Endothelial Cells
Arterioscler. Thromb. Vasc. Biol., February 1, 2003; 23(2): 190 - 197.
[Abstract] [Full Text] [PDF]

H. Fujiwara, S. Yoshioka, K. Tatsumi, K. Kosaka, Y. Satoh, Y. Nishioka, M. Egawa, T. Higuchi, and S. Fujii
Human Endometrial Epithelial Cells Express Ephrin A1: Possible Interaction between Human Blastocysts and Endometrium via Eph-Ephrin System
J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5801 - 5807.
[Abstract] [Full Text] [PDF]

K.-I. Nagashima, A. Endo, H. Ogita, A. Kawana, A. Yamagishi, A. Kitabatake, M. Matsuda, and N. Mochizuki
Adaptor Protein Crk Is Required for Ephrin-B1-induced Membrane Ruffling and Focal Complex Assembly of Human Aortic Endothelial Cells
Mol. Biol. Cell, December 1, 2002; 13(12): 4231 - 4242.
[Abstract] [Full Text] [PDF]

N. Cheng, D. M. Brantley, H. Liu, Q. Lin, M. Enriquez, N. Gale, G. Yancopoulos, D. P. Cerretti, T. O. Daniel, and J. Chen
Blockade of EphA Receptor Tyrosine Kinase Activation Inhibits Vascular Endothelial Cell Growth Factor-Induced Angiogenesis
Mol. Cancer Res.,

				R Holm, S Knopp, Z Suo, C Trope, and J M Nesland Expression of EphA2 and EphrinA-1 in vulvar carcinomas and its relation to prognosis J. Clin. Pathol., October 1, 2007; 60(10): 1086 - 1091. [Abstract] [Full Text] [PDF]

				E. C. Bolton, A. Y. So, C. Chaivorapol, C. M. Haqq, H. Li, and K. R. Yamamoto Cell- and gene-specific regulation of primary target genes by the androgen receptor Genes & Dev., August 15, 2007; 21(16): 2005 - 2017. [Abstract] [Full Text] [PDF]

				S. Alam, J Fujimoto, I Jahan, E Sato, and T Tamaya Overexpression of ephrinB2 and EphB4 in tumor advancement of uterine endometrial cancers Ann. Onc., March 1, 2007; 18(3): 485 - 490. [Abstract] [Full Text] [PDF]

				F. Liu, P. J. Park, W. Lai, E. Maher, A. Chakravarti, L. Durso, X. Jiang, Y. Yu, A. Brosius, M. Thomas, et al. A Genome-Wide Screen Reveals Functional Gene Clusters in the Cancer Genome and Identifies EphA2 as a Mitogen in Glioblastoma Cancer Res., November 15, 2006; 66(22): 10815 - 10823. [Abstract] [Full Text] [PDF]

				U. K. Sinha, K. Mazhar, S. B. Chinn, V. K. Dhillon, L. Liu, R. Masood, D. H. Rice, and P. S. Gill The Association Between Elevated EphB4 Expression, Smoking Status, and Advanced-Stage Disease in Patients With Head and Neck Squamous Cell Carcinoma. Arch Otolaryngol Head Neck Surg, October 1, 2006; 132(10): 1053 - 1059. [Abstract] [Full Text] [PDF]

				H. Guo, H. Miao, L. Gerber, J. Singh, M. F. Denning, A. C. Gilliam, and B. Wang Disruption of EphA2 Receptor Tyrosine Kinase Leads to Increased Susceptibility to Carcinogenesis in Mouse Skin. Cancer Res., July 15, 2006; 66(14): 7050 - 7058. [Abstract] [Full Text] [PDF]

				S. R. Kumar, J. Singh, G. Xia, V. Krasnoperov, L. Hassanieh, E. J. Ley, J. Scehnet, N. G. Kumar, D. Hawes, M. F. Press, et al. Receptor Tyrosine Kinase EphB4 Is a Survival Factor in Breast Cancer Am. J. Pathol., July 1, 2006; 169(1): 279 - 293. [Abstract] [Full Text] [PDF]

				M. Takano-Maruyama, K. Hase, H. Fukamachi, Y. Kato, H. Koseki, and H. Ohno Foxl1-deficient mice exhibit aberrant epithelial cell positioning resulting from dysregulated EphB/EphrinB expression in the small intestine Am J Physiol Gastrointest Liver Physiol, July 1, 2006; 291(1): G163 - G170. [Abstract] [Full Text] [PDF]

				S. Abraham, D. W. Knapp, L. Cheng, P. W. Snyder, S. K. Mittal, D. S. Bangari, M. Kinch, L. Wu, J. Dhariwal, and S. I. Mohammed Expression of EphA2 and Ephrin A-1 in Carcinoma of the Urinary Bladder Clin. Cancer Res., January 15, 2006; 12(2): 353 - 360. [Abstract] [Full Text] [PDF]

				M. Parri, F. Buricchi, M. L. Taddei, E. Giannoni, G. Raugei, G. Ramponi, and P. Chiarugi EphrinA1 Repulsive Response Is Regulated by an EphA2 Tyrosine Phosphatase J. Biol. Chem., October 7, 2005; 280(40): 34008 - 34018. [Abstract] [Full Text] [PDF]

				H. Matsuoka, H. Obama, M. L. Kelly, T. Matsui, and M. Nakamoto Biphasic Functions of the Kinase-defective Ephb6 Receptor in Cell Adhesion and Migration J. Biol. Chem., August 12, 2005; 280(32): 29355 - 29363. [Abstract] [Full Text] [PDF]

