Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Kramer, S.
	Articles by Hiromi, Y.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Kramer, S.
	Articles by Hiromi, Y.

Allard, J. D., Chang, H. C., Herbst, R., McNeill, H., and Simon, M. A (1996). The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf. Development 122, 1137-1146.[Abstract]

Basler, K., Christen, B. and Hafen, E (1991). Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell 64, 1069-1081.[Medline]

Beiman, M., Shilo, B. Z. and Volk, T (1996). Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages. Genes Dev 10, 2993-3002.[Abstract/Free Full Text]

Brunner, D., Ducker, K., Oellers, N., Hafen, E., Scholz, H. and Kl\212mbt, C (1994). The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature 370, 386-389.[Medline]

Carthew, R. W. and Rubin, G. M (1990). seven in absentia , a gene required for specification of R7 cell fate in the Drosophila eye. Cell 63, 561-577.[Medline]

Clifford, R. J. and Schupbach, T (1989). Coordinately and differentially mutable activities of torpedo , the Drosophila melanogaster homolog of the vertebrate EGF receptor gene. Genetics 123, 771-787.[Abstract/Free Full Text]

Dickson, B (1995). Nuclear factors in sevenless signalling. Trends Genet 11, 106-111.[Medline]

Dickson, B., Sprenger, F., Morrison, D. and Hafen, E (1992). Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature 360, 600-603.[Medline]

Dong, R. and Jacobs, J. R (1997). Origin and differentiation of supernumerary midline glia in Drosophila embryos deficient for apoptosis. Dev. Biol 190, 165-177.[Medline]

Fortini, M. E., Simon, M. A. and Rubin, G. M (1992). Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature 355, 559-561.[Medline]

Freeman, M (1997). Cell determination strategies in the Drosophila eye. Development 124, 261-270.[Abstract]

Freeman, M (1996). Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87, 651-660.[Medline]

Freeman, M (1994). The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor. Mech. Dev 48, 25-33.[Medline]

Freeman, M., Kimmel, B. E. and Rubin, G. M (1992). Identifying targets of the rough homeobox gene of Drosophila: evidence that rhomboid functions in eye development. Development 116, 335-346.[Medline]

Freeman, M., Kl\212mbt, C., Goodman, C. S. and Rubin, G. M (1992). The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye. Cell 69, 963-975.[Medline]

Fujita, S. C., Zipursky, S. L., Benzer, S., Ferrus, A. and Shotwell, S. L (1982). Monoclonal antibodies against the Drosophila nervous system. Proc. Natl. Acad. Sci. USA_Fb_79._Fb_Gaul, U., Mardon, G. and Rubin, G. M. (1992). A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase. Cell 68, 1007-1019.

Gisselbrecht, S., Skeath, J. B., Doe, C. Q. and Michelson, A. M (1996). heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo. Genes Dev 10, 3003-3017.[Abstract/Free Full Text]

Glazer, L. and Shilo, B. Z (1991). The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extension. Genes Dev 5, 697-705.[Abstract/Free Full Text]

Golembo, M., Schweitzer, R., Freeman, M. and Shilo, B. Z (1996). argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop. Development 122, 223-230.[Abstract]

Gonzalez-Reyes, A., Elliott, H. and St Johnston, D (1995). Polarization of both major body axes in Drosophila by gurken-torpedo signalling. Nature 375, 654-658.[Medline]

Hacohen, N., Kramer, S., Sutherland, D., Hiromi, Y. and Krasnow, M. A (1998). sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92, 253-263.[Medline]

Higashijima, S., Kojima, T., Michiue, T., Ishimaru, S., Emori, Y. and Saigo, K (1992). Dual Bar homeo box genes of Drosophila required in two photoreceptor cells, R1 and R6, and primary pigment cells for normal eye development. Genes Dev 6, 50-60.[Abstract/Free Full Text]

Kl\212mbt, C (1993). The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells. Development 117, 163-176.[Abstract]

Kl\212mbt, C., Glazer, L. and Shilo, B. Z (1992). breathless , a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells. Genes Dev 6, 1668-1678.[Abstract/Free Full Text]

Kl\212mbt, C., Jacobs, J. R. and Goodman, C. S (1991). The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance. Cell 64, 801-815.[Medline]

Kramer, S., West, S. R. and Hiromi, Y (1995). Cell fate control in the Drosophila retina by the orphan receptor seven-up: its role in the decisions mediated by the ras signaling pathway. Development 121, 1361-1372.[Abstract]

