Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Sasaki, H.
	Articles by Kondoh, H.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Sasaki, H.
	Articles by Kondoh, H.

Akimaru, H., Chen, Y., Dai, P., Hou, D.-X., Nonaka, M., Smolik, S. M., Armstrong, S., Goodman, R. H. and Ishii, S (1997). Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature 386, 735-737.[Medline]

Alexandre, C., Jacinto, A. and Ingham, P. W (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev 10, 2003-2013.[Abstract/Free Full Text]

Aza-Blanc, P., Ramirez-Weber, F.-A., Laget, M.-P., Schwanrtz, C. and Kornberg, T. B (1997). Proteolysis that is inhibited by hedgehog targets Cubutus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.[Medline]

Borycki, A.-G., Mendham, L. and C.P., E. J (1998). Control of somite patterning by Sonic hedgehog and its downstream signal response genes. Development 125, 777-790.[Abstract]

Chen, Y., Gallaher, N., Goodman, R. H. and Smolik, S. M (1998). Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. Proc. Natl. Acad. Sci. USA 95, 2349-54.[Abstract/Free Full Text]

Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A (1996). Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413.[Medline]

Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M. and Ishii, S (1999). Sonic hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem 274, 8143-8152.[Abstract/Free Full Text]

Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J. and Hui, C (1998). Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125, 2533-2543.[Abstract]

Dom\222nguez, M., Brunner, M., Hafen, E. and Basler, K (1996). Sending and recieveing the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science 272, 1621-1625.[Abstract]

Echelard, Y., D.J., E., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P (1993). Sonic hedgenog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.[Medline]

Ericson, J., Muhr, J., Placzek, M., Lints, T., Jessell, T. M. and Edlund, T (1995). Sonic hedgehog induces the differentiation of ventral forbrain neurons: a common signal for ventral patterning within the neural tube. Cell 81, 747-756.[Medline]

Goodrich, L. V. and Scott, M. P (1998). Hedgehog and patched in neural development and disease. Neuron 21, 1243-1257.[Medline]

Hammerschmidt, M., Brook, A. and McMahon, A (1997). The world according to hedgehog. Trends Genet 13, 14-21.[Medline]

Hughes, D. C., Allen, J., Morley, G., Sutherland, K., Ahmed, W., Prosser, J., Lettice, L., Allen, G., Mattei, M. G., Farrall, M. and Hill, R. E (1997). Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region. Genomics 39, 205-215.[Medline]

Hui, C.-C., Slusarski, D., Platt, K. A., Holmgreen, R. and Joyner, A. L (1994). Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2 and Gli-3, in ectoderm-and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol 162, 402-413.[Medline]

Hynes, M., Porter, J. A., Chiang, C., Chang, D., Tessier-Lavigne, M., Beachy, P. A. and Rosenthal, A (1995). Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron 15, 35-44.[Medline]

Hynes, M., Stone, D., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A. and Rosenthal, A (1997). Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19, 15-26.[Medline]

Karlstrom, R. O., Talbot, W. S. and Schier, A. F (1999). Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning. Genes Dev 13, 388-393.[Abstract/Free Full Text]

Kinzler, K. W., Ruppert, J. M., Bigner, S. H. and Vogelstein, B (1988). The GLI gene is a member of Kruppel family of zinc finger proteins. Nature 332, 371-374.[Medline]

Krishnan, V., Pereira, F., Qiu, Y., Chen, C., Beachy, P., Tsai, S. and Tsai, M (1997). Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science 278, 1947-1950.[Abstract/Free Full Text]

Lee, J., Platt, K. A., Censullo, P. and Ruiz i Altaba, A (1997). Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124, 1528-1537.

Liu, C., Yang, J., Yoon, J., Villavicencio, E., Pfendler, K., Walterhouse, D. and Iannaccone, P (1998). Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway. Gene 209, 1-11.[Medline]

Logan, C., Khoo, W. K., Cado, D. and Joyner, A. L (1993). Two enchancer regions in the mouse En-2 locus direct expression to the mid/hindbrain region and mandibular myoblasts. Development 117, 905-916.[Abstract]

Marigo, V., Davey, R. A., Zuo, Y., Cunninghan, J. M. and Tabin, C. J (1996). Biochemical evidence that Patched is the Hedgehog receptor. Nature 384, 176-179.[Medline]

