PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Huang, H.
	Articles by Xu, T.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Huang, H.
	Articles by Xu, T.

Bohni, R., Riesgo-Escovar, J., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B. F., Beckingham, K. and Hafen, E (1999). Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell 97, 865-875.[Medline]

Brand, A. H. and Perrimon, N (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.[Abstract]

Cairns, P., Okami, K., Halachmi, S., Halachmi, N., Esteller, M., Herman, J. G., Jen, J., Isaacs, W. B., Bova, G. S. and Sidransky, D (1997). Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res 57, 4997-5000.[Abstract/Free Full Text]

Cantley, L. C. and Neel, B. G (1999). New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA 96, 4240-4245.[Abstract/Free Full Text]

Cheney, I. W., Johnson, D. E., Vaillancourt, M. T., Avanzini, J., Morimoto, A., Demers, G. W., Wills, K. N., Shabram, P. W., Bolen, J. B., Tavtigian, S. V. et al (1998). Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. Cancer Res 58, 2331-2334.[Abstract/Free Full Text]

de Nooij, J. C. and Hariharan, I. K (1995). Uncoupling cell fate determination from patterned cell division in the Drosophila eye [see comments]. Science 270, 983-985.[Abstract/Free Full Text]

Denu, J. M., Stuckey, J. A., Saper, M. A. and Dixon, J. E (1996). Form and function in protein dephosphorylation. Cell 87, 361-364.[Medline]

Di Cristofano, A., Pesce, B., Cordon-Cardo, C. and Pandolfi, P. P (1998). Pten is essential for embryonic development and tumour suppression. Nat. Genet 19, 348-355.[Medline]

Furnari, F. B., Huang, H. J. and Cavenee, W. K (1998). The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1growth arrest in glioma cells. Cancer Res 58, 5002-5008.[Abstract/Free Full Text]

Furnari, F. B., Lin, H., Huang, H. S. and Cavenee, W. K (1997). Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc. Natl. Acad. Sci. USA 94, 12479-12484.[Abstract/Free Full Text]

Gil, E. B., Malone Link, E., Liu, L. X., Johnson, C. D. and Lees, J. A (1999). Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene. Proc. Natl. Acad. Sci. USA 96, 2925-2930.[Abstract/Free Full Text]

Gu, J., Tamura, M., Pankov, R., Danen, E. H., Takino, T., Matsumoto, K. and Yamada, K. M (1999). Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J. Cell Biol 146, 389-403.[Abstract/Free Full Text]

Guldberg, P., thor Straten, P., Birck, A., Ahrenkiel, V., Kirkin, A. F. and Zeuthen, J (1997). Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 57, 3660-3663.[Abstract/Free Full Text]

Halder, G., Callaerts, P., Flister, S., Walldorf, U., Kloter, U. and Gehring, W. J (1998). Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development 125, 2181-2191.[Abstract]

Hay, B. A., Wolff, T. and Rubin, G. M (1994). Expression of baculovirus P35 prevents cell death in Drosophila. Development 120, 2121-2129.[Abstract]

Leevers, S. J., Weinkove, D., MacDougall, L. K., Hafen, E. and Waterfield, M. D (1996). The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J 15, 6584-6594.[Medline]

Li, D. M. and Sun, H (1997). TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res 57, 2124-2129.[Abstract/Free Full Text]

Li, D. M. and Sun, H (1998). PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1cell cycle arrest in human glioblastoma cells. Proc. Natl. Acad. Sci. USA 95, 15406-15411.[Abstract/Free Full Text]

Li, J., Simpson, L., Takahashi, M., Miliaresis, C., Myers, M. P., Tonks, N. and Parsons, R (1998). The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res 58, 5667-5672.[Abstract/Free Full Text]

Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R. et al (1997). PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer [see comments]. Science 275, 1943-1947.[Abstract/Free Full Text]

Li, L., Ernsting, B. R., Wishart, M. J., Lohse, D. L. and Dixon, J. E (1997). A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. J. Biol. Chem 272, 29403-29406.[Abstract/Free Full Text]

