Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development

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Barnard, J. A., Beauchamp, R. D., Russell, W. E., Dubois, R. N. and Coffey, R. J (1995). Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology 108, 564-580.[Medline]

Beardmore, J. M. and Richards, R. C (1983). Concentrations of epidermal growth factor in mouse milk throughout lactation. J. Endocrinol 96, 287-292.[Abstract]

Beerli, R. R. and Hynes, N. E (1996). Epidermal growth factor-related peptides activate distinct subsets of erbB receptors and differ in their biological activities. J. Biol. Chem 271, 6071-6076.[Abstract/Free Full Text]

Berkowitz, E. A., Seroogy, K. B., Schroeder, J. A., Russell, W. E., Evans, E. P., Riedel, R. F., Phillips, H. K., Harrison, C. A., Lee, D. C. and Luetteke, N. C (1996). Characterization of the mouse transforming growth factorgene: its expression during eyelid development and in waved-1 tissues. Cell Growth Diff 7, 1271-1282.[Abstract]

Brown, C. F., Teng, C. T., Pentecost, B. T. and DiAugustine, R. P (1989). Epidermal growth factor precursor in mouse lactating mammary gland alveolar cells. Mol. Endocrinol 3, 1077-1083.[Abstract]

Carraway III, K. L., Weber, J. L., Unger, M. J., Ledesma, J., Yu, N., Gassmann, M. andLai, C (1997). Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature 387, 512-516.[Medline]

Coleman, S., Silberstein, G. B. and Daniel, C. W (1988). Ductal morphogenesis in the mouse mammary gland: evidence supporting a role for epidermal growth factor. Dev. Biol 127, 304-315.[Medline]

David, M., Wong, L., Flavell, R., Thompson, S. A., Wells, A., Larner, A. C. and Johnson, G. R (1996). STAT activation by epidermal growth factor (EGF) and amphiregulin. Requirement for the EGF receptor tyrosine kinase but not for tyrosine phosphorylation sites or JAK1. J. Biol. Chem 271, 9185-9188.[Abstract/Free Full Text]

Elenius, K., Paul, S., Allison, G., Sun, J. and Klagsbrun, M (1997). Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. EMBO J 16, 1268-1278.[Medline]

Fantl, V., Stamp, G., Andrews, A., Rosewell, I. and Dickson, C (1995). Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev 9, 2364-2372.[Abstract/Free Full Text]

Fowler, K. J., Walker, F., Alexander, W., Hibbs, M. L., Nice, E. C., Bohmer, R. M., Mann, G. B., Thumwood, C., Maglitto, R., Danks, J. A., Chetty, R., Burgess, A. W. and Dunn A. R (1995). A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc. Natl. Acad. Sci. USA 92, 1465-1469.[Abstract/Free Full Text]

Hansen, L. A., Alexander, N., Hogan, M. E., Sundberg, J. P., Dlugosz, A., Threadgill, D. W., Magnuson, T. and Yuspa, S. H (1997). Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. Am. J. Pathol 150, 1959-1975.[Abstract]

Hardy, M. H (1992). The secret life of the hair follicle. Trends Genet 8, 55-61.[Medline]

Heldin, C.-H (1995). Dimerization of cell surface receptors in signal transduction. Cell 80, 213-223.[Medline]

Hennighausen, L. and Robinson, G. W (1998). Think globally, act locally: the making of a mouse mammary gland. Genes Dev 12, 449-455.[Free Full Text]

Humphreys, R. C., Krajewska, M., Krnacik, S., Jaeger, R., Weiher, H.,Krajewski, S., Reed, J. C. and Rosen, J. M (1996). Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. Development 122, 4013-4022.[Abstract]

Jones, F. E., Jerry, D. J., Guarino, B. C., Andrews, G. C. and Stern, D. F (1996). Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli. Cell Growth Diff 7, 1031-1038.[Abstract]

Kenney, N. J., Huang, R. P., Johnson, G. R., Wu, J. X., Okamura, D., Matheny, W., Kordon, E., Gullick, W. J., Plowman, G., Smith, G. H., Salomon, D. S. and Adamson E. D (1995). Detection and location of amphiregulin and Cripto-1 expression in the developing postnatal mouse mammary gland. Mol. Reprod. Dev 41, 277-286.[Medline]

