Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice

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Ashley, T., Plug, A. W., Xu, J., Solari, A. J., Reddy, G., Golub, E. I. and Ward, D. C (1995). Dynamic changes in Rad51 distribution on chromatin during meiosis in male and female vertebrates. Chromosoma 104, 19-28.[Medline]

Attramadal, A., Bardin, C. W., Gunsalus, G. L., Musto, N. A. and Hansson, V (1981). Immunocytochemical localization of androgen binding protein in rat Sertoli and epididymal cells. Biol. Reprod 25, 983-988.[Abstract]

Baker, S. M., Bronner, C. E., Zhang, L., Plug, A. W., Robatzek, M., Warren, G., Elliott, E. A., Yu, J., Ashley, T., Arnheim, N. et al (1995). Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell 82, 309-319.[Medline]

Baker, S. M., Plug, A. W., Prolla, T. A., Bronner, C. E., Harris, A. C., Yao, X., Christie, D. M., Monell, C., Arnheim, N., Bradley, A. et al (1996). Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat. Genet 13, 336-342.[Medline]

Blendy, J. A., Kaestner, K. H., Weinbauer, G. F., Nieschlag, E. and Schutz, G (1996). Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature 380, 162-165.[Medline]

Browning, J. Y., D'Agata, R. and Grotjan, H. E., Jr (1981). Isolation of purified rat Leydig cells using continuous Percoll gradients. Endocrinology 109, 667-669.[Abstract]

Cantu, J. M., Rivas, F., Hernandez-Jauregui, P., Diaz, M., Cortes-Gallegos, V., Vaca, G., Velaszquez, A. and Ibarra, B (1981). Meiotic arrest at the first spermatocyte level: a new inherited infertility disorder. Hum. Genet 59, 380-385.[Medline]

Cooke, H. J., Hargreave, T. and Elliott, D. J (1998). Understanding the genes involved in spermatogenesis: a progress report. Fertil. Steril 69, 989-995.[Medline]

Crosby, S. D., Puetz, J. J., Simburger, K. S., Fahrner, T. J. and Milbrandt, J (1991). The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family. Mol. Cell. Biol 11, 3835-3841.[Abstract/Free Full Text]

Crosby, S. D., Veile, R. A., Donis-Keller, H., Baraban, J. M., Bhat, R. V., Simburger, K. S. and Milbrandt, J (1992). Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. Proc. Natl. Acad. Sci. U S A 89, 4739-4743.[Abstract/Free Full Text]

de Wind, N., Dekker, M., Berns, A., Radman, M. and te Riele, H (1995). Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 82, 321-330.[Medline]

Eddy, E. M., Washburn, T. F., Bunch, D. O., Goulding, E. H., Gladen, B. C., Lubahn, D. B. and Korach, K. S (1996). Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinol 137, 4796-4805.[Abstract]

Edelmann, W., Cohen, P. E., Kane, M., Lau, K., Morrow, B., Bennett, S., Umar, A., Kunkel, T., Cattoretti, G., Chaganti, R. et al (1996). Meiotic pachytene arrest in MLH1-deficient mice. Cell 85, 1125-1134.[Medline]

Enders, G. C. and May, J. J., 2nd (1994). Developmentally regulated expression of a mouse germ cell nuclear antigen examined from embryonic day 11 to adult in male and female mice. Dev. Biol 163, 331-340.[Medline]

Erickson-Lawrence, M., Zabludoff, S. D. and Wright, W. W (1991). Cylic protein-2, a secretory product of rat Sertoli cells, is the proenzyme for of cathepsin L. Mol. Endo 5, 1789-1798.[Abstract]

Gavrieli, Y., Sherman, Y. and Ben-Sasson, S. A (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell. Biol 119, 493-501.[Abstract/Free Full Text]

Gunduz, G., Luleci, G. and Baykara, M (1998). Cytogenetic study in 102 infertile men. Urol. Int 61, 32-34.[Medline]

Haaf, T., Golub, E. I., Reddy, G., Radding, C. M. and Ward, D. C (1995). Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes. Proc. Natl. Acad. Sci. U S A 92, 2298-2302.[Abstract/Free Full Text]

Higgy, N. A., Pastoor, T., Renz, C., Tarnasky, H. A. and Van der Hoorn, F. A (1994). Testis-specific RT7 protein localizes to the sperm tail and asociates with itself. Biol. Reprod 50, 1357-1366.[Abstract]

Hintz, M. and Goldberg, E (1977). Immunohistochemical localization of LDH-x during spermatogenesis in mouse testes. Dev. Biol 57, 375-384.[Medline]

