Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex

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Abu-Shaar, M. and Mann, R. S (1998). Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development. Development 125, 3821-3830.[Abstract]

Abu-Shaar, M., Ryoo, H. D. and Mann, R. S (1999). Control of the nuclear localization of Extradenticle by competing localization and export signals. Genes Dev 13, 935-945.[Abstract/Free Full Text]

Bachiller, D., Macias, A., Duboule, D. and Morata, G (1994). Conservation of a functional hierarchy between mammalian and insect Hox/HOM genes. EMBO J 13, 1930-1941.[Medline]

Berthelsen, J., Kilstrup-Nielsen, C., Blasi, F., Mavilio, F. and Zappavigna, V (1999). The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes Dev 13, 946-953.[Abstract/Free Full Text]

Berthelsen, J., Zappavigna, V., Ferretti, E., Mavilio, F. and Blasi, F (1998). The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. EMBO J 17, 1434-1445.[Medline]

Berthelsen, J., Zappavigna, V., Mavilio, F. and Blasi, F (1998). Prep1, a novel functional partner of Pbx proteins. EMBO J 17, 1423-1433.[Medline]

Brand, A. and Perrimon, N (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.[Abstract]

Burglin, T (1997). Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals. Nucl. Acid Res 25, 4173-4180.[Abstract/Free Full Text]

Burke, A. C., Nelson, C. E., Morgan, B. A. and Tabin, C (1995). Hox genes and the evolution of vertebrate axial morphology. Development 121, 333-346.[Abstract]

Calleja, M., Moreno, E., Pelaz, S. and Morata, G (1996). Visualization of Gene Expression in Living Adult Drosophila. Science 274, 252-255.[Abstract/Free Full Text]

Casares, F. and Mann, R. S (1998). Control of antennal versus leg development in Drosophila. Nature 392, 723-726.[Medline]

Chan, S.-K., Jaffe, L., Capovilla, M., Botas, J. and Mann, R. S (1994). The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with Extradenticle, another homeoprotein. Cell 78, 603-615.[Medline]

Chan, S.-K. and Mann, R. S (1996). A structural model for an extradenticle-HOX-DNA complex accounts for the choice of HOX protein in the heterodimer. Proc. Natl. Acad. Sci. USA 93, 5223-5228.[Abstract/Free Full Text]

Chan, S.-K., P\232pperl, H., Krumlauf, R. and Mann, R. S (1996). An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif. EMBO J 15, 2477-2488.

Chan, S.-K., Ryoo, H. D., Gould, A., Krumlauf, R. and Mann, R (1997). Switching the in vivo specificity of a minimal Hox-responsive element. Development 124, 2007-2014.[Abstract]

Chang, C. P., Jacobs, Y., Nakamura, T., Jenkins, N. A., Copeland, N. G. and Cleary, M. L (1997). Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol. Cell. Biol 17, 5679-5687.[Abstract]

Cohen, S. M., Bronner, G., Kuttner, F., Jurgens, G. and Jackle, H (1989). Distal-less encodes a homoeodomain protein required for limb development in Drosophila. Nature 338, 432-434.[Medline]

Czerny, T., Halder, G., Kloter, U., Souabni, A., Gehring, W. J. and Busslinger, M (1999). twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development. Mol. Cell 3, 297-307.

Di Rocco, G., Mavilio, F. and Zappavigna, V (1997). Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex. EMBO J 16, 3644-3654.[Medline]

Ekker, S. C., Jackson, D. G., von Kessler, D. P., Sun, B. I., Young, K. E. and Beachy, P. A (1994). The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J 13, 3551-3560.[Medline]

Gehring, W. J., Affolter, M. and Burglin, T (1994). Homeodomain proteins. Ann. Rev. Biochem 63, 487-526.[Medline]

Gibson, G., Schier, A., LeMotte, P. and Gehring, W. J (1990). The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain. Cell 62, 1087-1103.[Medline]

Gonzalez-Crespo, S., Abu-Shaar, M., Torres, M., Mart\222nez-A, C., Mann, R. S. and Morata, G (1998). Antagonism between extradenticle function and Hedgehog signalling in the development limb. Nature_Fb_394,._Fb_Gonzalez-Crespo, S. and Morata, G. (1995). Control of Drosophila adult pattern by extradenticle. Development 121, 2117-2125.[Abstract]

