Mechanisms of GDF-5 action during skeletal development

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				P. Purcell, B. W. Joo, J. K. Hu, P. V. Tran, M. L. Calicchio, D. J. O'Connell, R. L. Maas, and C. J. Tabin Temporomandibular joint formation requires two distinct hedgehog-dependent steps PNAS, October 27, 2009; 106(43): 18297 - 18302. [Abstract] [Full Text] [PDF]

				K. Chapman, A. Takahashi, I. Meulenbelt, C. Watson, J. Rodriguez-Lopez, R. Egli, A. Tsezou, K. N. Malizos, M. Kloppenburg, D. Shi, et al. A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility Hum. Mol. Genet., May 15, 2008; 17(10): 1497 - 1504. [Abstract] [Full Text] [PDF]

				K. Fujimura, Y. Terai, N. Ishiguro, M. Miya, M. Nishida, and N. Okada Heterotypy in the N-Terminal Region of Growth/Differentiation Factor 5 (GDF5) Mature Protein during Teleost Evolution Mol. Biol. Evol., May 1, 2008; 25(5): 797 - 800. [Abstract] [Full Text] [PDF]

				H. Masuya, K. Nishida, T. Furuichi, H. Toki, G. Nishimura, H. Kawabata, H. Yokoyama, A. Yoshida, S. Tominaga, J. Nagano, et al. A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice Hum. Mol. Genet., October 1, 2007; 16(19): 2366 - 2375. [Abstract] [Full Text] [PDF]

				L. Southam, J. Rodriguez-Lopez, J. M. Wilkins, M. Pombo-Suarez, S. Snelling, J. J. Gomez-Reino, K. Chapman, A. Gonzalez, and J. Loughlin An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage Hum. Mol. Genet., September 15, 2007; 16(18): 2226 - 2232. [Abstract] [Full Text] [PDF]

				J. T. Thomas, D. Prakash, K. Weih, and M. Moos Jr. CDMP1/GDF5 Has Specific Processing Requirements That Restrict Its Action to Joint Surfaces J. Biol. Chem., September 8, 2006; 281(36): 26725 - 26733. [Abstract] [Full Text] [PDF]

				R. Meech, D. B. Edelman, F. S. Jones, and H. P. Makarenkova The homeobox transcription factor Barx2 regulates chondrogenesis during limb development Development, May 1, 2005; 132(9): 2135 - 2146. [Abstract] [Full Text] [PDF]

				O Demirhan, S Turkmen, G C Schwabe, S Soyupak, E Akgul, D Tastemir, D Karahan, S Mundlos, and K Lehmann A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies J. Med. Genet., April 1, 2005; 42(4): 314 - 317. [Abstract] [Full Text] [PDF]

				M. Sammar, S. Stricker, G. C. Schwabe, C. Sieber, A. Hartung, M. Hanke, I. Oishi, J. Pohl, Y. Minami, W. Sebald, et al. Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2 Genes Cells, December 1, 2004; 9(12): 1227 - 1238. [Abstract] [Full Text] [PDF]

				X. Guo, T. F. Day, X. Jiang, L. Garrett-Beal, L. Topol, and Y. Yang Wnt/{beta}-catenin signaling is sufficient and necessary for synovial joint formation Genes & Dev., October 1, 2004; 18(19): 2404 - 2417. [Abstract] [Full Text] [PDF]

				D. Garciadiego-Cazares, C. Rosales, M. Katoh, and J. Chimal-Monroy Coordination of chondrocyte differentiation and joint formation by {alpha}5{beta}1 integrin in the developing appendicular skeleton Development, October 1, 2004; 131(19): 4735 - 4742. [Abstract] [Full Text] [PDF]

				K. Lehmann, P. Seemann, S. Stricker, M. Sammar, B. Meyer, K. Suring, F. Majewski, S. Tinschert, K.-H. Grzeschik, D. Muller, et al. From the Cover: Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2 PNAS, October 14, 2003; 100(21): 12277 - 12282. [Abstract] [Full Text] [PDF]

				P. G. Buxton, B. Hall, C. W. Archer, and P. Francis-West Secondary chondrocyte-derived Ihh stimulates proliferation of periosteal cells during chick development Development, October 1, 2003; 130(19): 4729 - 4739. [Abstract] [Full Text] [PDF]

				K. Anakwe, L. Robson, J. Hadley, P. Buxton, V. Church, S. Allen, C. Hartmann, B. Harfe, T. Nohno, A. M. C. Brown, et al. Wnt signalling regulates myogenic differentiation in the developing avian wing Development, August 1, 2003; 130(15): 3503 - 3514. [Abstract] [Full Text] [PDF]

				E. Canalis, A. N. Economides, and E. Gazzerro Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton Endocr. Rev., April 1, 2003; 24(2): 218 - 235. [Abstract] [Full Text] [PDF]

				C. T. Miller, D. Yelon, D. Y. R. Stainier, and C. B. Kimmel Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint Development, April 1, 2003; 130(7): 1353 - 1365. [Abstract] [Full Text] [PDF]

				V. Church, T. Nohno, C. Linker, C. Marcelle, and P. Francis-West Wnt regulation of chondrocyte differentiation J. Cell Sci., March 14, 2003; 115(24): 4809 - 4818. [Abstract] [Full Text] [PDF]

				R. Rivas and F. Shapiro Structural Stages in the Development of the Long Bones and Epiphyses : A Study in the New Zealand White Rabbit J. Bone Joint Surg. Am., January 1, 2002; 84(1): 85 - 100. [Abstract] [Full Text] [PDF]

				P. Buxton, C. Edwards, C. W. Archer, and P. Francis-West Growth/Differentiation Factor-5 (GDF-5) and Skeletal Development J. Bone Joint Surg. Am., April 1, 2001; 83(90010): S23 - 30. [Abstract] [Full Text] [PDF]

				S. Baur, J. Mai, and S. Dymecki Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity Development, January 2, 2000; 127(3): 605 - 619. [Abstract] [PDF]

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