Marigo, V., Johnson, R. L., Vortkamp, A. and Tabin, C. J (1996). Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol 180, 273-283.[Medline]

Marigo, V., Scott, M. P., Johnson, R. L., Goodrich, L. V. and Tabin, C. J (1996). Conservation in hedgehog signalling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development 122, 1225-1233.[Abstract]

Marti, E., Bumcrot, D. A., Takada, R. and McMahon, A. P (1995). Requirement of 19K form of Sonic hedgehog for inductionn of distinct ventral cell types in CNS explants. Nature 375, 322-325.[Medline]

Marti, E., Takada, R., Bumcrot, D. A., Sasaki, H. and McMahon, A. P (1995). Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development 121, 2537-2547.[Abstract]

Matise, M., Epstein, D., Park, H., Platt, K. and Joyner, A (1998). Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125, 2759-2770.[Abstract]

Nakagawa, Y., Kanako, T., Ogura, T., Suzuki, T., Torii, M., Kaibuchi, K., Arai, K.-I., Nakamura, S. and Nakafuku, M (1996). Roles of cell-autonomous mechanisms for differential expression of region-specific transcription factors in neuroepithelial cells. Development 122, 2449-2464.[Abstract]

Ohlmeyer, T. J. and Kalderon, D (1998). Hedgehog stimulates maturation of Cubitus interruptus into a labile transcrptional activator. Nature 396, 749-753.[Medline]

Platt, K., Michaud, J. and Joyner, A (1997). Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice. Mech. Dev 62, 121-135.[Medline]

Roelink, H., Porter, J., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A. and Jessell, T. M (1995). Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81, 445-455.[Medline]

Ruiz i Altaba, A (1998). Combinatorial Gli gene function in floor plate and neural inductions by Sonic hedgehog. Development 125, 2203-2212.[Abstract]

Ruiz i Altaba, A., Placzek, M., Baldassare, M., Dodd, J. and Jessell, T (1995). Early stages of notochord and floor plate development in the chickembryo defined by normal and induced expression of HNF-3. Dev. Biol 170, 299-313.[Medline]

Ruppert, J. M., Kinzler, K. W., Wong, A. J., Bigner, S. H., Kao, F., Law, M. L., Seuanez, H. N., O'Brien, J. O. and Vogelstein, B (1988). The GLI-Kruppel family of human genes. Mol. Cell. Biol 8, 3104-3113.[Abstract/Free Full Text]

Ruppert, J. M., Vogelstein, B., Arheden, K. and Kinzler, K. W (1990). GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol. Cell.Biol 10, 5408-5415.[Abstract/Free Full Text]

Sasaki, H. and Hogan, B. L. M (1994). HNF-3as a regulator of floor plate development. Cell 76, 103-115.[Medline]

Sasaki, H., Hui, C.-c., Nakafuku, M. and Kondoh, H (1997). A binding site for Gli proteins is essential for HNF-3floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-1322.[Abstract]

Stone, D. M., Hynes, M., Armanini, M., Swanson, T. A., Gu, Q., Johnson, R. L., Scott, M. P., Pennica, D., Goddard, A., Phillips, H., Noll, M., Hooper, J. E., de Sauvage, F. and Rosenthal, A (1996). The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384, 126-134.

Thien, H., Buscher, D. and Ruther, U (1996). Cloning and sequence analysis of the murine Gli3 cDNA. Biochim. Biophys. Acta 1307, 267-169.[Medline]

Tsuchida, T., Ensini, M., Morton, S. B., Baldassare, M., Edlund, T., Jessell, T. M. and Pfaff, S. L (1994). Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79, 957-970.[Medline]

Von Ohlen, T., Lessing, D., Nusse, R. and Hooper, J. E (1997). Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc. Nat. Acad. Sci. USA 94, 2404-2409.[Abstract/Free Full Text]

Wall, N. A., Blessing, M., Wright, C. V. E. and Hogan, B. L. M (1993). Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (Bone Morphogenetic Protein-6). J. Cell Biol 120, 493-502.[Abstract/Free Full Text]

Yasui, K., Sasaki, H., Arakai, R. and Uemura, M (1997). Distribution pattern of HNF-3proteins in developing embryos of two mammalian species, the house shrew and the mouse. Dev. Growth Differ 39, 667-676.[Medline]