Gonzalez-Crespo, S. and Morata, G (1996). Genetic evidence for the subdivision of the arthropod limb into coxopodite and telopodite. Development 122, 3921-3928.[Abstract]

Gorfinkiel, N., Morata, G. and Guerrero, I (1997). The homeobox geneDistal-less induces ventral appendage development in Drosophila. Genes Dev 11, 2259-2271.[Abstract/Free Full Text]

Grieder, N., Marty, T., Ryoo, H.-D., Mann, R. S. and Affolter, M (1997). Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling. EMBO J 16, 7402-7410.[Medline]

Halder, G., Callaerts, P. and Gehring, W. J (1995). Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267, 1788-1792.[Abstract/Free Full Text]

Jacobs, Y., Schnabel, C. A. and Cleary, M. L (1999). Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol. Cell. Biol 19, 5134-5142.[Abstract/Free Full Text]

Kenyon, C (1994). If birds can fly, why can't we? Homeotic genes and evolution. Cell 78, 175-180.[Medline]

Kim, J., Sebring, A., Esch, J. J., Kraus, M. E., Vorwerk, K., Magee, J. and Carroll, S. B (1996). Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 382, 133-138.[Medline]

Knoepfler, P., Calvo, K., Chen, H., Antonarakis, S. and Kamps, M (1997). Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc. Natl. Acad. Sci. USA 94, 14553-14558.[Abstract/Free Full Text]

Kurant, E., Pai, C.-Y., Sharf, R., Halachmi, N., Sun, Y. and Salzberg, A (1998). dorsotonals / homothorax , the Drosophila homologue of meis1 , interacts with extradenticle in patterning of the embryonic PNS. Development 125, 1037-1048.[Abstract]

Lewis, E. B (1978). A gene complex controlling segmentation in Drosophila. Nature 276, 565-570.[Medline]

Li, X. and McGinnis, W. M (1999). Activity regulation of Hox proteins, a mechanism for altering functional specificity in development and evolution. Proc. Natl. Acad. Sci. USA 96, 6802-6807.[Abstract/Free Full Text]

Li, X., Murre, C. and McGinnis, W (1999). Activity regulation of a Hox protein and a role for the homeodomain in inhibiting transcriptional activation. EMBO J 18, 198-211.[Medline]

Lu, Q., Knoepfler, P., Scheele, J., Wright, D. and Kamps, M (1995). Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. Mol. Cell. Biol 15, 3786-3795.[Abstract]

Maconochie, M. K., Nonchev, S., Studer, M., Chan, S. K., Popperl, H., Sham, M. H., Mann, R. S. and Krumlauf, R (1997). Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1. Genes Dev 11, 1885-1895.[Abstract/Free Full Text]

Malicki, J., Schughart, K. and McGinnis, W (1990). Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae. Cell 63, 961-967.[Medline]

Mann, R. S (1995). The specificity of homeotic gene function. BioEssays 17, 855-863.[Medline]

Mann, R. and Abu-Shaar, M (1996). Nuclear import of the homeodomain protein Extradenticle in response to Decapentaplegic and Wingless signalling. Nature 383, 630-633.[Medline]

Mann, R. S. and Affolter, M (1998). Hox proteins meet more partners. Curr. Op. Genet. Dev 8, 423-429.[Medline]

Mann, R. S. and Chan, S.-K (1996). Extra specificity from extradenticle : The partnership between HOX and exd/pbx homeodomain proteins. Trends Gen 12, 258-262.[Medline]

Mann, R. S. and Hogness, D. S (1990). Functional dissection of Ultrabithorax proteins in D. melanogaster. Cell 60, 597-610.[Medline]

Martin-Bermudo, M. D., Dunin-Borkowski, O. M. and Brown, N. H (1997). Specificity of PS integrin function during embryogenesis resides in the alpha subunit extracellular domain. EMBO J 16, 4184-4193.[Medline]

McGinnis, N., Kuziora, M. A. and McGinnis, W (1990). Human Hox-4.2 and Drosophila deformed encode similar regulatory specificities in Drosophila embryos and larvae. Cell 63, 969-976.[Medline]