Liaw, D., Marsh, D. J., Li, J., Dahia, P. L., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M. et al (1997). Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet 16, 64-67.[Medline]

Liu, W., James, C. D., Frederick, L., Alderete, B. E. and Jenkins, R. B (1997). PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. Cancer Res 57, 5254-5257.[Abstract/Free Full Text]

Maehama, T. and Dixon, J. E (1998). The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem 273, 13375-13378.[Abstract/Free Full Text]

Marsh, D. J., Dahia, P. L., Zheng, Z., Liaw, D., Parsons, R., Gorlin, R. J. and Eng, C (1997). Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat. Genet 16, 333-334.[Medline]

Mihaylova, V. T., Borland, C. Z., Manjarrez, L., Stern, M. J. and Sun, H (1999). The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway. Proc. Natl. Acad. Sci. USA 96, 7427-7432.[Abstract/Free Full Text]

Myers, M. P., Pass, I., Batty, I. H., Van der Kaay, J., Stolarov, J. P., Hemmings, B. A., Wigler, M. H., Downes, C. P. and Tonks, N. K (1998). The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc. Natl. Acad. Sci. USA 95, 13513-13518.[Abstract/Free Full Text]

Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R. and Tonks, N. K (1997). P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl. Acad. Sci. USA 94, 9052-9057.[Abstract/Free Full Text]

Myers, M. P. and Tonks, N. K (1997). PTEN: sometimes taking it off can be better than putting it on. Am. J. Hum. Genet 61, 1234-1238.[Medline]

Neufeld, T. P., de la Cruz, A. F., Johnston, L. A. and Edgar, B. A (1998). Coordination of growth and cell division in the Drosophila wing. Cell 93, 1183-1193.[Medline]

Ogg, S. and Ruvkun, G (1998). The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell 2, 887-893.

Podsypanina, K., Ellenson, L. H., Nemes, A., Gu, J., Tamura, M., Yamada, K. M., Cordon-Cardo, C., Catoretti, G., Fisher, P. E. and Parsons, R (1999). Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc. Natl. Acad. Sci. USA 96, 1563-1568.[Abstract/Free Full Text]

Rasheed, B. K., Stenzel, T. T., McLendon, R. E., Parsons, R., Friedman, A. H., Friedman, H. S., Bigner, D. D. and Bigner, S. H (1997). PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Cancer Res 57, 4187-4190.[Abstract/Free Full Text]

Risinger, J. I., Hayes, A. K., Berchuck, A. and Barrett, J. C (1997). PTEN/MMAC1 mutations in endometrial cancers. Cancer Res 57, 4736-4738.[Abstract/Free Full Text]

Robinow, S. and White, K (1991). Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. J. Neurobiol 22, 443-461.[Medline]

Rouault, J. P., Kuwabara, P. E., Sinilnikova, O. M., Duret, L., Thierry-Mieg, D. and Billaud, M (1999). Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN. Curr. Biol 9, 329-332.[Medline]

Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P. and Mak, T. W (1998). Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29-39.[Medline]

Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T. et al (1997). Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet 15, 356-362.[Medline]

Sun, H., Lesche, R., Li, D. M., Liliental, J., Zhang, H., Gao, J., Gavrilova, N., Mueller, B., Liu, X. and Wu, H (1999). PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA 96, 6199-6204.[Abstract/Free Full Text]

Suzuki, A., de la Pompa, J. L., Stambolic, V., Elia, A. J., Sasaki, T., del Barco Barrantes, I., Ho, A., Wakeham, A., Itie, A., Khoo, W. et al (1998). High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol 8, 1169-1178.[Medline]

Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R. and Yamada, K. M (1998). Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280, 1614-1617.[Abstract/Free Full Text]

Tao, W., Zhang, S., Turenchalk, G. S., Stewart, R. A., St John, M. A., Chen, W. and Xu, T (1999). Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat. Genet 21, 177-181.[Medline]

Tashiro, H., Blazes, M. S., Wu, R., Cho, K. R., Bose, S., Wang, S. I., Li, J., Parsons, R. and Ellenson, L. H (1997). Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res 57, 3935-3940.[Abstract/Free Full Text]

