Dosage requirement of Pitx2 for development of multiple organs

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Paired-like Repression/Activation in Pituitary Development
Recent Prog. Horm. Res., January 1, 2003; 58(1): 249 - 261.
[Abstract] [Full Text] [PDF]

G. K. H. Przemeck, U. Heinzmann, J. Beckers, and M. Hrabe de Angelis
Node and midline defects are associated with left-right development in Delta1 mutant embryos
Development, January 1, 2003; 130(1): 3 - 13.
[Abstract] [Full Text] [PDF]

A. Marcil, E. Dumontier, M. Chamberland, S. A. Camper, and J. Drouin
Pitx1 and Pitx2 are required for development of hindlimb buds
Development, January 1, 2003; 130(1): 45 - 55.
[Abstract] [Full Text] [PDF]

M.-H. Quentien, I. Manfroid, D. Moncet, G. Gunz, M. Muller, M. Grino, A. Enjalbert, and I. Pellegrini
Pitx Factors Are Involved in Basal and Hormone-regulated Activity of the Human Prolactin Promoter
J. Biol. Chem., November 8, 2002; 277(46): 44408 - 44416.
[Abstract] [Full Text] [PDF]

J. Brennan, D. P. Norris, and E. J. Robertson
Nodal activity in the node governs left-right asymmetry
Genes & Dev., September 15, 2002; 16(18): 2339 - 2344.
[Abstract] [Full Text] [PDF]

L. E. Cohen and S. Radovick
Molecular Basis of Combined Pituitary Hormone Deficiencies
Endocr. Rev., August 1, 2002; 23(4): 431 - 442.
[Abstract] [Full Text] [PDF]

T. C. Voss and R. N. Day
Editorial: Pitx-2 Mutants and Somatolactotroph Gene Regulation--Deciphering the Combinatorial Code
Endocrinology, August 1, 2002; 143(8): 2836 - 2838.

				S. T. MacDonald, S. D. Bamforth, C.-M. Chen, C. R. Farthing, A. Franklyn, C. Broadbent, J. E. Schneider, Y. Saga, M. Lewandoski, and S. Bhattacharya Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency Cardiovasc Res, August 1, 2008; 79(3): 448 - 457. [Abstract] [Full Text] [PDF]

				Y. Shima, M. Zubair, T. Komatsu, S. Oka, C. Yokoyama, T. Tachibana, T. A. Hjalt, J. Drouin, and K.-i. Morohashi Pituitary Homeobox 2 Regulates Adrenal4 Binding Protein/Steroidogenic Factor-1 Gene Transcription in the Pituitary Gonadotrope through Interaction with the Intronic Enhancer Mol. Endocrinol., July 1, 2008; 22(7): 1633 - 1646. [Abstract] [Full Text] [PDF]

				P. Lamba, V. Khivansara, A. C. D'Alessio, M. M. Santos, and D. J. Bernard Paired-Like Homeodomain Transcription Factors 1 and 2 Regulate Follicle-Stimulating Hormone {beta}-Subunit Transcription through a Conserved cis-Element Endocrinology, June 1, 2008; 149(6): 3095 - 3108. [Abstract] [Full Text] [PDF]

				Y. Shang, T. Yoshida, B. A. Amendt, J. F. Martin, and G. K. Owens Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation J. Cell Biol., May 1, 2008; 181(3): 461 - 473. [Abstract] [Full Text] [PDF]

				A. Tessari, M. Pietrobon, A. Notte, G. Cifelli, P. J. Gage, M. D. Schneider, G. Lembo, and M. Campione Myocardial Pitx2 Differentially Regulates the Left Atrial Identity and Ventricular Asymmetric Remodeling Programs Circ. Res., April 11, 2008; 102(7): 813 - 822. [Abstract] [Full Text] [PDF]

				M. Hayashi, S. Maeda, H. Aburatani, K. Kitamura, H. Miyoshi, K. Miyazono, and T. Imamura Pitx2 Prevents Osteoblastic Transdifferentiation of Myoblasts by Bone Morphogenetic Proteins J. Biol. Chem., January 4, 2008; 283(1): 565 - 571. [Abstract] [Full Text] [PDF]

				S. Guioli and R. Lovell-Badge PITX2 controls asymmetric gonadal development in both sexes of the chick and can rescue the degeneration of the right ovary Development, December 1, 2007; 134(23): 4199 - 4208. [Abstract] [Full Text] [PDF]

				D. Ai, J. Wang, M. Amen, M.-F. Lu, B. A. Amendt, and J. F. Martin Nuclear Factor 1 and T-Cell Factor/LEF Recognition Elements Regulate Pitx2 Transcription in Pituitary Development Mol. Cell. Biol., August 15, 2007; 27(16): 5765 - 5775. [Abstract] [Full Text] [PDF]

				X. Zhu, A. S. Gleiberman, and M. G. Rosenfeld Molecular Physiology of Pituitary Development: Signaling and Transcriptional Networks Physiol Rev, July 1, 2007; 87(3): 933 - 963. [Abstract] [Full Text] [PDF]

				I. C. Rulifson, S. K. Karnik, P. W. Heiser, D. ten Berge, H. Chen, X. Gu, M. M. Taketo, R. Nusse, M. Hebrok, and S. K. Kim Wnt signaling regulates pancreatic beta cell proliferation PNAS, April 10, 2007; 104(15): 6247 - 6252. [Abstract] [Full Text] [PDF]

				H. P. Shih, M. K. Gross, and C. Kioussi Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch PNAS, April 3, 2007; 104(14): 5907 - 5912. [Abstract] [Full Text] [PDF]

