Gli proteins encode context-dependent positive and negative functions: implications for development and disease

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Akimaru, H., Chen, Y., Dai, P., Hou, D. X., Nonaka, M., Smolik, S. M., Armstrong, S., Goodman, R. H. and Ishii, S (1997). Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signaling. Nature 386, 735-738.[Medline]

Alexandre, C., Jacinto, A. and Ingham, P. W (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev 10, 2003-2013.[Abstract/Free Full Text]

Aza-Blanc, P., Ram\222rez-Weber, F.-A., Laget, M.-P., Schwartz, C. and Kornberg, T (1997). Proteolysis that is inhibited by hedgehog targets cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.[Medline]

Brewster, R., Lee, J. and Ruiz i Altaba, A (1998). Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. Nature 398, 579-583.

Buscher, D., Bosse, B., Heymer, J. and Ruther, U (1997). Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech. Dev 62, 175-182.[Medline]

Chiang C., Litingtung Y., Lee E., Young K. E., Corden J. L., Westphal H. and Beachy P. A (1996). Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413.[Medline]

Chen, Y., Gallaher, N., Goodman, R. H. and Smolik, S. M. ( (1998). Protein kinase A directly regulates activity and proteolysis of cubitus interruptus. Proc. Natl. Acad. Sci. USA 95, 2349-2354.[Abstract/Free Full Text]

Clegg, C. H., Correll, L. A., Cadd, G. G. and McKnight, G. S (1987). Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit. J. Biol. Chem 262, 13111-13119.[Abstract/Free Full Text]

Concordet, J.-P., Lewis, K. E., Moore, J. W., Goodrich, L. V., Johnson, R. L., Scott, M. P. and Ingham, P. W (1996). Spatial distribution of a zebrafish patched homologue reflects the roles of sonic hedgehog and proteins kinase A in neural tube and somite patterning. Development 122, 2835-2846.[Abstract]

Dahmane, N., Lee, J., Robins, P., Heller, P. and Ruiz i Altaba, A (1997). Activation of Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors. Nature 389, 876-881.[Medline]

Dahmane, N. and Ruiz i Altaba, A (1999). Sonic hedgehog regulates the development of the cerebellum. Development 126, 3089-3100.[Abstract]

Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M. and Ishii, S (1999). Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by Gli3. J.Biol. Chem 274, 8143-8152.[Abstract/Free Full Text]

Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J. and Hui C. C., (1998). Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125, 2533-2543.[Abstract]

Eriscon, J., Morton, S., Kawakami, A., Roelink, H. and Jessell, T. M (1996). Two critical periods of Sonic hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661-673.[Medline]

Fan, C. M., Porter, J. A., Chiang, C., Chang, D. T., Beachy, P. A. and Tessier-Lavigne, M (1995). Long range sclerotome induction by sonic hedgehog: direct role of the amino-acid terminal cleavage product and modulation by cyclic AMP signaling pathway. Cell 81, 457-465.[Medline]

Goodrich, L. V., Milenkovic, L., Higgins, K. M. and Scott, M. P (1997). Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants. Science 277, 1109-1113.[Abstract/Free Full Text]

Hammerschmidt, M., Bitgood, M. J. and McMahon, A (1996). Proteinkinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev 10, 647-658.[Abstract/Free Full Text]

Hepker, J., Wang, Q. T., Motzny, C. K., Holmgren, R. and Orenic, T. V (1997). Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes. Development 124, 549-558.[Abstract]

Hughes, D. C., Allen, J., Morley, G., Sutherland, K., Ahmed, W., Prosser, J., Lettice, L., Allan, G., Mattei, M.-G., Farrall, M. and Hill, R. E (1997). Cloning and sequencing of the mouse Gli2 gene: localization to the dominant hemimelia critical region. Genomics 39, 205-215.[Medline]

Hui, C. C. and Joyner, A. L (1993). A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nature Genetics 3, 241-246.[Medline]

Hui, C.-C., Slusarski, D., Platt, K. A., Holmgren, R. and Joyner, A. L (1994). Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus , Gli, Gli-2 , and Gli-3 , in Ectoderm and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development. Dev. Biol 162, 402-413.[Medline]