Theodosiou, N. A., Zhang, S., Wang, W. Y. and Xu, T (1998). slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development. Development 125, 3411-3416.[Abstract]

Wang, S. I., Puc, J., Li, J., Bruce, J. N., Cairns, P., Sidransky, D. and Parsons, R (1997). Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res 57, 4183-4186.[Abstract/Free Full Text]

White, K., Tahaoglu, E. and Steller, H (1996). Cell killing by the Drosophila gene reaper. Science 271, 805-807.[Abstract]

Wolff, T. and Ready, D. F (1991). Cell death in normal and rough eye mutants of Drosophila. Development 113, 825-839.[Abstract]

Xu, T. and Harrison, S. D (1994). Mosaic analysis using FLP recombinase. Meth. Cell Biol 44, 655-681.[Medline]

Xu, T., Wang, W., Zhang, S., Stewart, R. A. and Yu, W (1995). Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 121, 1053-1063.[Abstract]

This article has been cited by other articles:

X. Ju, S. Katiyar, C. Wang, M. Liu, X. Jiao, S. Li, J. Zhou, J. Turner, M. P. Lisanti, R. G. Russell, et al.
Akt1 governs breast cancer progression in vivo
PNAS, May 1, 2007; 104(18): 7438 - 7443.
[Abstract] [Full Text] [PDF]

N. Vereshchagina and C. Wilson
Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells
Development, December 1, 2006; 133(23): 4731 - 4735.
[Abstract] [Full Text] [PDF]

L. Mahimainathan, F. Das, B. Venkatesan, and G. G. Choudhury
Mesangial Cell Hypertrophy by High Glucose Is Mediated by Downregulation of the Tumor Suppressor PTEN.
Diabetes, July 1, 2006; 55(7): 2115 - 2125.
[Abstract] [Full Text] [PDF]

A. Dekanty, S. Lavista-Llanos, M. Irisarri, S. Oldham, and P. Wappner
The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-{alpha}/Sima
J. Cell Sci., December 1, 2005; 118(23): 5431 - 5441.
[Abstract] [Full Text] [PDF]

Y. Yang, S. Gehrke, Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito, et al.
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
PNAS, September 20, 2005; 102(38): 13670 - 13675.
[Abstract] [Full Text] [PDF]

W. von Stein, A. Ramrath, A. Grimm, M. Muller-Borg, and A. Wodarz
Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling
Development, April 1, 2005; 132(7): 1675 - 1686.
[Abstract] [Full Text] [PDF]

J. H. Reiling and E. Hafen
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
Genes & Dev., December 1, 2004; 18(23): 2879 - 2892.
[Abstract] [Full Text] [PDF]

D. K. Scheidenhelm and D. H. Gutmann
Mouse Models of Tuberous Sclerosis Complex
J Child Neurol, September 1, 2004; 19(9): 726 - 733.
[Abstract] [PDF]

R. D. Read, E. A. Bach, and R. L. Cagan
Drosophila C-Terminal Src Kinase Negatively Regulates Organ Growth and Cell Proliferation through Inhibition of the Src, Jun N-Terminal Kinase, and STAT Pathways
Mol. Cell. Biol., August 1, 2004; 24(15): 6676 - 6689.
[Abstract] [Full Text] [PDF]

L. Mahimainathan and G. G. Choudhury
Inactivation of Platelet-derived Growth Factor Receptor by the Tumor Suppressor PTEN Provides a Novel Mechanism of Action of the Phosphatase
J. Biol. Chem., April 9, 2004; 279(15): 15258 - 15268.
[Abstract] [Full Text] [PDF]

M. Raftopoulou, S. Etienne-Manneville, A. Self, S. Nicholls, and A. Hall
Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN
Science, February 20, 2004; 303(5661): 1179 - 1181.
[Abstract] [Full Text] [PDF]

D. J. Emlen and C. E. Allen
Genotype to Phenotype: Physiological Control of Trait Size and Scaling in Insects
Integr. Comp. Biol., November 1, 2003; 43(5): 617 - 634.
[Abstract] [Full Text] [PDF]

