Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5

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Andree, B., Duprez, D., Vorbusch, B., Arnold, H.-H. and Brand, T (1998). BMP-2 induces ectopic expression of cardiac lineage markers and interferes with somite formation in chicken embryos. Mech. Dev 70, 119-131.[Medline]

Arceci, R. J., King, A. A., Simon, M. C., Orkin, S. H. andWilson, D. B (1993). Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Molec. Cell. Biol 13, 2235-2246.[Abstract/Free Full Text]

Azpiazu, N. and Frasch, M (1993). tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev 7, 1325-1340.[Abstract/Free Full Text]

Behringer, R. R., Crotty, D. A., Tennyson, V. M., Brinster, R. L., Palmiter, R. D. and Wolgemuth, D. L (1993). Sequences 5of the homeobox of the Hox-1.4 gene direct tissue-specific expression of lacZ during mouse development. Development 117, 823-833.[Abstract]

Biben, C. and Harvey, R. P (1997). Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes Dev 11, 1357-1369.[Abstract/Free Full Text]

Biben, C., Hatzistavrou, T. and Harvey, R. P (1998). Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart. Mech. Dev 73, 125-127.[Medline]

Bodmer, R., Jan, L. Y. and Jan, Y. N (1990). A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Development 110, 661-669.[Abstract/Free Full Text]

Chen, C. Y. and Schwartz, R. J (1995). Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5. J. Biol. Chem 270, 15628-15633.[Abstract/Free Full Text]

Chen, C. Y., Croissant, J., Majesky, M., Topouzis, S., McQuinn, T., Frankovsky, M. J. and Schwartz, R. J (1996). Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements. Developmental Genetics 19, 119-130.[Medline]

Chen, C. Y. and Schwartz, R. J (1996). Recruitment of the tinman homologue Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription. Molec. Cell. Biol 16, 6372-6384.[Abstract]

Croissant, J. D., Kim, J. H., Eichele, G., Goering, L., Lough, J., Prywes, R. and Schwartz, R. J (1996). Avian serum response factor expression restricted primarily to muscle cell lineages is required for alpha-actin gene transcription. Dev. Biol 177, 250-264.[Medline]

Damante, G., Fabbro, D., Pellizzari, L., Civitareale, D., Guazzi, S., Polycarpou-Schwartz, M., Cauci, S., Quadrifoglio, F., Formisano, S. and Di Lauro, R (1994). Sequence-specific DNA recognition by the thyroid transcription factor-1 homeodomain. Nucleic Acids Res 22, 3075-3083.[Abstract/Free Full Text]

Durocher, D., Chen, C. Y., Ardati, A., Schwartz, R. J. and Nemer, M (1996). The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium. Molec. Cell. Biol 16, 4648-4655.[Abstract]

Edmondson, D. G., Lyons, G. E., Martin, J. F. and Olson, E. N (1994). Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development 120, 1251-1263.[Abstract]

Evans, S., Yan, W., Murillo, M. P., Ponce, J. and Papalopulu, N (1995). Tinman , a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3 , a second homologue of tinman. Development 121, 3889-3899.[Abstract]

Fire, A., Harrison, S. W. and Dixon, D (1990). A modular set of LacZ fusion vectors for studying gene expression in Caenorhabditis elegans. Gene 93, 189-198.[Medline]

Fishman, M. C. and Chien, K. R (1997). Fashioning the vertebrate heart: earliest embryonic decisions. Development 124, 2099-2117.[Abstract]

Fishman, M. C. and Olson, E. N (1997). Parsing the heart: genetic modules for organ assembly. Cell 91, 153-156.[Medline]

Franco, D., Kelly, R., Lameres, W. H., Buckingham, M. and Moorman, A. F. M (1997). Regionalized transcriptional domains of myosin light chain 3f transgenes in the embryonic mouse heart: morphogenetic implications. Dev. Biol 188, 17-33.[Medline]

Frasch, M (1995). Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo. Nature 374, 464-467.[Medline]