Kretzschmar, D., Brunner, A., Wiersdorff, V., Pflugfelder, G. O.,Heisenberg, M. and Schneuwly, S (1992). Giant lens , a gene involved in cell determination and axon guidance in the visual system of Drosophila melanogaster. EMBO J 11, 2531-2539.[Medline]

Kulkarni, S. J., Newby, L. M. and Jackson, F. R (1994). Drosophila GABAergic systems. II. Mutational analysis of chromosomal segment 64AB, a region containing the glutamic acid decarboxylase gene. Mol. Gen. Genet 243, 555-564.[Medline]

Kumar, J. P., Tio, M., Hsiung, F., Akopyan, S., Gabay, L., Seger, R., Shilo, B. Z. and Moses, K (1998). Dissecting the role ot the Drosophila EGF receptor in eye development and MAP kinase activation. Development 125, 3875-3885.[Abstract]

Lage, P., Jan, Y. N. and Jarman, A. P (1997). Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters. Curr. Biol 7, 166-175.[Medline]

Lai, Z. C. and Rubin, G. M (1992). Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. Cell 70, 609-620.[Medline]

Lawrence, P. A. and Green, S. M (1979). Cell lineage in the developing retina of Drosophila. Dev. Biol 71, 142-152.[Medline]

Lin, D. M. and Goodman, C. S (1994). Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance. Neuron 13, 507-523.[Medline]

Livneh, E., Glazer, L., Segal, D., Schlessinger, J. and Shilo, B. Z (1985). The Drosophila EGF receptor gene homolog: conservation of both hormone binding and kinase domains. Cell 40, 599-607.[Medline]

Mlodzik, M., Hiromi, Y., Goodman, C. S. and Rubin, G. M (1992). The presumptive R7 cell of the developing Drosophila eye receives positional information independent of sevenless , boss and sina. Mech. Dev 37, 37-42.[Medline]

Mlodzik, M., Hiromi, Y., Weber, U., Goodman, C. S. and Rubin, G. M (1990). The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell 60, 211-224.[Medline]

Neuman-Silberberg, F. S. and Schupbach, T (1993). The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein. Cell 75, 165-174.[Medline]

O'Neill, E. M., Rebay, I., Tjian, R. and Rubin, G. M (1994). The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78, 137-147.[Medline]

O'Neill, J. W. and Bier, E (1994). Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes. Biotechniques 17, 870-.

Okabe, M. and Okano, H (1997). Two-step induction of chordotonal organ precursors in Drosophila embryogenesis. Development 124, 1045-1053.[Abstract]

Okabe, M., Sawamoto, K. and Okano, H (1996). The function of the Drosophila argos gene product in the development of embryonic chordotonal organs. Dev. Biol 175, 37-49.[Medline]

Okano, H., Hayashi, S., Tanimura, T., Sawamoto, K., Yoshikawa, S., Watanabe, J., Iwasaki, M., Hirose, S., Mikoshiba, K. and Montell, C (1992). Regulation of Drosophila neural development by a putative secreted protein. Differentiation 52, 1-11.[Medline]

Peifer, M. and Wieschaus, E (1990). The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell 63, 1167-1176.[Medline]

Perrimon, N. and Perkins, L. A (1997). There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor. Cell 89, 13-16.[Medline]

Queenan, A. M., Ghabrial, A. and Schupbach, T (1997). Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo. Development 124, 3871-3880.[Abstract]

Ready, D. F., Hanson, T. E. and Benzer, S (1976). Development of the Drosophila retina, a neurocrystalline lattice. Dev. Biol 53, 217-240.[Medline]

Roth, S., Neuman-Silberberg, F. S., Barcelo, G. and Schupbach, T (1995). cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila. Cell 81, 967-978.[Medline]

Rutledge, B. J., Zhang, K., Bier, E., Jan, Y. N. and Perrimon, N (1992). The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev 6, 1503-1517.[Abstract/Free Full Text]

Schlessinger, J (1993). How receptor tyrosine kinases activate Ras. Trends Biochem. Sci 18, 273-275.[Medline]

Schnepp, B., Grumbling, G., Donaldson, T. and Simcox, A (1996). Vein is a novel component in the Drosophila epidermal growth factor receptorpathway with similarity to the neuregulins. Genes Dev 10, 2302-2313.[Abstract/Free Full Text]

Scholz, H., Sadlowski, E., Klaes, A. and Kl\212mbt, C (1997). Control of midline glia development in the embryonic Drosophila CNS. Mech. Dev 64, 137-151.[Medline]

Schupbach, T (1987). Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster. Cell 49, 699-707.[Medline]

Schupbach, T. and Wieschaus, E (1998). Probing patterns of gene expression in Drosophila epithelial development. Int. J. Dev. Biol._Fb_42._Fb_Schweitzer, R., Howes, R., Smith, R., Shilo, B. Z. and Freeman, M. (1995). Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature 376, 699-702.