Kenney, N. J., Smith, G. H., Rosenberg, K., Cutler, M. L. and Dickson, R. B (1996). Induction of ductal morphogenesis and lobular hyperplasia by amphiregulin in the mouse mammary gland. Cell Growth Diff 7, 1769-1781.[Abstract]

Kondapaka, S. B., Fridman, R. and Reddy, K. B (1997). Epidermal growth factor and amphiregulin up-regulate matrix matalloproteinase-9 (MMP-9) in human breast cancer cells. Int. J. Cancer 7, 722-726.

Lee, D. C., Fenton, S. E., Berkowitz, E. A. and Hissong, M. A (1995). Transforming growth factor-: expression, regulation, and biological activities. Pharm. Rev 47, 51-85.[Medline]

Li, M., Liu, X., Robinson, G., Bar-Peled, U., Wagner, K-U., Young, W. S., Hennighausen, L. and Furth, P. A (1997). Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution. Proc. Natl. Acad. Sci. USA 94, 3425-3430.[Abstract/Free Full Text]

Liu, X., Robinson, G. W. and Hennighausen, L (1996). Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation. Mol. Endocrinol 10, 1496-1506.[Abstract]

Liu, X., Robinson, G. W., Wagner, K.-U., Garrett, L., Wynshaw-Boris, A. and Hennighausen, L (1997). Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev 11, 179-186.[Abstract/Free Full Text]

Liu, X., Gallego, M. I., Smith, G. H., Robinson, G. W. and Hennighausen, L (1998). Functional rescue of Stat5a-null mammary tissue through the activation of compensating signals including Stat 5b. Cell Growth Diff 9, 795-803.[Abstract]

Luetteke, N. C., Qiu, T. H., Peiffer, R. L., Oliver, P., Smithies, O. and Lee, D.C (1993). TGFdeficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73, 263-278.[Medline]

Luetteke, N. C., Phillips, H. K., Qiu, T. H., Copeland, N. G., Earp, H. S., Jenkins, N.A. and Lee, D. C (1994). The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8, 399-413.[Abstract/Free Full Text]

Mainiero, F., Pepe, A., Yeon, M., Ren, Y. and Giancotti, F. G (1996). The intracellular functions of6 4integrin are regulated by EGF. J. Cell Biol 134, 241-253.[Abstract/Free Full Text]

Mann, G. B., Fowler, K. J., Gabriel, A., Nice, E. C., Williams, R. L. and Dunn, A. R (1993). Mice with a null mutation of the TGF-gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell 73, 249-261.[Medline]

Matsui, Y., Halter, S. A., Holt, J. T., Hogan, B. L. M. and Coffey, R. J (1990). Development of mammary hyperplasia and neoplasia in MMTV-TGFtransgenic mice. Cell 61, 1147-1155.[Medline]

Miettinen, P. J., Berger, J. E., Meneses, J., Phung, Y., Pedersen, R. A., Werb, Z. and Derynck R (1995). Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376, 337-341.[Medline]

Mortensen, R. M., Conner, D. A., Chao, S., Geisterfer-Lowrance, A. A. T. and Seidman, J. G (1992). Production of homozygous mutant ES cells with a single targeting construct. Mol. Cell. Biol 12, 2391-2395.[Abstract/Free Full Text]

Ormandy, C. J., Camus, A., Barra, J., Damotte, D., Lucas, B., Buteau, H., Edery, M., Brousse, N., Babinet, C., Binart, N. and Kelly, P. A (1997). Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev 11, 167-178.[Abstract/Free Full Text]

Philp, J. A. C., Burdon, T. G. and Watson, C. J (1996). Differential activation of Stats 3 and 5 during mammary gland development. FEBS Lett 396, 77-80.[Medline]

Pinkas-Kramarski, R., Shelly, M., Glathe, S., Ratzkins, B. J. and Yarden, Y (1996). Neu differentiation factor/neuregulin isoforms activate distinct receptor combinations. J. Biol. Chem 271, 19029-19032.[Abstract/Free Full Text]