J. Faridi, J. Fawcett, L. Wang, and R. A. Roth
Akt promotes increased mammalian cell size by stimulating protein synthesis and inhibiting protein degradation
Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E964 - E972.
[Abstract] [Full Text] [PDF]

D. C.I. Goberdhan and C. Wilson
PTEN: tumour suppressor, multifunctional growth regulator and more
Hum. Mol. Genet., October 15, 2003; 12(90002): R239 - 248.
[Abstract] [Full Text] [PDF]

S. Szuplewski, B. Kottler, and R. Terracol
The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth
Development, August 15, 2003; 130(16): 3651 - 3662.
[Abstract] [Full Text] [PDF]

P. K. Majumder, J. J. Yeh, D. J. George, P. G. Febbo, J. Kum, Q. Xue, R. Bikoff, H. Ma, P. W. Kantoff, T. R. Golub, et al.
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model
PNAS, June 24, 2003; 100(13): 7841 - 7846.
[Abstract] [Full Text] [PDF]

D. J. Frank, B. A. Edgar, and M. B. Roth
The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis
Development, March 3, 2003; 129(2): 399 - 407.
[Abstract] [Full Text] [PDF]

R. Gupta, J. T. L. Ting, L. N. Sokolov, S. A. Johnson, and S. Luan
A Tumor Suppressor Homolog, AtPTEN1, Is Essential for Pollen Development in Arabidopsis
PLANT CELL, October 1, 2002; 14(10): 2495 - 2507.
[Abstract] [Full Text] [PDF]

S. Oldham, H. Stocker, M. Laffargue, F. Wittwer, M. Wymann, and E. Hafen
The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP3 levels
Development, September 1, 2002; 129(17): 4103 - 4109.
[Abstract] [Full Text] [PDF]

D. A. Prober and B. A. Edgar
Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing
Genes & Dev., September 1, 2002; 16(17): 2286 - 2299.
[Abstract] [Full Text] [PDF]

Z. Xu, D. Stokoe, L. P. Kane, and A. Weiss
The Inducible Expression of the Tumor Suppressor Gene PTEN Promotes Apoptosis and Decreases Cell Size by Inhibiting the PI3K/Akt Pathway in Jurkat T Cells
Cell Growth Differ., July 1, 2002; 13(7): 285 - 296.
[Abstract] [Full Text]

B. Stiles, V. Gilman, N. Khanzenzon, R. Lesche, A. Li, R. Qiao, X. Liu, and H. Wu
Essential Role of AKT-1/Protein Kinase B{alpha} in PTEN-Controlled Tumorigenesis
Mol. Cell. Biol., June 1, 2002; 22(11): 3842 - 3851.
[Abstract] [Full Text] [PDF]

J. Huang and C. D. Kontos
PTEN Modulates Vascular Endothelial Growth Factor-Mediated Signaling and Angiogenic Effects
J. Biol. Chem., March 22, 2002; 277(13): 10760 - 10766.
[Abstract] [Full Text] [PDF]

F. Rintelen, H. Stocker, G. Thomas, and E. Hafen
PDK1 regulates growth through Akt and S6K in Drosophila
PNAS, December 18, 2001; 98(26): 15020 - 15025.
[Abstract] [Full Text] [PDF]

M. Miron and N. Sonenberg
Regulation of Translation via TOR Signaling: Insights from Drosophila melanogaster
J. Nutr., November 1, 2001; 131(11): 2988S - 2993.
[Abstract] [Full Text] [PDF]

W. S. Chen, P.-Z. Xu, K. Gottlob, M.-L. Chen, K. Sokol, T. Shiyanova, I. Roninson, W. Weng, R. Suzuki, K. Tobe, et al.
Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene
Genes & Dev., September 1, 2001; 15(17): 2203 - 2208.
[Abstract] [Full Text] [PDF]

M. S. Neshat, I. K. Mellinghoff, C. Tran, B. Stiles, G. Thomas, R. Petersen, P. Frost, J. J. Gibbons, H. Wu, and C. L. Sawyers
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
PNAS, August 10, 2001; (2001) 171076798.
[Abstract] [Full Text] [PDF]