Hynes, M., Stone, D. M., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A. and Rosenthal, A (1997). Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli1. Neuron 19, 15-26.[Medline]

Ingham, P. W (1998). Transducing Hedgehog. The story so far. EMBO J 17, 3505-3511.[Medline]

Jan, E., Yoon, J. W., Walterhouse, D., Iannaccone, P. and Goodwin, E. B (1997). Conservation of the C.elegans tra-2 3-UTR translational control. EMBO J 16, 6301-6313.[Medline]

Kang, S., Graham, J. M., Olney, A. H. and Biesecker, L. G (1997). Gli3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome. Nature Genet 15, 266-268.[Medline]

Katagiri, T., Yamaguchi, A., Komaki, M., Abe, E., Takahashi, N., Ikeda, T., Rosen, V., Wozney, J. M., Fujisawa-Sehara, A. and Suda, T (1994). Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J. Cell Biol 127, 1755-1766.[Abstract/Free Full Text]

Kelsey Motzny, C. and Holmgren, R (1995). The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech. Dev 52, 137-150.[Medline]

Kinto, N., Iwamoto, M., Enomoto-Iwamoto, M; Noji, S., Ohuchi, H. YoshiokaKataoka, H., Wada, Y., Yuhao, G., Takahashi, H. E., Yoshiki, S. and Yamaguchi, A (1997). Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation. FEBS Lett 404, 319-323.[Medline]

Kinzler, K. W., Bigner, S. H., Bigner, D. D., Trent, J. M., Law, M. L., O'Brien, S. J., Wong, A. J. and Vogelstein, B (1987). Identification of an amplified, highly expressed gene in a human glioma. Science 236, 70-73.[Abstract/Free Full Text]

Kinzler, K. W., Ruppert, J. M., Bigner, S. H. and Vogelstein, B (1988). The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature 332, 371-374.[Medline]

Krishnan, V., Pereira, F. A., Qiu, Y., Chen, C.-H., Beachy, P. A., Tsai, S. Y. and Tsai, M.-J (1997). Mediation of Sonic Hedgehog-Induced Expression of COUP-TFII by a Protein phosphatase. Science 278, 1947-1949.[Abstract/Free Full Text]

Lee, J., Platt, K., Censullo, P. and Ruiz i Altaba, A (1997). Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124, 2537-2552.[Abstract]

Lessing, D. and Nusse, R (1998). Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression. Development 125, 1469-1476.[Abstract]

Liu, F., Massague, J. and Ruiz i Altaba, A (1998). C-terminally truncated GLI3 proteins associate with Smads. Nature Genetics 20, 325-326.[Medline]

Marigo, V., Johnson, R. L., Vortkamp, A. and Tabin, C. J (1996). Sonic hedgehog differentiatlly regulates expression of Gli and Gli3 during limb development. Dev. Biol 180, 273-283.[Medline]

Marine, J.-C., Bellefroid, E. J., Pendeville, H., Martial, J. A. and Pieler, T (1997). A role for Xenopus Gli-type zinc finger proteins in early embryonic patterning of the mesoderm and neuroectoderm. Mech. Dev 63, 211-225.[Medline]

Mart\222, E., Bumcrot, D. A., Takada, R. and McMahon, A. P (1995). Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature 375, 322-325.[Medline]

Masuya, H., Sagai, T., Wakana, S., Moriwaki, K. and Shiroishi, T (1995). A duplicated zone of polarizing activity in polydactylous mouse mutants. Genes Dev 13, 1645-1653.

Matise, M. P., Epstein, D. J., Park, H. L., Platt, K. A. and Joyner, A. L (1998). Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125, 2759-2770.[Abstract]

Mo, R., Freer, A. M., Zinyk, D. L., Crackower, M. A., Michaud, J., Heng, H. H.-Q., Chik, K. W., Shi, X.-M., Tsui, L.-C., Cheng, S. H., Joyner, A. L. and Hui, C.-C (1997). Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 124, 113-123.[Abstract]

Murone, M., Rosenthal, A. and de Sauvage, F. J (1999). Sonic hedgehog signlaing by the Patched-Smoothened receptor complex. Curr. Biol 9, 76-84.[Medline]

