Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Brown, D.
	Articles by Olson, E. N.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Brown, D.
	Articles by Olson, E. N.

Arsenian, S., Weinhold, B., Oelgeschlager, M., Ruther, U. and Nordheim A (1998). Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J 71, 6289-6299.

Basheeruddin, K., Stein, P., Strickland, S. and Williams, D. L (1987). Expression of the murine apolipoprotein E gene is coupled to the differentiated state of F9 embryonal carcinoma cells. Proc. Natl. Acad. Sci. USA 84, 709-713.[Abstract/Free Full Text]

Blum, M., Gaunt, S. J., Cho, K. W. Y., Steinbeisser, H., Blumberg, B., Bittner, D. and DeRobertis, E. M (1992). Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69, 1097-1106.[Medline]

Burgess, R., Cserjesi, P., Ligon, K. L. and Olson, E. N (1995). Paraxis: A basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites. Dev. Biol 168, 296-306.[Medline]

Burgess, R., Rawls, A., Brown, D., Bradley, A. and Olson, E. N (1996). Requirement of the paraxis gene for somite epithelialization and musculoskeletal patterning. Nature 384, 570-574.[Medline]

Chen, Z-F. and Behringer, R. R (1995). Twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev 9, 686-699.[Abstract/Free Full Text]

Cheng, T.-C., Wallace, M., Merlie, J. P. and Olson, E. N (1993). Separable regulatory elements govern myogenin transcription in embryonic somites and limb buds. Science 261, 215-218.[Abstract/Free Full Text]

Christ, B. and Ordahl, C. P (1995). Early stages of chick somite development. Anat. Embryol 191, 381-396.[Medline]

Conlon, F. L., Lyons, K. M., Takaesu, N., Barth, K. S., Kispert, A., Herrmann, B. and Robertson, E. J (1994). A primary requirement fornodal in the formation and maintenance of the primitive streak in the mouse. Development 120, 1919-1928.[Abstract]

Crossley, P. H. and Martin, G. R (1995). The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121, 439-451.[Abstract]

Cserjesi, P., Brown, D., Ligon, K.L., Lyons, G., Copeland, N. G., Gilbert, D. J., Jenkins, N. A. and Olson, E. N (1995). Scleraxis: A basic-helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis. Development 121, 1099-1110.[Abstract]

Cserjesi, P., Brown, D., Lyons, G. E. and Olson, E. N (1995). Expression of the novel basic-helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev. Biol 170, 664-678.[Medline]

Doetschman, T. C., Eistetter, H., Katz, M., Schmidt, W. and Kemler, R (1985). The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J. Embryol. Exp. Morph 87, 27-45.[Medline]

Dono, R., Scalera, L., Pacifico, F., Acampora, D., Persico, M. G. and Simeone, A (1993). The murine cripto gene: expression during mesoderm induction and early heart morphogenesis. Development 118, 1157-1168.[Abstract]

Edmondson, D. G., Lyons, G. E., Martin, J. F. and Olson, E. N (1994). Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development 120, 1251-1263.[Abstract]

Filosa, S., Rivera-Perez, J. A., Gomez, A. P., Gansmuller, A., Sasaki, H., Behringer, R. R. and Ang, S.-L (1997). goosecoid and HNF-3 genetically interact to regulate neural tube patterning during mouse embryogenesis. Development 124, 2843-2854.[Abstract]

Friedrich, G. and Soriano P (1991). Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice. Genes Dev 5, 1513-1523.[Abstract/Free Full Text]

Fuchtbauer, E. M (1995). Expression of M-twist during postimplantation development of the mouse. Dev. Dyn 204, 316-322.[Medline]

Gitelman, I (1997). The Twist protein in mouse embryogenesis. Dev. Biol 189, 205-214.[Medline]

Hayashi, Y., Koike, M., Mattsutani, M. and Hoshino, T (1988). Effects of fixation time and enzymatic digestion on immunohistochemical demonstration of bromodeoxyuridine in formalin-fixed, paraffin-embedded tissue. J. Histochem. Cytochem 36, 511-514.[Abstract]

