Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Filvaroff, E.
	Articles by Derynck, R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Filvaroff, E.
	Articles by Derynck, R.

Baker, A. R., Hollingshead, P. G., Pitts, M. S., Hansen, S., Taylor, R. and Stewart, T. A (1992). Osteoblast-specific expression of growth hormone stimulates bone growth in transgenic mice. Mol. Cell. Biol 12, 5541-5547.[Abstract/Free Full Text]

Beaudreuil, J., Mbalaviele, G., Cohen-Solal, M., Morieux, C., De Vernejoul, M. C. and Orcel, P (1995). Short-term local injections of transforming growth factor-1 decrease ovariectomy-stimulated osteoclastic resorption in vivo in rats. J. Bone Miner. Res 10, 971-977.[Medline]

Beck, L. S., DeGuzman, L., Lee, W. P., Xu, Y., McFatridge, L. A., Gillett,N. A. and Amento, E. P. ( (1991). TGF-1 induces bone closure of skull defects. J. Bone Miner. Res 6, 1257-1265.[Medline]

Bonewald, L. F. and Dallas, S. L (1994). Role of active and latent transforming growth factorin bone formation. J. Cell. Biochem 55, 350-357.[Medline]

Brand, T., McClellan, W. R. and Schneider, M. D (1993). A dominant-negative receptor for typetransforming growth factors created by deletion of the kinase domain. J. Biol.Chem 268, 11500-11503.[Abstract/Free Full Text]

Brand, T. and Schneider, M. D (1995). Inactive type II and type I receptors for TGF-are dominant negative inhibitors of TGF- dependent transcription. J. Biol. Chem 270, 8274-8284.[Abstract/Free Full Text]

Breen, E. C., Ignotz, R. A., McCabe, L., Stein, J. L., Stein, G. S. and Lian, J. B. ( (1994). TGF-alters growth and differentiation related gene expression in proliferating osteoblasts in vitro, preventing development of the mature bone phenotype. J. Cell. Physiol 160, 323-335.[Medline]

Bronckers, A. L., Gay, S., Dimuzio, M. T. and Butler, W. T. ( (1985). Immunolocalization of-carboxyglutamic acid containing proteins in developing rat bones. Coll. Relat. Res 5, 273-281.[Medline]

Bucay, N., Sarosi, I., Dunstan, C.R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L., Boyle, W. J. and Simonet, W. S (1998). Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12, 1260-1268.[Abstract/Free Full Text]

Carrington, J. L., Roberts, A. B., Flanders, K. C., Roche, N. S. and Reddi, A. H (1988). Accumulation, localization, and compartmentation of transforming growth factorduring endochondral bone development. J. Cell Biol 107, 1969-1975.[Abstract/Free Full Text]

Cauley, J. A., Seeley, D. G., Ensrud, R., Ettinger, B., Black, D. and Cummings, S. R (1995). Estrogen replacement therapy and fractures in older women. Ann. Int. Med 122, 9-16.[Abstract/Free Full Text]

Centrella, M., McCarthy, T. L. and Canalis, E (1988). Parathyroid hormone modulates transforming growth factoractivity and binding in osteoblastic cells. Proc. Natl.Acad. Sci. USA 85, 5889-5893.[Abstract/Free Full Text]

Centrella, M., Horowitz, M. C., Wozney, J. M. and McCarthy, T. L (1994). Transforming growth factor-gene family members and bone. Endocr. Rev 15, 27-39.[Medline]

Centrella, M., Casinghino, S., Kim, J., Pham, T., Rosen, V., Wozney, J. and McCarthy, T. L (1995). Independent changes in type I and type II receptors for transforming growth factorinduced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype. Mol. Cell. Biol 15, 3273-3281.[Abstract]

Chen, R.-H., Ebner, R. and Derynck, R (1993). Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-activities. Science 260, 1335-1338.[Abstract/Free Full Text]

Chenu, C., Pfeilschifter, J., Mundy, G. R. and Roodman, G. D (1988). Transforming growth factor-inhibits formation of osteoclast-like cells in long-term human marrow cultures. Proc. Natl. Acad. Sci. USA 85, 5683-5687.[Abstract/Free Full Text]