				G. Xia, S. R. Kumar, R. Masood, M. Koss, C. Templeman, D. Quinn, S. Zhu, R. Reddy, V. Krasnoperov, and P. S. Gill Up-Regulation of EphB4 in Mesothelioma and Its Biological Significance Clin. Cancer Res., June 15, 2005; 11(12): 4305 - 4315. [Abstract] [Full Text] [PDF]

				G. Xia, S. R. Kumar, R. Masood, S. Zhu, R. Reddy, V. Krasnoperov, D. I. Quinn, S. M. Henshall, R. L. Sutherland, J. K. Pinski, et al. EphB4 Expression and Biological Significance in Prostate Cancer Cancer Res., June 1, 2005; 65(11): 4623 - 4632. [Abstract] [Full Text] [PDF]

				X. Ran and J. Song Structural Insight into the Binding Diversity between the Tyr-phosphorylated Human EphrinBs and Nck2 SH2 Domain J. Biol. Chem., May 13, 2005; 280(19): 19205 - 19212. [Abstract] [Full Text] [PDF]

				H.-C. Aasheim, J. Delabie, and E. F. Finne Ephrin-A1 binding to CD4+ T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2 Blood, April 1, 2005; 105(7): 2869 - 2876. [Abstract] [Full Text] [PDF]

				S. R. F. Twigg, R. Kan, C. Babbs, E. G. Bochukova, S. P. Robertson, S. A. Wall, G. M. Morriss-Kay, and A. O. M. Wilkie Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome PNAS, June 8, 2004; 101(23): 8652 - 8657. [Abstract] [Full Text] [PDF]

				B. R. Shepherd, H. Y.S. Chen, C. M. Smith, G. Gruionu, S. K. Williams, and J. B. Hoying Rapid Perfusion and Network Remodeling in a Microvascular Construct After Implantation Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 898 - 904. [Abstract] [Full Text]

				B. Fuss, F. Josten, M. Feix, and M. Hoch Cell movements controlled by the Notch signalling cascade during foregut development in Drosophila Development, April 1, 2004; 131(7): 1587 - 1595. [Abstract] [Full Text] [PDF]

				S. H. Wimmer-Kleikamp, P. W. Janes, A. Squire, P. I.H. Bastiaens, and M. Lackmann Recruitment of Eph receptors into signaling clusters does not require ephrin contact J. Cell Biol., March 1, 2004; 164(5): 661 - 666. [Abstract] [Full Text] [PDF]

				W. Mao, E. Luis, S. Ross, J. Silva, C. Tan, C. Crowley, C. Chui, G. Franz, P. Senter, H. Koeppen, et al. EphB2 as a Therapeutic Antibody Drug Target for the Treatment of Colorectal Cancer Cancer Res., February 1, 2004; 64(3): 781 - 788. [Abstract] [Full Text] [PDF]

				J. G. Wohlfahrt, C. Karagiannidis, S. Kunzmann, M. M. Epstein, W. Kempf, K. Blaser, and C. B. Schmidt-Weber Ephrin-A1 Suppresses Th2 Cell Activation and Provides a Regulatory Link to Lung Epithelial Cells J. Immunol., January 15, 2004; 172(2): 843 - 850. [Abstract] [Full Text] [PDF]

				M. Kaneko and A. Nighorn Interaxonal Eph-Ephrin Signaling May Mediate Sorting of Olfactory Sensory Axons in Manduca sexta J. Neurosci., December 17, 2003; 23(37): 11523 - 11538. [Abstract] [Full Text] [PDF]

				P. M. S. Alves, O. Faure, S. Graff-Dubois, D.-A. Gross, S. Cornet, S. Chouaib, I. Miconnet, F. A. Lemonnier, and K. Kosmatopoulos *EphA2 as Target of Anticancer Immunotherapy: Identification of HLA-A0201-Restricted Epitopes** Cancer Res., December 1, 2003; 63(23): 8476 - 8480. [Abstract] [Full Text] [PDF]

				A. P. SOMLYO and A. V. SOMLYO Ca2+ Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase Physiol Rev, October 1, 2003; 83(4): 1325 - 1358. [Abstract] [Full Text] [PDF]

				H. Miao, C. H. Nickel, L. G. Cantley, L. A. Bruggeman, L. N. Bennardo, and B. Wang EphA kinase activation regulates HGF-induced epithelial branching morphogenesis J. Cell Biol., September 29, 2003; 162(7): 1281 - 1292. [Abstract] [Full Text] [PDF]

				M. Egawa, S. Yoshioka, T. Higuchi, Y. Sato, K. Tatsumi, H. Fujiwara, and S. Fujii Ephrin B1 Is Expressed on Human Luteinizing Granulosa Cells in Corpora Lutea of the Early Luteal Phase: The Possible Involvement of the B Class Eph-Ephrin System during Corpus Luteum Formation J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4384 - 4392. [Abstract] [Full Text] [PDF]

				J. Song Tyrosine Phosphorylation of the Well Packed EphrinB Cytoplasmic {beta}-Hairpin for Reverse Signaling: STRUCTURAL CONSEQUENCES AND BINDING PROPERTIES J. Biol. Chem., June 27, 2003; 278(27): 24714 - 24720. [Abstract] [Full Text] [PDF]

				D. W. Houston and C. Wylie The Xenopus LIM-homeodomain protein Xlim5 regulates the differential adhesion properties of early ectoderm cells Development, June 15, 2003; 130(12): 2695 - 2704. [Abstract] [Full Text] [PDF]

				A. Palmer and R. Klein Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function Genes & Dev., June 15, 2003; 17(12): 1429 - 1450. [Full Text] [PDF]

				C. R. COFFMAN Cell Migration and Programmed Cell Death of Drosophila Germ Cells Ann. N.Y. Acad. Sci., May 1, 2003; 995(1): 117 - 126. [Abstract] [Full Text] [PDF]