Herrmann, B. G (1991). Expression pattern of the brachyury gene in the whole-mount Twis/Twismutant embryos. Development 113, 913-917.[Abstract]

Hogan, B. L. M (1996). Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 10, 1580-1594.[Free Full Text]

Katagiri, T., Yamaguchi, A., Komaki, M., Abe, E., Takahashi, N., Ikeda, T., Rosen, V., Wozney, J., Sehara, A. F. and Suda, T (1994). Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J. Cell Biol 127, 1755-1766.[Abstract/Free Full Text]

Kawa-uchi, T., Nifuji, A., Mataga, N., Olson, E. N., Bonaventure, J., Shinomiya, K., Liu, Y. and Noda, M (1998). Fibroblast growth factor downregulates expression of a basic helix-loop-helix-type transcription factor, scleraxis in a chondrocyte-like cell line, TC6. J. Cell. Biochem 70, 468-477.[Medline]

Kimelman, D., Christian, J. O. and Moon, R. T (1992). Synergistic principles of development: overlapping patterning systems in Xenopus mesoderm induction. Development 116, 1-9.[Abstract]

Kimelman, D. and Kirschner, M (1987). Synergistic induction of mesoderm by FGF and TGF-and the identification of an mRNA coding for FGF in the early Xenopus embryo. Cell 51, 869-877.[Medline]

Lewandoski, M., Meyers, E. N. and Martin, G. R (1997). Analysis of Fgf8 function in the developing vertebrate embryo. Cold Spring Harbor Symp. Quant. Biol 62, 159-168.[Medline]

Li, L., Cserjesi, P. and Olson, E. N (1995). Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis. Dev. Biol 172, 280-292.[Medline]

Lin, Q., Lu, J., Yanagisawa, H., Webb, R., Lyons, G. E., Richardson, J. A.and Olson, E. N (1998). Requirement of the MADS-box transcription factor MEF2C for vascular development. Development 125, 4564-4574.

Liu, Y., Cserjesi, P., Nifuji, A., Olson, E. N. and Noda, M (1996). Sclerotome related helix-loop-helix type transcription factor, scleraxis , mRNA is expressed in osteoblasts and its level is enhanced by type-transforming growth factor. J. Endocrinology 151, 491-499.[Abstract]

Liu, Y., Nifuji, A., Wozney, J. M., Olson, E. N. and Noda, M (1997). Scleraxis messenger ribonucleic acid is expressed in C2C12 myoblasts and its level is down-regulated by bone morphogenetic protein-2 (BMP2). J. Cell. Biochem 67, 66-74.[Medline]

Liu, Y., Watanabe, H., Nifuji, A., Yamada, Y., Olson, E. N. and Noda, M (1997). Overexpression of a single helix-loop-helix type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells. J. Biol. Chem 272, 29880-29885.[Abstract/Free Full Text]

Manova, K., Paynton, B. V. and Bacharova, R. F (1992). Expression of activins and TGF - 1 and-2 RNAs in early postimplantation mouse embryos and uterine decidual. Mech. Dev 36, 141-152.[Medline]

Meyers, E. N., Lewandoski, M. and Martin, G. R (1998). An Fgf8 mutant allelic series generated by Cre-and Flp-mediated recombination. Nature Gen 18, 136-141.[Medline]

Mishina, Y., Suzuki, A., Ueno, N. and Behringer, R. R (1995). Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev 9, 3027-3037.[Abstract/Free Full Text]

Nomura, M. and Li, E (1998). Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature 393, 786-789.[Medline]

Poirier, F., Chan, C.-T. J., Timmons, P. M., Robertson, E. J., Evans, M. J. and Rigby, P. W. J (1991). The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo. Development 113, 1105-1114.[Abstract]

Power, M.-A. and Tam, P. P. L (1993). Onset of gastrulation, morphogenesis and somitogenesis in mouse embryos displaying compensatory growth. Anat. Embryol 187, 493-504.[Medline]

Sasaki, H. and Hogan, B. L. M (1993). Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118, 47-59.[Abstract]

Sirard, C., Pompa, J. L., Elia, A., Itie, A., Mirtsos, C., Cheung, A., Hahn, S., Wakeham, A., Schwartz, L., Kern, S. E., Rossant, J. and Mak, T. W (1998). The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev 12, 107-119.[Abstract/Free Full Text]

Smith, J. C., Pierce, B. M. J., Van Nimmen, K. and Huylebroeck, D (1990). Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A. Nature 345, 729-731.[Medline]

Snow, M. H. L (1977). Gastrulation in the mouse: growth and regionalisation of the epiblast. J. Embryol. Exp. Morph 42, 293-303.