Chomczynski P, and Sacchi, N (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162, 156-159.[Medline]

Cohen, M. M (1997). Transforming growth factors and fibroblast growth factors and their receptors: role in sutural biology and craniosynostosis. J. Bone and Min. Res 12, 322-331.[Medline]

Corral, D. A., Amling, M., Priemel, M., Loyer, E., Fuchs, S., Ducy, P., Baron, R. and Karsenty, G (1998). Dissociation between bone resorption and bone formation in osteopenic transgenic mice. Proc. Natl. Acad. Sci. USA 95, 13835-13840.[Abstract/Free Full Text]

Diebold, R. J., Eis, M. J., Yin, M., Ormsby, I., Boivin, G. P., Darrow, B. J., Saffitz, J. E. and Doetschman, T (1995). Early-onset multifocal inflammation in the transforming growth factor1-null mouse is lymphocyte mediated. Proc. Natl. Acad. Sci. USA 92, 12215-12219.[Abstract/Free Full Text]

Dieudonne, S. C., Foo, P., van Zoelen, E. J. and Burger, E. H (1991). Inhibiting and stimulating effects of TGF-1 on osteoclastic bone resorption in fetal mouse bone organ cultures. J. Bone Miner. Res 6, 479-487.[Medline]

Engler, B. G., Meier, M., Frank, J. and Muller, G. A (1993). Reduction of background problems in nonradioactive northern and southern blot analyses enables higher sensitivity thatn 32P-based hybridizations. Anal. Biochem 210, 235-244.[Medline]

Erlebacher, A., Filvaroff, E. H., Gitelman, S. E. and Derynck, R (1995). Toward a molecular understanding of skeletal morphogenesis. Cell 80, 371-378.[Medline]

Erlebacher, A. and Derynck, R (1996). Increased expression of TGF-2 in osteoblasts results in an osteoporosis-like phenotype. J. Cell Biol 132, 195-210.[Abstract/Free Full Text]

Erlebacher, A., Filvaroff, E. H., Ye, J.-Q. and Derynck, R (1998). Osteoblastic responses to TGF-beta during bone remodeling. Mol Biol Cell 7, 1903-1918.

Evan, G. I., Lewis, G. K., Ramsay, G. and Bishop, J. M (1985). Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol 5, 3610-3616.[Abstract/Free Full Text]

Filvaroff, E., Ebner, R. and Derynck, R. ( (1994). Inhibition of myogenic differentation in myoblasts expressing a truncated type II TGF-receptor. Development 120, 1085-1095.[Abstract]

Filvaroff, E. and Derynck, R (1998). Bone remodelling: a signalling system for osteoclast regulation. Curr. Biol 8, 679-.

Finkelman, R. D., Bell, N. H., Strong, D. D., Demers, L. M. and Baylink, D. J. ( (1992). Ovariectomy selectively reduces the concentration of transforming growth factorin rat bone: implication for estrogen deficiency-associated bone loss. Proc. Natl. Acad.Sci. USA 89, 12190-12193.[Abstract/Free Full Text]

Frenkel, B., Capparelli, C., Van Auken, M., Baran, D., Bryan, J., Stein, J. L. Stein, G. S. and Lian, J. B. ( (1997). Activity of the osteocalcin promoter in skeletal sites of transgenic mice and during osteoblast differentiation in bone marrow-derived stromal cell cultures: effect of age and sex. Endocrinology 138, 2109-2116.[Abstract/Free Full Text]

Gazit, D., Ebner, R., Kahn, A. J. and Derynck, R (1993). Modulation of expression and cell surface binding of members of the transforming growth factor-superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. Mol. Endocrinol 7, 189-198.[Abstract]

Geiser, A. G., Zeng, Q. Q., Sato, M., Helvering, L. M., Hirano, T. and Turner, C. H (1998). Decreased bone mass and bone elasticity in mice lacking the transforming growth factor-b1 gene. Bone 23, 87-93.[Medline]