Yoon, J. W., Liu, C. Z., Yang, J. T., Swart, R., Iannaccone, P. and Walterhouse, D (1998). GLI activates transcription through a helpes symplex viral protein 16-like activation domains. J. Biol. Chem 273, 3496-3501.[Abstract/Free Full Text]

This article has been cited by other articles:

E. C. Driver, S. P. Pryor, P. Hill, J. Turner, U. Ruther, L. G. Biesecker, A. J. Griffith, and M. W. Kelley
Hedgehog Signaling Regulates Sensory Cell Formation and Auditory Function in Mice and Humans
J. Neurosci., July 16, 2008; 28(29): 7350 - 7358.
[Abstract] [Full Text] [PDF]

S. Krauss, J. Foerster, R. Schneider, and S. Schweiger
Protein Phosphatase 2A and Rapamycin Regulate the Nuclear Localization and Activity of the Transcription Factor GLI3
Cancer Res., June 15, 2008; 68(12): 4658 - 4665.
[Abstract] [Full Text] [PDF]

T. Eichberger, A. Kaser, C. Pixner, C. Schmid, S. Klingler, M. Winklmayr, C. Hauser-Kronberger, F. Aberger, and A.-M. Frischauf
GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells
J. Biol. Chem., May 2, 2008; 283(18): 12426 - 12437.
[Abstract] [Full Text] [PDF]

O. J. Becher, D. Hambardzumyan, E. I. Fomchenko, H. Momota, L. Mainwaring, A.-M. Bleau, A. M. Katz, M. Edgar, A. M. Kenney, C. Cordon-Cardo, et al.
Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor-Induced Gliomas
Cancer Res., April 1, 2008; 68(7): 2241 - 2249.
[Abstract] [Full Text] [PDF]

M. Dentice, C. Luongo, S. Huang, R. Ambrosio, A. Elefante, D. Mirebeau-Prunier, A. M. Zavacki, G. Fenzi, M. Grachtchouk, M. Hutchin, et al.
Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes
PNAS, September 4, 2007; 104(36): 14466 - 14471.
[Abstract] [Full Text] [PDF]

P. Hill, B. Wang, and U. Ruther
The molecular basis of Pallister Hall associated polydactyly
Hum. Mol. Genet., September 1, 2007; 16(17): 2089 - 2096.
[Abstract] [Full Text] [PDF]

M. Wagner and M. A. Q. Siddiqui
Signal Transduction in Early Heart Development (I): Cardiogenic Induction and Heart Tube Formation
Experimental Biology and Medicine, July 1, 2007; 232(7): 852 - 865.
[Abstract] [Full Text] [PDF]

A. Shimoyama, M. Wada, F. Ikeda, K. Hata, T. Matsubara, A. Nifuji, M. Noda, K. Amano, A. Yamaguchi, R. Nishimura, et al.
Ihh/Gli2 Signaling Promotes Osteoblast Differentiation by Regulating Runx2 Expression and Function
Mol. Biol. Cell, July 1, 2007; 18(7): 2411 - 2418.
[Abstract] [Full Text] [PDF]

R. D. Bayly, M. Ngo, G. V. Aglyamova, and S. Agarwala
Regulation of ventral midbrain patterning by Hedgehog signaling
Development, June 1, 2007; 134(11): 2115 - 2124.
[Abstract] [Full Text] [PDF]

N. J. Rowbotham, A. L. Hager-Theodorides, M. Cebecauer, D. K. Shah, E. Drakopoulou, J. Dyson, S. V. Outram, and T. Crompton
Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation
Blood, May 1, 2007; 109(9): 3757 - 3766.
[Abstract] [Full Text] [PDF]

Y. Kim, J. W. Yoon, X. Xiao, N. M. Dean, B. P. Monia, and E. G. Marcusson
Selective Down-Regulation of Glioma-Associated Oncogene 2 Inhibits the Proliferation of Hepatocellular Carcinoma Cells
Cancer Res., April 15, 2007; 67(8): 3583 - 3593.
[Abstract] [Full Text] [PDF]

C. D. Peacock, Q. Wang, G. S. Gesell, I. M. Corcoran-Schwartz, E. Jones, J. Kim, W. L. Devereux, J. T. Rhodes, C. A. Huff, P. A. Beachy, et al.
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
PNAS, March 6, 2007; 104(10): 4048 - 4053.
[Abstract] [Full Text] [PDF]

