Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed

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Basilico, C. and Moscatelli, D (1992). The FGF family of growth factors and oncogenes. Adv. Cancer Res 59, 115-165.[Medline]

Bergmann, A., Agapite, J., McCall, K. and Steller, H (1998). The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331-341.[Medline]

Burke, D., Wilkes, D., Blundell, T. L. and Malcolm, S (1998). Fibroblast growth factor receptors: lessons from the genes. Trends Biochem. Sci 23, 59-62.[Medline]

Casci, T., Vinos, J. and Freeman, M (1999). Sprouty, an intracellular inhibitor of Ras signaling. Cell 96, 655-665.[Medline]

Chen, E. B. and Stern, M. J (1998). Understanding cell migration guidance: lessons from sex myoblast migration in C. elegans. Trends Genet 14, 322-327.[Medline]

Ciruna, B., Schwartz, L., Harpal, K., Yamaguchi, T. and Rossant, J (1997). Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak. Development 124, 2829-2841.[Abstract]

Coffin, J. D., Florkiewicz, R. Z., Neumann, J., Mort-Hopkins, T., Dorn, G. W., 2nd, Lightfoot, P., German, R., Howles, P. N., Kier, A., O'Toole, B. A., Sasse, J., Gonzalez, A. M., Baird, A. and Doetschman, T (1995). Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice. Mol. Cell. Biol 6, 1861-1873.

Cohn, M. J., Izpis\234a-Belmonte, J.-C., Abud, H., Heath, J. K. and Tickle, C (1995). Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell 80, 739-746.[Medline]

Colvin, J. S., Bohne, B. A., Harding, G. W., McEwen, D. G. and Ornitz, D. M (1996). Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat. Genet 12, 390-397.[Medline]

Coulier, F., Pontarotti, P., Roubin, R., Hartung, H., Goldfarb, M. and Birnbaum, D (1997). Of worms and men: an evolutionary perspective on the fibroblast growth factor (FGF) and FGF receptor families. J. Mol. Evol 44, 43-56.[Medline]

Crossley, P. H. and Martin, G. R (1995). The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121, 439-451.[Abstract]

Crossley, P. H., Martinez, S. and Martin, G. R (1996). Midbrain development induced by FGF8 in the chick embryo. Nature 380, 66-68.[Medline]

Crossley, P. H., Minowada, G., MacArthur, C. A. and Martin, G. R (1996). Roles for FGF8 in the induction, initiation and maintenance of chick limb development. Cell 84, 127-136.[Medline]

de Maximy, A. A., Nakatake, Y., Moncada, S., Itoh, N., Thiery, J. P. and Bellusci, S (1999). Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo. Mech. Dev 81, 213-216.[Medline]

Deloukas, P., Schuler, G. D., Gyapay, G., Beasley, E. M., C. Soderlund, Rodriguez-Tome, P., Hui, L., Matise, T. C., McKusick, K. B., Beckmann, J. S., and others (1998). A Physical Map of 30,000 Human Genes. Science 282, 744-746.[Abstract/Free Full Text]

Deng, C., Wynshaw-Boris, A., Zhou, F., Kuo, A. and Leder, P (1996). Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84, 911-921.[Medline]

Deng, C.-X., Wynshaw-Boris, A., Shen, M. M., Daugherty, C., Ornitz, D.M. and Leder, P (1995). Murine FGFR-1 is required for early postimplantation growth and axial formation. Genes Dev 8, 3045-3057.[Abstract/Free Full Text]

Fallon, J., Lopez, A., Ros, M., Savage, M., Olwin, B. and Simandl, B (1994). FGF-2: Apical ectodermal ridge growth signal for chick limb development. Science 264, 104-107.[Abstract/Free Full Text]

Feldman, B., Poueymirou, W., Papaioannou, V. E., DeChiara, T. M. and Goldfarb, M (1995). Requirement of FGF-4 for postimplantation mouse development. Science 267, 246-249.[Abstract/Free Full Text]

Friesel, R. E. and Maciag, T (1995). Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. Faseb. J 9, 919-925.[Abstract]

Goldfarb, M (1996). Functions of fibroblast growth factors in vertebrate development. Cytokine and Growth Factor Reviews 7, 311-325.[Medline]

Hacohen, N., Kramer, S., Sutherland, D., Hiromi, Y. and Krasnow, M. A (1998). sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92, 253-263.[Medline]

Hamburger, V. and Hamilton, H (1951). A series of normal stages in the development of the chick embryo. J. Morphol._Fb_88, 49-92. Reprinted in. Dev. Dynamics 195, 231-272.