Ohlmeyer, J. T. and Kalderon, D (1997). Dual pathways for induction of wingless expression by protein kinase A and Hedgehog expression in Drosophila embryos. Genes Dev 11, 2250-2258.[Abstract/Free Full Text]

Orellana, S. A. and McKnight, G. S (1992). Mutations in the catalytic subunit of cAMP-dependent proteins kinase result in unregulated biological activity. Proc. Natl. Acad. Sci. USA 89, 4726-4730.[Abstract/Free Full Text]

Platt K. A., Michaud J. and Joyner A. L (1997). Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice. Mech. Dev 62, 121-135.[Medline]

Radhakrishna, U., Wild, A. Grzeschik, K.-H. and Antonarakis, S. E (1997). Mutation in Gli3 in postaxial polydactyly type A. Nature Genetics 17, 269-271.[Medline]

Reifenberger, J., Wolter, M., Weber, R. G., Mgahed, M., Ruzicka, T., Lichter, P. and Reifenberger, G (1998). Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res 58, 1798-1803.[Abstract/Free Full Text]

Ruiz i Altaba, A (1997). Catching a Gli-mpse of hedgehog. Cell 90, 193-196.[Medline]

Ruiz i Altaba, A (1998). Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development 125, 2203-2212.[Abstract]

Ruiz i Altaba, A., Jessell, T. M. and Roelink, H (1995). Restrictions to Floor Plate Induction by hedgehog and Winged Helix Genes in the Neural Tube of Frog Embryos. Mol. Cell. Neurosci 6, 106-121.[Medline]

Ruppert, J. M., Kinzler, K. W., Wong, A. J., Bigner, S. H., Kao, F. T., Law, M. L., Seuanez, H. N., O'Brien, S. J. and Vogelstein, B (1988). The Gli-Kruppel family of human genes. Mol. Cell Biol 8, 3104-3113.[Abstract/Free Full Text]

Ruppert, J. M., Vogelstein, B., Arheden, K. and Kinzler, K. W. ( (1990). GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol. Cell Biol 10, 5408-5415.[Abstract/Free Full Text]

Ruppert, J. M., Vogelstein, B. and Kinzler, K. W (1991). The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A. Mol. Cell. Biol 11, 1724-1728.[Abstract/Free Full Text]

Sasaki, H., Hui, C. C., Nakafuku, M. and Kondoh, H (1997). A binding site for Gli proteins is essential for HNF-3floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-1322.[Abstract]

Shin, S. H., Kogerman, P., Lindstrom, E., T\232ftgard, R. and Biesecker, L. G (1999). Gli3 mutations in human disorders mimic Drosophila cubitus interruptus proteins functions and localizations. Proc. Natl. Acad. Sci. USA 96, 2880-2884.[Abstract/Free Full Text]

Tanimura, A., Dan, Shingo and Yoshida, M (1998). Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance Tax-dependent transcription of the human T-cell leukemia virus type 1 genome. J. Virol 72, 3958-3964.[Abstract/Free Full Text]

Turner, D. L. and Weintraub, H (1994). Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. GenesDev 8, 1434-1447.[Abstract/Free Full Text]

von Ohlen, T., Lessing, D., Nusse, R. and Hooper, J. E (1997). Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc. Natl. Acad. Sci. USA 94, 2404-2409.[Abstract/Free Full Text]

Vortkamp, A., Gessler, M. and Grzeschik, K.-H (1991). GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families. Nature 352, 539-540.[Medline]

Walterhouse, D., Ahmed, M., Slusarski, D., Kalamaras, J., Boucher, D., Holmgren, R. and Iannaccone, P (1993). gli , a Zinc Finger Transcription Factor and Oncogene, Is Expressed During Normal Mouse Development. Dev. Dyn 196, 91-102.[Medline]

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[Abstract] [Full Text] [PDF]

P. Dai, T. Shinagawa, T. Nomura, J. Harada, S. C. Kaul, R. Wadhwa, M. M. Khan, H. Akimaru, H. Sasaki, C. Colmenares, et al.
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3
Genes & Dev., November 15, 2002; 16(22): 2843 - 2848.
[Abstract] [Full Text] [PDF]