H. Zhou, S. Kim, S. Ishii, and T. G. Boyer
Mediator Modulates Gli3-Dependent Sonic Hedgehog Signaling
Mol. Cell. Biol., December 1, 2006; 26(23): 8667 - 8682.
[Abstract] [Full Text] [PDF]

S. J. Hatsell and P. Cowin
Gli3-mediated repression of Hedgehog targets is required for normal mammary development
Development, September 15, 2006; 133(18): 3661 - 3670.
[Abstract] [Full Text] [PDF]

M. Zhao, M. Qiao, S. E. Harris, D. Chen, B. O. Oyajobi, and G. R. Mundy
The zinc finger transcription factor gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling.
Mol. Cell. Biol., August 1, 2006; 26(16): 6197 - 6208.
[Abstract] [Full Text] [PDF]

M. Kasper, H. Schnidar, G. W. Neill, M. Hanneder, S. Klingler, L. Blaas, C. Schmid, C. Hauser-Kronberger, G. Regl, M. P. Philpott, et al.
Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes.
Mol. Cell. Biol., August 1, 2006; 26(16): 6283 - 6298.
[Abstract] [Full Text] [PDF]

J. A. Sterling, B. O. Oyajobi, B. Grubbs, S. S. Padalecki, S. A. Munoz, A. Gupta, B. Story, M. Zhao, and G. R. Mundy
The hedgehog signaling molecule gli2 induces parathyroid hormone-related Peptide expression and osteolysis in metastatic human breast cancer cells.
Cancer Res., August 1, 2006; 66(15): 7548 - 7553.
[Abstract] [Full Text] [PDF]

H. Nakashima, M. Nakamura, H. Yamaguchi, N. Yamanaka, T. Akiyoshi, K. Koga, K. Yamaguchi, M. Tsuneyoshi, M. Tanaka, and M. Katano
Nuclear Factor-{kappa}B Contributes to Hedgehog Signaling Pathway Activation through Sonic Hedgehog Induction in Pancreatic Cancer.
Cancer Res., July 15, 2006; 66(14): 7041 - 7049.
[Abstract] [Full Text] [PDF]

N. Bhatia, S. Thiyagarajan, I. Elcheva, M. Saleem, A. Dlugosz, H. Mukhtar, and V. S. Spiegelman
Gli2 Is Targeted for Ubiquitination and Degradation by beta-TrCP Ubiquitin Ligase
J. Biol. Chem., July 14, 2006; 281(28): 19320 - 19326.
[Abstract] [Full Text] [PDF]

V. Dasari, M. Gallup, H. Lemjabbar, I. Maltseva, and N. McNamara
Epithelial-Mesenchymal Transition in Lung Cancer: Is Tobacco the "Smoking Gun"?
Am. J. Respir. Cell Mol. Biol., July 1, 2006; 35(1): 3 - 9.
[Full Text] [PDF]

T Akiyoshi, M Nakamura, K Koga, H Nakashima, T Yao, M Tsuneyoshi, M Tanaka, and M Katano
Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation
Gut, July 1, 2006; 55(7): 991 - 999.
[Abstract] [Full Text] [PDF]

Y. Pan, C. B. Bai, A. L. Joyner, and B. Wang
Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation.
Mol. Cell. Biol., May 1, 2006; 26(9): 3365 - 3377.
[Abstract] [Full Text] [PDF]

E. G. Huntzicker, I. S. Estay, H. Zhen, L. A. Lokteva, P. K. Jackson, and A. E. Oro
Dual degradation signals control Gli protein stability and tumor formation
Genes & Dev., February 1, 2006; 20(3): 276 - 281.
[Abstract] [Full Text] [PDF]

N. A. Riobo, G. M. Haines, and C. P. Emerson Jr.
Protein Kinase C-{delta} and Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase-1 Control GLI Activation in Hedgehog Signaling
Cancer Res., January 15, 2006; 66(2): 839 - 845.
[Abstract] [Full Text] [PDF]

S.-C. Kim, Y.-S. Kim, and A. M. Jetten
Kruppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1)
Nucleic Acids Res., December 2, 2005; 33(21): 6805 - 6815.
[Abstract] [Full Text] [PDF]

G. Vila, M. Theodoropoulou, J. Stalla, J. C. Tonn, M. Losa, U. Renner, G. K. Stalla, and M. Paez-Pereda
Expression and Function of Sonic Hedgehog Pathway Components in Pituitary Adenomas: Evidence for a Direct Role in Hormone Secretion and Cell Proliferation
J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6687 - 6694.
[Abstract] [Full Text] [PDF]