Gajewski, K., Kim, Y., Lee, Y. M., Olson, E. N. and Schulz, R. A (1997). D-mef2 is a target for Tinman activation during Drosophila heart development. EMBO J 16, 515-522.[Medline]

Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C. and Niehrs, C (1998). Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391, 357-362.[Medline]

Harvey, R. P (1996). NK-2 homeobox genes and heart development. Dev. Biol 178, 203-216.[Medline]

He, C. Z. and Burch, J. B. E (1997). The chicken GATA-6 locus contains multiple control regions that confer distinct patterns of heart region-specific expression in transgenic mouse embryos. J. Biol. Chem 272, 28550-28556.[Abstract/Free Full Text]

Kozak, M (1984). Compilation and analysis of sequences upstream from the translation start site in eukaryotic mRNAs. Nucleic Acids Research 12, 857-872.[Abstract/Free Full Text]

Kuo, C. T., Morrisey, E. E., Anandappa, R., Sigrist, K., Lu, M. M. X., Parmacek, M. S., Soudais, C. and Leiden, J. M (1997). GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev 11, 1048-1060.[Abstract/Free Full Text]

Lazzaro, D., Price, M., De Felice, M. and Di Lauro, R (1991). The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development 113, 1093-1104.[Abstract]

Lee, K. H., Xu, Q. and Breitbart, R. E (1996). A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Dev. Biol 180, 722-731.[Medline]

Lee, Y.M., Park, T., Schulz, R.A., Kim, Y (1997). Twist-mediated activation of the NK-4 homeobox gene in the visceral mesoderm of Drosophila requires two distinct clusters of E-box regulatory elements. J. Biol. Chem 272, 17531-17541.[Abstract/Free Full Text]

Lints, T. J., Parsons, L. M., Hartley, L., Lyons, I. and Harvey, R. P (1993). Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119, 419-431.[Abstract]

Lyons, I., Parsons, L. M., Hartley, L., Li, R., Andrews, J. E., Robb, L. and Harvey, R. P (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev 9, 1654-1666.[Abstract/Free Full Text]

Mizuno, K., Gonzalez, F. J. and Kimura, S (1991). Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional characterization, and structural identity with thyroid transcription factor TTF-1. Molec. Cell. Biol 11, 4927-4933.[Abstract/Free Full Text]

Molkentin, J. D., Kalvakolanu, D. V. and Markham, B. E (1994). Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Molec. Cell. Biol 14, 4947-4957.[Abstract/Free Full Text]

Molkentin, J. D., Firulli, A. B., Black, B. L., Martin, J. F., Hustad, C. M., Copeland, N., Jenkins, N., Lyons, G. and Olson, E. N (1996). MEF2B is a potent transactivator expressed in early myogenic lineages. Molecular & Cellular Biology 16, 3814-3824.[Abstract]

Molkentin, J. D., Lin, Q., Duncan, S. A. and Olson, E. N (1997). Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev 11, 1061-1072.[Abstract/Free Full Text]

Nascone, N. and Mercola, M (1995). An inductive role for the endoderm in Xenopus cardiogenesis. Development 121, 515-523.[Abstract]

Nikolova, M., Chen, X. and Lufkin, T (1997). Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos. Mech. Dev 69, 215-218.[Medline]

Oka, T., Komuro, I., Shiojima, I., Hiroi, Y., Mizuno, T., Aikawa, R., Akazawa, H., Yamazaki, T. and Yazaki, Y (1997). Autoregulation of human cardiac gene CSX1: mediation by the enhancer element in the first intron. Heart Vessels 12, 10-14.[Medline]

Pabst, O., Schneider, A., Brand, T. and Arnold, H. H (1997). The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre-and postnatal mouse development. Dev. Dynamics 209, 29-35.[Medline]

Park, M., Wu, X., Golden, K., Axelrod, J. D. and Bodmer, R (1996). The wingless signaling pathway is directly involved in Drosophila heart development. Dev. Biol 177, 104-116.[Medline]