Hattersley, G., and Chambers, T. J (1991). Effects of transforming growth factor1 on the regulation of osteoclastic development and function. J. Bone Miner. Res 6, 165-172.[Medline]

Hughes, D.E., Dai, A., Tiffee, J.C., Li, H. H., Mundy, G. R. and Boyce, B. F (1996). Estrogen promotes apoptosis of murine osteoclasts mediates by TGF-. Nat. Med 2, 1132-1136.[Medline]

Iba, K., Sawada, N., Nuka, S., Chiba, H., Obata, H., Isomura, H., Satoh, M., Ishii, S. and Mori, M. ( (1996). Phase-dependent effects of transforming growth factor1 on osteoblastic markers of human osteoblastic cell line SV-HFO during mineralization. Bone 19, 363-369.[Medline]

Ikeda, T., Shigeno, C., Kasai, R., Kohno, H., Ohta, S., Okumura, H., Konishi, J. and Yamamuro, T. ( (1993). Ovariectomy decreases the mRNA levels of transforming growth factor-1 and increases the mRNA levels of osteocalcin in rat bone in vivo. Biochem. Biophys. Res. Comm 194, 1228-1233.[Medline]

Kalu, D. N., Salerno, E., Liu, C. C., Ferarro, F., Arjmandi, B. N. and Salih, M. A. ( (1993). Ovariectomy-induced bone loss and the hematopoietic system. Bone and Mineral 23, 145-161.[Medline]

Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R. and Berns,A (1991). Simplified mammalian DNA isolation procedure. Nucleic Acids Res 19, 4293-.[Free Full Text]

Lin, H.Y., Wang, X.-F., Ng-Eaton, E., Weinberg, R. A. and Lodish, H. F. ( (1992). Expression cloning of the TGF-type II receptor, a functional transmembrane serine/threonine kinase. Cell 68, 775-785.[Medline]

Mackie, E. J. and Trechsel, U (1990). Stimulation of bone formation in vivo by transforming growth factor-: remodeling of woven bone and lack of inhibition by indomethacin. Bone 11, 295-300.[Medline]

Manolagas, S.C. and Jilka, R. L. ( (1995). Bone marrow, cytokines, and bone remodeling: emerging insights into the pathophysiology of osteoporosis. New Engl. J. Med 332, 305-311.[Free Full Text]

Marcelli, C., Yates, A. J. and Mundy, G. R (1990). In vivo effects of human recombinant transforming growth factoron bone turnover in normal mice. J. Bone Min. Res 5, 1087-1096.[Medline]

Marcus, R (1996). Clinical review 76. The nature of osteoporosis. J. Clin. Endocrinol.Metab 81, 1-5.[Medline]

Miettinen P.J., Ebner, R., Lopez, A. R. and Derynck, R (1994). TGF--induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J. Cell Biol 127, 2021-2036.[Abstract/Free Full Text]

Most, D., Levine, J. P., Chang, J., Sung, J., McCarthy, J. G., Schendel, S. A. and Longaker, M. T. ( (1998). Studies in cranial suture biology: up-regulation of transforming growth factor-1 and basic fibroblast growth factor mRNA correlates with posterior frontal cranial suture fusion in the rat. Plast. Reconstr. Surg 101, 1431-1440.[Medline]

Murakami, T., Yamamoto, M., Yamamoto, M., Ono, K., Nishikawa, M., Nagata, N., Motoyoshi, K. and Akatsu, T (1998). Transforming growth factor-1 increase mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoblast-like cells. Biochem. Biophys. Res. Comm 252, 747-752.[Medline]

O'Hare, K., Benoist, C. and Breathnach, R (1981). Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase. Proc. Natl. Acad. Sci. USA 78, 1527-1531.[Abstract/Free Full Text]

Oreffo, R. O., Mundy, G. R., Seyedin, S. M. and Bonewald, L. F (1989). Activation of the bone-derived latent TGF-complex by isolated osteoclasts. Biochem. Biophys. Res. Commun 158, 817-823.[Medline]