A. Sawada, Y. Nishizaki, H. Sato, Y. Yada, R. Nakayama, S. Yamamoto, N. Nishioka, H. Kondoh, and H. Sasaki
Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor
Development, November 1, 2005; 132(21): 4719 - 4729.
[Abstract] [Full Text] [PDF]

M. J. Hilton, X. Tu, J. Cook, H. Hu, and F. Long
Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development
Development, October 1, 2005; 132(19): 4339 - 4351.
[Abstract] [Full Text] [PDF]

N. Sanai, A. Alvarez-Buylla, and M. S. Berger
Neural Stem Cells and the Origin of Gliomas
N. Engl. J. Med., August 25, 2005; 353(8): 811 - 822.
[Full Text] [PDF]

M.-H. Chen, N. Gao, T. Kawakami, and P.-T. Chuang
Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development
Mol. Cell. Biol., August 15, 2005; 25(16): 7042 - 7053.
[Abstract] [Full Text] [PDF]

A. L. Hager-Theodorides, J. T. Dessens, S. V. Outram, and T. Crompton
The transcription factor Gli3 regulates differentiation of fetal CD4-CD8- double-negative thymocytes
Blood, August 15, 2005; 106(4): 1296 - 1304.
[Abstract] [Full Text] [PDF]

E. Roessler, A. N. Ermilov, D. K. Grange, A. Wang, M. Grachtchouk, A. A. Dlugosz, and M. Muenke
A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2
Hum. Mol. Genet., August 1, 2005; 14(15): 2181 - 2188.
[Abstract] [Full Text] [PDF]

M. Wijgerde, M. Ooms, J. W. Hoogerbrugge, and J. A. Grootegoed
Hedgehog Signaling in Mouse Ovary: Indian Hedgehog and Desert Hedgehog from Granulosa Cells Induce Target Gene Expression in Developing Theca Cells
Endocrinology, August 1, 2005; 146(8): 3558 - 3566.
[Abstract] [Full Text] [PDF]

C. Colarossi, Y. Chen, H. Obata, V. Jurukovski, L. Fontana, B. Dabovic, and D. B. Rifkin
Lung Alveolar Septation Defects in Ltbp-3-Null Mice
Am. J. Pathol., August 1, 2005; 167(2): 419 - 428.
[Abstract] [Full Text] [PDF]

A. Liu, B. Wang, and L. A. Niswander
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
Development, July 1, 2005; 132(13): 3103 - 3111.
[Abstract] [Full Text] [PDF]

P. J. Gianakopoulos and I. S. Skerjanc
Hedgehog Signaling Induces Cardiomyogenesis in P19 Cells
J. Biol. Chem., June 3, 2005; 280(22): 21022 - 21028.
[Abstract] [Full Text] [PDF]

N. Nishioka, S. Nagano, R. Nakayama, H. Kiyonari, T. Ijiri, K. Taniguchi, W. Shawlot, Y. Hayashizaki, H. Westphal, R. R. Behringer, et al.
Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex
Development, June 1, 2005; 132(11): 2535 - 2546.
[Abstract] [Full Text] [PDF]

V. Stepan, S. Ramamoorthy, H. Nitsche, Y. Zavros, J. L. Merchant, and A. Todisco
Regulation and Function of the Sonic Hedgehog Signal Transduction Pathway in Isolated Gastric Parietal Cells
J. Biol. Chem., April 22, 2005; 280(16): 15700 - 15708.
[Abstract] [Full Text] [PDF]

D. Stamataki, F. Ulloa, S. V. Tsoni, A. Mynett, and J. Briscoe
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
Genes & Dev., March 1, 2005; 19(5): 626 - 641.
[Abstract] [Full Text] [PDF]

A. McDermott, M. Gustafsson, T. Elsam, C.-C. Hui, C. P. Emerson Jr, and A.-G. Borycki
Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation
Development, January 15, 2005; 132(2): 345 - 357.
[Abstract] [Full Text] [PDF]

G. Regl, M. Kasper, H. Schnidar, T. Eichberger, G. W. Neill, M. P. Philpott, H. Esterbauer, C. Hauser-Kronberger, A.-M. Frischauf, and F. Aberger
Activation of the BCL2 Promoter in Response to Hedgehog/GLI Signal Transduction Is Predominantly Mediated by GLI2
Cancer Res., November 1, 2004; 64(21): 7724 - 7731.
[Abstract] [Full Text] [PDF]