Schweitzer, R. and Shilo, B. Z (1997). A thousand and one roles for the Drosophila EGF receptor. Trends Genet 13, 191-196.[Medline]

Shishido, E., Ono, N., Kojima, T. and Saigo, K (1997). Requirements of DFR1/Heartless, a mesoderm-specific Drosophila FGF-receptor, for the formation of heart, visceral and somatic muscles, and ensheathing of longitudinal axon tracts in CNS. Development 124, 2119-2128.[Abstract]

Simcox, A. A., Grumbling, G., Schnepp, B., Bennington-Mathias, C., Hersperger, E. and Shearn, A (1996). Molecular, phenotypic, and expression analysis of vein , a gene required for growth of the Drosophila wing disc. Dev. Biol 177, 475-489.[Medline]

Sonnenfeld, M. J. and Jacobs, J. R (1995). Apoptosis of the midline glia during Drosphila embryogenesis: a correlation with axon contact. Development 121, 569-578.[Abstract]

Sturtevant, M. A., O'Neill, J. W. and Bier, E (1994). Down-regulation of Drosophila Egf-r mRNA levels following hyperactivated receptor signaling. Development 120, 2593-2600.[Abstract/Free Full Text]

Sutherland, D., Samakovlis, C. and Krasnow, M. A (1996). branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. Cell 87, 1091-1101.[Medline]

Tio, M., Ma, C. and Moses, K (1994). spitz , a Drosophila homolog of transforming growth factor-alpha, is required in the founding photoreceptor cells of the compound eye facets. Mech. Dev 48, 13-23.[Medline]

Tomlinson, A. and Ready, D. F (1987). Neuronal differentiation in the Drosophila ommatidium. Dev. Biol 120, 366-376.[Medline]

Tomlinson, A. and Ready, D. F (1986). sevenless : a cell specific homeotic mutation of the Drosophila eye. Science 231, 400-402.[Abstract/Free Full Text]

Van Vactor, D. L., Jr., Cagan, R. L., Kr\212mer, H. and Zipursky, S. L (1991). Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell. Cell 67, 1145-1155.[Medline]

Wohlwill, A. D. and Bonner, J. J (1991). Genetic analysis of chromosome region 63 of Drosophila melanogaster. Genetics 128, 763-775.[Abstract]

Wolff, T. and Ready, D. F (1991). The beginning of pattern formation in the Drosophila compound eye: the morphogenetic furrow and the second mitotic wave. Development 113, 841-850.[Abstract]

Wolff, T. and Ready, D. F (1991). Cell death in normal and rough eye mutants of Drosophila. Development 113, 825-839.[Abstract]

Xu, T. and Rubin, G. M (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.[Abstract]

Zipursky, S. L. and Rubin, G. M (1994). Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Ann. Rev. Neurosci 17, 373-397.[Medline]

Casci, T., Vinos, J. and Freeman, M (1999). Sprouty, an intracellular inhibitor of Ras signaling. Cell 96, 655-665.[Medline]

This article has been cited by other articles:

S. Chandramouli, C. Y. Yu, P. Yusoff, D.-H. Lao, H. F. Leong, K. Mizuno, and G. R. Guy
Tesk1 Interacts with Spry2 to Abrogate Its Inhibition of ERK Phosphorylation Downstream of Receptor Tyrosine Kinase Signaling
J. Biol. Chem., January 18, 2008; 283(3): 1679 - 1691.
[Abstract] [Full Text] [PDF]

E. Rottinger, A. Saudemont, V. Duboc, L. Besnardeau, D. McClay, and T. Lepage
FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis and regulate gastrulation during sea urchin development
Development, January 15, 2008; 135(2): 353 - 365.
[Abstract] [Full Text] [PDF]

M. Sese, M. Corominas, H. Stocker, T. I. Heino, E. Hafen, and F. Serras
The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in the Drosophila eye
J. Cell Sci., December 15, 2006; 119(24): 5047 - 5056.
[Abstract] [Full Text] [PDF]

K. Bundschu, U. Walter, and K. Schuh
The VASP-Spred-Sprouty Domain Puzzle
J. Biol. Chem., December 1, 2006; 281(48): 36477 - 36481.
[Abstract] [Full Text] [PDF]