Johnson, D. E. and Williams, L. T (1993). Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res 60, 1-41.[Medline]

Karsenty, G (1998). Genetics of skeletogenesis. Dev. Genet 22, 301-313.[Medline]

Kettunen, P. and Thesleff, I (1998). Expression and function of FGFs-4,-8, and-9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesis. Dev. Dynamics 211, 256-268.[Medline]

Kramer, S., Hacohen, N., Okabe, M., Krasnow, M. A. and Hiromi, Y (1999). Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. Development 126, 2515-2525.[Abstract]

Martin, G. R (1998). The roles of FGFs in the early development of vertebrate limbs. Genes Dev 12, 1571-1586.[Free Full Text]

Meyers, E. N., Lewandoski, M. and Martin, G. R (1998). An Fgf8 mutant allelic series generated by Cre-and Flp-mediated recombination. Nat. Genet 18, 136-141.[Medline]

Morgan, B. A. and Fekete, D. M (1996). Manipulating gene expression with replication-competent retroviruses. Methods Cell Biol 51, 185-218.[Medline]

Muesch, A., Hartmann, E., Rohde, K., Rubartelli, A., Sitia, R. and Rapoport, T. A (1990). A novel pathway for secretory proteins?. Trends Biochem. Sci 15, 86-88.[Medline]

Naski, M. C., Colvin, J. S., Coffin, J. D. and Ornitz, D. M (1998). Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development 125, 4977-4988.[Abstract]

Neubuser, A., Peters, H., Balling, R. and Martin, G. R (1997). Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 90, 247-255.[Medline]

Niswander, L. and Martin, G. R (1992). Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development 114, 755-768.[Abstract]

Niswander, L., Tickle, C., Vogel, A., Booth, I. and Martin, G. R (1993). FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell 75, 579-587.[Medline]

Ohbayashi, N., Hoshikawa, M., Kimura, S., Yamasaki, M., Fukui, S. andItoh, N (1998). Structure and expression of the mRNA encoding anovel fibroblast growth factor, FGF-18. J. Biol. Chem 273, 18161-18164.[Abstract/Free Full Text]

Otto, F., Thornell, A. P., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G. W., Beddington, R. S., Mundlos, S., Olsen, B. R., Selby, P. B. and Owen, M. J (1997). Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89, 765-771.[Medline]

Peters, K. G., Werner, S., Chen, G. and Williams, L. T (1992). Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development 114, 233-243.[Abstract]

Rogner, U. C., Heiss, N. S., Kioschis, P., Wiemann, S., Korn, B. and Poustka, A (1996). Transcriptional analysis of the candidate region for incontinentia pigmenti (IP2) in Xq28. Genome Res 6, 922-934.[Abstract/Free Full Text]

Rowe, L. B., Nadeau, J. H., Turner, R., Frankel, W. N., Letts, V. A., Eppig, J. T., Ko, M. S., Thurston, S. J. and Birkenmeier, E. H (1994). Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm. Genome 5, 253-274.[Medline]

Saunders, J. W., Jr (1948). The proximo-distal sequence of the origin of the parts of the chick wing and the role of the ectoderm. J. Exp. Zool 108, 363-403.

Sekine, K., Ohuchi, H., Fujiwara, M., Yamasaki, M., Yoshizawa, T., Sato, T., Yagishita, N., Matsui, D., Koga, Y., Itoh, N. and Kato, S (1999). Fgf10 is essential for limb and lung formation. Nat Genet 21, 138-141.[Medline]

Skaer, H (1997). Morphogenesis: FGF branches out. Curr. Biol 7, 238-241.

