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Alexandre, C., Jacinto, A. and Ingham, P. W (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev 10, 2003-2013.[Abstract/Free Full Text]

Aza-Blanc, P., Ramirezweber, F., Laget, M., Schwartz, C. and Kornberg, T (1997). Proteolysis that is inhibited by hedgehog targets cubitus-interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.[Medline]

Belloni, E., Muenke, M., Roessler, E., Traverso, G., Siegel-Bartelt, J., Frumkin, A., Mitchell, H., Donis-Keller, H., Helms, C., Hing, A. et al (1996). Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat. Genet 14, 353-356.[Medline]

Borycki, A.-G., Mendhma, L. and Emerson, C. P (1998). Control of somitepatterning by sonic hedgehog and its downstream signal response genes. Development 125, 777-790.[Abstract]

Buscher, D., Bosse, B., Heymer, J. and Ruther, U (1997). Evidence for genetic control of sonic hedgehog by gli3 in mouse limb development. Mech. Dev 62, 175-182.[Medline]

Buscher, D. and Ruther, U (1998). Expression profile of gli family members and shh in normal and mutant mouse limb development. Dev. Dynam 211, 88-96.[Medline]

Capdevila, J., Estrada, M. P., Sanchez-Herrero, E. and Guerrero, I (1994). The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J 13, 71-82.[Medline]

Chan, S. C., Laufer, E., Tabin, C. and Leder, P (1995). Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity. Development 121, 1971-1978.[Abstract]

Chen, Y. and Struhl, G (1996). Dual roles for Patched in sequestering and transducing Hedgehog. Cell 87, 553-563.[Medline]

Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A (1996). Cyclopia and defective axial patterning in mice lacking Sonic Hedgehog gene function. Nature 383, 407-413.[Medline]

Cohn, M. J., Izpisua-Belmonte, J. C., Abud, H., Heath, J. K. and Tickle, C (1995). Fibroblast growth-factors induce additional limb development from the flank of chick-embryos. Cell 80, 739-746.[Medline]

Cohn, M. J. and Tickle, C (1996). Limbs: a model for pattern formation within the vertebrate body plan. Trends in Genetics 12, 253-257.[Medline]

Concordet, J.-P., Lewis, K., Moore, J., Goodrich, L. V., Johnson, R. L., Scott, M. P. and Ingham, P. W (1996). Spatial regulation of a Zebrafish patched Homologue reflects the roles of sonic hedgehog and Protein Kinase A in neural tube and somite patterning. Development 122, 2835-2846.[Abstract]

Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J. and Hui, C.-C (1998). Diminished Sonic hedgehog signalling and lack of floor plate differentiation in Gli2 mutant mice. Development 125, 2533-2543.[Abstract]

Dominguez, M., Brunner, M., Hafen, E. and Basler, K (1996). Sending and receiving the hedgehog signal \320 control by the Drosophila gli protein cubitus-interruptus. Science 272, 1621-1625.[Abstract]

Ede, D. A. and Kelly, W. A (1964). Developmental abnormalities in the head region of the talpid 3mutant of the fowl. J. Embryol. Exp. Morph 12, 161-182.[Medline]

Ede, D. A. and Kelly, W. A (1964). Developmental abnormalities in the trunk and limbs of the talpid 3 mutant of the fowl. J. Embryol. Exp. Morph 12, 339-356.[Medline]

Forbes, A. J., Nakano, Y., Taylor, A. M. and Ingham, P. W (1993). Genetic analysis of hedgehog signalling in the Drosophila embryo. Development 1993, 115-124.

Francis, P. H., Richardson, M. K., Brickell, P. M. and Tickle, C (1994). Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb. Development 120, 209-218.[Abstract]

Francis-West, P. H., Robertson, K. E., Ede, D. A., Rodriguez, C., Izpisua-Belmonte, J. C., Houston, B., Burt, D. W., Gribbin, C., Brickell, P. M. and Tickle, C (1995). Expression of genes encoding Bone Morphogenetic Proteins and Sonic Hedgehog in Talpid limb buds: their relationships in the signalling cascade involved in limb patterning. Dev. Dynam 203, 187-197.[Medline]

Goodrich, L., Milenkovic, L., Higgins, K. and Scott, M (1997). Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 22, 1109-1113.

Goodrich, L. V., Johnson, R. L., Milenkovic, L., McMahon, J. A. and Scott, M. P (1996). Conservation of the hedgehog/patched signalling pathway from flies to mice \320 induction of a mouse patched gene by hedgehog. Genes Dev 10, 301-312.[Abstract/Free Full Text]

Hahn, H., Wicking, C., Zaphiropoulos, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vorechovsky, I., Holmberg, E., Unden, A. B., Gillies, S. et al (1996). Mutations of the human homolog of Drosophila patched in the nevoid basal-cell carcinoma syndrome. Cell 85, 841-851.[Medline]

Hamburger, V. and Hamilton, H (1951). A series of normal stages in the development of the chick embryo. J. Morph 88, 49-92.

