Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle

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Akiyama, M., Smith, L. T. and Holbrook, K. A (1996). Growth factor and growth factor receptor localization in the hair follicle bulge and associated tissue in human fetus. J. Invest. Dermatol 106, 391-396.[Medline]

Betsholtz, C., Westermark, B., Ek, B. and Heldin, C.-H (1984). Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: Implications for autocrine receptor activation. Cell 39, 447-457.[Medline]

Bitgood, M. J. and McMahon, A. P (1995). Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interactions in the mouse embryo. Dev. Biol 172, 126-138.[Medline]

Bostr\232m, H., Willetts, K., Pekny, M., Leveen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellstr\232m, M., Gebre-Medhin, S., Schalling, M., Nilsson, M., Kurland, S., T\232rnell, J., Heath, J. K. and Betsholtz, C (1996). PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 85, 863-873.[Medline]

Calver, A. R., Hall, A. C., Yu, W.,-P., Walsh, F. S., Heath, J. K., Betsholtz, C. and Richardson, W. D (1998). Oligodendrocyte population dynamics and the role of PDGF in vivo. Neuron 20, 869-882.[Medline]

Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A (1996). Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413.[Medline]

Chiang, C., Swan, R. Z., Grachtchouk, M., Bolinger, M., Litingtung, Y., Robertson, E. K., Cooper, M. K., Gaffield, W., Westphal, H., Beachy, P. A. and Dlugosz, A. A (1999). Essential role for sonic hedgehog during hair follicle morphogenesis. Dev. Biol 20, 1-9.

Fruttiger, M., Karlsson, L., Hall, A. C., Abramsson, A., Calver, A. R., Bostr\232m, H., Willetts, K., Berthold, C.-H., Heath, J. K., Betsholtz, C. and Richardson, W. D (1999). Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice. Development 126, 457-467.[Abstract]

Gat, U., DasGupta, R., Degenstein, L. and Fuchs, E (1998). De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95, 605-614.[Medline]

Guo, L., Degenstein, L. and Fuchs, E (1996). Keratinocyte growth factor is required for hair development but not for would healing. Genes Dev 10, 165-175.[Abstract/Free Full Text]

Hansen, L. A., Alexander, N., Hogan, M. E., Sundberg, J. P., Dlugosz, A., Threadgill, D. W., Magnuson, T. and Yuspa, S. H (1997). Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. Am. J. Pathol 150, 1959-1975.[Abstract]

Hardy, M. H (1992). The secret life of the hair follicle. Trends Genet 2, 55-61.

Hebert, J. M., Rosenquist, T., G\232tz, J. and Martin, G (1994). FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell 78, 1017-1025.[Medline]

Horne, K. A., Jahoda, C. A. B. and Oliver, R. F (1986). Whisker growth induced by implantation of cultured vibrissa dermal papilla cells in the adult rat. J. Embryo. Exp. Morphol 72, 111-124.

Ibrahim, L. and Wright, E. A (1982). A quantitative study of hair growth using mouse and rat vibrissae follicles. J. Embryol. Exp. Morphol 72, 209-224.[Medline]

Iseki, S., Araga, A., Ohuchi, H., Nohno, T., Yoshioka, H., Hayashi, F. and Noji, S (1996). Sonic hedgehog is expressed in epithelial cells during development of whisker, hair, and tooth. Biochem. Biophys. Res. Commun 218, 688-693.[Medline]

Jahoda, C. A. B., Horne, K. A. and Oliver, R. F (1984). Induction of hair growth by implantation of cultured dermal papilla cells. Nature 311, 560-562.[Medline]

Jahoda, C. A. B., Reynolds, A. J. and Oliver, R. F (1993). Induction of hair growth in ear wounds by cultured dermal papilla cells. J. Invest. Dermatol._Fb_101 ,584-590._Fb_Jones, C. M., Lyons, K. M. and Hogan, B. L. (1991). Involvement of bone morphogenetic protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse.. Development 111, 531-542.[Abstract]

Kollar, E. J (1970). The induction of hair follicles by embryonic dermal papillae. J. Invest. Dermatol 55, 374-378.[Medline]

Leveen, P., Pekny, M., Gebre-Medhin, S., Swolin, B., Larsson, E. and Betsholtz, C (1994). Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev 8, 1875-1887.[Abstract/Free Full Text]

Lindahl, P., Hellstr\232m, M., Kalen, M., Karlsson, L., Pekny, M., Pekna, M., Soriano, P. and Betsholtz, C (1998). Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell growth in the development of kidney glomeruli. Development 125, 3313-3322.[Abstract]

Lindahl, P., Johansson, B., Leveen, P. and Betsholtz, C (1997). Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277, 242-245.[Abstract/Free Full Text]