M. A. Cabrita, F. Jaggi, S. P. Widjaja, and G. Christofori
A Functional Interaction between Sprouty Proteins and Caveolin-1
J. Biol. Chem., September 29, 2006; 281(39): 29201 - 2912.
[Abstract] [Full Text] [PDF]

L. Chi, P. Itaranta, S. Zhang, and S. Vainio
Sprouty2 Is Involved in Male Sex Organogenesis by Controlling Fibroblast Growth Factor 9-Induced Mesonephric Cell Migration to the Developing Testis
Endocrinology, August 1, 2006; 147(8): 3777 - 3788.
[Abstract] [Full Text] [PDF]

L. A. Jarvis, S. J. Toering, M. A. Simon, M. A. Krasnow, and R. K. Smith-Bolton
Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases
Development, March 15, 2006; 133(6): 1133 - 1142.
[Abstract] [Full Text] [PDF]

J. DaSilva, L. Xu, H. J. Kim, W. T. Miller, and D. Bar-Sagi
Regulation of sprouty stability by mnk1-dependent phosphorylation.
Mol. Cell. Biol., March 1, 2006; 26(5): 1898 - 1907.
[Abstract] [Full Text] [PDF]

K.-i. Ozaki, S. Miyazaki, S. Tanimura, and M. Kohno
Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms
J. Cell Sci., December 15, 2005; 118(24): 5861 - 5871.
[Abstract] [Full Text] [PDF]

J. Anderson, R. Bhandari, and J. P. Kumar
A Genetic Screen Identifies Putative Targets and Binding Partners of CREB-Binding Protein in the Developing Drosophila Eye
Genetics, December 1, 2005; 171(4): 1655 - 1672.
[Abstract] [Full Text] [PDF]

A. A. Pieper, X. Wu, T. W. Han, S. J. Estill, Q. Dang, L. C. Wu, S. Reece-Fincanon, C. A. Dudley, J. A. Richardson, D. J. Brat, et al.
The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice
PNAS, September 27, 2005; 102(39): 14052 - 14057.
[Abstract] [Full Text] [PDF]

B.-Z. Shilo
Regulating the dynamics of EGF receptor signaling in space and time
Development, September 15, 2005; 132(18): 4017 - 4027.
[Abstract] [Full Text] [PDF]

A. Nonami, T. Taketomi, A. Kimura, K. Saeki, H. Takaki, T. Sanada, K. Taniguchi, M. Harada, R. Kato, and A. Yoshimura
The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1
Genes Cells, September 1, 2005; 10(9): 887 - 895.
[Abstract] [Full Text] [PDF]

R. Haimov-Kochman, A. Ravhon, D. Prus, C. Greenfield, Z. Finci-Yeheskel, D. S.Goldman-Wohl, S. Natanson-Yaron, R. Reich, S. Yagel, and A. Hurwitz
Expression and regulation of Sprouty-2 in the granulosa-lutein cells of the corpus luteum
Mol. Hum. Reprod., August 1, 2005; 11(8): 537 - 542.
[Abstract] [Full Text] [PDF]

M. Iwanami, Y. Hiromi, and M. Okabe
Cell-type specific utilization of multiple negative feedback loops generates developmental constancy
Genes Cells, July 1, 2005; 10(7): 743 - 752.
[Abstract] [Full Text] [PDF]

Y. Takayama, P. May, R. G. W. Anderson, and J. Herz
Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Controls Endocytosis and c-CBL-mediated Ubiquitination of the Platelet-derived Growth Factor Receptor {beta} (PDGFR{beta})
J. Biol. Chem., May 6, 2005; 280(18): 18504 - 18510.
[Abstract] [Full Text] [PDF]

C. Rubin, Y. Zwang, N. Vaisman, D. Ron, and Y. Yarden
Phosphorylation of Carboxyl-terminal Tyrosines Modulates the Specificity of Sprouty-2 Inhibition of Different Signaling Pathways
J. Biol. Chem., March 11, 2005; 280(10): 9735 - 9744.
[Abstract] [Full Text] [PDF]

R. Wilson, E. Vogelsang, and M. Leptin
FGF signalling and the mechanism of mesoderm spreading in Drosophila embryos
Development, February 1, 2005; 132(3): 491 - 501.
[Abstract] [Full Text] [PDF]

A. Suzuki-Hirano, T. Sato, and H. Nakamura
Regulation of isthmic Fgf8 signal by sprouty2
Development, January 15, 2005; 132(2): 257 - 265.
[Abstract] [Full Text] [PDF]