Schwartz, L., Kern, S. E., Rossant, J. and Mak, T. W (1998). The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev 12, 107-119.[Abstract/Free Full Text]

Tam, P. P. and Behringer, R. R (1997). Mouse gastrulation: the formation of a mammalian body plan. Mech. Dev 68, 3-25.[Medline]

Thisse, B., Messal, M. El. and Perrin-Schmitt, F (1987). The twist gene: Isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern. Nucleic Acids Res 15, 3439-3453.[Abstract/Free Full Text]

Varlet, I., Collingnon, J. and Robertson, E. J (1997). nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development 124, 1033-1044.[Abstract]

Waldrip, W. R., Bikoff, E. K., Hoodless, P. A., Wrana, J. L. and Robertson, E. J (1998). SMAD2 signaling in extra embryonic tissue determines anterior-posterior polarity of the early mouse embryo. Cell 92, 797-808.[Medline]

Weinstein, M., Yang, X., Li, C., Xu, X., Gotay, J. and Deng, C.-X (1998). Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc. Natl. Acad. Sci. USA 95, 9378-9383.[Abstract/Free Full Text]

Wilkinson, D. G., Bhatt, S. and Herrmann, B. G (1990). Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 343, 657-659.[Medline]

Wilson, V. and Beddington, R (1996). Cell fate and morphogenetic movement in the late mouse primitive streak. Mech. Dev 55, 79-89.[Medline]

Winnier, G., Blessing, M., Labosky, P. A. and Hogan, B. L. M (1995). Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 9, 2105-2116.[Abstract/Free Full Text]

Yamaguchi, T. P., Harpal, K., Henkemeyer, M. and Rossant, J (1994). fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev 8, 3032-3044.[Abstract/Free Full Text]

This article has been cited by other articles:

N. D. Murchison, B. A. Price, D. A. Conner, D. R. Keene, E. N. Olson, C. J. Tabin, and R. Schweitzer
Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons
Development, July 15, 2007; 134(14): 2697 - 2708.
[Abstract] [Full Text] [PDF]

T. Muir, I. Sadler-Riggleman, and M. K. Skinner
Role of the Basic Helix-Loop-Helix Transcription Factor, Scleraxis, in the Regulation of Sertoli Cell Function and Differentiation
Mol. Endocrinol., August 1, 2005; 19(8): 2164 - 2174.
[Abstract] [Full Text] [PDF]

Y. Takahashi, S. Kitajima, T. Inoue, J. Kanno, and Y. Saga
Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites
Development, February 15, 2005; 132(4): 787 - 796.
[Abstract] [Full Text] [PDF]

L. Soustelle, C. Jacques, B. Altenhein, G. M. Technau, T. Volk, and A. Giangrande
Terminal tendon cell differentiation requires the glide/gcm complex
Development, September 15, 2004; 131(18): 4521 - 4532.
[Abstract] [Full Text] [PDF]

J. Wilson-Rawls, J. M. Rhee, and A. Rawls
Paraxis Is a Basic Helix-Loop-Helix Protein That Positively Regulates Transcription through Binding to Specific E-box Elements
J. Biol. Chem., September 3, 2004; 279(36): 37685 - 37692.
[Abstract] [Full Text] [PDF]

Y. Yao, W. Li, J. Wu, U. A. Germann, M. S. S. Su, K. Kuida, and D. M. Boucher
Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
PNAS, October 28, 2003; 100(22): 12759 - 12764.
[Abstract] [Full Text] [PDF]