Holst, C., Skerka, C., Lichter, P., Bialonski, A. and Zipfel, P. F (1993). Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133. Hum. Mol. Genet 2, 367-372.[Abstract/Free Full Text]

Irvine, D. S (1997). Declining sperm quality: a review of facts and hypotheses. Baillieres. Clin. Obstet. Gynaecol 11, 655-671.[Medline]

Janca, F. C., Jost, L. K. and Evenson, D. P (1986). Mouse testicular and sperm cell development characterized from birth to adulthood by dual parameter flow cytometry. Biol. Reprod 34, 613-623.[Abstract]

Krishan, A (1990). Rapid DNA content analysis by the propidium iodide-hypotonic citrate method. Methods. Cell. Biol 33, 121-125.[Medline]

Lee, S. L., Sadovsky, Y., Swirnoff, A. H., Polish, J. A., Goda, P., Gavrilina, G. and Milbrandt, J (1996). Luteinizing hormone deficiency and femaleinfertility in mice lacking the transcription factor NGFI-A (Egr-1). Science 273, 1219-1221.[Abstract]

Lian, G., Miller, K. A. and Enders, G. C (1992). Localization and synthesis of entactin in seminiferous tubules of the mouse. Biol. Reprod 47, 316-325.[Abstract]

Lin, T., Chen, G. C., Murono, E. P., Osterman, J. and Nankin, H. R (1982). Estradiol receptors of two distince populations of Leydig cells. Steroids 40, 53-63.[Medline]

Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A. and Jacks, T (1993). p53 is required for radiation-inducde apoptosis in mouse thymocytes. Nature 362, 847-849.[Medline]

McLachlan, R. I., Mallidis, C., Ma, K., Bhasin, S. and de Kretser, D. M (1998). Genetic disorders and spermatogenesis. Reprod. Fertil. Dev 10, 97-104.[Medline]

McMahon, A. P. and Bradley, A (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073-1085.[Medline]

Nantel, F., Monaco, L., Foulkes, N. S., Masquilier, D., LeMeur, M., Henriksen, K., Dierich, A., Parvinen, M. and Sassone-Corsi, P (1996). Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature 380, 159-162.[Medline]

Oakberg, E. F (1956). A description of spermatogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal. Am. J. Anat 99, 391-413.[Medline]

Odorisio, T., Rodriguez, T. A., Evans, E. P., Clarke, A. R. and Burgoyne, P. S (1998). The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis. Nat. Genet 18, 257-261.[Medline]

Payne, A. H., Downing, J. R. and Wong, K. L (1980). Luteinizing hormone receptors and testosterone synthesis in two distinct populations of Leydig cells. Endocrinol 106, 1424-1429.[Abstract]

Prolla, T. A., Baker, S. M., Harris, A. C., Tsao, J.-L., Yao, X., Bronner, C. E., Zheng, B., Gordon, M., Reneker, J., Arnheim, N. et al (1998). Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat. Genet 18, 276-279.[Medline]

Reddy, J. K. and Ohno, S (1981). Testicular feminization of the mouse: paucity of peroxisomes in Leydig cell of the testis. Am. J. Pathol 103, 96-104.[Abstract]

Sah, V. P., Attardi, L. D., Mulligan, G. J., Williams, B. O., Bronson, R. T. and Jacks, T (1995). A subset of p53-deficient embryos exhibit exencephaly. Nat. Genet 10, 175-180.[Medline]

Sassone-Corsi, P (1997). Transcriptional checkpoints determining the fate of male germ cells. Cell 88, 163-166.[Medline]

Schneider-Maunoury, S., Topilko, P., Seitandou, T., Levi, G., Cohen-Tannoudji, M., Pournin, S., Babinet, C. and Charnay, P (1993). Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain. Cell 75, 1199-1214.[Medline]

Spano, M. and Evenson, D. P (1993). Flow cytometric analysis for reproductive biology. Biol. Cell 78, 53-62.[Medline]

Swiatek, P. J. and Gridley, T (1993). Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes. Dev 7, 2071-2084.[Abstract/Free Full Text]

Symonds, H., Krall, L., Remington, L., Saenz-Robles, M., Lowe, S., Jacks, T. and Van Dyke, T (1994). p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78, 703-711.[Medline]

Topilko, P., Schneider-Maunoury, S., Levi, G., Baron-Van Evercooren, A., Chennoufi, A. B., Seitanidou, T., Babinet, C. and Charnay, P (1994). Krox-20 controls myelination in the peripheral nervous system. Nature 371, 796-799.[Medline]