McGinnis, W. and Krumlauf, R (1992). Homeobox genes and axial patterning. Cell 68, 283-302.[Medline]

Moskow, J., Bullrich, F., Juebner, K., Daar, I. and Buchberg, A (1995). Meis1 , a PBX1 -related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol. Cell. Biol 15, 5434-5443.[Abstract]

Nakamura, T., Jenkins, N. A. and Copeland, N. G (1996). Identification of a new family of Pbx-related homeobox genes. Oncogene 13, 2235-2242.[Medline]

Pai, C.-Y., Kuo, T., Jaw, T., Kurant, E., Chen, C., Bessarab, D., Salzberg, A. and Sun, Y (1998). The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila. Genes Dev 12, 435-446.[Abstract/Free Full Text]

Passner, J. M., Ryoo, H. D., Shen, L., Mann, R. S. and Aggarwal, A. K (1999). Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature 397, 714-718.[Medline]

Phelan, M. L. and Featherstone, M. S (1997). Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers. J. Biol. Chem 272, 8635-8643.[Abstract/Free Full Text]

Phelan, M. L., Rambaldi, I. and Featherstone, M (1995). Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif. Mol. Cell. Bio 15, 3989-3997.[Abstract]

Pinsonneault, J., Florence, B., Vaessin, H. and McGinnis, W (1997). A model for extradenticle function as a switch that changes HOX proteins from repressors to activators. EMBO J 16, 2032-2042.[Medline]

Piper, D. E., Batchelor, A. H., Chang, C.-P., Cleary, M. L. and Wolberger, C (1999). Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation. Cell 96, 587-597.[Medline]

P\232pperl, H., Bienz, M., Studer, M., Chan, S.-K., Aparicio, S., Brenner, S., Mann, R. and Krumlauf, R (1995). Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/Pbx. Cell 81, 1031-1042.[Medline]

Rauskolb, C., Peifer, M. and Wieschaus, E (1993). extradenticle , a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell 74, 1-20.[Medline]

Rauskolb, C., Smith, K., Peifer, M. and Wieschaus, E (1995). extradenticle determines segmental identities throughout development. Development 121, 3663-3671.[Abstract]

Rieckhof, G., Casares, F., Ryoo, H. D., Abu-Shaar, M. and Mann, R. S (1997). Nuclear translocation of Extradenticle requires homothorax , which encodes an Extradenticle-related homeodomain protein. Cell 91, 171-183.[Medline]

Ryoo, H.-D. and Mann, R. S (1999). The control of trunk Hox specficity and activity by Extradenticle. Genes Dev 13, 1704-1716.[Abstract/Free Full Text]

S\207nchez-Herrero, E., Vernos, I., Marco, R. and Morata, G (1985). Genetic organization of Drosophila bithorax complex. Nature 313, 108-113.[Medline]

Shen, W. F., Chang, C. P., Rozenfeld, S., Sauvageau, G., Humphries, R. K., Lu, M., Lawrence, H. J., Cleary, M. L. and Largman, C (1996). Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA. Nuc. Acid Res 24, 898-906.[Abstract/Free Full Text]

Steelman, S., Moskow, J. J., Muzynski, K., North, C., Druck, T., Montgomery, J. C., Huebner, K., Daar, I. O. and Buchberg, A. M (1997). Identification of a conserved family of Meis1-related homeobox genes. Gen. Res 7, 142-156.

Swift, G. H., Liu, Y., Rose, S. D., Bischof, L. J., Steelman, S., Buchberg, A. M., Wright, C. V. and MacDonald, R. J (1998). An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2). Mol. Cell. Biol 18, 5109-5120.[Abstract/Free Full Text]

Tremml, G. and Bienz, M (1992). Induction of labial expression in the Drosophila endoderm: response elements for dpp signalling and for autoregulation. Development 116, 447-456.[Medline]

Warren, R. W., Nagy, L., Selegue, J., Gates, J. and Carroll, S (1994). Evolution of homeotic gene regulation and function in flies and butterflies. Nature 372, 458-461.[Medline]

Weatherbee, S., Halder, G., Kim, J., Hudson, A. and Carroll, S (1998). Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila hatere. Genes Dev 12, 1474-1482.[Abstract/Free Full Text]