Summerbell, D (1974). A quantitative analysis of the effect of excision of the AER from the chick limb bud. J. Embryol. Exp. Morph 32, 651-660.[Medline]

Summerbell, D., Lewis, J. H. and Wolpert, L (1973). Positional information in chick limb morphogenesis. Nature 224, 492-496.

Sun, X., Meyers, E. N., Lewandoski, M. and Martin, G. R (1999). Targeteddisruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev 13, 1834-1846.[Abstract/Free Full Text]

Sutherland, D., Samakovlis, C. and Krasnow, M. A (1996). branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. Cell 87, 1091-1101.[Medline]

Szebenyi, G. and Fallon, J. F (1999). Fibroblast growth factors as multifunctional signaling factors. Int. Rev. Cytol 185, 45-106.[Medline]

Vogel, A., Rodriguez, C. and Izpis\234a-Belmonte, J.-C (1996). Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development 122, 1737-1750.[Abstract]

Vortkamp, A., Lee, K., Lanske, B., Segre, G. V., Kronenberg, H. M. and Tabin, C. J (1996). Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273, 613-622.[Abstract]

Webster, M. K. and Donoghue, D. J (1997). FGFR activation in skeletal disorders: too much of a good thing. Trends Genet 13, 178-182.[Medline]

Weinstein, M., Xu, X., Ohyama, K. and Deng, C.-X (1998). FGFR-3 andFGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development 125, 3615-3623.[Abstract]

Wright, E., Hargrave, M. R., Christiansen, J., Cooper, L., Kun, J., Evans, T., Gangadharan, U., Greenfield, A. and Koopman, P (1995). The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nat. Genet 9, 15-20.[Medline]

Xu, X., Weinstein, M., Li, C., Naski, M., Cohen, R. I., Ornitz, D. M., Leder, P. and Deng, C (1998). Fibroblast growth factor receptor 2 (FGFR2) mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 125, 767-775.[Abstract]

Yamaguchi, T. P., Harpal, K., Henkemeyer, M. and Rossant, J (1995). fgfr1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev 8, 3032-3044.[Abstract/Free Full Text]

Zou, H., Wieser, R., Massague, J. and Niswander, L (1997). Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev 11, 2191-2203.[Abstract/Free Full Text]

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Physiol Genomics, August 11, 2004; 18(3): 284 - 289.
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Cancer Res., July 15, 2004; 64(14): 4728 - 4735.
[Abstract] [Full Text] [PDF]

L. Chi, S. Zhang, Y. Lin, R. Prunskaite-Hyyrylainen, R. Vuolteenaho, P. Itaranta, and S. Vainio
Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development
Development, July 15, 2004; 131(14): 3345 - 3356.
[Abstract] [Full Text] [PDF]

W. Ding, S. Bellusci, W. Shi, and D. Warburton
Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis
Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L52 - L59.
[Abstract] [Full Text] [PDF]

O. G. Kelly, K. I. Pinson, and W. C. Skarnes
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
Development, June 15, 2004; 131(12): 2803 - 2815.
[Abstract]

				F. Jaggi, M. A. Cabrita, A.-K. T. Perl, and G. Christofori Modulation of Endocrine Pancreas Development but not {beta}-Cell Carcinogenesis by Sprouty4 Mol. Cancer Res., March 1, 2008; 6(3): 468 - 482. [Abstract] [Full Text] [PDF]

				M. A. Basson, D. Echevarria, C. Petersen Ahn, A. Sudarov, A. L. Joyner, I. J. Mason, S. Martinez, and G. R. Martin Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development Development, March 1, 2008; 135(5): 889 - 898. [Abstract] [Full Text] [PDF]

				F. Edwin and T. B. Patel A Novel Role of Sprouty 2 in Regulating Cellular Apoptosis J. Biol. Chem., February 8, 2008; 283(6): 3181 - 3190. [Abstract] [Full Text] [PDF]