K. Podsypanina, R. T. Lee, C. Politis, I. Hennessy, A. Crane, J. Puc, M. Neshat, H. Wang, L. Yang, J. Gibbons, et al.
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
PNAS, August 10, 2001; (2001) 171060098.
[Abstract] [Full Text] [PDF]

L. Simpson, J. Li, D. Liaw, I. Hennessy, J. Oliner, F. Christians, and R. Parsons
PTEN Expression Causes Feedback Upregulation of Insulin Receptor Substrate 2
Mol. Cell. Biol., June 15, 2001; 21(12): 3947 - 3958.
[Abstract] [Full Text]

X. Zhu, C.-H. Kwon, P. W. Schlosshauer, L. H. Ellenson, and S. J. Baker
PTEN Induces G1 Cell Cycle Arrest and Decreases Cyclin D3 Levels in Endometrial Carcinoma Cells
Cancer Res., June 1, 2001; 61(11): 4569 - 4575.
[Abstract] [Full Text] [PDF]

X. Gao and D. Pan
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
Genes & Dev., June 1, 2001; 15(11): 1383 - 1392.
[Abstract] [Full Text] [PDF]

A.-C. Gingras, B. Raught, and N. Sonenberg
Regulation of translation initiation by FRAP/mTOR
Genes & Dev., April 1, 2001; 15(7): 807 - 826.
[Full Text]

K. M. Yamada and M. Araki
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis
J. Cell Sci., January 7, 2001; 114(13): 2375 - 2382.
[Abstract] [Full Text] [PDF]

F Wittwer, A van der Straten, K Keleman, B. Dickson, and E Hafen
Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth
Development, January 3, 2001; 128(5): 791 - 800.
[Abstract] [PDF]

A. Tang, T. Neufeld, G. Rubin, and H. Muller
Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian
Development, January 3, 2001; 128(5): 801 - 813.
[Abstract] [PDF]

J. Heymont, L. Berenfeld, J. Collins, A. Kaganovich, B. Maynes, A. Moulin, I. Ratskovskaya, P. P. Poon, G. C. Johnston, M. Kamenetsky, et al.
TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation
PNAS, November 7, 2000; 97(23): 12672 - 12677.
[Abstract] [Full Text] [PDF]

S. Oldham, J. Montagne, T. Radimerski, G. Thomas, and E. Hafen
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
Genes & Dev., November 1, 2000; 14(21): 2689 - 2694.
[Abstract] [Full Text]

C. Coelho and S. Leevers
Do growth and cell division rates determine cell size in multicellular organisms?
J. Cell Sci., January 9, 2000; 113(17): 2927 - 2934.
[Abstract] [PDF]

R. M. K. Poltilove, A. R. Jacobs, C. R. Haft, P. Xu, and S. I. Taylor
Characterization of Drosophila Insulin Receptor Substrate
J. Biol. Chem., July 21, 2000; 275(30): 23346 - 23354.
[Abstract] [Full Text] [PDF]

Y. Li, D. Dowbenko, and L. A. Lasky
Caenorhabditis elegans PIAK, a Phospholipid-independent Kinase That Activates the AKT/PKB Survival Kinase
J. Biol. Chem., June 1, 2001; 276(23): 20323 - 20329.
[Abstract] [Full Text] [PDF]

G. Schwartzbauer and J. Robbins
The Tumor Suppressor Gene PTEN Can Regulate Cardiac Hypertrophy and Survival
J. Biol. Chem., September 14, 2001; 276(38): 35786 - 35793.
[Abstract] [Full Text] [PDF]

K. Podsypanina, R. T. Lee, C. Politis, I. Hennessy, A. Crane, J. Puc, M. Neshat, H. Wang, L. Yang, J. Gibbons, et al.
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
PNAS, August 28, 2001; 98(18): 10320 - 10325.
[Abstract] [Full Text] [PDF]

M. S. Neshat, I. K. Mellinghoff, C. Tran, B. Stiles, G. Thomas, R. Petersen, P. Frost, J. J. Gibbons, H. Wu, and C. L. Sawyers
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
PNAS, August 28, 2001; 98(18): 10314 - 10319.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Huang, H.