Price, M., Lazzaro, D., Pohl, T., Mattei, M. G., Ruther, U., Olivo, J. C., Duboule, D. and Di Lauro, R (1992). Regional expression of homeobox gene Nkx-2.2 in developing mammalian forebrain. Neuron 8, 241-255.[Medline]

Ray, M. K., Chen, C.-Y., Schwartz, R. J. and DeMayo, F. J (1996). Transcriptional regulation of mouse clara cell-specific protein (mCC10)gene by the NKx transcription factor family members Thyroid Transcription Factor 1 and cardiac muscle specific homeobox protein (CSX). Mol. Cell. Biol 16, 2056-2064.[Abstract]

Reecy, J. M., Yamada, M., Cummings, K., Sosic, D., Chen, C. Y., Eichele, G., Olson, E. N. and Schwartz, R. J (1997). Chicken Nkx-2.8: a novel homeobox gene expressed in early heart progenitor cells and pharyngeal pouch-2 and-3 endoderm. Dev. Biol 188, 295-311.[Medline]

Ross, R. S., Navankasattusas, S., Harvey, R. P. and Chien, K. R (1996). An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and establishes an anterior-posterior gradient of expression. Development 122, 1799-1809.[Abstract]

Sater, A. K. and Jacobson, A. G (1989). The specification of heart mesoderm occurs during gastrulation in Xenopus laevis. Development 105, 821-830.[Abstract/Free Full Text]

Sater, A. K. and Jacobson, A. G (1990). The restriction of the heart morphogenetic field in Xenopus laevis. Dev. Biol 140, 328-336.[Medline]

Schultheiss, T. M., Xydas, S. and Lassar, A. B (1995). Induction of avian cardiac myogenesis by anterior endoderm. Development 121, 4203-4214.[Abstract]

Schultheiss, T. M., Burch, J. B. and Lassar, A. B (1997). A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev 11, 451-462.[Abstract/Free Full Text]

Searcy, R. D., Vincent, E. B., Liberatore, C. M. and Yutzey, K. E (1998). A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice. Development 125, 4461-4470.[Abstract]

Sepulveda, J. L., Belaguli, N., Nigam, V., Chen, C.-Y., Nemer, M. and Schwartz, R. J (1998). GATA4 and Nkx2-5 coactivate Nkx-2 DNA binding targets: Role for regulating early cardiac gene expression. Molec. Cell. Biol 18, 3405-3415.[Abstract/Free Full Text]

Shiojima, I., Komuro, I., Mizuno, T., Aikawa, R., Akazawa, H., Oka, T., Yamazaki, T, Yazaki, Y. and Yamazaki, T (1996). Molecular cloning and characterization of human cardiac homeobox gene CSX1. Circulation Research 79, 920-929.[Abstract/Free Full Text]

Tonissen, K. F., Drysdale, T. A., Lints, T. J., Harvey, R. P. and Krieg, P. A (1994). XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development. Dev. Biol 162, 325-328.[Medline]

Xu, X., Yin, Y., Hudson, J. B., Ferguson, E. L. and Frasch, M (1998). Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev 12, 2354-2370.[Abstract/Free Full Text]

Yin, Z., Xu, X. L. and Frasch, M (1997). Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development. Development 124, 4971-4982.[Abstract]

Zou, Y., Evans, S., Chen, J., Kuo, H. C., Harvey, R. P. and Chien, K. R (1997). CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. Development 124, 793-804.[Abstract]

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				M. Xin, C. A. Davis, J. D. Molkentin, C.-L. Lien, S. A. Duncan, J. A. Richardson, and E. N. Olson A threshold of GATA4 and GATA6 expression is required for cardiovascular development PNAS, July 25, 2006; 103(30): 11189 - 11194. [Abstract] [Full Text] [PDF]

