The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development

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C.-F. Peng, Y. Wei, J. M. Levsky, T. V. McDonald, G. Childs, and R. N. Kitsis
Microarray analysis of global changes in gene expression during cardiac myocyte differentiation
Physiol Genomics, June 3, 2002; 9(3): 145 - 155.
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P. E.M.H. Habets, A. F.M. Moorman, D. E.W. Clout, M. A. van Roon, M. Lingbeek, M. van Lohuizen, M. Campione, and V. M. Christoffels
Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation
Genes & Dev., May 15, 2002; 16(10): 1234 - 1246.
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B. G. Bruneau
Transcriptional Regulation of Vertebrate Cardiac Morphogenesis
Circ. Res., March 22, 2002; 90(5): 509 - 519.
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M. Jamali, P. J. Rogerson, S. Wilton, and I. S. Skerjanc
Nkx2-5 Activity Is Essential for Cardiomyogenesis
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				N. Sultana, K. Nag, K. Hoshijima, D. W. Laird, A. Kawakami, and S. Hirose Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression PNAS, March 25, 2008; 105(12): 4763 - 4768. [Abstract] [Full Text] [PDF]

				L. Ryckebusch, Z. Wang, N. Bertrand, S.-C. Lin, X. Chi, R. Schwartz, S. Zaffran, and K. Niederreither Retinoic acid deficiency alters second heart field formation PNAS, February 26, 2008; 105(8): 2913 - 2918. [Abstract] [Full Text] [PDF]

				K.-L. Laugwitz, A. Moretti, L. Caron, A. Nakano, and K. R. Chien Islet1 cardiovascular progenitors: a single source for heart lineages? Development, January 15, 2008; 135(2): 193 - 205. [Abstract] [Full Text] [PDF]

				Y. Chen, W. H. Yuen, J. Fu, G. Huang, A. J. Melendez, F. B. M. Ibrahim, H. Lu, and X. Cao The Mitochondrial Respiratory Chain Controls Intracellular Calcium Signaling and NFAT Activity Essential for Heart Formation in Xenopus laevis Mol. Cell. Biol., September 15, 2007; 27(18): 6420 - 6432. [Abstract] [Full Text] [PDF]

				J. L. Lucitti, E. A. V. Jones, C. Huang, J. Chen, S. E. Fraser, and M. E. Dickinson Vascular remodeling of the mouse yolk sac requires hemodynamic force Development, September 15, 2007; 134(18): 3317 - 3326. [Abstract] [Full Text] [PDF]

				S. Unezaki, R. Horai, K. Sudo, Y. Iwakura, and S. Ito Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice Genes Cells, June 1, 2007; 12(6): 773 - 785. [Abstract] [Full Text] [PDF]

				S. J. Matkovich, A. Diwan, J. L. Klanke, D. J. Hammer, Y. Marreez, A. M. Odley, E. W. Brunskill, W. J. Koch, R. J. Schwartz, and G. W. Dorn II Cardiac-Specific Ablation of G-Protein Receptor Kinase 2 Redefines Its Roles in Heart Development and {beta}-Adrenergic Signaling Circ. Res., October 27, 2006; 99(9): 996 - 1003. [Abstract] [Full Text] [PDF]

				C. Karamboulas, G. D. Dakubo, J. Liu, Y. De Repentigny, K. Yutzey, V. A. Wallace, R. Kothary, and I. S. Skerjanc Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis J. Cell Sci., October 15, 2006; 119(20): 4315 - 4321. [Abstract] [Full Text] [PDF]

				S. Zaffran, I. Reim, L. Qian, P. C. Lo, R. Bodmer, and M. Frasch Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila Development, October 15, 2006; 133(20): 4073 - 4083. [Abstract] [Full Text] [PDF]

				J. Rivera-Feliciano, K.-H. Lee, S. W. Kong, S. Rajagopal, Q. Ma, Z. Springer, S. Izumo, C. J. Tabin, and W. T. Pu Development of heart valves requires Gata4 expression in endothelial-derived cells Development, September 15, 2006; 133(18): 3607 - 3618. [Abstract] [Full Text] [PDF]

				N. Gude, J. Muraski, M. Rubio, J. Kajstura, E. Schaefer, P. Anversa, and M. A. Sussman Akt Promotes Increased Cardiomyocyte Cycling and Expansion of the Cardiac Progenitor Cell Population Circ. Res., August 18, 2006; 99(4): 381 - 388. [Abstract] [Full Text] [PDF]

				R. Majumdar, M. Yagubyan, G. Sarkar, M. E. Bolander, and T. M. Sundt III Bicuspid aortic valve and ascending aortic aneurysm are not associated with germline or somatic homeobox NKX2-5 gene polymorphism in 19 patients J. Thorac. Cardiovasc. Surg., June 1, 2006; 131(6): 1301 - 1305. [Abstract] [Full Text] [PDF]

				F. A. Stennard and R. P. Harvey T-box transcription factors and their roles in regulatory hierarchies in the developing heart Development, November 15, 2005; 132(22): 4897 - 4910. [Abstract] [Full Text] [PDF]