Playford, R. J. and Wright, N. A (1996). Why is epidermal growth factor present in the gut lumen?. Gut 38, 303-305.[Abstract/Free Full Text]

Riese, D. J., Bermingham, Y., Raaij, T. M. V., Buckley, S., Plowman, G. D. and Stern, D. F (1996). Betacellulin activates the epidermal growth factor receptor and erbB4, and induces cellular response patterns distinct fromthose stimulated by epidermal growth factor or neuregulin-. Oncogene 12, 345-353.[Medline]

Riese, D. J. and Stern, D. F (1998). Specificity within the EGF family/ErbB receptor family signaling network. BioEssays 20, 41-48.[Medline]

Robinson, G. W. and Hennighausen, L (1997). Inhibins and activins regulate mammary epithelial cell differentiation through mesenchymal-epithelial interactions. Development 124, 2701-2708.[Abstract]

Sandgren, E. P., Schroeder, J. A. Qiu, T. H. Palmiter, R. D. Brinster, R. L. and Lee, D. C (1995). Inhibition of mammary gland involution is associated with transforming growth factor a but not c-myc-induced tumorigenesis in transgenic mice. Cancer Res 55, 3915-3927.[Abstract/Free Full Text]

Schroeder, J. A. and Lee, D. C (1998). Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland. Cell Growth Diff 9, 451-464.[Abstract]

Schweitzer, R. and Shilo, B.-Z (1997). A thousand and one roles for the Drosophila EGF receptor. Trends Genet 13, 191-196.[Medline]

Sebastian, J., Richards, R. G., Walker, M. P., Wiesen, J. F., Werb, Z., Derynck, R., Hom, Y. K., Cunha, G. R. and DiAugustine R. P (1998). Activation and function of the epidermal growth factor receptor and erbB2 during mammary gland morphogenesis. Cell Growth Diff 9, 777-785.[Abstract]

Shoyab, M., Plowman, G. D., McDonald, V. L., Bradley, J. G. and Todaro, G. J (1989). Structure and function of human amphiregulin: a member of the epidermal growth factor family. Science 243, 1074-1076.[Abstract/Free Full Text]

Shuger, L., Johnson, G. R., Gilbride, K., Plowman, G.D. and Mandel, R (1996). Amphiregulin in lung branching morphogenesis: interaction with heparan sulfate proteoglycan modulates cell proliferation. Development 122, 1759-1767.[Abstract]

Sibilia, M. and Wagner, E. F (1995). Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269, 234-238.[Abstract/Free Full Text]

Sicinski, P., Donaher, J. L., Parker, S. B., Li, T., Fazeli, A., Gardner, H., Haslam, S. Z., Bronson, R. T., Elledge, S. J. and Weinberg, R. A (1995). Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82, 621-630.[Medline]

Stahl, S., Weitzman, S. and Jones, J. C. R (1997). The role of laminin-5 and its receptors in mammary epithelial cell branching morphogenesis. J. Cell Sci 110, 55-63.[Abstract]

Threadgill, D. W., Dlgosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., Barnard, J. A., Yuspa, S. H., Coffey, R. J. and Magnuson, T (1995). Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269, 230-234.[Abstract/Free Full Text]

Wen, D., Suggs, S. V., Karunagaran, D., Liu, N., Cupples, R. L., Luo, Y., Janssen, A. M., Ben-Baruch, N., Trollinger, D. B., Jacobsen, V. L., Meng, S.-Y., Lu, H. S., Hu, S., Chang, D., Yang, W., Yanigahara, D., Koski, R. A. and Yarden, Y (1994). Structural and functional aspects of the the multiplicity of neu differentiation factors. Mol. Cell. Biol 14, 1909-1919.[Abstract/Free Full Text]

Wiesen, J. F., Young, P., Werb, Z. and Cunha, G. R (1999). Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development. Development 126, 335-344.[Abstract]

Xie, W., Paterson, A. J., Chin, E., Nabell, L. M. and Kudlow, J. E (1997). Targeted expression of a dominant negative epidermal growth factor receptor in the mammary gland of transgenic mice inhibits pubertal mammary duct development. Mol. Endocrinol 11, 1766-1781.[Abstract/Free Full Text]