B Kwabi-Addo, M Ozen, and M Ittmann
The role of fibroblast growth factors and their receptors in prostate cancer
Endocr. Relat. Cancer, December 1, 2004; 11(4): 709 - 724.
[Abstract] [Full Text] [PDF]

S. Torii, K. Nakayama, T. Yamamoto, and E. Nishida
Regulatory Mechanisms and Function of ERK MAP Kinases
J. Biochem., November 1, 2004; 136(5): 557 - 561.
[Abstract] [Full Text] [PDF]

T. L. Lo, P. Yusoff, C. W. Fong, K. Guo, B. J. McCaw, W. A. Phillips, H. Yang, E. S. M. Wong, H. F. Leong, Q. Zeng, et al.
The Ras/Mitogen-Activated Protein Kinase Pathway Inhibitor and Likely Tumor Suppressor Proteins, Sprouty 1 and Sprouty 2 Are Deregulated in Breast Cancer
Cancer Res., September 1, 2004; 64(17): 6127 - 6136.
[Abstract] [Full Text] [PDF]

B. Kwabi-Addo, J. Wang, H. Erdem, A. Vaid, P. Castro, G. Ayala, and M. Ittmann
The Expression of Sprouty1, an Inhibitor of Fibroblast Growth Factor Signal Transduction, Is Decreased in Human Prostate Cancer
Cancer Res., July 15, 2004; 64(14): 4728 - 4735.
[Abstract] [Full Text] [PDF]

W. Ding, S. Bellusci, W. Shi, and D. Warburton
Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis
Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L52 - L59.
[Abstract] [Full Text] [PDF]

D. Alvarado, A. H. Rice, and J. B. Duffy
Bipartite Inhibition of Drosophila Epidermal Growth Factor Receptor by the Extracellular and Transmembrane Domains of Kekkon1
Genetics, May 1, 2004; 167(1): 187 - 202.
[Abstract] [Full Text] [PDF]

J. M. Mason, D. J. Morrison, B. Bassit, M. Dimri, H. Band, J. D. Licht, and I. Gross
Tyrosine Phosphorylation of Sprouty Proteins Regulates Their Ability to Inhibit Growth Factor Signaling: A Dual Feedback Loop
Mol. Biol. Cell, May 1, 2004; 15(5): 2176 - 2188.
[Abstract] [Full Text] [PDF]

T. Yamada, M. Okabe, and Y. Hiromi
EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed
Development, September 1, 2003; 130(17): 4085 - 4096.
[Abstract] [Full Text] [PDF]

R.-B. Yang, C. K. D. Ng, S. M. Wasserman, L. G. Komuves, M. E. Gerritsen, and J. N. Topper
A Novel Interleukin-17 Receptor-like Protein Identified in Human Umbilical Vein Endothelial Cells Antagonizes Basic Fibroblast Growth Factor-induced Signaling
J. Biol. Chem., August 29, 2003; 278(35): 33232 - 33238.
[Abstract] [Full Text] [PDF]

G. R. Guy, E. S. M. Wong, P. Yusoff, S. Chandramouli, T. L. Lo, J. Lim, and C. W. Fong
Sprouty: how does the branch manager work?
J. Cell Sci., August 1, 2003; 116(15): 3061 - 3068.
[Abstract] [Full Text] [PDF]

V. Sudarsan, S. Pasalodos-Sanchez, S. Wan, A. Gampel, and H. Skaer
A genetic hierarchy establishes mitogenic signalling and mitotic competence in the renal tubules of Drosophila
Development, March 4, 2003; 129(4): 935 - 944.
[Abstract] [Full Text] [PDF]

J. E. Egan, A. B. Hall, B. A. Yatsula, and D. Bar-Sagi
The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins
PNAS, April 30, 2002; 99(9): 6041 - 6046.
[Abstract] [Full Text] [PDF]

F. Kheradmand, K. Rishi, and Z. Werb
Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2
J. Cell Sci., February 15, 2002; 115(4): 839 - 848.
[Abstract] [Full Text] [PDF]

I. Gross, B. Bassit, M. Benezra, and J. D. Licht
Mammalian Sprouty Proteins Inhibit Cell Growth and Differentiation by Preventing Ras Activation
J. Biol. Chem., November 30, 2001; 276(49): 46460 - 46468.
[Abstract] [Full Text] [PDF]

J. P. Kumar and K. Moses
The EGF receptor and notch signaling pathways control the initiation of the morphogenetic furrow during Drosophila eye development
Development, July 15, 2001; 128(14): 2689 - 2697.
[Abstract] [Full Text] [PDF]