Lindahl, P., Karlsson, L., Hellstr\232m, M., Gebre-Medhin, S., Willetts, K., Heath, J. K. and Betsholtz, C (1997). Alveogenesis failure in PDGF-A deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Development 124, 3943-3953.[Abstract]

Luetteke, N. C., Phillips, H. K., Qiu, T. H., Copeland, N. G., Earp, H. S., Jenkins, N. A. and Lee, D. C (1994). The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8, 399-413.[Abstract/Free Full Text]

Luetteke, N. C., Qiu, T. H., Pfeiffer, R. L., Oliver, P. Smithies, O. S. and Lee, D. C (1993). TGF adeficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73, 263-278.[Medline]

Lyons, K. M., Peltonen, R. W. and Hogan, B. L (1990). Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development 109, 833-844.[Abstract/Free Full Text]

Mann, B. G., Fowler, K. J., Gabriel, A., Nice, E. C., Williams, R. L. and Dunn, A. R (1993). Mice with a null mutation of the TGF-a gene have abnormal skin architecture, wavy hair, curly wiskers and frequently develop corneal inflammation. Cell 73, 249-261.[Medline]

Mann, S. J (1962). Prenatal formation of hair follicle types. Anat. Rec 144, 135-142.

Moore, G. P. M., Jackson, N., Isaacs, K. and Brown, G (1998). Pattern and morphogenesis in skin. J. theor. Biol 191, 87-94.[Medline]

Motoyama, J., Takabatake, T., Takeshima, K. and Hui, C.-C (1998). Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nature Genet 18, 104-106.[Medline]

Oliver, R. F (1967). The experimental induction of whisker growth in the hooded rat by implantation of dermal papillae. J. Embryol. Exp. Morphol 18, 83-125.

Oro, A. E., Higgins, K. M., Hu, Z., Bonifas, J. M., Epstein Jr., E. H. and Scott, M. P (1997). Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 276, 817-821.[Abstract/Free Full Text]

Orr-Urtreger, A., Bedford, M. T., Do, M.-S., Eisenbach, L. and Lonai, P (1992). Developmental expression of the alpha-receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation. Development 115, 289-303.[Abstract]

Orr-Urtreger, A. and Lonai, P (1992). Platelet-derived growth factor-A and its receptor are expressed in separate but adjacent cell layers of the mouse embryo. Development 115, 1045-1058.[Abstract]

Orwin, D. F. G (1979). The cytology and cytochemistry of the wool follicle. Int. Rev. Cytol 60, 331-374.[Medline]

\205stman, A., B\212ckstr\232m, G., Fong, N., Betsholtz, C., Wernstedt, C., Hellman, U., Westermark, B., Valenzuela, P., and Heldin, C. H (1989). Expression of three recombinant homodimeric isoforms of PDGF in Saccharomyces cerevisiae: evidence for difference in receptor binding and functional activities. Growth Factors 1, 271-81.[Medline]

Ponten, F., Ren, Z., Nister, M., Westermark, B. and Ponten, J (1994). Epithelial-stromal interactions in basal cell cancer: the PDGF system. J. Invest. Dermatol 102, 304-309.[Medline]

Schatteman, G. C., Morrison-Graham, K., van Koppen, A., Weston, J. A. and Bowen-Pope, D. F (1992). Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis. Development 115, 123-131.[Abstract]

Slee, J (1962). Developmental morphology of the skin and hair follicles in normal and \324ragged' mice. J. Embryol. Exp. Morphol 10, 507-529.

Smith, E. A., Seldin, M. F., Martinez, L., Watson, M. L., Choudhury, G. G., Lalley, P. A., Pierce, J., Aaronson, S. A., Barker, J., Naylor, S. L. and Sakaguchi, A. Y (1991). Mouse platelet-derived growth factor receptor a gene is deleted in W19H and patch mutations on chromosome 5. Proc. Natl. Acad. Sci. USA 88, 4811-4815.[Abstract/Free Full Text]

Soriano, P (1994). Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev 8, 1888-1896.[Abstract/Free Full Text]

Soriano, P (1997). The PDGF alpha receptor is required for neural crest cell survival and for normal patterning of the somites. Development 124, 2691-2700.[Abstract]

St-Jacques, B., Dassule, H. R., Karavanova, I., Botchkarev, V. A., Li, J., Danielian, P. S., McMahon, J. A., Lewis, P. M., Paus, R. and McMahon, A. P (1998). Sonic Hedgehog signaling is essential for hair development. Curr. Biol 8, 1058-1068.[Medline]

Stephenson, D. A., Mercola, M., Anderson, E., Wang, C., Stiles, C. D., Bowen-Pope, D. F. and Chapman, V. M (1991). Platelet-derived growth factor receptor a-subunit gene (Pdgfra) is deleted in the patch (Ph) mutation. Proc. Natl. Acad. Sci. USA 88, 6-10.[Abstract/Free Full Text]