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[Abstract] [Full Text] [PDF]

B. D. Abbott, T.-M. Lin, N. T. Rasmussen, R. M. Albrecht, J. E. Schmid, and R. E. Peterson
Lack of Expression of EGF and TGF-{alpha} in the Fetal Mouse Alters Formation of Prostatic Epithelial Buds and Influences the Response to TCDD
Toxicol. Sci., December 1, 2003; 76(2): 427 - 436.
[Abstract] [Full Text] [PDF]

K. K. L. Mak and S. Y. Chan
Epidermal Growth Factor as a Biologic Switch in Hair Growth Cycle
J. Biol. Chem., July 3, 2003; 278(28): 26120 - 26126.
[Abstract] [Full Text] [PDF]

K. L. Schwertfeger, J. L. McManaman, C. A. Palmer, M. C. Neville, and S. M. Anderson
Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation
J. Lipid Res., June 1, 2003; 44(6): 1100 - 1112.
[Abstract] [Full Text] [PDF]

R.-A. Wang, R. K. Vadlamudi, R. Bagheri-Yarmand, I. Beuvink, N. E. Hynes, and R. Kumar
Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands
J. Cell Biol., May 12, 2003; 161(3): 583 - 592.
[Abstract] [Full Text] [PDF]

D. C. LEE, S. W. SUNNARBORG, C. L. HINKLE, T. J. MYERS, M. STEVENSON, W. E. RUSSELL, B. J. CASTNER, M. J. GERHART, R. J. PAXTON, R. A. BLACK, et al.
TACE/ADAM17 Processing of EGFR Ligands Indicates a Role as a Physiological Convertase
Ann. N.Y. Acad. Sci., May 1, 2003; 995(1): 22 - 38.
[Abstract] [Full Text] [PDF]

M. NILSEN-HAMILTON, Q. LIU, J. RYON, L. BENDICKSON, P. LEPONT, and Q. CHANG
Tissue Involution and the Acute Phase Response
Ann. N.Y. Acad. Sci., May 1, 2003; 995(1): 94 - 108.
[Abstract] [Full Text] [PDF]

R. Iwamoto, S. Yamazaki, M. Asakura, S. Takashima, H. Hasuwa, K. Miyado, S. Adachi, M. Kitakaze, K. Hashimoto, G. Raab, et al.
Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function
PNAS, March 18, 2003; 100(6): 3221 - 3226.
[Abstract] [Full Text] [PDF]

C. J. Ormandy, M. Naylor, J. Harris, F. Robertson, N. D. Horseman, G. J. Lindeman, J. Visvader, and P. A. Kelly
Investigation of the Transcriptional Changes Underlying Functional Defects in the Mamma

				K. Britt, A. Ashworth, and M. Smalley Pregnancy and the risk of breast cancer Endocr. Relat. Cancer, December 1, 2007; 14(4): 907 - 933. [Abstract] [Full Text] [PDF]

				H. Xie, H. Wang, S. Tranguch, R. Iwamoto, E. Mekada, F. J. DeMayo, J. P. Lydon, S. K. Das, and S. K. Dey Maternal heparin-binding-EGF deficiency limits pregnancy success in mice PNAS, November 13, 2007; 104(46): 18315 - 18320. [Abstract] [Full Text] [PDF]

				M. C Farach-Carson and D. D Carson Perlecan a multifunctional extracellular proteoglycan scaffold Glycobiology, September 1, 2007; 17(9): 897 - 905. [Abstract] [Full Text] [PDF]

				N. Heldring, A. Pike, S. Andersson, J. Matthews, G. Cheng, J. Hartman, M. Tujague, A. Strom, E. Treuter, M. Warner, et al. Estrogen Receptors: How Do They Signal and What Are Their Targets Physiol Rev, July 1, 2007; 87(3): 905 - 931. [Abstract] [Full Text] [PDF]

				S. Lee, D. Medina, A. Tsimelzon, S. K. Mohsin, S. Mao, Y. Wu, and D. C. Allred Alterations of Gene Expression in the Development of Early Hyperplastic Precursors of Breast Cancer Am. J. Pathol., July 1, 2007; 171(1): 252 - 262. [Abstract] [Full Text] [PDF]