C.-Y. Ou, Y.-F. Lin, Y.-J. Chen, and C.-T. Chien
Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development
Genes & Dev., September 15, 2002; 16(18): 2403 - 2414.
[Abstract] [Full Text] [PDF]

Y.-S. Kim, M. Lewandoski, A. O. Perantoni, S. Kurebayashi, G. Nakanishi, and A. M. Jetten
Identification of Glis1, a Novel Gli-related, Kruppel-like Zinc Finger Protein Containing Transactivation and Repressor Functions
J. Biol. Chem., August 16, 2002; 277(34): 30901 - 30913.
[Abstract] [Full Text] [PDF]

R. A. Deckelbaum, G. Chan, D. Miao, D. Goltzman, and A. C. Karaplis
Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes PTHrP-mediated activation of PKA
J. Cell Sci., July 15, 2002; 115(14): 3015 - 3025.
[Abstract] [Full Text] [PDF]

D. J. Solecki, M. Gromeier, S. Mueller, G. Bernhardt, and E. Wimmer
Expression of the Human Poliovirus Receptor/CD155 Gene Is Activated by Sonic Hedgehog
J. Biol. Chem., July 5, 2002; 277(28): 25697 - 25702.
[Abstract] [Full Text] [PDF]

P. S. AMIEUX and G. S. MCKNIGHT
The Essential Role of RI{alpha} in the Maintenance of Regulated PKA Activity
Ann. N.Y. Acad. Sci., June 1, 2002; 968(1): 75 - 95.
[Abstract] [Full Text] [PDF]

J. Bose, L. Grotewold, and U. Ruther
Pallister-Hall syndrome phenotype in mice mutant for Gli3
Hum. Mol. Genet., May 1, 2002; 11(9): 1129 - 1135.
[Abstract] [Full Text] [PDF]

F. Zhang, G. Nakanishi, S. Kurebayashi, K. Yoshino, A. Perantoni, Y.-S. Kim, and A. M. Jetten
Characterization of Glis2, a Novel Gene Encoding a Gli-related, Kruppel-like Transcription Factor with Transactivation and Repressor Functions. ROLES IN KIDNEY DEVELOPMENT AND NEUROGENESIS
J. Biol. Chem., March 15, 2002; 277(12): 10139 - 10149.
[Abstract] [Full Text] [PDF]

M. J. Smith, S. D. Gitlin, C. M. Browning, B. R. Lane, N. M. Clark, N. Shah, S. Rainier, and D. M. Markovitz
GLI-2 Modulates Retroviral Gene Expression
J. Virol., March 1, 2001; 75(5): 2301 - 2313.
[Abstract] [Full Text]

C. M. Browning, M. J. Smith, N. M. Clark, B. R. Lane, C. Parada, M. Montano, V. N. KewalRamani, D. R. Littman, M. Essex, R. G. Roeder, et al.
Human GLI-2 Is a Tat Activation Response Element-Independent Tat Cofactor
J. Virol., March 1, 2001; 75(5): 2314 - 2323.
[Abstract] [Full Text]

M. K. Thomas, J. H. Lee, N. Rastalsky, and J. F. Habener
Hedgehog Signaling Regulation of Homeodomain Protein Islet Duodenum Homeobox-1 Expression in Pancreatic {{beta}}-Cells
Endocrinology, March 1, 2001; 142(3): 1033 - 1040.
[Abstract] [Full Text] [PDF]

M. Dyer, S. Farrington, D Mohn, J. Munday, and M. Baron
Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo
Development, January 5, 2001; 128(10): 1717 - 1730.

