Cbfa2 is required for the formation of intra-aortic hematopoietic clusters

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The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region
Blood, December 1, 2004; 104(12): 3558 - 3564.
[Abstract] [Full Text] [PDF]

W. Sun and J. R. Downing
Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors
Blood, December 1, 2004; 104(12): 3565 - 3572.
[Abstract] [Full Text] [PDF]

S. K. Zaidi, D. W. Young, J.-Y. Choi, J. Pratap, A. Javed, M. Montecino, J. L. Stein, J. B. Lian, A. J. van Wijnen, and G. S. Stein
Intranuclear Trafficking: Organization and Assembly of Regulatory Machinery for Combinatorial Biological Control
J. Biol. Chem., October 15, 2004; 279(42): 43363 - 43366.
[Abstract] [Full Text] [PDF]

F. M. Theriault, P. Roy, and S. Stifani
AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons
PNAS, July 13, 2004; 101(28): 10343 - 10348.
[Abstract] [Full Text] [PDF]

T. J. Sadlon, I. D. Lewis, and R. J. D'Andrea
BMP4: Its Role in Development of the Hematopoietic System and Potential as a Hematopoietic Growth Factor
Stem Cells, July 1, 2004; 22(4): 457 - 474.
[Abstract] [Full Text] [PDF]

F. Bernardin-Fried, T. Kummalue, S. Leijen, M. I. Collector, K. Ravid, and A. D. Friedman
AML1/RUNX1 Increases During G1 to S Cell Cycle Progression Independent of Cytokine-dependent Phosphorylation and Induces Cyclin D3 Gene Expression
J. Biol. Chem., April 9, 2004; 279(15): 15678 - 15687.
[Abstract] [Full Text] [PDF]

J. C. Telfer, E. E. Hedblom, M. K. Anderson, M. N. Laurent, and E. V. Rothenberg
Localization of the Domains in Runx Transcription Factors Required for the Repression of CD4 in Thymocytes
J. Immunol., April 1, 2004; 172(7): 4359 - 4370.
[Abstract] [Full Text] [PDF]

R. B. Lorsbach, J. Moore, S. O. Ang, W. Sun, N. Lenny, and J. R. Downing
Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression
Blood, April 1, 2004; 103(7): 2522 - 2529.
[Abstract] [Full Text] [PDF]

T. E. North, T. Stacy, C. J. Matheny, N. A. Speck, and M. F.T.R. de Bruijn
Runx1 Is Expressed in Adult Mouse Hematopoietic Stem Cells and Differentiating Myeloid and Lymphoid Cells, But Not in Maturing Erythroid Cells
Stem Cells, March 1, 2004; 22(2): 158 - 168.
[Abstract] [Full Text] [PDF]

J. C. Hartner, C. Schmittwolf, A. Kispert, A. M. Muller, M. Higuchi, and P. H. Seeburg
Liver Disintegration in the Mouse Embryo Caused by Deficiency in the RNA-editing Enzyme ADAR1
J. Biol. Chem., February 6, 2004; 279(6): 4894 - 4902.
[Abstract] [Full Text] [PDF]

M. Nishimura, Y. Fukushima-Nakase, Y. Fujita, M. Nakao, S. Toda, N. Kitamura, T. Abe, and T. Okuda
VWRPY motif-dependent and -independent roles of AML1/Runx1 transcription factor in murine hematopoietic development
Blood, January 15, 2004; 103(2): 562 - 570.
[Abstract] [Full Text] [PDF]

Z. Wang, K. Cohen, Y. Shao, P. Mole, D. Dombkowski, and D. T. Scadden
Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels
Blood, January 1, 2004; 103(1): 100 - 109.
[Abstract] [Full Text] [PDF]

M. Alvarez-Silva, P. Belo-Diabangouaya, J. Salaun, and F. Dieterlen-Lievre
Mouse placenta is a major hematopoietic organ
Development, November 15, 2003; 130(22): 5437 - 5444.
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M. J. Ferkowicz, M. Starr, X. Xie, W. Li, S. A. Johnson, W. C. Shelley, P. R. Morrison, and M. C. Yoder
CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo
Development, September 15, 2003; 130(18): 4393 - 4403.
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				E. Dzierzak and A. Medvinsky The discovery of a source of adult hematopoietic cells in the embryo Development, July 15, 2008; 135(14): 2343 - 2346. [Abstract] [Full Text] [PDF]