Hammerschmidt, M., Brook, A. and McMahon, A (1997). The world according to hedgehog. Trends Genetics 13, 14-21.[Medline]

Hardy, A., Richardson, M. K., Francis-West, P. H., Rodriguez, C., Izpisua-Belmote, J.-C., Duprez, D. and Wolpert, L (1995). Gene expression, polarising activity and skeletal patterning in reaggregated hind limb mesenchyme. Development 121, 4329-4337.[Abstract]

Hayes, C., Brown, J. M., Lyon, M. F. and Morriss-Kay, G. M (1998). Sonichedgehog is not required for polarising activity in the Doublefoot mutant mouse limb bud. Development 125, 351-357.[Abstract]

Hinchliffe, J. R. and Ede, D. A (1967). Limb development in the polydactylous talpid3mutant of the fowl. J. Embryol. Exp. Morph 17, 385-404.

Hynes, M., Stone, D., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A. and Rosenthal, A (1997). Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19, 15-26.[Medline]

Ingham, P. W (1993). Localised hedgehog activity controls spatially restricted transcription of wingless in the Drosophila embryo. Nature 366, 560-562.[Medline]

Ingham, P. W (1998). Transducing hedgehog: the story so far. EMBO J 17, 3305-3511.

Ingham, P. W (1998). The patched gene in development and cancer. Current Opinion in Genet. Dev 8, 88-94.[Medline]

Ingham, P. W. and Hidalgo, A (1993). Regulation of wingless transcription in the Drosophila embryo. Development 117, 283-291.[Abstract]

Ingham, P. W., Taylor, A. M. and Nakano, Y (1991). Role of the Drosophila patched gene in positional signalling. Nature 353, 184-187.[Medline]

Izpisua-Belmonte, J.-C., Ede, D. A., Tickle, C. and Duboule, D (1992). The mis-expression of posterior Hox-4 genes in talpid ( ta3 ) mutant wings correlates with the absence of anteroposterior polarity. Development 114, 959-.[Abstract]

Izpisua-Belmonte, J. C., Tickle, C., Dolle, P., Wolpert, L. and Duboule, D (1991). Expression of homeobox Hox-4 genes and the specification of position in chick wing development. Nature 350, 585-589.[Medline]

Johnson, R. L., Grenier, J. K. and Scott, M. P (1995). Patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets. Development 121, 4161-4170.[Abstract]

Johnson, R. L., Rothman, A. L., Xie, J. W., Goodrich, L. V., Bare, J. W., Bonifas, J. M., Quinn, A. G., Myers, R. M., Cox, D. R., Epstein, E. H. and Scott, M. P (1996). Human homolog of patched , a candidate gene for the basal-cell nevus syndrome. Science 272, 1668-1671.[Abstract]

Johnson, R. L. and Scott, M. P (1998). New players and puzzles in the Hedgehog signalling pathway. Current Opinion in Genet. Dev 8, 450-456.[Medline]

Johnson, R. and Tabin, C. J (1997). Molecular models for vertebrate limb development. Cell 90, 979-990.[Medline]

Jones, C. T., Morrice, D. R., Paton, I. R. and burt, D. W (1997). Gene homologs on human chromosome 15q21-q26 and chicken microchromosome identify a new conserved segment. Mammalian Genome 8, 436-440.[Medline]

Krishnan, V., Pereira, F. A., Qiu, Y., Chen, C. H., Beachy, P. A., Tsai, S. Y. and Tsai, M. J (1997). Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science 278, 1947-1950.[Abstract/Free Full Text]

Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A. and Tabin, C (1994). Sonic hedgehog and Fgf-4 act through a signalling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79, 993-1003.[Medline]

Lee, J., Platt, K., Censullo, P. and Ruiz i Altaba, A (1997). Gli1 is a target of sonic hedgehog that induces ventral neural-tube development. Development 124, 2537-2552.[Abstract]

Lessing, D. and Nusse, R (1998). Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved ci-binding sites is required for patched -mediated repression. Development 125, 1469-1476.[Abstract]

Lewis, K. E., Concordet, J. P. and Ingham, P. W (1998). Characterisation of a second patched gene in zebrafish D. rerio and the differential response of patched genes to Hedgehog signalling. Dev. Biol 208, 14-29.