A. Brancaccio, A. Minichiello, M. Grachtchouk, D. Antonini, H. Sheng, R. Parlato, N. Dathan, A. A. Dlugosz, and C. Missero
Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis
Hum. Mol. Genet., November 1, 2004; 13(21): 2595 - 2606.
[Abstract] [Full Text] [PDF]

M. Merchant, F. F. Vajdos, M. Ultsch, H. R. Maun, U. Wendt, J. Cannon, W. Desmarais, R. A. Lazarus, A. M. de Vos, and F. J. de Sauvage
Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism
Mol. Cell. Biol., October 1, 2004; 24(19): 8627 - 8641.
[Abstract] [Full Text] [PDF]

B. Ganss and A. Jheon
ZINC FINGER TRANSCRIPTION FACTORS IN SKELETAL DEVELOPMENT
Crit. Rev. Oral. Biol. Med., September 1, 2004; 15(5): 282 - 297.
[Abstract] [Full Text] [PDF]

C. Cui, T. Elsam, Q. Tian, J. T. Seykora, M. Grachtchouk, A. Dlugosz, and H. Tseng
Gli Proteins Up-Regulate the Expression of Basonuclin in Basal Cell Carcinoma
Cancer Res., August 15, 2004; 64(16): 5651 - 5658.
[Abstract] [Full Text] [PDF]

Q. Lei, A. K. Zelman, E. Kuang, S. Li, and M. P. Matise
Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
Development, August 1, 2004; 131(15): 3593 - 3604.
[Abstract] [Full Text] [PDF]

L. Di Marcotullio, E. Ferretti, E. De Smaele, B. Argenti, C. Mincione, F. Zazzeroni, R. Gallo, L. Masuelli, M. Napolitano, M. Maroder, et al.
RENKCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
PNAS, July 20, 2004; 101(29): 10833 - 10838.
[Abstract] [Full Text] [PDF]

H. Petropoulos, P. J. Gianakopoulos, A. G. Ridgeway, and I. S. Skerjanc
Disruption of Meox or Gli Activity Ablates Skeletal Myogenesis in P19 Cells
J. Biol. Chem., June 4, 2004; 279(23): 23874 - 23881.
[Abstract] [Full Text] [PDF]

K. Sekimizu, N. Nishioka, H. Sasaki, H. Takeda, R. O. Karlstrom, and A. Kawakami
The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling
Development, June 1, 2004; 131(11): 2521 - 2532.
[Abstract] [Full Text] [PDF]

R. L. H. Bigelow, N. S. Chari, A. B. Unden, K. B. Spurgers, S. Lee, D. R. Roop, R. Toftgard, and T. J. McDonnell
Transcriptional Regulation of bcl-2 Mediated by the Sonic Hedgehog Signaling Pathway through gli-1
J. Biol. Chem., January 9, 2004; 279(2): 1197 - 1205.
[Abstract] [Full Text] [PDF]

L. Buttitta, R. Mo, C.-C. Hui, and C.-M. Fan
Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction
Development, December 22, 2003; 130(25): 6233 - 6243.
[Abstract] [Full Text] [PDF]

M. Allen, M. Grachtchouk, H. Sheng, V. Grachtchouk, A. Wang, L. Wei, J. Liu, A. Ramirez, D. Metzger, P. Chambon, et al.
Hedgehog Signaling Regulates Sebaceous Gland Development
Am. J. Pathol., December 1, 2003; 163(6): 2173 - 2178.
[Abstract] [Full Text]

				S. Krauss, J. Foerster, R. Schneider, and S. Schweiger Protein Phosphatase 2A and Rapamycin Regulate the Nuclear Localization and Activity of the Transcription Factor GLI3 Cancer Res., June 15, 2008; 68(12): 4658 - 4665. [Abstract] [Full Text] [PDF]

				T. Eichberger, A. Kaser, C. Pixner, C. Schmid, S. Klingler, M. Winklmayr, C. Hauser-Kronberger, F. Aberger, and A.-M. Frischauf GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells J. Biol. Chem., May 2, 2008; 283(18): 12426 - 12437. [Abstract] [Full Text] [PDF]