				H.-S. Kim, M. S. Kim, A. L. Hancock, J. C. P. Harper, J. Y. Park, G. Poy, A. O. Perantoni, M. Cam, K. Malik, and S. B. Lee Identification of Novel Wilms' Tumor Suppressor Gene Target Genes Implicated in Kidney Development J. Biol. Chem., June 1, 2007; 282(22): 16278 - 16287. [Abstract] [Full Text] [PDF]

				C. J. Xian Roles of Epidermal Growth Factor Family in the Regulation of Postnatal Somatic Growth Endocr. Rev., May 1, 2007; 28(3): 284 - 296. [Abstract] [Full Text] [PDF]

				D. L. Russell and R. L. Robker Molecular mechanisms of ovulation: co-ordination through the cumulus complex Hum. Reprod. Update, May 1, 2007; 13(3): 289 - 312. [Abstract] [Full Text] [PDF]

				L. Ciarloni, S. Mallepell, and C. Brisken Amphiregulin is an essential mediator of estrogen receptor {alpha} function in mammary gland development PNAS, March 27, 2007; 104(13): 5455 - 5460. [Abstract] [Full Text] [PDF]

				M. Hsieh, D. Lee, S. Panigone, K. Horner, R. Chen, A. Theologis, D. C. Lee, D. W. Threadgill, and M. Conti Luteinizing Hormone-Dependent Activation of the Epidermal Growth Factor Network Is Essential for Ovulation Mol. Cell. Biol., March 1, 2007; 27(5): 1914 - 1924. [Abstract] [Full Text] [PDF]

				J.-I. Huh, T. H. Qiu, G. V. R. Chandramouli, R. Charles, M. Wiench, G. L. Hager, R. Catena, A. Calvo, T. M. LaVallee, P.-Y. Desprez, et al. 2-Methoxyestradiol Induces Mammary Gland Differentiation through Amphiregulin-Epithelial Growth Factor Receptor-Mediated Signaling: Molecular Distinctions from the Mammary Gland of Pregnant Mice Endocrinology, March 1, 2007; 148(3): 1266 - 1277. [Abstract] [Full Text] [PDF]

				D. M. Zaiss, L. Yang, P. R. Shah, J. J. Kobie, J. F. Urban, and T. R. Mosmann Amphiregulin, a TH2 Cytokine Enhancing Resistance to Nematodes Science, December 15, 2006; 314(5806): 1746 - 1746. [Abstract] [Full Text] [PDF]

				P. J. Miettinen, J. Ustinov, P. Ormio, R. Gao, J. Palgi, E. Hakonen, L. Juntti-Berggren, P.-O. Berggren, and T. Otonkoski Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal {beta}-Cell Growth Diabetes, December 1, 2006; 55(12): 3299 - 3308. [Abstract] [Full Text] [PDF]

				J. M. Fleming, G. Desury, T. A. Polanco, and W. S. Cohick Insulin Growth Factor-I and Epidermal Growth Factor Receptors Recruit Distinct Upstream Signaling Molecules to Enhance AKT Activation in Mammary Epithelial Cells Endocrinology, December 1, 2006; 147(12): 6027 - 6035. [Abstract] [Full Text] [PDF]

				S. SH. Choi, M. A. Miller, and P. A. Harper In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Amphiregulin Gene Expression in the Developing Mouse Ureter Toxicol. Sci., November 1, 2006; 94(1): 163 - 174. [Abstract] [Full Text] [PDF]

				E.A. Campbell, L. O'Hara, R.D. Catalano, A.M. Sharkey, T.C. Freeman, and M. H. Johnson Temporal expression profiling of the uterine luminal epithelium of the pseudo-pregnant mouse suggests receptivity to the fertilized egg is associated with complex transcriptional changes Hum. Reprod., October 1, 2006; 21(10): 2495 - 2513. [Abstract] [Full Text] [PDF]

				M. Conti, M. Hsieh, J.-Y. Park, and Y.-Q. Su Role of the Epidermal Growth Factor Network in Ovarian Follicles Mol. Endocrinol., April 1, 2006; 20(4): 715 - 723. [Abstract] [Full Text] [PDF]