				T. Eichberger, A. Kaser, C. Pixner, C. Schmid, S. Klingler, M. Winklmayr, C. Hauser-Kronberger, F. Aberger, and A.-M. Frischauf GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells J. Biol. Chem., May 2, 2008; 283(18): 12426 - 12437. [Abstract] [Full Text] [PDF]

				M. F. Bijlsma, M. P. Peppelenbosch, C. A. Spek, and H. Roelink Leukotriene Synthesis Is Required for Hedgehog-Dependent Neurite Projection in Neuralized Embryoid Bodies but Not for Motor Neuron Differentiation Stem Cells, May 1, 2008; 26(5): 1138 - 1145. [Abstract] [Full Text] [PDF]

				P. Hill, B. Wang, and U. Ruther The molecular basis of Pallister Hall associated polydactyly Hum. Mol. Genet., September 1, 2007; 16(17): 2089 - 2096. [Abstract] [Full Text] [PDF]

				S. Ohba, T. Ikeda, F. Kugimiya, F. Yano, A. C. Lichtler, K. Nakamura, T. Takato, H. Kawaguchi, and U.-i. Chung Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor FASEB J, June 1, 2007; 21(8): 1777 - 1787. [Abstract] [Full Text] [PDF]

				Z. Ji, F. C. Mei, J. Xie, and X. Cheng Oncogenic KRAS Activates Hedgehog Signaling Pathway in Pancreatic Cancer Cells J. Biol. Chem., May 11, 2007; 282(19): 14048 - 14055. [Abstract] [Full Text] [PDF]

				Y. Pan and B. Wang A Novel Protein-processing Domain in Gli2 and Gli3 Differentially Blocks Complete Protein Degradation by the Proteasome J. Biol. Chem., April 13, 2007; 282(15): 10846 - 10852. [Abstract] [Full Text] [PDF]

				B. Stecca, C. Mas, V. Clement, M. Zbinden, R. Correa, V. Piguet, F. Beermann, and A. Ruiz i Altaba Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways PNAS, April 3, 2007; 104(14): 5895 - 5900. [Abstract] [Full Text] [PDF]

				C. J. Haycraft, Q. Zhang, B. Song, W. S. Jackson, P. J. Detloff, R. Serra, and B. K. Yoder Intraflagellar transport is essential for endochondral bone formation Development, January 15, 2007; 134(2): 307 - 316. [Abstract] [Full Text] [PDF]

				H. Zhou, S. Kim, S. Ishii, and T. G. Boyer Mediator Modulates Gli3-Dependent Sonic Hedgehog Signaling Mol. Cell. Biol., December 1, 2006; 26(23): 8667 - 8682. [Abstract] [Full Text] [PDF]

				M. F. Bijlsma, M. P. Peppelenbosch, and C. A. Spek Hedgehog Morphogen in Cardiovascular Disease Circulation, October 31, 2006; 114(18): 1985 - 1991. [Abstract] [Full Text] [PDF]

				U. Borello, B. Berarducci, P. Murphy, L. Bajard, V. Buffa, S. Piccolo, M. Buckingham, and G. Cossu The Wnt/{beta}-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis Development, September 15, 2006; 133(18): 3723 - 3732. [Abstract] [Full Text] [PDF]

				M. Kasper, H. Schnidar, G. W. Neill, M. Hanneder, S. Klingler, L. Blaas, C. Schmid, C. Hauser-Kronberger, G. Regl, M. P. Philpott, et al. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes. Mol. Cell. Biol., August 1, 2006; 26(16): 6283 - 6298. [Abstract] [Full Text] [PDF]

				T. Camarata, B. Bimber, A. Kulisz, T.-L. Chew, J. Yeung, and H.-G. Simon LMP4 regulates Tbx5 protein subcellular localization and activity J. Cell Biol., July 31, 2006; 174(3): 339 - 348. [Abstract] [Full Text] [PDF]

				T Akiyoshi, M Nakamura, K Koga, H Nakashima, T Yao, M Tsuneyoshi, M Tanaka, and M Katano Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation Gut, July 1, 2006; 55(7): 991 - 999. [Abstract] [Full Text] [PDF]

				Y. Pan, C. B. Bai, A. L. Joyner, and B. Wang Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation. Mol. Cell. Biol., May 1, 2006; 26(9): 3365 - 3377. [Abstract] [Full Text] [PDF]

				K. Saha and D. V. Schaffer Signal dynamics in Sonic hedgehog tissue patterning Development, March 1, 2006; 133(5): 889 - 900. [Abstract] [Full Text] [PDF]

				T. Sheng, S. Chi, X. Zhang, and J. Xie Regulation of Gli1 Localization by the cAMP/Protein Kinase A Signaling Axis through a Site Near the Nuclear Localization Signal J. Biol. Chem., January 6, 2006; 281(1): 9 - 12. [Abstract] [Full Text] [PDF]