Articles by Xu, T.

Search for Related Content

PubMed

PubMed Citation

Articles by Huang, H.

Articles by Xu, T.

				N. Vereshchagina and C. Wilson Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells Development, December 1, 2006; 133(23): 4731 - 4735. [Abstract] [Full Text] [PDF]

				L. Mahimainathan, F. Das, B. Venkatesan, and G. G. Choudhury Mesangial Cell Hypertrophy by High Glucose Is Mediated by Downregulation of the Tumor Suppressor PTEN. Diabetes, July 1, 2006; 55(7): 2115 - 2125. [Abstract] [Full Text] [PDF]

				A. Dekanty, S. Lavista-Llanos, M. Irisarri, S. Oldham, and P. Wappner The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-{alpha}/Sima J. Cell Sci., December 1, 2005; 118(23): 5431 - 5441. [Abstract] [Full Text] [PDF]

				Y. Yang, S. Gehrke, Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito, et al. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling PNAS, September 20, 2005; 102(38): 13670 - 13675. [Abstract] [Full Text] [PDF]

				W. von Stein, A. Ramrath, A. Grimm, M. Muller-Borg, and A. Wodarz Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling Development, April 1, 2005; 132(7): 1675 - 1686. [Abstract] [Full Text] [PDF]

				J. H. Reiling and E. Hafen The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila Genes & Dev., December 1, 2004; 18(23): 2879 - 2892. [Abstract] [Full Text] [PDF]

				D. K. Scheidenhelm and D. H. Gutmann Mouse Models of Tuberous Sclerosis Complex J Child Neurol, September 1, 2004; 19(9): 726 - 733. [Abstract] [PDF]

				R. D. Read, E. A. Bach, and R. L. Cagan Drosophila C-Terminal Src Kinase Negatively Regulates Organ Growth and Cell Proliferation through Inhibition of the Src, Jun N-Terminal Kinase, and STAT Pathways Mol. Cell. Biol., August 1, 2004; 24(15): 6676 - 6689. [Abstract] [Full Text] [PDF]

				L. Mahimainathan and G. G. Choudhury Inactivation of Platelet-derived Growth Factor Receptor by the Tumor Suppressor PTEN Provides a Novel Mechanism of Action of the Phosphatase J. Biol. Chem., April 9, 2004; 279(15): 15258 - 15268. [Abstract] [Full Text] [PDF]

				M. Raftopoulou, S. Etienne-Manneville, A. Self, S. Nicholls, and A. Hall Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN Science, February 20, 2004; 303(5661): 1179 - 1181. [Abstract] [Full Text] [PDF]

				D. J. Emlen and C. E. Allen Genotype to Phenotype: Physiological Control of Trait Size and Scaling in Insects Integr. Comp. Biol., November 1, 2003; 43(5): 617 - 634. [Abstract] [Full Text] [PDF]

				J. Faridi, J. Fawcett, L. Wang, and R. A. Roth Akt promotes increased mammalian cell size by stimulating protein synthesis and inhibiting protein degradation Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E964 - E972. [Abstract] [Full Text] [PDF]

				D. C.I. Goberdhan and C. Wilson PTEN: tumour suppressor, multifunctional growth regulator and more Hum. Mol. Genet., October 15, 2003; 12(90002): R239 - 248. [Abstract] [Full Text] [PDF]

				S. Szuplewski, B. Kottler, and R. Terracol The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth Development, August 15, 2003; 130(16): 3651 - 3662. [Abstract] [Full Text] [PDF]

				P. K. Majumder, J. J. Yeh, D. J. George, P. G. Febbo, J. Kum, Q. Xue, R. Bikoff, H. Ma, P. W. Kantoff, T. R. Golub, et al. Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model PNAS, June 24, 2003; 100(13): 7841 - 7846. [Abstract] [Full Text] [PDF]

				D. J. Frank, B. A. Edgar, and M. B. Roth The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis Development, March 3, 2003; 129(2): 399 - 407. [Abstract] [Full Text] [PDF]