				X. Chi, P. K. Chatterjee, W. Wilson III, S.-X. Zhang, F. J. DeMayo, and R. J. Schwartz Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modules PNAS, September 20, 2005; 102(38): 13490 - 13495. [Abstract] [Full Text] [PDF]

				A. C. Houweling, M. M. van Borren, A. F.M. Moorman, and V. M. Christoffels Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease Cardiovasc Res, September 1, 2005; 67(4): 583 - 593. [Abstract] [Full Text] [PDF]

				L. C. Mounkes, S. V. Kozlov, J. N. Rottman, and C. L. Stewart Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice Hum. Mol. Genet., August 1, 2005; 14(15): 2167 - 2180. [Abstract] [Full Text] [PDF]

				J. K. Takeuchi, M. Mileikovskaia, K. Koshiba-Takeuchi, A. B. Heidt, A. D. Mori, E. P. Arruda, M. Gertsenstein, R. Georges, L. Davidson, R. Mo, et al. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development Development, May 15, 2005; 132(10): 2463 - 2474. [Abstract] [Full Text] [PDF]

				A. M. Riazi, H. Lee, C. Hsu, and G. Van Arsdell CSX/Nkx2.5 Modulates Differentiation of Skeletal Myoblasts and Promotes Differentiation into Neuronal Cells in Vitro J. Biol. Chem., March 18, 2005; 280(11): 10716 - 10720. [Abstract] [Full Text] [PDF]

				E. M. Small, A. S. Warkman, D.-Z. Wang, L. B. Sutherland, E. N. Olson, and P. A. Krieg Myocardin is sufficient and necessary for cardiac gene expression in Xenopus Development, March 1, 2005; 132(5): 987 - 997. [Abstract] [Full Text] [PDF]

				D. G. McFadden, A. C. Barbosa, J. A. Richardson, M. D. Schneider, D. Srivastava, and E. N. Olson The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner Development, January 1, 2005; 132(1): 189 - 201. [Abstract] [Full Text] [PDF]

				Z. Harrelson, R. G. Kelly, S. N. Goldin, J. J. Gibson-Brown, R. J. Bollag, L. M. Silver, and V. E. Papaioannou Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development Development, October 15, 2004; 131(20): 5041 - 5052. [Abstract] [Full Text] [PDF]

				S. Li, D. Zhou, M. M. Lu, and E. E. Morrisey Advanced Cardiac Morphogenesis Does Not Require Heart Tube Fusion Science, September 10, 2004; 305(5690): 1619 - 1622. [Abstract] [Full Text] [PDF]

				A. M. Masino, T. D. Gallardo, C. A. Wilcox, E. N. Olson, R. S. Williams, and D. J. Garry Transcriptional Regulation of Cardiac Progenitor Cell Populations Circ. Res., August 20, 2004; 95(4): 389 - 397. [Abstract] [Full Text] [PDF]

				M. Ponticos, T. Partridge, C. M. Black, D. J. Abraham, and G. Bou-Gharios Regulation of Collagen Type I in Vascular Smooth Muscle Cells by Competition between Nkx2.5 and {delta}EF1/ZEB1 Mol. Cell. Biol., July 15, 2004; 24(14): 6151 - 6161. [Abstract] [Full Text] [PDF]

				H. Xu, M. Morishima, J. N. Wylie, R. J. Schwartz, B. G. Bruneau, E. A. Lindsay, and A. Baldini Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract Development, July 1, 2004; 131(13): 3217 - 3227. [Abstract] [Full Text] [PDF]

				K. Togi, T. Kawamoto, R. Yamauchi, Y. Yoshida, T. Kita, and M. Tanaka Role of Hand1/eHAND in the Dorso-Ventral Patterning and Interventricular Septum Formation in the Embryonic Heart Mol. Cell. Biol., June 1, 2004; 24(11): 4627 - 4635. [Abstract] [Full Text] [PDF]

				S. M. Reamon-Buettner, H. Hecker, K. Spanel-Borowski, S. Craatz, E. Kuenzel, and J. Borlak Novel NKX2-5 Mutations in Diseased Heart Tissues of Patients with Cardiac Malformations Am. J. Pathol., June 1, 2004; 164(6): 2117 - 2125. [Abstract] [Full Text] [PDF]

				J. R. McMullen, T. Shioi, W.-Y. Huang, L. Zhang, O. Tarnavski, E. Bisping, M. Schinke, S. Kong, M. C. Sherwood, J. Brown, et al. The Insulin-like Growth Factor 1 Receptor Induces Physiological Heart Growth via the Phosphoinositide 3-Kinase(p110{alpha}) Pathway J. Biol. Chem., February 6, 2004; 279(6): 4782 - 4793. [Abstract] [Full Text] [PDF]

				T. Ueyama, H. Kasahara, T. Ishiwata, Q. Nie, and S. Izumo Myocardin Expression Is Regulated by Nkx2.5, and Its Function Is Required for Cardiomyogenesis Mol. Cell. Biol., December 15, 2003; 23(24): 9222 - 9232. [Abstract] [Full Text] [PDF]

				C. Huang, F. Sheikh, M. Hollander, C. Cai, D. Becker, P.-H. Chu, S. Evans, and J. Chen Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis Development, December 15, 2003; 130(24): 6111 - 6119. [Abstract] [Full Text] [PDF]