				S.-C. Kim, Y.-S. Kim, and A. M. Jetten Kruppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1) Nucleic Acids Res., December 2, 2005; 33(21): 6805 - 6815. [Abstract] [Full Text] [PDF]

				M.-H. Chen, N. Gao, T. Kawakami, and P.-T. Chuang Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development Mol. Cell. Biol., August 15, 2005; 25(16): 7042 - 7053. [Abstract] [Full Text] [PDF]

				A. L. Hager-Theodorides, J. T. Dessens, S. V. Outram, and T. Crompton The transcription factor Gli3 regulates differentiation of fetal CD4-CD8- double-negative thymocytes Blood, August 15, 2005; 106(4): 1296 - 1304. [Abstract] [Full Text] [PDF]

				E. Roessler, A. N. Ermilov, D. K. Grange, A. Wang, M. Grachtchouk, A. A. Dlugosz, and M. Muenke A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2 Hum. Mol. Genet., August 1, 2005; 14(15): 2181 - 2188. [Abstract] [Full Text] [PDF]

				M. Wijgerde, M. Ooms, J. W. Hoogerbrugge, and J. A. Grootegoed Hedgehog Signaling in Mouse Ovary: Indian Hedgehog and Desert Hedgehog from Granulosa Cells Induce Target Gene Expression in Developing Theca Cells Endocrinology, August 1, 2005; 146(8): 3558 - 3566. [Abstract] [Full Text] [PDF]

				V. Nguyen, A. L. Chokas, B. Stecca, and A. R. i Altaba Cooperative requirement of the Gli proteins in neurogenesis Development, July 15, 2005; 132(14): 3267 - 3279. [Abstract] [Full Text] [PDF]

				T. Yamamoto and N. Suzuki Expression and Function of cGMP-dependent Protein Kinase Type I during Medaka Fish Embryogenesis J. Biol. Chem., April 29, 2005; 280(17): 16979 - 16986. [Abstract] [Full Text] [PDF]

				P. Sanchez, V. Clement, and A. Ruiz i Altaba Therapeutic Targeting of the Hedgehog-GLI Pathway in Prostate Cancer Cancer Res., April 15, 2005; 65(8): 2990 - 2992. [Abstract] [Full Text] [PDF]

				R. Sacedon, B. Diez, V. Nunez, C. Hernandez-Lopez, C. Gutierrez-Frias, T. Cejalvo, S. V. Outram, T. Crompton, A. G. Zapata, A. Vicente, et al. Sonic Hedgehog Is Produced by Follicular Dendritic Cells and Protects Germinal Center B Cells from Apoptosis J. Immunol., February 1, 2005; 174(3): 1456 - 1461. [Abstract] [Full Text] [PDF]

				A. McDermott, M. Gustafsson, T. Elsam, C.-C. Hui, C. P. Emerson Jr, and A.-G. Borycki Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation Development, January 15, 2005; 132(2): 345 - 357. [Abstract] [Full Text] [PDF]

				C. Gutierrez-Frias, R. Sacedon, C. Hernandez-Lopez, T. Cejalvo, T. Crompton, A. G. Zapata, A. Varas, and A. Vicente Sonic Hedgehog Regulates Early Human Thymocyte Differentiation by Counteracting the IL-7-Induced Development of CD34+ Precursor Cells J. Immunol., October 15, 2004; 173(8): 5046 - 5053. [Abstract] [Full Text] [PDF]

				L. Di Marcotullio, E. Ferretti, E. De Smaele, B. Argenti, C. Mincione, F. Zazzeroni, R. Gallo, L. Masuelli, M. Napolitano, M. Maroder, et al. RENKCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma PNAS, July 20, 2004; 101(29): 10833 - 10838. [Abstract] [Full Text] [PDF]

				K. Sekimizu, N. Nishioka, H. Sasaki, H. Takeda, R. O. Karlstrom, and A. Kawakami The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling Development, June 1, 2004; 131(11): 2521 - 2532. [Abstract] [Full Text] [PDF]