Williams, J. A., Bell, J. B. and Carroll, S. B (1991). Control of Drosophila wing and haltere development by the nuclear vestigial gene product. Genes Dev 5, 2481-2495.[Abstract/Free Full Text]

Wu, J. and Cohen, S. M (1999). Proximodistal axis formation in the Drosophila leg: subdivision into proximal and distal domains by Homothorax and Distal-less. Development 126, 109-117.[Abstract]

Zhao, J. J., Lazzarini, R. A. and Pick, L (1993). The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene. Genes Dev 7, 343-354.[Abstract/Free Full Text]

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Development, July 15, 2001; 128(14): 2833 - 2845.
[Abstract] [Full Text] [PDF]

E. Kurant, D. Eytan, and A. Salzberg
Mutational Analysis of the Drosophila homothorax Gene
Genetics, February 1, 2001; 157(2): 689 - 698.
[Abstract] [Full Text]

N Vlachakis, S. Choe, and C. Sagerstrom
Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish
Development, January 4, 2001; 128(8): 1299 - 1312.
[Abstract] [PDF]

U. Thorsteinsdottir, E. Kroon, L. Jerome, F. Blasi, and G. Sauvageau
Defining Roles for HOX and MEIS1 Genes in Induction of Acute Myeloid Leukemia
Mol. Cell. Biol., January 1, 2001; 21(1): 224 - 234.
[Abstract] [Full Text]

J Liu and A Fire
Overlapping roles of two Hox genes and the exd ortholog ceh-20 in diversification of the C. elegans postembryonic mesoderm
Development, January 12, 2000; 127(23): 5179 - 5190.
[Abstract] [PDF]

A Veraksa, N McGinnis, X Li, J Mohler, and W McGinnis
Cap 'n' collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress deformed homeotic function in the Drosophila head
Development, January 9, 2000; 127(18): 4023 - 4037.
[Abstract] [PDF]

S. Herzig, L. Fuzesi, and W. Knepel
Heterodimeric Pbx-Prep1 Homeodomain Protein Binding to the Glucagon Gene Restricting Transcription in a Cell Type-dependent Manner
J. Biol. Chem., September 1, 2000; 275(36): 27989 - 27999.
[Abstract] [Full Text] [PDF]

M. Guiral, K. Bess, G. Goodwin, and P.-S. Jayaraman
PRH Represses Transcription in Hematopoietic Cells by at Least Two Independent Mechanisms
J. Biol. Chem., January 19, 2001; 276(4): 2961 - 2970.
[Abstract] [Full Text] [PDF]

L. Pan, Y. Xie, T. A. Black, C. A. Jones, S. C. Pruitt, and K. W. Gross
An Abd-B Class HOX{middle dot}PBX Recognition Sequence Is Required for Expression from the Mouse Ren-1c Gene
J. Biol. Chem., August 24, 2001; 276(35): 32489 - 32494.
[Abstract] [Full Text] [PDF]

Y. Liu, R. J. MacDonald, and G. H. Swift
DNA Binding and Transcriptional Activation by a PDX1{middle dot}PBX1b{middle dot}MEIS2b Trimer and Cooperation with a Pancreas-specific Basic Helix-Loop-Helix Complex
J. Biol. Chem., May 18, 2001; 276(21): 17985 - 17993.
[Abstract] [Full Text] [PDF]

D. Penkov, S. Tanaka, G. Di Rocco, J. Berthelsen, F. Blasi, and F. Ramirez
Cooperative Interactions between PBX, PREP, and HOX Proteins Modulate the Activity of the alpha 2(V) Collagen (COL5A2) Promoter
J. Biol. Chem., May 26, 2000; 275(22): 16681 - 16689.
[Abstract] [Full Text] [PDF]

				D. Q. Matus, K. M. Halanych, and M. Q. Martindale The Hox gene complement of a pelagic chaetognath, Flaccisagitta enflata Integr. Comp. Biol., December 1, 2007; 47(6): 854 - 864. [Abstract] [Full Text] [PDF]

				P. Wong, M. Iwasaki, T. C.P. Somervaille, C. W. E. So, and M. L. Cleary Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential Genes & Dev., November 1, 2007; 21(21): 2762 - 2774. [Abstract] [Full Text] [PDF]