				P. Lito, B. D. Mets, S. Kleff, S. O'Reilly, V. M. Maher, and J. J. McCormick Evidence That Sprouty 2 Is Necessary for Sarcoma Formation by H-Ras Oncogene-transformed Human Fibroblasts J. Biol. Chem., January 25, 2008; 283(4): 2002 - 2009. [Abstract] [Full Text] [PDF]

				S. Chandramouli, C. Y. Yu, P. Yusoff, D.-H. Lao, H. F. Leong, K. Mizuno, and G. R. Guy Tesk1 Interacts with Spry2 to Abrogate Its Inhibition of ERK Phosphorylation Downstream of Receptor Tyrosine Kinase Signaling J. Biol. Chem., January 18, 2008; 283(3): 1679 - 1691. [Abstract] [Full Text] [PDF]

				A. Shimada, M. Yabusaki, H. Niwa, H. Yokoi, K. Hatta, D. Kobayashi, and H. Takeda Maternal-zygotic medaka mutants for fgfr1 reveal its essential role in the migration of the axial mesoderm but not the lateral mesoderm Development, January 15, 2008; 135(2): 281 - 290. [Abstract] [Full Text] [PDF]

				O. D. Klein, D. B. Lyons, G. Balooch, G. W. Marshall, M. A. Basson, M. Peterka, T. Boran, R. Peterkova, and G. R. Martin An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors Development, January 15, 2008; 135(2): 377 - 385. [Abstract] [Full Text] [PDF]

				C. Tabin and L. Wolpert Rethinking the proximodistal axis of the vertebrate limb in the molecular era Genes & Dev., June 15, 2007; 21(12): 1433 - 1442. [Full Text] [PDF]

				Q. Guo and J. Y. H. Li Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation Development, June 15, 2007; 134(12): 2251 - 2260. [Abstract] [Full Text] [PDF]

				I. Olivera-Martinez and K. G. Storey Wnt signals provide a timing mechanism for the FGF-retinoid differentiation switch during vertebrate body axis extension Development, June 1, 2007; 134(11): 2125 - 2135. [Abstract] [Full Text] [PDF]

				H. Sutterluty, C.-E. Mayer, U. Setinek, J. Attems, S. Ovtcharov, M. Mikula, W. Mikulits, M. Micksche, and W. Berger Down-Regulation of Sprouty2 in Non-Small Cell Lung Cancer Contributes to Tumor Malignancy via Extracellular Signal-Regulated Kinase Pathway-Dependent and -Independent Mechanisms Mol. Cancer Res., May 1, 2007; 5(5): 509 - 520. [Abstract] [Full Text] [PDF]

				K. Sato, Y. Koizumi, M. Takahashi, A. Kuroiwa, and K. Tamura Specification of cell fate along the proximal-distal axis in the developing chick limb bud Development, April 1, 2007; 134(7): 1397 - 1406. [Abstract] [Full Text] [PDF]

				A. T. Shaw, A. Meissner, J. A. Dowdle, D. Crowley, M. Magendantz, C. Ouyang, T. Parisi, J. Rajagopal, L. J. Blank, R. T. Bronson, et al. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis Genes & Dev., March 15, 2007; 21(6): 694 - 707. [Abstract] [Full Text] [PDF]

				M.-L. Dequeant, E. Glynn, K. Gaudenz, M. Wahl, J. Chen, A. Mushegian, and O. Pourquie A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock Science, December 8, 2006; 314(5805): 1595 - 1598. [Abstract] [Full Text] [PDF]

				K. Bundschu, U. Walter, and K. Schuh The VASP-Spred-Sprouty Domain Puzzle J. Biol. Chem., December 1, 2006; 281(48): 36477 - 36481. [Abstract] [Full Text] [PDF]

				S. D. Weatherbee, R. R. Behringer, J. J. Rasweiler IV, and L. A. Niswander Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification PNAS, October 10, 2006; 103(41): 15103 - 15107. [Abstract] [Full Text] [PDF]