Oursler, M. J., Cortese, C., Keeting, P., Anderson, M. A., Bonde, S. K. Riggs, B. L. and Spelsberg, T. C (1991). Modulation of transforming growth factor-production in normal human osteoblast-like cells by 17 -estradiol and parathyroid hormone. Endocrinology 129, 3313-3320.[Abstract]

Parfitt, A. M., Drezner, M. K., Glorieux, G. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M. and Recker, R. R (1987). Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res 2, 595-610.[Medline]

Parfitt, A. M (1994). Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J. Cell. Biochem 55, 273-286.[Medline]

Pelton, R. W., Saxena, B., Jones, M., Moses, H. L. and Gold, L. I (1991). Immunohistochemical localization of TGF-1, TGF- 2, and TGF-3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J. Cell. Biol 115, 1091-105.[Abstract/Free Full Text]

Pereira, R., Khillan, J. S., Helminen, H. J., Hume, E. L. and Prockop, D. J (1993). Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral. J. Clin. Invest 91, 709-716.

Pfeilschifter, J. and Mundy, G. R (1987). Modulation of typetransforming growth factor activity in bone cultures by osteotropic hormones. Proc. Natl. Acad. Sci. USA 84, 2024-2028.[Abstract/Free Full Text]

Pfeilschifter, J., Seyedin, S. M. and Mundy, G. R (1988). Transforming growth factorinhibits bone resorption in fetal rat long bone cultures. J. Clin. Invest 82, 680-685.

Pfeilschifter, J., Diel, I., Scheppach, B., Bretz, A., Krempien, R., Erdmann, J., Schmid, G., Reske, N., Bismar, H., Seck, T., Krempien, B. and Ziegler, R (1998). Concentration of transforming growth factor beta in human bone tissue: relationship to age, menopause, bone turnover, and bone volume. J. Bone Min. Res 13, 716-730.[Medline]

Pfeilschifter, F., Laukhuf, F., Muller-Beckmann, B., Blum, W. F., Pfister, T. and Ziegler, R. ( (1995). Parathyroid hormone increases the concentration of insulin-like growth factor I and transforming growth factor-1 in rat bone. J. Clin. Invest 96, 767-774.

Robey, P. G., Young, M. F., Flanders, K. C., Roche, N. S., Kondaiah, P., Reddi, A. H., Termine, J. D., Sporn, M. B. and Roberts, A. B. ( (1987). Osteoblasts synthesize and respond to transforming growth factor-type(TGF- ) in vitro. J. Cell. Biol 105, 457-463.[Abstract/Free Full Text]

Rosen, D. M., Stempien, S. A., Thompson, A. Y. and Seyedin, S. M (1988). Transforming growth factor-modulates the expression of osteoblast and chondrocyte phenotypes in vitro. J. Cell. Physiol 134, 337-346.[Medline]

Rosier, R. N., O'Keefe, R. J. and Hicks, D. G (1998). The potential role of transforming growth factorin fracture healing. Clin. Orthop. Rel. Res 355, 294-.

Serra, R., Johnson, M., Filvaroff, E. H., LaBorde, J., Sheehan, D., Derynck, R. and Moses, H. J (1997). Expression of a truncated, kinase-defective TGF-type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J. Cell Biol 139, 541-552.[Abstract/Free Full Text]

Seyedin, S. M., Thomas, T. C., Thompson, A. Y., Rosen, D. M. and Piez, K. A. ( (1985). Purification and characterization of two cartilage-inducing factors from bovine demineralized bone. Proc. Natl. Acad. Sci. USA 82, 2267-2271.[Abstract/Free Full Text]

Seyedin, S., Thompson, A.Y., Bentz, H., Rosen, D. M., McPherson, J. M., Conti, A., Siegel, N. R., Gallupi, G. R. and Piez, K. A (1986). Cartilage-inducing factor-A: apparent identity to transforming frowth factor-. J. Biol. Chem 261, 5693-5695.[Abstract/Free Full Text]