				O. J. Becher, D. Hambardzumyan, E. I. Fomchenko, H. Momota, L. Mainwaring, A.-M. Bleau, A. M. Katz, M. Edgar, A. M. Kenney, C. Cordon-Cardo, et al. Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor-Induced Gliomas Cancer Res., April 1, 2008; 68(7): 2241 - 2249. [Abstract] [Full Text] [PDF]

				M. Dentice, C. Luongo, S. Huang, R. Ambrosio, A. Elefante, D. Mirebeau-Prunier, A. M. Zavacki, G. Fenzi, M. Grachtchouk, M. Hutchin, et al. Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes PNAS, September 4, 2007; 104(36): 14466 - 14471. [Abstract] [Full Text] [PDF]

				P. Hill, B. Wang, and U. Ruther The molecular basis of Pallister Hall associated polydactyly Hum. Mol. Genet., September 1, 2007; 16(17): 2089 - 2096. [Abstract] [Full Text] [PDF]

				M. Wagner and M. A. Q. Siddiqui Signal Transduction in Early Heart Development (I): Cardiogenic Induction and Heart Tube Formation Experimental Biology and Medicine, July 1, 2007; 232(7): 852 - 865. [Abstract] [Full Text] [PDF]

				A. Shimoyama, M. Wada, F. Ikeda, K. Hata, T. Matsubara, A. Nifuji, M. Noda, K. Amano, A. Yamaguchi, R. Nishimura, et al. Ihh/Gli2 Signaling Promotes Osteoblast Differentiation by Regulating Runx2 Expression and Function Mol. Biol. Cell, July 1, 2007; 18(7): 2411 - 2418. [Abstract] [Full Text] [PDF]

				R. D. Bayly, M. Ngo, G. V. Aglyamova, and S. Agarwala Regulation of ventral midbrain patterning by Hedgehog signaling Development, June 1, 2007; 134(11): 2115 - 2124. [Abstract] [Full Text] [PDF]

				N. J. Rowbotham, A. L. Hager-Theodorides, M. Cebecauer, D. K. Shah, E. Drakopoulou, J. Dyson, S. V. Outram, and T. Crompton Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation Blood, May 1, 2007; 109(9): 3757 - 3766. [Abstract] [Full Text] [PDF]

				Y. Kim, J. W. Yoon, X. Xiao, N. M. Dean, B. P. Monia, and E. G. Marcusson Selective Down-Regulation of Glioma-Associated Oncogene 2 Inhibits the Proliferation of Hepatocellular Carcinoma Cells Cancer Res., April 15, 2007; 67(8): 3583 - 3593. [Abstract] [Full Text] [PDF]

				C. D. Peacock, Q. Wang, G. S. Gesell, I. M. Corcoran-Schwartz, E. Jones, J. Kim, W. L. Devereux, J. T. Rhodes, C. A. Huff, P. A. Beachy, et al. Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma PNAS, March 6, 2007; 104(10): 4048 - 4053. [Abstract] [Full Text] [PDF]

				H. Zhou, S. Kim, S. Ishii, and T. G. Boyer Mediator Modulates Gli3-Dependent Sonic Hedgehog Signaling Mol. Cell. Biol., December 1, 2006; 26(23): 8667 - 8682. [Abstract] [Full Text] [PDF]

				S. J. Hatsell and P. Cowin Gli3-mediated repression of Hedgehog targets is required for normal mammary development Development, September 15, 2006; 133(18): 3661 - 3670. [Abstract] [Full Text] [PDF]

				M. Zhao, M. Qiao, S. E. Harris, D. Chen, B. O. Oyajobi, and G. R. Mundy The zinc finger transcription factor gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol. Cell. Biol., August 1, 2006; 26(16): 6197 - 6208. [Abstract] [Full Text] [PDF]

				M. Kasper, H. Schnidar, G. W. Neill, M. Hanneder, S. Klingler, L. Blaas, C. Schmid, C. Hauser-Kronberger, G. Regl, M. P. Philpott, et al. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes. Mol. Cell. Biol., August 1, 2006; 26(16): 6283 - 6298. [Abstract] [Full Text] [PDF]

				J. A. Sterling, B. O. Oyajobi, B. Grubbs, S. S. Padalecki, S. A. Munoz, A. Gupta, B. Story, M. Zhao, and G. R. Mundy The hedgehog signaling molecule gli2 induces parathyroid hormone-related Peptide expression and osteolysis in metastatic human breast cancer cells. Cancer Res., August 1, 2006; 66(15): 7548 - 7553. [Abstract] [Full Text] [PDF]

