spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    


This Article
Right arrow Summary Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schwartz, R. J.
Right arrow Articles by Olson, E. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schwartz, R. J.
Right arrow Articles by Olson, E. N.
Azpiazu, N. and Frasch, M (1993). tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev 7, 1325-1340.[Abstract/Free Full Text]

Bao, Z. Z., Bruneau, B. G., Seidman, J. G., Seidman, C. E. and Cepko, C. L (1999). Regulation of chamber-specific gene expression in the developing heart by Irx4. Science 283, 1161-1164.[Abstract/Free Full Text]

Biben, C. and Harvey, R. P (1997). Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHAND during murine heart development. Genes Dev 11, 1357-1369.[Abstract/Free Full Text]

Biben, C., Hatzistavrou, T. and Harvey, R. P (1998). Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart. Mech. Dev 73, 125-127.[Medline]

Brand T., Andree, B., Schneider, A., Buchberger, A. and Arnold H. H (1997). Chicken NKx2-8 , a novel homeobox gene expressed during early heart and foregut development. Mech. Dev 64, 53-59.[Medline]

Buchberger, A., Pabst O., Brand, T., Seidl, K. and Arnold, H. H (1996). Chick Nkx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman : differential expression of cNKx-2.5 during heart and gut development. Mech. Dev 56, 151-163.[Medline]

Chen, J. N. and Fishman, M. C (1996). Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development 122, 3809-3816.[Abstract]

Chen, C. Y. and Schwartz, R. J (1995). Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, Nkx-2.5. J. Biol.Chem 270, 15628-15633.[Abstract/Free Full Text]

Chen, C. Y. and Schwartz, R. J (1996). Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription. Mol. Cell. Biol 16, 6372-6384.[Abstract]

Cserjesi, P., Brown, D., Lyons, G. E. and Olson, E. N (1995). Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev Biol 170, 664-678.[Medline]

Damante, G., Fabbro, D., Pellizzari, L., Civitareale, D., Guazzi, S., Polycarpou-Schwartz, M., Cauci, S., Quadrifoglio, F., Formisano, S. and Di Lauro, R (1994). Sequence-specific DNA recognition by the thyroid transcription factor-1 homeodomain. Nucleic Acids Research 22, 3075-3083.[Abstract/Free Full Text]

Durocher, D., Chen, C. Y., Ardati, A., Schwartz, R. J. and Nemer, M (1996). The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium. Mol. Cell. Biol 16, 4648-4655.[Abstract]

Durocher, D., Warren, R., Charron, F., Schwartz, R. J. and Nemer, M (1997). Nkx2-5 and GATA-4 physically and functionally interact to activate cardiac transcription. EMBO J 16, 5687-5696.[Medline]

Evans, S. M., Yan, W., Murrillo, P. M., Ponce, J. and Papalopulu, N (1995). tinman , a Drosophila homeobox gene required for heart and visceral mesoderm specification may be represented by a family of gene in vertebrates: XNkx2-3 , a second vertebrate homologue of tinman. Development 121, 3889-3899.[Abstract]

Fishman, M. C. and Chien, K. R (1997). Fashioning the vertebrate heart: earliest embryonic decisions. Development 124, 2099-2117.[Abstract]

Fishman, M. C. and Olson, E. N (1997). Parsing the heart: genetic modules for organ assembly. Cell 91, 153-156.[Medline]

Firulli, A. B. and Olson, E. N (1997). Modular regulation of muscle gene transcription: a mechanism for muscle cell diversity. Trends Genet 13, 364-369.[Medline]

Firulli, A. B., McFadden, D. G., Lin, Q., Srivastava, D. and Olson, E. N (1998). Heart and extraembryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nature Gen 18, 266-270.[Medline]

Franco, D., Kelly R., Lamers, W., Buckingham, M. and Moorman, A. F. M (1997). Regionalised transcriptional domains of myosin light chain 3F transgenes in the embryonic mouse heart: morphogenetic implications. Dev. Biol 188, 17-33.[Medline]

Frasch, M (1995). Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo. Nature 374, 464-467.[Medline]

Fu, Y., Yan, W., Mohun, T. J. and Evans, S. M (1998). Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner. Development 125, 4439-4449.[Abstract]

Gajewski, K., Kim, Y., Lee, Y. M., Olson, E. N. and Schultz, R. A (1998). D-mef2 is a target for Tinman activation during Drosophila heart development. EMBO J 16, 515-522.[Medline]

Grow M. W. and Kreig, P. A (1998). Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman -related genes, XNkx2-3 and XNkx2-5. Dev. Biol 204, 187-96.[Medline]