Shinar, D. M. and Rodan, G. A (1990). Biphasic effects of transforming growth factor-beta on the production of osteoclast-like cells in mouse bone marrow cultures: the role of prostaglandins in the generation of these cells. Endocrinol 126, 3153-3158.[Abstract]

Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., Annunziata, N. and Doetschman, T. ( (1992). Targeted disruption of the mouse transforming growth factor-1 gene results in multifocal inflammatory disease. Nature 359, 693-699.[Medline]

Takai, H., Kanematsu, H., Yano, K., Tsuda, E., Higashio, K., Ikeda, K., Watanabe, K. and Yamada, Y (1998). Transforming growth factor-stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells. J. Biol. Chem 42, 27091-27096.

Takaishi, T., Matsui, T., Tsukamoto, T., Ito, M., Taniguchi, T., Fukase, M. and Chihara, K (1994). TGF--induced macrophage colony-stimulating factor gene expression in various mesenchymal cell lines. Am. J. Physiol 267, 25-.

Tashjian, A. J., Voelkel, E. F., Lazzaro, M., Singer, F. R., Roberts, A. B., Derynck, R., Winkler, M. E. and Levine, L. ( (1985). and human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria. Proc.Natl. Acad. Sci. USA 82, 4535-4538.[Abstract/Free Full Text]

Vermeulen, A. H., Vermeer, C. and Bosman, F. T (1989). Histochemical detection of osteocalcin in normal and pathological human bone. J. Histochem. Cytochem 37, 1503-1508.[Abstract/Free Full Text]

Weibel, E. R (1969). Stereological principles for morphometry in electron microscopic cytology. Int. Rev. Cytol 26, 235-302.[Medline]

Wrana, J. L., Attisano, L., Wieser, R., Ventura, F. and Massague, J (1994). Mechanism of activation of the TGF-receptor. Nature 370, 341-247.[Medline]

Wronski, T. J., Lowry, P. L., Walsh, C. C. and Ignaszewski, A (1985). Skeletal alterations in ovariectomized rats. Calcif. Tissue Int 37, 324-328.[Medline]

Wronski, T. J., Walsh, C. C. and Ignaszewski, A. ( (1986). Histologic evidence for osteopenia and increased bone turnover in ovariectomized rats. Bone 7, 119-123.[Medline]

This article has been cited by other articles:

X. Tan, T. Weng, J. Zhang, J. Wang, W. Li, H. Wan, Y. Lan, X. Cheng, N. Hou, H. Liu, et al.
Smad4 is required for maintaining normal murine postnatal bone homeostasis
J. Cell Sci., July 1, 2007; 120(13): 2162 - 2170.
[Abstract] [Full Text] [PDF]

T. Sasaki, Y. Ito, P. Bringas Jr, S. Chou, M. M. Urata, H. Slavkin, and Y. Chai
TGF{beta}-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development
Development, January 15, 2006; 133(2): 371 - 381.
[Abstract] [Full Text] [PDF]

G. Balooch, M. Balooch, R. K. Nalla, S. Schilling, E. H. Filvaroff, G. W. Marshall, S. J. Marshall, R. O. Ritchie, R. Derynck, and T. Alliston
TGF-{beta} regulates the mechanical properties and composition of bone matrix
PNAS, December 27, 2005; 102(52): 18813 - 18818.
[Abstract] [Full Text] [PDF]

K. Janssens, P. ten Dijke, S. Janssens, and W. Van Hul
Transforming Growth Factor-{beta}1 to the Bone
Endocr. Rev., October 1, 2005; 26(6): 743 - 774.
[Abstract] [Full Text] [PDF]

Y. Bi, C. H. Stuelten, T. Kilts, S. Wadhwa, R. V. Iozzo, P. G. Robey, X.-D. Chen, and M. F. Young
Extracellular Matrix Proteoglycans Control the Fate of Bone Marrow Stromal Cells
J. Biol. Chem., August 26, 2005; 280(34): 30481 - 30489.
[Abstract] [Full Text] [PDF]