				H. Nakashima, M. Nakamura, H. Yamaguchi, N. Yamanaka, T. Akiyoshi, K. Koga, K. Yamaguchi, M. Tsuneyoshi, M. Tanaka, and M. Katano Nuclear Factor-{kappa}B Contributes to Hedgehog Signaling Pathway Activation through Sonic Hedgehog Induction in Pancreatic Cancer. Cancer Res., July 15, 2006; 66(14): 7041 - 7049. [Abstract] [Full Text] [PDF]

				N. Bhatia, S. Thiyagarajan, I. Elcheva, M. Saleem, A. Dlugosz, H. Mukhtar, and V. S. Spiegelman Gli2 Is Targeted for Ubiquitination and Degradation by beta-TrCP Ubiquitin Ligase J. Biol. Chem., July 14, 2006; 281(28): 19320 - 19326. [Abstract] [Full Text] [PDF]

				V. Dasari, M. Gallup, H. Lemjabbar, I. Maltseva, and N. McNamara Epithelial-Mesenchymal Transition in Lung Cancer: Is Tobacco the "Smoking Gun"? Am. J. Respir. Cell Mol. Biol., July 1, 2006; 35(1): 3 - 9. [Full Text] [PDF]

				T Akiyoshi, M Nakamura, K Koga, H Nakashima, T Yao, M Tsuneyoshi, M Tanaka, and M Katano Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation Gut, July 1, 2006; 55(7): 991 - 999. [Abstract] [Full Text] [PDF]

				Y. Pan, C. B. Bai, A. L. Joyner, and B. Wang Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation. Mol. Cell. Biol., May 1, 2006; 26(9): 3365 - 3377. [Abstract] [Full Text] [PDF]

				E. G. Huntzicker, I. S. Estay, H. Zhen, L. A. Lokteva, P. K. Jackson, and A. E. Oro Dual degradation signals control Gli protein stability and tumor formation Genes & Dev., February 1, 2006; 20(3): 276 - 281. [Abstract] [Full Text] [PDF]

				N. A. Riobo, G. M. Haines, and C. P. Emerson Jr. Protein Kinase C-{delta} and Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase-1 Control GLI Activation in Hedgehog Signaling Cancer Res., January 15, 2006; 66(2): 839 - 845. [Abstract] [Full Text] [PDF]

				S.-C. Kim, Y.-S. Kim, and A. M. Jetten Kruppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1) Nucleic Acids Res., December 2, 2005; 33(21): 6805 - 6815. [Abstract] [Full Text] [PDF]

				G. Vila, M. Theodoropoulou, J. Stalla, J. C. Tonn, M. Losa, U. Renner, G. K. Stalla, and M. Paez-Pereda Expression and Function of Sonic Hedgehog Pathway Components in Pituitary Adenomas: Evidence for a Direct Role in Hormone Secretion and Cell Proliferation J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6687 - 6694. [Abstract] [Full Text] [PDF]

				A. Sawada, Y. Nishizaki, H. Sato, Y. Yada, R. Nakayama, S. Yamamoto, N. Nishioka, H. Kondoh, and H. Sasaki Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor Development, November 1, 2005; 132(21): 4719 - 4729. [Abstract] [Full Text] [PDF]

				M. J. Hilton, X. Tu, J. Cook, H. Hu, and F. Long Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development Development, October 1, 2005; 132(19): 4339 - 4351. [Abstract] [Full Text] [PDF]

				N. Sanai, A. Alvarez-Buylla, and M. S. Berger Neural Stem Cells and the Origin of Gliomas N. Engl. J. Med., August 25, 2005; 353(8): 811 - 822. [Full Text] [PDF]

				M.-H. Chen, N. Gao, T. Kawakami, and P.-T. Chuang Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development Mol. Cell. Biol., August 15, 2005; 25(16): 7042 - 7053. [Abstract] [Full Text] [PDF]

				A. L. Hager-Theodorides, J. T. Dessens, S. V. Outram, and T. Crompton The transcription factor Gli3 regulates differentiation of fetal CD4-CD8- double-negative thymocytes Blood, August 15, 2005; 106(4): 1296 - 1304. [Abstract] [Full Text] [PDF]