Harvey, R. P (1996). NK-2 homeobox genes and heart development. Dev. Biol 178, 203-216.[Medline]

Heldin, C.-H., Miyazono, K. and Dijke, P (1997). TGF-signaling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471.[Medline]

Komuro, I. and Izumo, S (1993). Csx : a murine homeobox-containing gene specifically expressed in the developing heart. Proc. Natl. Acad. Sci. USA 90, 8145-8149.[Abstract/Free Full Text]

Kuisk, I. R., Li, H., Tran, D. and Capetanaki, Y (1996). A single MEF2 site governs desmin transcription in both heart and skeletal muscle during mouse embryogenesis. Dev. Biol 174, 1-13.[Medline]

Ladd, A. N., Yatskievych, T. A. and Antin, P. B (1998). Regulation of avian cardiac myogenesis by activin/TGF beta and bone morphogenetic proteins. Dev. Biol 204, 407-419.[Medline]

Laverriere, A. C., MacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B. E. and Evans, T (1994). GATA4/5/6: a subfamily of three transcription factors transcribed in developing heart and gut. J. Biol. Chem 269, 23177-23184.[Abstract/Free Full Text]

Lee, K. H., Xu, Q. and Breitbart, R. E (1996). A new tinman -related gene, nkx2.7 , anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Dev. Biol 180, 722-731.[Medline]

Lee, Y. M., Park, T., Schulz, R. A. and Kim, Y (1997). Twist-mediated activation of the NK-4 homeobox gene in the visceral mesoderm of Drosophila requires two distinct clusters of E-box regulatory elements. J. Biol. Chem 272, 17351-17541.

Li, L., Miano, J. M., Mercer, B. and Olson, E. N (1996). Expression of the SM22 promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells. J. Cell Biol 132, 849-859.[Abstract/Free Full Text]

Lien, C.-L, Wu, C., Mercer, B., Webb, R., Richardson, J. A. and Olson, E. N (1999). Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer. Development 126, 75-84.[Abstract]

Lints, T. J., Parsons, L. M., Hartley, L., Lyons, I. and Harvey, R. P (1993). Nkx-2.5 : a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119, 419-431.[Abstract]

Lough, J., Barron, M., Brogley, M., Sugi, Y., Bolender, D. L. and Zhu, X (1996). Combined BMP-2 and FGF4, but neither factor alone, induces cardiogenesis in non-precardiac embryonic mesoderm. Dev. Biol 178, 198-202.[Medline]

Lyons, I., Parsons, L. M., Hartley, L., Li, R., Andrews, J. E., Robb, L. and Harvey, R. P (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev 9, 1654-1666.[Abstract/Free Full Text]

O'Brien, T. X., Lee, K. J. and Chien, K. R (1993). Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube. Proc. Natl. Acad. Sci. USA 90, 5157-5161.[Abstract/Free Full Text]

Olson, E. N. and Srivastava, D (1996). Molecular pathways controlling heart development. Science 272, 671-676.[Abstract]

Park, M., Wu, X., Golden, K., Azelrod, J. D. and Bodmer, R (1996). Thewingless signaling pathway is directly involved in Drosophila heart development. Dev. Biol 177, 104-116.[Medline]

Park, M., Lewis, C., Turbay, D., Chung, A., Chen, J.-N., Evans, S., Breitbart, R. E., Fishman, M. C., Izumo, S. and Bodmer, R (1998). Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman -related genes. Proc. Natl. Acad. Sci.USA 95, 9366-9371.[Abstract/Free Full Text]

Ranganayakulu, G., Elliot, D. A., Harvey, R. P. and Olson, E. N (1998). Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice. Development 125, 3037-3048.[Abstract]

Riley, P., Anson-Cartwright, L. and Cross, J. C (1998). The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nat. Gen 18, 271-275.[Medline]

Reecy, J. M., Yamada, M., Cummings, K., Sosic, D., Chen, C. Y., Eichele,G., Olson, E. N. and Schwartz, R. J (1997). Chicken Nkx-2.8 : a novel homeobox gene expressed in early heart progenitor cells and pharyngeal pouch-2 and-3 endoderm. Dev. Biol 188, 295-311.[Medline]

Schott, J.-J., Benson, D. W., Basson, C. T., Pease, W., Silberbach, G. M., Moak, J. P., Maron, B. J., Seidman, C. E. and Seidman, J. G (1998). Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science 281, 108-111.[Abstract/Free Full Text]