C. Colarossi, Y. Chen, H. Obata, V. Jurukovski, L. Fontana, B. Dabovic, and D. B. Rifkin
Lung Alveolar Septation Defects in Ltbp-3-Null Mice
Am. J. Pathol., August 1, 2005; 167(2): 419 - 428.
[Abstract] [Full Text] [PDF]

D. B. Rifkin
Latent Transforming Growth Factor-{beta} (TGF-{beta}) Binding Proteins: Orchestrators of TGF-{beta} Availability
J. Biol. Chem., March 4, 2005; 280(9): 7409 - 7412.
[Full Text] [PDF]

K. Toyo-oka, S. Hirotsune, M. J. Gambello, Z.-Q. Zhou, L. Olson, M. G. Rosenfeld, R. Eisenman, P. Hurlin, and A. Wynshaw-Boris
Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome
Hum. Mol. Genet., May 15, 2004; 13(10): 1057 - 1067.
[Abstract] [Full Text] [PDF]

M. A. Karsdal, P. Hjorth, K. Henriksen, T. Kirkegaard, K. L. Nielsen, H. Lou, J.-M. Delaisse, and N. T. Foged
Transforming Growth Factor-{beta} Controls Human Osteoclastogenesis through the p38 MAPK and Regulation of RANK Expression
J. Biol. Chem., November 7, 2003; 278(45): 44975 - 44987.
[Abstract] [Full Text] [PDF]

C. P. Denton, B. Zheng, L. A. Evans, X. Shi-wen, V. H. Ong, I. Fisher, K. Lazaridis, D. J. Abraham, C. M. Black, and B. de Crombrugghe
Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor {beta} (TGF{beta}) Receptor Leads to Paradoxical Activation of TGF{beta} Signaling Pathways with Fibrosis in Transgenic Mice
J. Biol. Chem., June 27, 2003; 278(27): 25109 - 25119.
[Abstract] [Full Text] [PDF]

J. P. Annes, J. S. Munger, and D. B Rifkin
Making sense of latent TGF{beta} activation
J. Cell Sci., January 15, 2003; 116(2): 217 - 224.
[Abstract] [Full Text] [PDF]

M. A. Karsdal, L. Larsen, M. T. Engsig, H. Lou, M. Ferreras, A. Lochter, J.-M. Delaisse, and N. T. Foged
Matrix Metalloproteinase-dependent Activation of Latent Transforming Growth Factor-beta Controls the Conversion of Osteoblasts into Osteocytes by Blocking Osteoblast Apoptosis
J. Biol. Chem., November 8, 2002; 277(46): 44061 - 44067.
[Abstract] [Full Text] [PDF]

M. Peacock, C. H. Turner, M. J. Econs, and T. Foroud
Genetics of Osteoporosis
Endocr. Rev., June 1, 2002; 23(3): 303 - 326.
[Abstract] [Full Text] [PDF]

M. Szweras, D. Liu, E. A. Partridge, J. Pawling, B. Sukhu, C. Clokie, W. Jahnen-Dechent, H. C. Tenenbaum, C. J. Swallow, M. D. Grynpas, et al.
alpha 2-HS Glycoprotein/Fetuin, a Transforming Growth Factor-beta /Bone Morphogenetic Protein Antagonist, Regulates Postnatal Bone Growth and Remodeling
J. Biol. Chem., May 24, 2002; 277(22): 19991 - 19997.
[Abstract] [Full Text] [PDF]

A. B. Roberts and R. Derynck
Meeting Report: Signaling Schemes for TGF-{beta}
Sci. Signal., December 18, 2001; 2001 (113): pe43 - pe43.
[Abstract] [Full Text] [PDF]

K. Itoh, N. Udagawa, T. Katagiri, S. Iemura, N. Ueno, H. Yasuda, K. Higashio, J. M. W. Quinn, M. T. Gillespie, T. J. Martin, et al.
Bone Morphogenetic Protein 2 Stimulates Osteoclast Differentiation and Survival Supported by Receptor Activator of Nuclear Factor-{kappa}B Ligand
Endocrinology, August 1, 2001; 142(8): 3656 - 3662.
[Abstract] [Full Text] [PDF]