				N. Stifani, A. R. O. Freitas, A. Liakhovitskaia, A. Medvinsky, A. Kania, and S. Stifani Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1 PNAS, April 29, 2008; 105(17): 6451 - 6456. [Abstract] [Full Text] [PDF]

				T. Yokomizo, K. Hasegawa, H. Ishitobi, M. Osato, M. Ema, Y. Ito, M. Yamamoto, and S. Takahashi Runx1 is involved in primitive erythropoiesis in the mouse Blood, April 15, 2008; 111(8): 4075 - 4080. [Abstract] [Full Text] [PDF]

				K. M. Osorio, S. E. Lee, D. J. McDermitt, S. K. Waghmare, Y. V. Zhang, H. N. Woo, and T. Tumbar Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation Development, March 15, 2008; 135(6): 1059 - 1068. [Abstract] [Full Text] [PDF]

				J.-R. Landry, S. Kinston, K. Knezevic, M. F.T.R. de Bruijn, N. Wilson, W. T. Nottingham, M. Peitz, F. Edenhofer, J. E. Pimanda, K. Ottersbach, et al. Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver Blood, March 15, 2008; 111(6): 3005 - 3014. [Abstract] [Full Text] [PDF]

				Y.-H. Kuo, R. M. Gerstein, and L. H. Castilla Cbf{beta}-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development Blood, February 1, 2008; 111(3): 1543 - 1551. [Abstract] [Full Text] [PDF]

				W. T. Nottingham, A. Jarratt, M. Burgess, C. L. Speck, J.-F. Cheng, S. Prabhakar, E. M. Rubin, P.-S. Li, J. Sloane-Stanley, J. Kong-a-San, et al. Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer Blood, December 15, 2007; 110(13): 4188 - 4197. [Abstract] [Full Text] [PDF]

				S. K. Zaidi, S. Pande, J. Pratap, T. Gaur, S. Grigoriu, S. A. Ali, J. L. Stein, J. B. Lian, A. J. van Wijnen, and G. S. Stein Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential PNAS, December 11, 2007; 104(50): 19861 - 19866. [Abstract] [Full Text] [PDF]

				S. Taoudi and A. Medvinsky Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta PNAS, May 29, 2007; 104(22): 9399 - 9403. [Abstract] [Full Text] [PDF]

				M. Magnusson, A. C. M. Brun, N. Miyake, J. Larsson, M. Ehinger, J. M. Bjornsson, A. Wutz, M. Sigvardsson, and S. Karlsson HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development Blood, May 1, 2007; 109(9): 3687 - 3696. [Abstract] [Full Text] [PDF]

				L. Zhao, J. L. Cannons, S. Anderson, M. Kirby, L. Xu, L. H. Castilla, P. L. Schwartzberg, R. Bosselut, and P. P. Liu CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus Blood, April 15, 2007; 109(8): 3432 - 3440. [Abstract] [Full Text] [PDF]

				G. Shinoda, K. Umeda, T. Heike, M. Arai, A. Niwa, F. Ma, H. Suemori, H. Y. Luo, D. H. K. Chui, R. Torii, et al. {alpha}4-Integrin+ endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells Blood, March 15, 2007; 109(6): 2406 - 2415. [Abstract] [Full Text] [PDF]

				J. E. Pimanda, I. J. Donaldson, M. F. T. R. de Bruijn, S. Kinston, K. Knezevic, L. Huckle, S. Piltz, J.-R. Landry, A. R. Green, D. Tannahill, et al. The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity PNAS, January 16, 2007; 104(3): 840 - 845. [Abstract] [Full Text] [PDF]

				H. K. A. Mikkola and S. H. Orkin The journey of developing hematopoietic stem cells. Development, October 1, 2006; 133(19): 3733 - 3744. [Abstract] [Full Text] [PDF]

				S. Willey, A. Ayuso-Sacido, H. Zhang, S. T. Fraser, K. E. Sahr, M. J. Adlam, M. Kyba, G. Q. Daley, G. Keller, and M. H. Baron Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor Blood, April 15, 2006; 107(8): 3122 - 3130. [Abstract] [Full Text] [PDF]

				C. Pouget, R. Gautier, M.-A. Teillet, and T. Jaffredo Somite-derived cells replace ventral aortic hemangioblasts and provide aortic smooth muscle cells of the trunk Development, March 15, 2006; 133(6): 1013 - 1022. [Abstract] [Full Text] [PDF]