				F. Dong, X. Sun, W. Liu, D. Ai, E. Klysik, M.-F. Lu, J. Hadley, L. Antoni, L. Chen, A. Baldini, et al. Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle Development, December 15, 2006; 133(24): 4891 - 4899. [Abstract] [Full Text] [PDF]

				M. Asai-Coakwell, C. Backhouse, R. J. Casey, P. J. Gage, and O. J. Lehmann Reduced Human and Murine Corneal Thickness in an Axenfeld-Rieger Syndrome Subtype Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 4905 - 4909. [Abstract] [Full Text] [PDF]

				B. S. Ellsworth, N. Egashira, J. L. Haller, D. L. Butts, J. Cocquet, C. M. Clay, R. Y. Osamura, and S. A. Camper FOXL2 in the Pituitary: Molecular, Genetic, and Developmental Analysis Mol. Endocrinol., November 1, 2006; 20(11): 2796 - 2805. [Abstract] [Full Text] [PDF]

				T. Brade, J. Manner, and M. Kuhl The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart Cardiovasc Res, November 1, 2006; 72(2): 198 - 209. [Abstract] [Full Text] [PDF]

				H. Shiratori, K. Yashiro, M. M. Shen, and H. Hamada Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs Development, August 1, 2006; 133(15): 3015 - 3025. [Abstract] [Full Text] [PDF]

				G. von Scheven, L. E. Alvares, R. C. Mootoosamy, and S. Dietrich Neural tube derived signals and Fgf8 act antagonistically to specify eye versus mandibular arch muscles Development, July 15, 2006; 133(14): 2731 - 2745. [Abstract] [Full Text] [PDF]

				A. G. Diehl, S. Zareparsi, M. Qian, R. Khanna, R. Angeles, and P. J. Gage Extraocular Muscle Morphogenesis and Gene Expression Are Regulated by Pitx2 Gene Dose Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 1785 - 1793. [Abstract] [Full Text] [PDF]

				S. Nowotschin, J. Liao, P. J. Gage, J. A. Epstein, M. Campione, and B. E. Morrow Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development, April 1, 2006; 133(8): 1565 - 1573. [Abstract] [Full Text] [PDF]

				F. B. Berry, M. A. Lines, J. M. Oas, T. Footz, D. A. Underhill, P. J. Gage, and M. A. Walter Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis Hum. Mol. Genet., March 15, 2006; 15(6): 905 - 919. [Abstract] [Full Text] [PDF]

				J. D. Porter, S. Israel, B. Gong, A. P. Merriam, J. Feuerman, S. Khanna, and H. J. Kaminski Distinctive morphological and gene/protein expression signatures during myogenesis in novel cell lines from extraocular and hindlimb muscle Physiol Genomics, February 23, 2006; 24(3): 264 - 275. [Abstract] [Full Text] [PDF]

				A. Kieusseian, J. Chagraoui, C. Kerdudo, P.-E. Mangeot, P. J. Gage, N. Navarro, B. Izac, G. Uzan, B. G. Forget, and A. Dubart-Kupperschmitt Expression of Pitx2 in stromal cells is required for normal hematopoiesis Blood, January 15, 2006; 107(2): 492 - 500. [Abstract] [Full Text] [PDF]

				M. A. Juarez, F. Su, S. Chun, M. J. Kiel, and S. E. Lyons Distinct Roles for SCL in Erythroid Specification and Maturation in Zebrafish J. Biol. Chem., December 16, 2005; 280(50): 41636 - 41644. [Abstract] [Full Text] [PDF]

				A. L. Evans and P. J. Gage Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development Hum. Mol. Genet., November 15, 2005; 14(22): 3347 - 3359. [Abstract] [Full Text] [PDF]

				R. Branicky and S. Hekimi Specification of muscle neurotransmitter sensitivity by a Paired-like homeodomain protein in Caenorhabditis elegans Development, November 15, 2005; 132(22): 4999 - 5009. [Abstract] [Full Text] [PDF]

				Q. Wei Pitx2a Binds to Human Papillomavirus Type 18 E6 Protein and Inhibits E6-mediated P53 Degradation in HeLa Cells J. Biol. Chem., November 11, 2005; 280(45): 37790 - 37797. [Abstract] [Full Text] [PDF]

				P. J. Gage, W. Rhoades, S. K. Prucka, and T. Hjalt Fate Maps of Neural Crest and Mesoderm in the Mammalian Eye Invest. Ophthalmol. Vis. Sci., November 1, 2005; 46(11): 4200 - 4208. [Abstract] [Full Text] [PDF]

				M. A. Charles, H. Suh, T. A. Hjalt, J. Drouin, S. A. Camper, and P. J. Gage PITX Genes Are Required for Cell Survival and Lhx3 Activation Mol. Endocrinol., July 1, 2005; 19(7): 1893 - 1903. [Abstract] [Full Text] [PDF]

				R. Toro, I. Saadi, A. Kuburas, M. Nemer, and A. F. Russo Cell-specific Activation of the Atrial Natriuretic Factor Promoter by PITX2 and MEF2A J. Biol. Chem., December 10, 2004; 279(50): 52087 - 52094. [Abstract] [Full Text] [PDF]

				C Y Gregory-Evans, M J Williams, S Halford, and K Gregory-Evans Ocular coloboma: a reassessment in the age of molecular neuroscience J. Med. Genet., December 1, 2004; 41(12): 881 - 891. [Abstract] [Full Text] [PDF]