				M. A. Cabrita, F. Jaggi, S. P. Widjaja, and G. Christofori A Functional Interaction between Sprouty Proteins and Caveolin-1 J. Biol. Chem., September 29, 2006; 281(39): 29201 - 2912. [Abstract] [Full Text] [PDF]

				L. Chi, P. Itaranta, S. Zhang, and S. Vainio Sprouty2 Is Involved in Male Sex Organogenesis by Controlling Fibroblast Growth Factor 9-Induced Mesonephric Cell Migration to the Developing Testis Endocrinology, August 1, 2006; 147(8): 3777 - 3788. [Abstract] [Full Text] [PDF]

				H. Choi, S.-Y. Cho, R. H. Schwartz, and K. Choi Dual Effects of Sprouty1 on TCR Signaling Depending on the Differentiation State of the T Cell J. Immunol., May 15, 2006; 176(10): 6034 - 6045. [Abstract] [Full Text] [PDF]

				E. E. Storm, S. Garel, U. Borello, J. M. Hebert, S. Martinez, S. K. McConnell, G. R. Martin, and J. L. R. Rubenstein Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers Development, May 1, 2006; 133(9): 1831 - 1844. [Abstract] [Full Text] [PDF]

				S. T. Waters and M. Lewandoski A threshold requirement for Gbx2 levels in hindbrain development. Development, May 1, 2006; 133(10): 1991 - 2000. [Abstract] [Full Text] [PDF]

				L. A. Jarvis, S. J. Toering, M. A. Simon, M. A. Krasnow, and R. K. Smith-Bolton Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases Development, March 15, 2006; 133(6): 1133 - 1142. [Abstract] [Full Text] [PDF]

				J. DaSilva, L. Xu, H. J. Kim, W. T. Miller, and D. Bar-Sagi Regulation of sprouty stability by mnk1-dependent phosphorylation. Mol. Cell. Biol., March 1, 2006; 26(5): 1898 - 1907. [Abstract] [Full Text] [PDF]

				F. Edwin, R. Singh, R. Endersby, S. J. Baker, and T. B. Patel The Tumor Suppressor PTEN Is Necessary for Human Sprouty 2-mediated Inhibition of Cell Proliferation J. Biol. Chem., February 24, 2006; 281(8): 4816 - 4822. [Abstract] [Full Text] [PDF]

				R. A. Deckelbaum, A. Majithia, T. Booker, J. E. Henderson, and C. A. Loomis The homeoprotein engrailed 1 has pleiotropic functions in calvarial intramembranous bone formation and remodeling Development, January 1, 2006; 133(1): 63 - 74. [Abstract] [Full Text] [PDF]

				K.-i. Ozaki, S. Miyazaki, S. Tanimura, and M. Kohno Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms J. Cell Sci., December 15, 2005; 118(24): 5861 - 5871. [Abstract] [Full Text] [PDF]

				J. M. Verheyden, M. Lewandoski, C. Deng, B. D. Harfe, and X. Sun Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning Development, October 1, 2005; 132(19): 4235 - 4245. [Abstract] [Full Text] [PDF]

				A. Nonami, T. Taketomi, A. Kimura, K. Saeki, H. Takaki, T. Sanada, K. Taniguchi, M. Harada, R. Kato, and A. Yoshimura The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1 Genes Cells, September 1, 2005; 10(9): 887 - 895. [Abstract] [Full Text] [PDF]

				S. N. Sansom, J. M. Hebert, U. Thammongkol, J. Smith, G. Nisbet, M. A. Surani, S. K. McConnell, and F. J. Livesey Genomic characterisation of a Fgf-regulated gradient-based neocortical protomap Development, September 1, 2005; 132(17): 3947 - 3961. [Abstract] [Full Text] [PDF]

				C. de Alvaro, N. Martinez, J. M. Rojas, and M. Lorenzo Sprouty-2 Overexpression in C2C12 Cells Confers Myogenic Differentiation Properties in the Presence of FGF2 Mol. Biol. Cell, September 1, 2005; 16(9): 4454 - 4461. [Abstract] [Full Text] [PDF]