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				K. Foshay, G. Rodriguez, B. Hoel, J. Narayan, and G. I. Gallicano JAK2/STAT3 Directs Cardiomyogenesis Within Murine Embryonic Stem Cells In Vitro Stem Cells, April 1, 2005; 23(4): 530 - 543. [Abstract] [Full Text] [PDF]

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				C. O. Brown III, X. Chi, E. Garcia-Gras, M. Shirai, X.-H. Feng, and R. J. Schwartz The Cardiac Determination Factor, Nkx2-5, Is Activated by Mutual Cofactors GATA-4 and Smad1/4 via a Novel Upstream Enhancer J. Biol. Chem., March 12, 2004; 279(11): 10659 - 10669. [Abstract] [Full Text] [PDF]

				M. T. Tetzlaff, W. Yu, M. Li, P. Zhang, M. Finegold, K. Mahon, J. W. Harper, R. J. Schwartz, and S. J. Elledge Inaugural Article, From The Cover: Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein PNAS, March 9, 2004; 101(10): 3338 - 3345. [Abstract] [Full Text] [PDF]

				S. Nagel, M. Kaufmann, H. G. Drexler, and R. A. F. MacLeod The Cardiac Homeobox Gene NKX2-5 Is Deregulated by Juxtaposition with BCL11B in Pediatric T-ALL Cell Lines via a Novel t(5;14)(q35.1;q32.2) Cancer Res., September 1, 2003; 63(17): 5329 - 5334. [Abstract] [Full Text] [PDF]

				B. V. Latinkic, S. Kotecha, and T. J. Mohun Induction of cardiomyocytes by GATA4 in Xenopus ectodermal explants Development, August 15, 2003; 130(16): 3865 - 3876. [Abstract] [Full Text] [PDF]

				P. E.M.H. Habets, A. F.M. Moorman, and V. M. Christoffels Regulatory modules in the developing heart Cardiovasc Res, May 1, 2003; 58(2): 246 - 263. [Abstract] [Full Text] [PDF]

				S. Zaffran and M. Frasch Early Signals in Cardiac Development Circ. Res., September 20, 2002; 91(6): 457 - 469. [Abstract] [Full Text] [PDF]

				K. L. Waldo, D. H. Kumiski, K. T. Wallis, H. A. Stadt, Mary. R. Hutson, D. H. Platt, and M. L. Kirby Conotruncal myocardium arises from a secondary heart field Development, August 15, 2001; 128(16): 3179 - 3188. [Abstract] [Full Text] [PDF]

				Y. Kong, J. M. Shelton, B. Rothermel, X. Li, J. A. Richardson, R. Bassel-Duby, and R. S. Williams Cardiac-Specific LIM Protein FHL2 Modifies the Hypertrophic Response to {beta}-Adrenergic Stimulation Circulation, June 5, 2001; 103(22): 2731 - 2738. [Abstract] [Full Text] [PDF]

				D. McFadden, J Charite, J. Richardson, D Srivastava, A. Firulli, and E. Olson A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart Development, January 12, 2000; 127(24): 5331 - 5341. [Abstract] [PDF]

				H Kuo, J Chen, P Ruiz-Lozano, Y Zou, M Nemer, and K. Chien Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis Development, January 10, 1999; 126(19): 4223 - 4234. [Abstract] [PDF]

				J. A. Carson, R. A. Fillmore, R. J. Schwartz, and W. E. Zimmer The Smooth Muscle gamma -Actin Gene Promoter Is a Molecular Target for the Mouse bagpipe Homologue, mNkx3-1, and Serum Response Factor J. Biol. Chem., December 8, 2000; 275(50): 39061 - 39072. [Abstract] [Full Text] [PDF]

				C. Morisco, K. Seta, S. E. Hardt, Y. Lee, S. F. Vatner, and J. Sadoshima Glycogen Synthase Kinase 3beta Regulates GATA4 in Cardiac Myocytes J. Biol. Chem., July 20, 2001; 276(30): 28586 - 28597. [Abstract] [Full Text] [PDF]