				S. Merabet, M. Saadaoui, N. Sambrani, B. Hudry, J. Pradel, M. Affolter, and Y. Graba A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax PNAS, October 23, 2007; 104(43): 16946 - 16951. [Abstract] [Full Text] [PDF]

				C. M. Walsh and S. B. Carroll Collaboration between Smads and a Hox protein in target gene repression Development, October 15, 2007; 134(20): 3585 - 3592. [Abstract] [Full Text] [PDF]

				K. E. Stevens and R. S. Mann A Balance Between Two Nuclear Localization Sequences and a Nuclear Export Sequence Governs Extradenticle Subcellular Localization Genetics, April 1, 2007; 175(4): 1625 - 1636. [Abstract] [Full Text] [PDF]

				S. Bondos Variations on a Theme: Hox and Wnt Combinatorial Regulation During Animal Development Sci. Signal., October 3, 2006; 2006(355): pe38 - pe38. [Abstract] [Full Text] [PDF]

				E. Ferretti, J. C. Villaescusa, P. Di Rosa, L. C. Fernandez-Diaz, E. Longobardi, R. Mazzieri, A. Miccio, N. Micali, L. Selleri, G. Ferrari, et al. Hypomorphic Mutation of the TALE Gene Prep1 (pKnox1) Causes a Major Reduction of Pbx and Meis Proteins and a Pleiotropic Embryonic Phenotype Mol. Cell. Biol., August 1, 2006; 26(15): 5650 - 5662. [Abstract] [Full Text] [PDF]

				A. Mamo, J. Krosl, E. Kroon, J. Bijl, A. Thompson, N. Mayotte, S. Girard, R. Bisaillon, N. Beslu, M. Featherstone, et al. Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation Blood, July 15, 2006; 108(2): 622 - 629. [Abstract] [Full Text] [PDF]

				B. Noro, J. Culi, D. J. McKay, W. Zhang, and R. S. Mann Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax. Genes & Dev., June 15, 2006; 20(12): 1636 - 1650. [Abstract] [Full Text] [PDF]

				M. Zubair, S. Ishihara, S. Oka, K. Okumura, and K.-i. Morohashi Two-Step Regulation of Ad4BP/SF-1 Gene Transcription during Fetal Adrenal Development: Initiation by a Hox-Pbx1-Prep1 Complex and Maintenance via Autoregulation by Ad4BP/SF-1. Mol. Cell. Biol., June 1, 2006; 26(11): 4111 - 4121. [Abstract] [Full Text] [PDF]

				E. Ferretti, F. Cambronero, S. Tumpel, E. Longobardi, L. M. Wiedemann, F. Blasi, and R. Krumlauf Hoxb1 Enhancer and Control of Rhombomere 4 Expression: Complex Interplay between PREP1-PBX1-HOXB1 Binding Sites Mol. Cell. Biol., October 1, 2005; 25(19): 8541 - 8552. [Abstract] [Full Text] [PDF]

				B. M. Hersh and S. B. Carroll Direct regulation of knot gene expression by Ultrabithorax and the evolution of cis-regulatory elements in Drosophila Development, April 1, 2005; 132(7): 1567 - 1577. [Abstract] [Full Text] [PDF]

				A. Ebner, C. Cabernard, M. Affolter, and S. Merabet Recognition of distinct target sites by a unique Labial/Extradenticle/Homothorax complex Development, April 1, 2005; 132(7): 1591 - 1600. [Abstract] [Full Text] [PDF]

				H. Huang, M. Rastegar, C. Bodner, S.-L. Goh, I. Rambaldi, and M. Featherstone MEIS C Termini Harbor Transcriptional Activation Domains That Respond to Cell Signaling J. Biol. Chem., March 18, 2005; 280(11): 10119 - 10127. [Abstract] [Full Text] [PDF]

				S. Aldaz, G. Morata, and N. Azpiazu Patterning function of homothorax/extradenticle in the thorax of Drosophila Development, February 1, 2005; 132(3): 439 - 446. [Abstract] [Full Text] [PDF]

				K. Haller, I. Rambaldi, E. Daniels, and M. Featherstone Subcellular Localization of Multiple PREP2 Isoforms Is Regulated by Actin, Tubulin, and Nuclear Export J. Biol. Chem., November 19, 2004; 279(47): 49384 - 49394. [Abstract] [Full Text] [PDF]