				L. M. Arendt, T. A. Rose-Hellekant, E. P. Sandgren, and L. A. Schuler Prolactin Potentiates Transforming Growth Factor {alpha} Induction of Mammary Neoplasia in Transgenic Mice Am. J. Pathol., April 1, 2006; 168(4): 1365 - 1374. [Abstract] [Full Text] [PDF]

				C. Hu, A. Dievart, M. Lupien, E. Calvo, G. Tremblay, and P. Jolicoeur Overexpression of Activated Murine Notch1 and Notch3 in Transgenic Mice Blocks Mammary Gland Development and Induces Mammary Tumors Am. J. Pathol., March 1, 2006; 168(3): 973 - 990. [Abstract] [Full Text] [PDF]

				X. Gao, X. Chen, M. Taglienti, B. Rumballe, M. H. Little, and J. A. Kreidberg Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa Development, December 15, 2005; 132(24): 5437 - 5449. [Abstract] [Full Text] [PDF]

				M. R. Schneider, M. Dahlhoff, N. Herbach, I. Renner-Mueller, C. Dalke, O. Puk, J. Graw, R. Wanke, and E. Wolf Betacellulin Overexpression in Transgenic Mice Causes Disproportionate Growth, Pulmonary Hemorrhage Syndrome, and Complex Eye Pathology Endocrinology, December 1, 2005; 146(12): 5237 - 5246. [Abstract] [Full Text] [PDF]

				B.-B. S. ZHOU Targeting Ligand Cleavage to Inhibit the ErbB Pathway in Cancer Ann. N.Y. Acad. Sci., November 1, 2005; 1059(1): 56 - 60. [Abstract] [Full Text] [PDF]

				N. Mine, R. Iwamoto, and E. Mekada HB-EGF promotes epithelial cell migration in eyelid development Development, October 1, 2005; 132(19): 4317 - 4326. [Abstract] [Full Text] [PDF]

				M. D. Sternlicht, S. W. Sunnarborg, H. Kouros-Mehr, Y. Yu, D. C. Lee, and Z. Werb Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin Development, September 1, 2005; 132(17): 3923 - 3933. [Abstract] [Full Text] [PDF]

				S. J Kimber Leukaemia inhibitory factor in implantation and uterine biology Reproduction, August 1, 2005; 130(2): 131 - 145. [Abstract] [Full Text] [PDF]

				K. Ejskjaer, B.S. Sorensen, S.S. Poulsen, O. Mogensen, A. Forman, and E. Nexo Expression of the epidermal growth factor system in human endometrium during the menstrual cycle Mol. Hum. Reprod., August 1, 2005; 11(8): 543 - 551. [Abstract] [Full Text] [PDF]

				S.-H. Chang, Y. Ai, R. M. Breyer, T. F. Lane, and T. Hla The Prostaglandin E2 Receptor EP2 Is Required for Cyclooxygenase 2-Mediated Mammary Hyperplasia Cancer Res., June 1, 2005; 65(11): 4496 - 4499. [Abstract] [Full Text] [PDF]

				Y. Shirakata, R. Kimura, D. Nanba, R. Iwamoto, S. Tokumaru, C. Morimoto, K. Yokota, M. Nakamura, K. Sayama, E. Mekada, et al. Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing J. Cell Sci., June 1, 2005; 118(11): 2363 - 2370. [Abstract] [Full Text] [PDF]

				C. Berasain, E. R. Garcia-Trevijano, J. Castillo, E. Erroba, M. Santamaria, D. C. Lee, J. Prieto, and M. A. Avila Novel Role for Amphiregulin in Protection from Liver Injury J. Biol. Chem., May 13, 2005; 280(19): 19012 - 19020. [Abstract] [Full Text] [PDF]

				E. K. Chu, J. S. Foley, J. Cheng, A. S. Patel, J. M. Drazen, and D. J. Tschumperlin Bronchial Epithelial Compression Regulates Epidermal Growth Factor Receptor Family Ligand Expression in an Autocrine Manner Am. J. Respir. Cell Mol. Biol., May 1, 2005; 32(5): 373 - 380. [Abstract] [Full Text] [PDF]