M. Furthauer, F. Reifers, M. Brand, B. Thisse, and C. Thisse
sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish
Development, June 15, 2001; 128(12): 2175 - 2186.
[Abstract] [Full Text] [PDF]

S. L. Nutt, K. S. Dingwell, C. E. Holt, and E. Amaya
Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning
Genes & Dev., May 1, 2001; 15(9): 1152 - 1166.
[Abstract] [Full Text]

M.-A. Impagnatiello, S. Weitzer, G. Gannon, A. Compagni, M. Cotten, and G. Christofori
Mammalian Sprouty-1 and -2 Are Membrane-anchored Phosphoprotein Inhibitors of Growth Factor Signaling in Endothelial Cells
J. Cell Biol., March 5, 2001; 152(5): 1087 - 1098.
[Abstract] [Full Text] [PDF]

T. Rusten, R Cantera, J Urban, G Technau, F. Kafatos, and R Barrio
Spalt modifies EGFR-mediated induction of chordotonal precursors in the embryonic PNS of Drosophila promoting the development of oenocytes
Development, January 3, 2001; 128(5): 711 - 722.
[Abstract] [PDF]

L. Firth, J. Manchester, J. A. Lorenzen, M. Baron, and L. A. Perkins
Identification of Genomic Regions That Interact With a Viable Allele of the Drosophila Protein Tyrosine Phosphatase Corkscrew
Genetics, October 1, 2000; 156(2): 733 - 748.
[Abstract] [Full Text]

D. C. Goldman, G. R. Martin, and P. P. Tam
Fate and function of the ventral ectodermal ridge during mouse tail development
Development, May 15, 2000; 127(10): 2113 - 2123.
[Abstract] [PDF]

A. Taguchi, K. Sawamoto, and H. Okano
Mutations Modulating the Argos-Regulated Signaling Pathway in Drosophila Eye Development
Genetics, April 1, 2000; 154(4): 1639 - 1648.
[Abstract] [Full Text]

M.-h. Jin, K. Sawamoto, M. Ito, and H. Okano
The Interaction between the Drosophila Secreted Protein Argos and the Epidermal Growth Factor Receptor Inhibits Dimerization of the Receptor and Binding of Secreted Spitz to the Receptor
Mol. Cell. Biol., March 15, 2000; 20(6): 2098 - 2107.
[Abstract] [Full Text]

A. Trumpp, M. J. Depew, J. L.R. Rubenstein, J. M. Bishop, and G. R. Martin
Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
Genes & Dev., December 1, 1999; 13(23): 3136 - 3148.
[Abstract] [Full Text]

G Minowada, L. Jarvis, C. Chi, A Neubuser, X Sun, N Hacohen, M. Krasnow, and G. Martin
Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed
Development, January 10, 1999; 126(20): 4465 - 4475.
[Abstract] [PDF]

A Reich, A Sapir, and B Shilo
Sprouty is a general inhibitor of receptor tyrosine kinase signaling
Development, January 9, 1999; 126(18): 4139 - 4147.
[Abstract] [PDF]

A. Sasaki, T. Taketomi, T. Wakioka, R. Kato, and A. Yoshimura
Identification of a Dominant Negative Mutant of Sprouty That Potentiates Fibroblast Growth Factor- but Not Epidermal Growth Factor-induced ERK Activation
J. Biol. Chem., September 21, 2001; 276(39): 36804 - 36808.
[Abstract] [Full Text] [PDF]

J. Lim, E. S. M. Wong, S. H. Ong, P. Yusoff, B. C. Low, and G. R. Guy
Sprouty Proteins Are Targeted to Membrane Ruffles upon Growth Factor Receptor Tyrosine Kinase Activation. IDENTIFICATION OF A NOVEL TRANSLOCATION DOMAIN
J. Biol. Chem., October 13, 2000; 275(42): 32837 - 32845.
[Abstract] [Full Text] [PDF]

S. H. Lee, D. J. Schloss, L. Jarvis, M. A. Krasnow, and J. L. Swain
Inhibition of Angiogenesis by a Mouse Sprouty Protein
J. Biol. Chem., February 2, 2001; 276(6): 4128 - 4133.
[Abstract] [Full Text] [PDF]

E. S. M. Wong, J. Lim, B. C. Low, Q. Chen, and G. R. Guy
Evidence for Direct Interaction between Sprouty and Cbl
J. Biol. Chem., February 16, 2001; 276(8): 5866 - 5875.
[Abstract] [Full Text] [PDF]

Y. Yigzaw, L. Cartin, S. Pierre, K. Scholich, and T. B. Patel
The C Terminus of Sprouty Is Important for Modulation of Cellular Migration and Proliferation
J. Biol. Chem., June 15, 2001; 276(25): 22742 - 22747.