M. E. Bahamonde and K. M Lyons
BMP3: To Be or Not To Be a BMP
J. Bone Joint Surg. Am., April 1, 2001; 83(90010): S56 - 62.
[Abstract] [Full Text] [PDF]

M. E. Bahamonde and K. M Lyons
BMP3: To Be or Not To Be a BMP
J. Bone Joint Surg. Am., March 1, 2001; 83(1_suppl_1): S56 - S62.
[Abstract] [Full Text] [PDF]

T. Kaneda, T. Nojima, M. Nakagawa, A. Ogasawara, H. Kaneko, T. Sato, H. Mano, M. Kumegawa, and Y. Hakeda
Endogenous Production of TGF-{beta} Is Essential for Osteoclastogenesis Induced by a Combination of Receptor Activator of NF-{kappa}B Ligand and Macrophage-Colony- Stimulating Factor
J. Immunol., October 15, 2000; 165(8): 4254 - 4263.
[Abstract] [Full Text] [PDF]

B. Dabovic, Y. Chen, C. Colarossi, H. Obata, L. Zambuto, M. A. Perle, and D. B. Rifkin
Bone abnormalities in latent TGF-{beta} binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-{beta} bioavailability
J. Cell Biol., January 21, 2002; 156(2): 227 - 232.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Filvaroff, E.

Articles by Derynck, R.

Search for Related Content

PubMed

PubMed Citation

Articles by Filvaroff, E.

Articles by Derynck, R.

				T. Sasaki, Y. Ito, P. Bringas Jr, S. Chou, M. M. Urata, H. Slavkin, and Y. Chai TGF{beta}-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development Development, January 15, 2006; 133(2): 371 - 381. [Abstract] [Full Text] [PDF]

				G. Balooch, M. Balooch, R. K. Nalla, S. Schilling, E. H. Filvaroff, G. W. Marshall, S. J. Marshall, R. O. Ritchie, R. Derynck, and T. Alliston TGF-{beta} regulates the mechanical properties and composition of bone matrix PNAS, December 27, 2005; 102(52): 18813 - 18818. [Abstract] [Full Text] [PDF]

				K. Janssens, P. ten Dijke, S. Janssens, and W. Van Hul Transforming Growth Factor-{beta}1 to the Bone Endocr. Rev., October 1, 2005; 26(6): 743 - 774. [Abstract] [Full Text] [PDF]

				Y. Bi, C. H. Stuelten, T. Kilts, S. Wadhwa, R. V. Iozzo, P. G. Robey, X.-D. Chen, and M. F. Young Extracellular Matrix Proteoglycans Control the Fate of Bone Marrow Stromal Cells J. Biol. Chem., August 26, 2005; 280(34): 30481 - 30489. [Abstract] [Full Text] [PDF]

				C. Colarossi, Y. Chen, H. Obata, V. Jurukovski, L. Fontana, B. Dabovic, and D. B. Rifkin Lung Alveolar Septation Defects in Ltbp-3-Null Mice Am. J. Pathol., August 1, 2005; 167(2): 419 - 428. [Abstract] [Full Text] [PDF]

				D. B. Rifkin Latent Transforming Growth Factor-{beta} (TGF-{beta}) Binding Proteins: Orchestrators of TGF-{beta} Availability J. Biol. Chem., March 4, 2005; 280(9): 7409 - 7412. [Full Text] [PDF]

				K. Toyo-oka, S. Hirotsune, M. J. Gambello, Z.-Q. Zhou, L. Olson, M. G. Rosenfeld, R. Eisenman, P. Hurlin, and A. Wynshaw-Boris Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome Hum. Mol. Genet., May 15, 2004; 13(10): 1057 - 1067. [Abstract] [Full Text] [PDF]