				N. Beslu, J. Krosl, M. Laurin, N. Mayotte, K. R. Humphries, and G. Sauvageau Molecular interactions involved in HOXB4-induced activation of HSC self-renewal Blood, October 15, 2004; 104(8): 2307 - 2314. [Abstract] [Full Text] [PDF]

				M. W. Kankel, D. M. Duncan, and I. Duncan A Screen for Genes That Interact With the Drosophila Pair-Rule Segmentation Gene fushi tarazu Genetics, September 1, 2004; 168(1): 161 - 180. [Abstract] [Full Text] [PDF]

				O. A. Samad, M. J. Geisen, G. Caronia, I. Varlet, V. Zappavigna, J. Ericson, C. Goridis, and F. M. Rijli Integration of anteroposterior and dorsoventral regulation of Phox2b transcription in cranial motoneuron progenitors by homeodomain proteins Development, August 15, 2004; 131(16): 4071 - 4083. [Abstract] [Full Text] [PDF]

				N. Rave-Harel, M. L. Givens, S. B. Nelson, H. A. Duong, D. Coss, M. E. Clark, S. B. Hall, M. P. Kamps, and P. L. Mellon TALE Homeodomain Proteins Regulate Gonadotropin-releasing Hormone Gene Expression Independently and via Interactions with Oct-1 J. Biol. Chem., July 16, 2004; 279(29): 30287 - 30297. [Abstract] [Full Text] [PDF]

				G. Deflorian, N. Tiso, E. Ferretti, D. Meyer, F. Blasi, M. Bortolussi, and F. Argenton Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation Development, February 1, 2004; 131(3): 613 - 627. [Abstract] [Full Text] [PDF]

				A. Grienenberger, S. Merabet, J. Manak, I. Iltis, A. Fabre, H. Berenger, M. P. Scott, J. Pradel, and Y. Graba Tgf{beta} signaling acts on a Hox response element to confer specificity and diversity to Hox protein function Development, November 15, 2003; 130(22): 5445 - 5455. [Abstract] [Full Text] [PDF]

				E. Longobardi and F. Blasi Overexpression of PREP-1 in F9 Teratocarcinoma Cells Leads to a Functionally Relevant Increase of PBX-2 by Preventing Its Degradation J. Biol. Chem., October 3, 2003; 278(40): 39235 - 39241. [Abstract] [Full Text] [PDF]

				Z. Wang and R. S. Mann Requirement for two nearly identical TGIF-related homeobox genes in Drosophila spermatogenesis Development, July 1, 2003; 130(13): 2853 - 2865. [Abstract] [Full Text] [PDF]

				H. Chen, F. M. Rosin, S. Prat, and D. J. Hannapel Interacting Transcription Factors from the Three-Amino Acid Loop Extension Superclass Regulate Tuber Formation Plant Physiology, July 1, 2003; 132(3): 1391 - 1404. [Abstract] [Full Text] [PDF]

				S. Bel-Vialar, N. Itasaki, and R. Krumlauf Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups Development, March 13, 2003; 129(22): 5103 - 5115. [Abstract] [Full Text] [PDF]

				K. Van Auken, D. Weaver, B. Robertson, M. Sundaram, T. Saldi, L. Edgar, U. Elling, M. Lee, Q. Boese, and W. B. Wood Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis Development, March 13, 2003; 129(22): 5255 - 5268. [Abstract] [Full Text] [PDF]

				J. Wu and S. M. Cohen Repression of Teashirt marks the initiation of wing development Development, March 7, 2003; 129(10): 2411 - 2418. [Abstract] [Full Text] [PDF]

				C. Alexandre and J.-P. Vincent Requirements for transcriptional repression and activation by Engrailed in Drosophila embryos Development, February 15, 2003; 130(4): 729 - 739. [Abstract] [Full Text] [PDF]

				M. Kobayashi, M. Fujioka, E. N. Tolkunova, D. Deka, M. Abu-Shaar, R. S. Mann, and J. B. Jaynes Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila Development, February 15, 2003; 130(4): 741 - 751. [Abstract] [Full Text] [PDF]