				E. Rottinger, A. Saudemont, V. Duboc, L. Besnardeau, D. McClay, and T. Lepage FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis and regulate gastrulation during sea urchin development Development, January 15, 2008; 135(2): 353 - 365. [Abstract] [Full Text] [PDF]

				M. Sese, M. Corominas, H. Stocker, T. I. Heino, E. Hafen, and F. Serras The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in the Drosophila eye J. Cell Sci., December 15, 2006; 119(24): 5047 - 5056. [Abstract] [Full Text] [PDF]

				K. Bundschu, U. Walter, and K. Schuh The VASP-Spred-Sprouty Domain Puzzle J. Biol. Chem., December 1, 2006; 281(48): 36477 - 36481. [Abstract] [Full Text] [PDF]

				M. A. Cabrita, F. Jaggi, S. P. Widjaja, and G. Christofori A Functional Interaction between Sprouty Proteins and Caveolin-1 J. Biol. Chem., September 29, 2006; 281(39): 29201 - 2912. [Abstract] [Full Text] [PDF]

				L. Chi, P. Itaranta, S. Zhang, and S. Vainio Sprouty2 Is Involved in Male Sex Organogenesis by Controlling Fibroblast Growth Factor 9-Induced Mesonephric Cell Migration to the Developing Testis Endocrinology, August 1, 2006; 147(8): 3777 - 3788. [Abstract] [Full Text] [PDF]

				L. A. Jarvis, S. J. Toering, M. A. Simon, M. A. Krasnow, and R. K. Smith-Bolton Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases Development, March 15, 2006; 133(6): 1133 - 1142. [Abstract] [Full Text] [PDF]

				J. DaSilva, L. Xu, H. J. Kim, W. T. Miller, and D. Bar-Sagi Regulation of sprouty stability by mnk1-dependent phosphorylation. Mol. Cell. Biol., March 1, 2006; 26(5): 1898 - 1907. [Abstract] [Full Text] [PDF]

				K.-i. Ozaki, S. Miyazaki, S. Tanimura, and M. Kohno Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms J. Cell Sci., December 15, 2005; 118(24): 5861 - 5871. [Abstract] [Full Text] [PDF]

				J. Anderson, R. Bhandari, and J. P. Kumar A Genetic Screen Identifies Putative Targets and Binding Partners of CREB-Binding Protein in the Developing Drosophila Eye Genetics, December 1, 2005; 171(4): 1655 - 1672. [Abstract] [Full Text] [PDF]

				A. A. Pieper, X. Wu, T. W. Han, S. J. Estill, Q. Dang, L. C. Wu, S. Reece-Fincanon, C. A. Dudley, J. A. Richardson, D. J. Brat, et al. The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice PNAS, September 27, 2005; 102(39): 14052 - 14057. [Abstract] [Full Text] [PDF]

				B.-Z. Shilo Regulating the dynamics of EGF receptor signaling in space and time Development, September 15, 2005; 132(18): 4017 - 4027. [Abstract] [Full Text] [PDF]

				A. Nonami, T. Taketomi, A. Kimura, K. Saeki, H. Takaki, T. Sanada, K. Taniguchi, M. Harada, R. Kato, and A. Yoshimura The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1 Genes Cells, September 1, 2005; 10(9): 887 - 895. [Abstract] [Full Text] [PDF]

				R. Haimov-Kochman, A. Ravhon, D. Prus, C. Greenfield, Z. Finci-Yeheskel, D. S.Goldman-Wohl, S. Natanson-Yaron, R. Reich, S. Yagel, and A. Hurwitz Expression and regulation of Sprouty-2 in the granulosa-lutein cells of the corpus luteum Mol. Hum. Reprod., August 1, 2005; 11(8): 537 - 542. [Abstract] [Full Text] [PDF]

				M. Iwanami, Y. Hiromi, and M. Okabe Cell-type specific utilization of multiple negative feedback loops generates developmental constancy Genes Cells, July 1, 2005; 10(7): 743 - 752. [Abstract] [Full Text] [PDF]

				Y. Takayama, P. May, R. G. W. Anderson, and J. Herz Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Controls Endocytosis and c-CBL-mediated Ubiquitination of the Platelet-derived Growth Factor Receptor {beta} (PDGFR{beta}) J. Biol. Chem., May 6, 2005; 280(18): 18504 - 18510. [Abstract] [Full Text] [PDF]