Lutz B., Kuratani S., Cooney A.J., Wawersik S, Tsai S.Y., Eichele G. and Tsai M.J (1994). Developmental regulation of the orphan receptor COUP-TF II gene in spinal motor neurons. Development 120, 25-36.[Abstract]

Marigo, V., Scott, M. P., Johnson, R. L., Goodrich, L. V. and Tabin, C. J (1996). Conservation in hedgehog signalling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development 122, 1225-1233.[Abstract]

Marigo, V., Johnson, R., Vortkamp, A. and Tabin, C (1996). Sonic hedgehog differentially regulates expression of Gli and Gli3 during limb development. Dev. Biol 180, 273-283.[Medline]

Marti, E., Bumcrot, D. A., Takada, R. and McMahon, A. P (1995). Requirement of 19kDalton form of Sonic hedgehog for induction of distinct ventral cell types in vertebrate CNS explants. Nature 375, 322-325.[Medline]

Masuya, H., Sagai, T., Wakana, S., Moriwaki, K. and Shiroishi, T (1995). A duplicated zone of polarizing activity in polydactylous mouse mutants. Genes Dev 9, 1645-1653.[Abstract/Free Full Text]

Masuya, H., Sagai, T., Moriwaki, K. and Shiroishi, T (1997). Multigenic Control of the localisation of the zone of polarising activity in limb morphogenesis in the mouse. Dev. Biol 182, 42-51.[Medline]

Matise, M. P., Epstein, D. J., Park, H. L., Platt, K. A. and Joyner, A. L (1998). Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125, 2759-2770.[Abstract]

Niswander, L., Jeffrey, S., Martin, G. R. and Tickle, C (1994). A positive feedback loop co-ordinates growth and patterning in the vertebrate limb. Nature 371, 609-612.[Medline]

Ohlmeyer, J. T. and Kalderon, D (1997). Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev 11, 2250-2258.[Abstract/Free Full Text]

Oro, A., Higgins, K., Hu, Z., Bonifas, J., Epstein, E. and Scott, M (1997). Basal cell carcinomas in mice overexpressing Sonic Hedgehog. Science 276, 817-821.[Abstract/Free Full Text]

Platt, K. A., Michaud, J. and Joyner, A. L (1997). Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice. Mech. Dev 62, 121-135.[Medline]

Porter, J., Young, K. and Beachy, P (1996). Cholesterol modification of hedgehog signalling proteins in animal development. Science 274, 255-259.[Abstract/Free Full Text]

Qu, S., Niswander, K. D., Qunsheng, J., van der Meer, R., Keeney, D. and Magnuson, M. A (1997). Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development 124, 3999-4008.[Abstract]

Quirk, J., Vandenheuvel, M., Henrique, D., Marigo, V., Jones, T. A., Tabin, C. and Ingham, P (1997). The smoothened gene and hedgehog signal-transduction in Drosophila and vertebrate development. Cold Spring Harbor Symposia Quant. Biol 62, 217-266.[Medline]

Riddle, R., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic Hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.[Medline]

Roelink, H., Porter, J., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A. and Jessell, T. M (1995). Floor plate and motor neuron induction by different concentrations of the amino terminal cleavage product of Sonic Hedgehog autoproteolysis. Cell 81, 445-455.[Medline]

Roessler, E., Belloni, E., Gaudenz, K., Jay, P., Berta, P., Scherer, S. W., Tsui, L.-C. and Muenke, M (1996). Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nature Genetics 14, 357-360.[Medline]

Ruiz iAltaba, A (1998). Combinatorial gli gene function in floor plate and neuronal inductions by sonic hedgehog. Development 125, 2203-2212.[Abstract]

Sasaki, H., Hui, C., Nakafuku, M. and Kondoh, H (1997). A binding-site for Gli proteins is essential for Hnf3 floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-1322.[Abstract]

Strigini, M. and Cohen, S. M (1997). A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124, 4697-4705.[Abstract]

Struhl, G., Barbash, D. and Lawrence, P (1997). Hedgehog acts by distinct gradient and signal relay mechanisms to organize cell-type and cell polarity in the Drosophila abdomen. Development 124, 2155-2165.[Abstract]

Taylor, A. M., Nakano, Y., Mohler, J. and Ingham, P. W (1993). Contrasting distributions of patched and hedgehog proteins in Drosophila. Mech. Dev 43, 89-96.

Tickle, C., Summerbell, D. and Wolpert, L (1975). Positional signalling and specification of digits in chick limb morphogenesis. Nature 254, 199-202.[Medline]

Yang, Y., Drossopoulou, G., Chuang, P.-T., Duprez, D., Marti, E., Bumcroft, D., Vargesson, N., Clarke, J., Niswander, L., McMahon, A. and Tickle, C (1997). Relationship between dose, distance and time in Sonic Hedgehog mediated regulation of anteroposterior polarity in the chick limb. Development 124, 4393-4404.[Abstract]

Yang, Y., Guillot, P., Boyd, Y., Lyon, M. F. and McMahon, A. P (1998). Evidence that preaxial polydactyly in the doublefoot mutant is due to ectopic Indian hedgehog signalling. Development 125, 3123-3132.[Abstract]




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