				M. A. Karsdal, P. Hjorth, K. Henriksen, T. Kirkegaard, K. L. Nielsen, H. Lou, J.-M. Delaisse, and N. T. Foged Transforming Growth Factor-{beta} Controls Human Osteoclastogenesis through the p38 MAPK and Regulation of RANK Expression J. Biol. Chem., November 7, 2003; 278(45): 44975 - 44987. [Abstract] [Full Text] [PDF]

				C. P. Denton, B. Zheng, L. A. Evans, X. Shi-wen, V. H. Ong, I. Fisher, K. Lazaridis, D. J. Abraham, C. M. Black, and B. de Crombrugghe Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor {beta} (TGF{beta}) Receptor Leads to Paradoxical Activation of TGF{beta} Signaling Pathways with Fibrosis in Transgenic Mice J. Biol. Chem., June 27, 2003; 278(27): 25109 - 25119. [Abstract] [Full Text] [PDF]

				J. P. Annes, J. S. Munger, and D. B Rifkin Making sense of latent TGF{beta} activation J. Cell Sci., January 15, 2003; 116(2): 217 - 224. [Abstract] [Full Text] [PDF]

				M. A. Karsdal, L. Larsen, M. T. Engsig, H. Lou, M. Ferreras, A. Lochter, J.-M. Delaisse, and N. T. Foged Matrix Metalloproteinase-dependent Activation of Latent Transforming Growth Factor-beta Controls the Conversion of Osteoblasts into Osteocytes by Blocking Osteoblast Apoptosis J. Biol. Chem., November 8, 2002; 277(46): 44061 - 44067. [Abstract] [Full Text] [PDF]

				M. Peacock, C. H. Turner, M. J. Econs, and T. Foroud Genetics of Osteoporosis Endocr. Rev., June 1, 2002; 23(3): 303 - 326. [Abstract] [Full Text] [PDF]

				M. Szweras, D. Liu, E. A. Partridge, J. Pawling, B. Sukhu, C. Clokie, W. Jahnen-Dechent, H. C. Tenenbaum, C. J. Swallow, M. D. Grynpas, et al. alpha 2-HS Glycoprotein/Fetuin, a Transforming Growth Factor-beta /Bone Morphogenetic Protein Antagonist, Regulates Postnatal Bone Growth and Remodeling J. Biol. Chem., May 24, 2002; 277(22): 19991 - 19997. [Abstract] [Full Text] [PDF]

				A. B. Roberts and R. Derynck Meeting Report: Signaling Schemes for TGF-{beta} Sci. Signal., December 18, 2001; 2001 (113): pe43 - pe43. [Abstract] [Full Text] [PDF]

				K. Itoh, N. Udagawa, T. Katagiri, S. Iemura, N. Ueno, H. Yasuda, K. Higashio, J. M. W. Quinn, M. T. Gillespie, T. J. Martin, et al. Bone Morphogenetic Protein 2 Stimulates Osteoclast Differentiation and Survival Supported by Receptor Activator of Nuclear Factor-{kappa}B Ligand Endocrinology, August 1, 2001; 142(8): 3656 - 3662. [Abstract] [Full Text] [PDF]

				M. E. Bahamonde and K. M Lyons BMP3: To Be or Not To Be a BMP J. Bone Joint Surg. Am., April 1, 2001; 83(90010): S56 - 62. [Abstract] [Full Text] [PDF]

				T. Kaneda, T. Nojima, M. Nakagawa, A. Ogasawara, H. Kaneko, T. Sato, H. Mano, M. Kumegawa, and Y. Hakeda Endogenous Production of TGF-{beta} Is Essential for Osteoclastogenesis Induced by a Combination of Receptor Activator of NF-{kappa}B Ligand and Macrophage-Colony- Stimulating Factor J. Immunol., October 15, 2000; 165(8): 4254 - 4263. [Abstract] [Full Text] [PDF]

				B. Dabovic, Y. Chen, C. Colarossi, H. Obata, L. Zambuto, M. A. Perle, and D. B. Rifkin Bone abnormalities in latent TGF-{beta} binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-{beta} bioavailability J. Cell Biol., January 21, 2002; 156(2): 227 - 232. [Abstract] [Full Text] [PDF]