A. Hoffmann, S. Czichos, C. Kaps, D. Bachner, H. Mayer, Y. Zilberman, G. Turgeman, G. Pelled, G. Gross, and D. Gazit
The T-box transcription factor Brachyury mediates cartilage development in mesenchymal stem cell line C3H10T1/2
J. Cell Sci., February 15, 2002; 115(4): 769 - 781.
[Abstract] [Full Text] [PDF]

C Jorgensen, D Noel, and G Gross
Could inflammatory arthritis be triggered by progenitor cells in the joints?
Ann Rheum Dis, January 1, 2002; 61(1): 6 - 9.
[Abstract] [Full Text] [PDF]

R. Schweitzer, J. H. Chyung, L. C. Murtaugh, A. E. Brent, V. Rosen, E. N. Olson, A. Lassar, and C. J. Tabin
Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments
Development, October 1, 2001; 128(19): 3855 - 3866.
[Abstract] [Full Text] [PDF]

I. Castanon, S. Von Stetina, J. Kass, and M. K. Baylies
Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development
Development, August 15, 2001; 128(16): 3145 - 3159.
[Abstract] [Full Text] [PDF]

M Leitges, L Neidhardt, B Haenig, B. Herrmann, and A Kispert
The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column
Development, January 6, 2000; 127(11): 2259 - 2267.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Brown, D.

Articles by Olson, E. N.

Search for Related Content

PubMed

PubMed Citation

Articles by Brown, D.

Articles by Olson, E. N.

				T. Muir, I. Sadler-Riggleman, and M. K. Skinner Role of the Basic Helix-Loop-Helix Transcription Factor, Scleraxis, in the Regulation of Sertoli Cell Function and Differentiation Mol. Endocrinol., August 1, 2005; 19(8): 2164 - 2174. [Abstract] [Full Text] [PDF]

				Y. Takahashi, S. Kitajima, T. Inoue, J. Kanno, and Y. Saga Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites Development, February 15, 2005; 132(4): 787 - 796. [Abstract] [Full Text] [PDF]

				L. Soustelle, C. Jacques, B. Altenhein, G. M. Technau, T. Volk, and A. Giangrande Terminal tendon cell differentiation requires the glide/gcm complex Development, September 15, 2004; 131(18): 4521 - 4532. [Abstract] [Full Text] [PDF]

				J. Wilson-Rawls, J. M. Rhee, and A. Rawls Paraxis Is a Basic Helix-Loop-Helix Protein That Positively Regulates Transcription through Binding to Specific E-box Elements J. Biol. Chem., September 3, 2004; 279(36): 37685 - 37692. [Abstract] [Full Text] [PDF]

				Y. Yao, W. Li, J. Wu, U. A. Germann, M. S. S. Su, K. Kuida, and D. M. Boucher Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation PNAS, October 28, 2003; 100(22): 12759 - 12764. [Abstract] [Full Text] [PDF]

				A. Hoffmann, S. Czichos, C. Kaps, D. Bachner, H. Mayer, Y. Zilberman, G. Turgeman, G. Pelled, G. Gross, and D. Gazit The T-box transcription factor Brachyury mediates cartilage development in mesenchymal stem cell line C3H10T1/2 J. Cell Sci., February 15, 2002; 115(4): 769 - 781. [Abstract] [Full Text] [PDF]

				C Jorgensen, D Noel, and G Gross Could inflammatory arthritis be triggered by progenitor cells in the joints? Ann Rheum Dis, January 1, 2002; 61(1): 6 - 9. [Abstract] [Full Text] [PDF]

				R. Schweitzer, J. H. Chyung, L. C. Murtaugh, A. E. Brent, V. Rosen, E. N. Olson, A. Lassar, and C. J. Tabin Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments Development, October 1, 2001; 128(19): 3855 - 3866. [Abstract] [Full Text] [PDF]

				I. Castanon, S. Von Stetina, J. Kass, and M. K. Baylies Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development Development, August 15, 2001; 128(16): 3145 - 3159. [Abstract] [Full Text] [PDF]

				M Leitges, L Neidhardt, B Haenig, B. Herrmann, and A Kispert The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column Development, January 6, 2000; 127(11): 2259 - 2267. [Abstract] [PDF]