Schultheiss, T. M., Xydas, S. and Lassar, A. B (1995). Induction of avian cardiac myogenesis by anterior endoderm. Development 121, 4203-4214.[Abstract]

Schultheiss, T. M., Burch, J. B. E. and Lassar, A. B (1997). A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev 11, 451-462.[Abstract/Free Full Text]

Searcy, R. D., Vincent, E. B., Liberatore, C. M. and Yutzey, K. E (1998). A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice. Development 125, 4461-4470.[Abstract]

Sepulveda, J. L., Belaguli, N., Nigam, V., Chen, C. Y., Nemer, M. and Schwartz, R. J (1998). GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. Mol. Cell Biol 18, 3405-3415.[Abstract/Free Full Text]

Srivastava, D., Thomas, T., Lin, Q., Kirby, M. L., Brown, D. and Olson, E. N (1997). Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nature Gen 16, 154-160.[Medline]

Tanaka, M., Chen, Z., Bartunkova, S., Yamasaki, N. and Izumo, S (1999). The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development 126, 1269-1280.[Abstract]

Tanaka, M., Burns S., Lee, I. W., Yamasaki, N., Lawitts, J. A. and Izumo, S (1999). Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5. Development 126, 1439-1450.[Abstract]

Tonissen, K. F., Drysdale, T. A., Lints, T. J., Harvey, R. P. and Krieg, P. A (1994). XNkx-2.5 , a Xenopus gene related to Nkx-2.5 and tinman : evidence for a conserved role in cardiac development. Dev. Biol 162, 325-328.[Medline]

Xu, X., Yin, Z., Hudson, J. B., Ferguson, E. L. and Frasch, M (1998). Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev 12, 2354-2370.[Abstract/Free Full Text]

Yin, Z., Xu, X. L. and Frasch, M (1997). Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development. Development 124, 4971-4982.[Abstract]

Yutzey, K. E. and Bader, D (1995). Diversification of cardiomyogenic cell lineages during early heart development. Circ. Res 77, 216-219.[Free Full Text]




This article has been cited by other articles:


Home page
Proc. Natl. Acad. Sci. USAHome page
D. Ai, X. Fu, J. Wang, M.-F. Lu, L. Chen, A. Baldini, W. H. Klein, and J. F. Martin
Canonical Wnt signaling functions in second heart field to promote right ventricular growth
PNAS, May 29, 2007; 104(22): 9319 - 9324.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
T. Fukushige, T. M. Brodigan, L. A. Schriefer, R. H. Waterston, and M. Krause
Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development
Genes & Dev., December 15, 2006; 20(24): 3395 - 3406.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
B. Davidson, W. Shi, J. Beh, L. Christiaen, and M. Levine
FGF signaling delineates the cardiac progenitor field in the simple chordate, Ciona intestinalis
Genes & Dev., October 1, 2006; 20(19): 2728 - 2738.
[Abstract] [Full Text] [PDF]