				R. Gupta, J. T. L. Ting, L. N. Sokolov, S. A. Johnson, and S. Luan A Tumor Suppressor Homolog, AtPTEN1, Is Essential for Pollen Development in Arabidopsis PLANT CELL, October 1, 2002; 14(10): 2495 - 2507. [Abstract] [Full Text] [PDF]

				S. Oldham, H. Stocker, M. Laffargue, F. Wittwer, M. Wymann, and E. Hafen The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP3 levels Development, September 1, 2002; 129(17): 4103 - 4109. [Abstract] [Full Text] [PDF]

				D. A. Prober and B. A. Edgar Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing Genes & Dev., September 1, 2002; 16(17): 2286 - 2299. [Abstract] [Full Text] [PDF]

				Z. Xu, D. Stokoe, L. P. Kane, and A. Weiss The Inducible Expression of the Tumor Suppressor Gene PTEN Promotes Apoptosis and Decreases Cell Size by Inhibiting the PI3K/Akt Pathway in Jurkat T Cells Cell Growth Differ., July 1, 2002; 13(7): 285 - 296. [Abstract] [Full Text]

				B. Stiles, V. Gilman, N. Khanzenzon, R. Lesche, A. Li, R. Qiao, X. Liu, and H. Wu Essential Role of AKT-1/Protein Kinase B{alpha} in PTEN-Controlled Tumorigenesis Mol. Cell. Biol., June 1, 2002; 22(11): 3842 - 3851. [Abstract] [Full Text] [PDF]

				J. Huang and C. D. Kontos PTEN Modulates Vascular Endothelial Growth Factor-Mediated Signaling and Angiogenic Effects J. Biol. Chem., March 22, 2002; 277(13): 10760 - 10766. [Abstract] [Full Text] [PDF]

				F. Rintelen, H. Stocker, G. Thomas, and E. Hafen PDK1 regulates growth through Akt and S6K in Drosophila PNAS, December 18, 2001; 98(26): 15020 - 15025. [Abstract] [Full Text] [PDF]

				M. Miron and N. Sonenberg Regulation of Translation via TOR Signaling: Insights from Drosophila melanogaster J. Nutr., November 1, 2001; 131(11): 2988S - 2993. [Abstract] [Full Text] [PDF]

				W. S. Chen, P.-Z. Xu, K. Gottlob, M.-L. Chen, K. Sokol, T. Shiyanova, I. Roninson, W. Weng, R. Suzuki, K. Tobe, et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene Genes & Dev., September 1, 2001; 15(17): 2203 - 2208. [Abstract] [Full Text] [PDF]

				M. S. Neshat, I. K. Mellinghoff, C. Tran, B. Stiles, G. Thomas, R. Petersen, P. Frost, J. J. Gibbons, H. Wu, and C. L. Sawyers Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR PNAS, August 10, 2001; (2001) 171076798. [Abstract] [Full Text] [PDF]

				K. Podsypanina, R. T. Lee, C. Politis, I. Hennessy, A. Crane, J. Puc, M. Neshat, H. Wang, L. Yang, J. Gibbons, et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice PNAS, August 10, 2001; (2001) 171060098. [Abstract] [Full Text] [PDF]

				L. Simpson, J. Li, D. Liaw, I. Hennessy, J. Oliner, F. Christians, and R. Parsons PTEN Expression Causes Feedback Upregulation of Insulin Receptor Substrate 2 Mol. Cell. Biol., June 15, 2001; 21(12): 3947 - 3958. [Abstract] [Full Text]

				X. Zhu, C.-H. Kwon, P. W. Schlosshauer, L. H. Ellenson, and S. J. Baker PTEN Induces G1 Cell Cycle Arrest and Decreases Cyclin D3 Levels in Endometrial Carcinoma Cells Cancer Res., June 1, 2001; 61(11): 4569 - 4575. [Abstract] [Full Text] [PDF]

				X. Gao and D. Pan TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth Genes & Dev., June 1, 2001; 15(11): 1383 - 1392. [Abstract] [Full Text] [PDF]