Toscani, A., Mettus, R. V., Coupland, R., Simpkins, H., Litvin, J., Orth, J., Hatton, K. S. and Reddy, E. P (1997). Arrest of spermatogenesis and defective breast development in mice lacking A-myb. Nature 386, 713-717.[Medline]

Tourtellotte, W. G. and Milbrandt, J (1998). Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nat. Genet 20, 87-91.[Medline]

Tung, P. S. and Fritz, I. B (1990). Characterization of rat testicular peritubular myoid cells in culture: alpha-smooth muscle isoactin is a specific differentiation marker. Biol. Reprod 42, 351-365.[Abstract]

Vernon, R. B., Lane, T. F., Angello, J. C. and Sage, H (1991). Adhesion, shape, proliferation, and gene expression of mouse Leydig cells are influenced by extracellular matrix in vitro. Biol. Reprod 44, 157-170.[Abstract]

Vornberger, W., Prins, G., Musto, N. A. and Suarez-Quian, C. A (1994). Androgen receptor distribution in rate testis: new implications for androgen regulation of spermatogenesis. Endocrinol 134, 2307-2316.[Abstract]

Warner, L. E., Mancias, P., Butler, I. J., McDonald, C. M., Keppen, L., Koob, K. G. and Lupski, J. R (1998). Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Nat. Genet 18, 382-384.[Medline]

Yelick, P. C., Kwon, Y. H., Flynn, J. F., Borzorgzadeh, A., Kleene, K. C. and Hecht, N. B (1989). Mouse transition protein 1 is translationally regulated during the postmeiotic stages of spermatogenesis. Mol. Reprod. Dev 1, 193-200.[Medline]

Yin, Y., Stahl, B. C., DeWolf, W. C. and Morgentaler, A (1998). p53-mediated germ cell quality control in spermatogenesis. Dev. Biol 204, 165-171.[Medline]

Zakeri, Z. F. and Wolgemuth, D. J (1987). Developmental-stage-specific expression of the hsp70 gene family during differentiation of the mammalian male germ line. Mol. Cell. Biol 7, 1971-1976.

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				W. Xia, D. D Mruk, W. M Lee, and C Y. Cheng Unraveling the molecular targets pertinent to junction restructuring events during spermatogenesis using the Adjudin-induced germ cell depletion model J. Endocrinol., March 1, 2007; 192(3): 563 - 583. [Abstract] [Full Text] [PDF]

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				D. Yamada, M. Yoshida, Y. N. Williams, T. Fukami, S. Kikuchi, M. Masuda, T. Maruyama, T. Ohta, D. Nakae, A. Maekawa, et al. Disruption of Spermatogenic Cell Adhesion and Male Infertility in Mice Lacking TSLC1/IGSF4, an Immunoglobulin Superfamily Cell Adhesion Molecule. Mol. Cell. Biol., May 1, 2006; 26(9): 3610 - 3624. [Abstract] [Full Text] [PDF]

				C. S. Sarateanu, M. A. Retuerto, J. T. Beckmann, L. McGregor, J. Carbray, G. Patejunas, L. Nayak, J. Milbrandt, and T. K. Rosengart An Egr-1 master switch for arteriogenesis: Studies in Egr-1 homozygous negative and wild-type animals J. Thorac. Cardiovasc. Surg., January 1, 2006; 131(1): 138 - 145. [Abstract] [Full Text] [PDF]

				L. Li, J. Carter, X. Gao, J. Whitehead, and W. G. Tourtellotte The Neuroplasticity-Associated Arc Gene Is a Direct Transcriptional Target of Early Growth Response (Egr) Transcription Factors Mol. Cell. Biol., December 1, 2005; 25(23): 10286 - 10300. [Abstract] [Full Text] [PDF]

				Y. Kazeto, R. Goto-Kazeto, P. Thomas, and J. M Trant Molecular characterization of three forms of putative membrane-bound progestin receptors and their tissue-distribution in channel catfish, Ictalurus punctatus J. Mol. Endocrinol., June 1, 2005; 34(3): 781 - 791. [Abstract] [Full Text] [PDF]

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				B. Li, M. Nair, D. R. Mackay, V. Bilanchone, M. Hu, M. Fallahi, H. Song, Q. Dai, P. E. Cohen, and X. Dai Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression Development, March 15, 2005; 132(6): 1463 - 1473. [Abstract] [Full Text] [PDF]