Home page
ScienceHome page
E. N. Olson
Gene regulatory networks in the evolution and development of the heart.
Science, September 29, 2006; 313(5795): 1922 - 1927.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
X. Chi, P. K. Chatterjee, W. Wilson III, S.-X. Zhang, F. J. DeMayo, and R. J. Schwartz
Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modules
PNAS, September 20, 2005; 102(38): 13490 - 13495.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
A. Rojas, S. De Val, A. B. Heidt, S.-M. Xu, J. Bristow, and B. L. Black
Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element
Development, August 1, 2005; 132(15): 3405 - 3417.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. M. Riazi, H. Lee, C. Hsu, and G. Van Arsdell
CSX/Nkx2.5 Modulates Differentiation of Skeletal Myoblasts and Promotes Differentiation into Neuronal Cells in Vitro
J. Biol. Chem., March 18, 2005; 280(11): 10716 - 10720.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
J.-R. Hong, G.-H. Lin, C. J.-F. Lin, W.-p. Wang, C.-C. Lee, T.-L. Lin, and J.-L. Wu
Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish
Development, November 1, 2004; 131(21): 5417 - 5427.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
K.-H. Lee, S. Evans, T. Y. Ruan, and A. B. Lassar
SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer
Development, October 1, 2004; 131(19): 4709 - 4723.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
E. Dodou, M. P. Verzi, J. P. Anderson, S.-M. Xu, and B. L. Black
Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development
Development, August 15, 2004; 131(16): 3931 - 3942.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
M. Ponticos, T. Partridge, C. M. Black, D. J. Abraham, and G. Bou-Gharios
Regulation of Collagen Type I in Vascular Smooth Muscle Cells by Competition between Nkx2.5 and {delta}EF1/ZEB1
Mol. Cell. Biol., July 15, 2004; 24(14): 6151 - 6161.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
B. E.J Teunissen and M. F.A Bierhuizen
Transcriptional control of myocardial connexins
Cardiovasc Res, May 1, 2004; 62(2): 246 - 255.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
T. J. Nelson, S. A. Duncan, and R. P. Misra
Conserved Enhancer in the Serum Response Factor Promoter Controls Expression During Early Coronary Vasculogenesis
Circ. Res., April 30, 2004; 94(8): 1059 - 1066.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
C. O. Brown III, X. Chi, E. Garcia-Gras, M. Shirai, X.-H. Feng, and R. J. Schwartz
The Cardiac Determination Factor, Nkx2-5, Is Activated by Mutual Cofactors GATA-4 and Smad1/4 via a Novel Upstream Enhancer
J. Biol. Chem., March 12, 2004; 279(11): 10659 - 10669.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
P. J. Gruber and J. A. Epstein
Development Gone Awry: Congenital Heart Disease
Circ. Res., February 20, 2004; 94(3): 273 - 283.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
R. G. Kelly, M. Lemonnier, S. Zaffran, A. Munk, and M. E. Buckingham
Cell history determines the maintenance of transcriptional differences between left and right ventricular cardiomyocytes in the developing mouse heart
J. Cell Sci., December 15, 2003; 116(24): 5005 - 5013.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
D. B. McElhinney, E. Geiger, J. Blinder, D. Woodrow Benson, and E. Goldmuntz
NKX2.5 mutations in patients with congenital heart disease
J. Am. Coll. Cardiol., November 5, 2003; 42(9): 1650 - 1655.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
A. F. M. MOORMAN and V. M. CHRISTOFFELS
Cardiac Chamber Formation: Development, Genes, and Evolution
Physiol Rev, October 1, 2003; 83(4): 1223 - 1267.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
E. N. Olson and M. D. Schneider
Sizing up the heart: development redux in disease
Genes & Dev., August 15, 2003; 17(16): 1937 - 1956.
[Full Text] [PDF]


Home page
Cardiovasc ResHome page
P. E.M.H. Habets, A. F.M. Moorman, and V. M. Christoffels
Regulatory modules in the developing heart
Cardiovasc Res, May 1, 2003; 58(2): 246 - 263.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
M. J. Solloway and R. P. Harvey
Molecular pathways in myocardial development: a stem cell perspective
Cardiovasc Res, May 1, 2003; 58(2): 264 - 277.
[Abstract] [Full Text] [PDF]


Home page
J. Exp. Biol.Home page
F. Schachat and M. M. Briggs
Phylogenetic implications of the superfast myosin in extraocular muscles
J. Exp. Biol., August 1, 2002; 205(15): 2189 - 2201.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
H. Kodama, T. Hirotani, Y. Suzuki, S. Ogawa, and K. Yamazaki
Cardiomyogenic Differentiation in Cardiac Myxoma Expressing Lineage-Specific Transcription Factors
Am. J. Pathol., August 1, 2002; 161(2): 381 - 389.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Biol.Home page
J. Li, M. Puceat, C. Perez-Terzic, A. Mery, K. Nakamura, M. Michalak, K.-H. Krause, and M. E. Jaconi
Calreticulin reveals a critical Ca2+ checkpoint in cardiac myofibrillogenesis
J. Cell Biol., July 8, 2002; 158(1): 103 - 113.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
B. G. Bruneau
Transcriptional Regulation of Vertebrate Cardiac Morphogenesis
Circ. Res., March 22, 2002; 90(5): 509 - 519.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
I. Manabe and G. K. Owens
The Smooth Muscle Myosin Heavy Chain Gene Exhibits Smooth Muscle Subtype-selective Modular Regulation in Vivo
J. Biol. Chem., October 12, 2001; 276(42): 39076 - 39087.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Biol.Home page
F. A. Scholl, P. McLoughlin, E. Ehler, C. de Giovanni, and B. W. Schafer
DRAL Is a p53-responsive Gene Whose Four and a Half LIM Domain Protein Product Induces Apoptosis
J. Cell Biol., October 23, 2000; 151(3): 495 - 506.
[Abstract] [Full Text] [PDF]


This Article
Right arrow Summary Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schwartz, R. J.
Right arrow Articles by Olson, E. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schwartz, R. J.
Right arrow Articles by Olson, E. N.