				Z. Li, M. J. Chen, T. Stacy, and N. A. Speck Runx1 function in hematopoiesis is required in cells that express Tek Blood, January 1, 2006; 107(1): 106 - 110. [Abstract] [Full Text] [PDF]

				M. Kundu, S. Compton, L. Garrett-Beal, T. Stacy, M. F. Starost, M. Eckhaus, N. A. Speck, and P. P. Liu Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma Blood, November 15, 2005; 106(10): 3621 - 3624. [Abstract] [Full Text] [PDF]

				S. Taoudi, A. M. Morrison, H. Inoue, R. Gribi, J. Ure, and A. Medvinsky Progressive divergence of definitive haematopoietic stem cells from the endothelial compartment does not depend on contact with the foetal liver Development, September 15, 2005; 132(18): 4179 - 4191. [Abstract] [Full Text] [PDF]

				H. Hirai, I. M Samokhvalov, T. Fujimoto, S. Nishikawa, J. Imanishi, and S.-I. Nishikawa Involvement of Runx1 in the down-regulation of fetal liver kinase-1 expression during transition of endothelial cells to hematopoietic cells Blood, September 15, 2005; 106(6): 1948 - 1955. [Abstract] [Full Text] [PDF]

				J. D. Growney, H. Shigematsu, Z. Li, B. H. Lee, J. Adelsperger, R. Rowan, D. P. Curley, J. L. Kutok, K. Akashi, I. R. Williams, et al. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype Blood, July 15, 2005; 106(2): 494 - 504. [Abstract] [Full Text] [PDF]

				Y. Fukushima-Nakase, Y. Naoe, I. Taniuchi, H. Hosoi, T. Sugimoto, and T. Okuda Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development Blood, June 1, 2005; 105(11): 4298 - 4307. [Abstract] [Full Text] [PDF]

				E. M. Chan, E. M. Comer, F. C. Brown, K. E. Richkind, M. L. Holmes, B. H. Chong, R. Shiffman, D.-E. Zhang, M. L. Slovak, C. L. Willman, et al. AML1-FOG2 fusion protein in myelodysplasia Blood, June 1, 2005; 105(11): 4523 - 4526. [Abstract] [Full Text] [PDF]

				D. Vradii, S. K. Zaidi, J. B. Lian, A. J. van Wijnen, J. L. Stein, and G. S. Stein Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype PNAS, May 17, 2005; 102(20): 7174 - 7179. [Abstract] [Full Text] [PDF]

				L. J. Patterson, M. Gering, and R. Patient Scl is required for dorsal aorta as well as blood formation in zebrafish embryos Blood, May 1, 2005; 105(9): 3502 - 3511. [Abstract] [Full Text] [PDF]

				C. J. Lengner, M. Q. Hassan, R. W. Serra, C. Lepper, A. J. van Wijnen, J. L. Stein, J. B. Lian, and G. S. Stein Nkx3.2-mediated Repression of Runx2 Promotes Chondrogenic Differentiation J. Biol. Chem., April 22, 2005; 280(16): 15872 - 15879. [Abstract] [Full Text] [PDF]

				A. Robert-Moreno, L. Espinosa, J. L. de la Pompa, and A. Bigas RBPj{kappa}-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells Development, March 1, 2005; 132(5): 1117 - 1126. [Abstract] [Full Text] [PDF]

				S. C. Mendes, C. Robin, and E. Dzierzak Mesenchymal progenitor cells localize within hematopoietic sites throughout ontogeny Development, March 1, 2005; 132(5): 1127 - 1136. [Abstract] [Full Text] [PDF]

				F. M. Theriault, H. N. Nuthall, Z. Dong, R. Lo, F. Barnabe-Heider, F. D. Miller, and S. Stifani Role for Runx1 in the Proliferation and Neuronal Differentiation of Selected Progenitor Cells in the Mammalian Nervous System J. Neurosci., February 23, 2005; 25(8): 2050 - 2061. [Abstract] [Full Text] [PDF]

				N. Yoshida, T. Ogata, K. Tanabe, S. Li, M. Nakazato, K. Kohu, T. Takafuta, S. Shapiro, Y. Ohta, M. Satake, et al. Filamin A-Bound PEBP2{beta}/CBF{beta} Is Retained in the Cytoplasm and Prevented from Functioning as a Partner of the Runx1 Transcription Factor Mol. Cell. Biol., February 1, 2005; 25(3): 1003 - 1012. [Abstract] [Full Text] [PDF]