				C. Rubin, Y. Zwang, N. Vaisman, D. Ron, and Y. Yarden Phosphorylation of Carboxyl-terminal Tyrosines Modulates the Specificity of Sprouty-2 Inhibition of Different Signaling Pathways J. Biol. Chem., March 11, 2005; 280(10): 9735 - 9744. [Abstract] [Full Text] [PDF]

				R. Wilson, E. Vogelsang, and M. Leptin FGF signalling and the mechanism of mesoderm spreading in Drosophila embryos Development, February 1, 2005; 132(3): 491 - 501. [Abstract] [Full Text] [PDF]

				A. Suzuki-Hirano, T. Sato, and H. Nakamura Regulation of isthmic Fgf8 signal by sprouty2 Development, January 15, 2005; 132(2): 257 - 265. [Abstract] [Full Text] [PDF]

				B Kwabi-Addo, M Ozen, and M Ittmann The role of fibroblast growth factors and their receptors in prostate cancer Endocr. Relat. Cancer, December 1, 2004; 11(4): 709 - 724. [Abstract] [Full Text] [PDF]

				S. Torii, K. Nakayama, T. Yamamoto, and E. Nishida Regulatory Mechanisms and Function of ERK MAP Kinases J. Biochem., November 1, 2004; 136(5): 557 - 561. [Abstract] [Full Text] [PDF]

				T. L. Lo, P. Yusoff, C. W. Fong, K. Guo, B. J. McCaw, W. A. Phillips, H. Yang, E. S. M. Wong, H. F. Leong, Q. Zeng, et al. The Ras/Mitogen-Activated Protein Kinase Pathway Inhibitor and Likely Tumor Suppressor Proteins, Sprouty 1 and Sprouty 2 Are Deregulated in Breast Cancer Cancer Res., September 1, 2004; 64(17): 6127 - 6136. [Abstract] [Full Text] [PDF]

				B. Kwabi-Addo, J. Wang, H. Erdem, A. Vaid, P. Castro, G. Ayala, and M. Ittmann The Expression of Sprouty1, an Inhibitor of Fibroblast Growth Factor Signal Transduction, Is Decreased in Human Prostate Cancer Cancer Res., July 15, 2004; 64(14): 4728 - 4735. [Abstract] [Full Text] [PDF]

				W. Ding, S. Bellusci, W. Shi, and D. Warburton Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L52 - L59. [Abstract] [Full Text] [PDF]

				D. Alvarado, A. H. Rice, and J. B. Duffy Bipartite Inhibition of Drosophila Epidermal Growth Factor Receptor by the Extracellular and Transmembrane Domains of Kekkon1 Genetics, May 1, 2004; 167(1): 187 - 202. [Abstract] [Full Text] [PDF]

				J. M. Mason, D. J. Morrison, B. Bassit, M. Dimri, H. Band, J. D. Licht, and I. Gross Tyrosine Phosphorylation of Sprouty Proteins Regulates Their Ability to Inhibit Growth Factor Signaling: A Dual Feedback Loop Mol. Biol. Cell, May 1, 2004; 15(5): 2176 - 2188. [Abstract] [Full Text] [PDF]

				T. Yamada, M. Okabe, and Y. Hiromi EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed Development, September 1, 2003; 130(17): 4085 - 4096. [Abstract] [Full Text] [PDF]

				R.-B. Yang, C. K. D. Ng, S. M. Wasserman, L. G. Komuves, M. E. Gerritsen, and J. N. Topper A Novel Interleukin-17 Receptor-like Protein Identified in Human Umbilical Vein Endothelial Cells Antagonizes Basic Fibroblast Growth Factor-induced Signaling J. Biol. Chem., August 29, 2003; 278(35): 33232 - 33238. [Abstract] [Full Text] [PDF]

				G. R. Guy, E. S. M. Wong, P. Yusoff, S. Chandramouli, T. L. Lo, J. Lim, and C. W. Fong Sprouty: how does the branch manager work? J. Cell Sci., August 1, 2003; 116(15): 3061 - 3068. [Abstract] [Full Text] [PDF]

				V. Sudarsan, S. Pasalodos-Sanchez, S. Wan, A. Gampel, and H. Skaer A genetic hierarchy establishes mitogenic signalling and mitotic competence in the renal tubules of Drosophila Development, March 4, 2003; 129(4): 935 - 944. [Abstract] [Full Text] [PDF]

				J. E. Egan, A. B. Hall, B. A. Yatsula, and D. Bar-Sagi The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins PNAS, April 30, 2002; 99(9): 6041 - 6046. [Abstract] [Full Text] [PDF]