Takakura, N., Yoshida, H., Kunisada, T., Nishikawa, S. and Nishikawa, S.-H (1996). Involvement of platelet-derived growth factor receptor alpha in hair canal formation. J. Invest. Dermatol 107, 770-777.[Medline]

van Scott, E. J. and Eckel, T. M (1958). Geometric relationships between the matrix of the hair bulb and its dermal papilla in normal and alopecic scalp. J. Invest. Dermatol 31, 281-287.[Medline]

Watson, S. A. J., Pisansarakit, P. and Moore, G. P. M (1994). Induction of hair follicle formation in heterotypic skin equivalents. Br. J. Dermatol 131, 827-835.[Medline]

Wessels, N. K. and Roessner, K. D (1965). Nonproliferation in dermal condensations of mouse vibrissae and pelage hairs. Dev. Biol 12, 419-433.[Medline]

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				J. Andrae, R. Gallini, and C. Betsholtz Role of platelet-derived growth factors in physiology and medicine Genes & Dev., May 15, 2008; 22(10): 1276 - 1312. [Abstract] [Full Text] [PDF]

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				S. Basciani, S. Mariani, M. Arizzi, M. Brama, A. Ricci, C. Betsholtz, C. Bondjers, G. Ricci, A. Catizone, M. Galdieri, et al. Expression of Platelet-Derived Growth Factor (PDGF) in the Epididymis and Analysis of the Epididymal Development in PDGF-A, PDGF-B, and PDGF Receptor {beta} Deficient Mice Biol Reprod, January 1, 2004; 70(1): 168 - 177. [Abstract] [Full Text] [PDF]

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				W. E. Jenkinson, E. J. Jenkinson, and G. Anderson Differential Requirement for Mesenchyme in the Proliferation and Maturation of Thymic Epithelial Progenitors J. Exp. Med., July 21, 2003; 198(2): 325 - 332. [Abstract] [Full Text] [PDF]

				P. Mill, R. Mo, H. Fu, M. Grachtchouk, P. C.W. Kim, A. A. Dlugosz, and C.-c. Hui Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development Genes & Dev., January 15, 2003; 17(2): 282 - 294. [Abstract] [Full Text] [PDF]

				H. Sheng, S. Goich, A. Wang, M. Grachtchouk, L. Lowe, R. Mo, K. Lin, F. J. de Sauvage, H. Sasaki, C.-c. Hui, et al. Dissecting the Oncogenic Potential of Gli2: Deletion of an NH2-Terminal Fragment Alters Skin Tumor Phenotype Cancer Res., September 15, 2002; 62(18): 5308 - 5316. [Abstract] [Full Text] [PDF]

				S. Basciani, S. Mariani, M. Arizzi, S. Ulisse, N. Rucci, E. A. Jannini, C. D. Rocca, A. Manicone, C. Carani, G. Spera, et al. Expression of Platelet-Derived Growth Factor-A (PDGF-A), PDGF-B, and PDGF Receptor-{alpha} and -{beta} during Human Testicular Development and Disease J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 2310 - 2319. [Abstract] [Full Text] [PDF]

				K. S. Stenn and R. Paus Controls of Hair Follicle Cycling Physiol Rev, January 1, 2001; 81(1): 449 - 494. [Abstract] [Full Text] [PDF]

				M. Sachs, H. Brohmann, D. Zechner, T. Muller, J. Hulsken, I. Walther, U. Schaeper, C. Birchmeier, and W. Birchmeier Essential Role of Gab1 for Signaling by the c-Met Receptor In Vivo J. Cell Biol., September 18, 2000; 150(6): 1375 - 1384. [Abstract] [Full Text] [PDF]

				L. Gnessi, S. Basciani, S. Mariani, M. Arizzi, G. Spera, C. Wang, C. Bondjers, L. Karlsson, and C. Betsholtz Leydig Cell Loss and Spermatogenic Arrest in Platelet-derived Growth Factor (PDGF)-A-deficient Mice J. Cell Biol., May 29, 2000; 149(5): 1019 - 1026. [Abstract] [Full Text] [PDF]

				M. Itoh, Y. Yoshida, K. Nishida, M. Narimatsu, M. Hibi, and T. Hirano Role of Gab1 in Heart, Placenta, and Skin Development and Growth Factor- and Cytokine-Induced Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Activation Mol. Cell. Biol., May 15, 2000; 20(10): 3695 - 3704. [Abstract] [Full Text]

				L Karlsson, P Lindahl, J. Heath, and C Betsholtz Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis Development, January 8, 2000; 127(16): 3457 - 3466. [Abstract] [PDF]

				M. Nilsson, A. B. Unden, D. Krause, U. Malmqwist, K. Raza, P. G. Zaphiropoulos, and R. Toftgard Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 PNAS, March 28, 2000; 97(7): 3438 - 3443. [Abstract] [Full Text] [PDF]