				P. Schalch, G. Patejunas, M. Retuerto, S. Sarateanu, J. Milbrandt, G. Thakker, D. Kim, J. Carbray, R. G. Crystal, and T. K. Rosengart Homozygous deletion of early growth response 1 gene and critical limb ischemia after vascular ligation in mice: Evidence for a central role in vascular homeostasis J. Thorac. Cardiovasc. Surg., October 1, 2004; 128(4): 595 - 601. [Abstract] [Full Text] [PDF]

				J. S. Jorgensen, C. C. Quirk, and J. H. Nilson Multiple and Overlapping Combinatorial Codes Orchestrate Hormonal Responsiveness and Dictate Cell-Specific Expression of the Genes Encoding Luteinizing Hormone Endocr. Rev., August 1, 2004; 25(4): 521 - 542. [Abstract] [Full Text] [PDF]

				T. Nakamoto, A. Shiratsuchi, H. Oda, K. Inoue, T. Matsumura, M. Ichikawa, T. Saito, S. Seo, K. Maki, T. Asai, et al. Impaired spermatogenesis and male fertility defects in CIZ/Nmp4-disrupted mice Genes Cells, June 1, 2004; 9(6): 575 - 589. [Abstract] [Full Text] [PDF]

				S. Kuramochi-Miyagawa, T. Kimura, T. W. Ijiri, T. Isobe, N. Asada, Y. Fujita, M. Ikawa, N. Iwai, M. Okabe, W. Deng, et al. Mili, a mammalian member of piwi family gene, is essential for spermatogenesis Development, February 15, 2004; 131(4): 839 - 849. [Abstract] [Full Text] [PDF]

				E. L. Decker, N. Nehmann, E. Kampen, H. Eibel, P. F. Zipfel, and C. Skerka Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression Nucleic Acids Res., February 1, 2003; 31(3): 911 - 921. [Abstract] [Full Text] [PDF]

				K. H. Burns and M. M. Matzuk Minireview: Genetic Models for the Study of Gonadotropin Actions Endocrinology, August 1, 2002; 143(8): 2823 - 2835. [Abstract] [Full Text] [PDF]

				N. Lei and L. L. Heckert Sp1 and Egr1 Regulate Transcription of the Dmrt1 Gene in Sertoli Cells Biol Reprod, March 1, 2002; 66(3): 675 - 684. [Abstract] [Full Text] [PDF]

				X. Meng, H. Akutsu, K. Schoene, C. Reifsteck, E. P. Fox, S. Olson, H. Sariola, R. Yanagimachi, and M. Baetscher Transgene Insertion Induced Dominant Male Sterility and Rescue of Male Fertility Using Round Spermatid Injection Biol Reprod, March 1, 2002; 66(3): 726 - 734. [Abstract] [Full Text] [PDF]

				E. M. Eddy Male Germ Cell Gene Expression Recent Prog. Horm. Res., January 1, 2002; 57(1): 103 - 128. [Abstract] [Full Text] [PDF]

				Z. Wang, R. Yu, and S. Melmed Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere Division Mol. Endocrinol., November 1, 2001; 15(11): 1870 - 1879. [Abstract] [Full Text] [PDF]

				F. Zindy, W. den Besten, B. Chen, J. E. Rehg, E. Latres, M. Barbacid, J. W. Pollard, C. J. Sherr, P. E. Cohen, and M. F. Roussel Control of Spermatogenesis in Mice by the Cyclin D-Dependent Kinase Inhibitors p18Ink4c and p19Ink4d Mol. Cell. Biol., May 1, 2001; 21(9): 3244 - 3255. [Abstract] [Full Text]

				G. Blanco, G. Sánchez, R. J. Melton, W. G. Tourtellotte, and R. W. Mercer The {alpha}4 Isoform of the Na,K-ATPase Is Expressed in the Germ Cells of the Testes J. Histochem. Cytochem., August 1, 2000; 48(8): 1023 - 1032. [Abstract] [Full Text]

				W. G. Tourtellotte, R. Nagarajan, A. Bartke, and J. Milbrandt Functional Compensation by Egr4 in Egr1-Dependent Luteinizing Hormone Regulation and Leydig Cell Steroidogenesis Mol. Cell. Biol., July 15, 2000; 20(14): 5261 - 5268. [Abstract] [Full Text]

				B. R. Sevetson, J. Svaren, and J. Milbrandt A Novel Activation Function for NAB Proteins in EGR-dependent Transcription of the Luteinizing Hormone beta Gene J. Biol. Chem., March 24, 2000; 275(13): 9749 - 9757. [Abstract] [Full Text] [PDF]