Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

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E. A. Morgan, S. B. Nguyen, V. Scott, and H. S. Stadler
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
Development, July 15, 2003; 130(14): 3095 - 3109.
[Abstract] [Full Text] [PDF]

L. A. Naiche and V. E. Papaioannou
Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois
Development, June 15, 2003; 130(12): 2681 - 2693.
[Abstract] [Full Text] [PDF]

S. S. Chirala, H. Chang, M. Matzuk, L. Abu-Elheiga, J. Mao, K. Mahon, M. Finegold, and S. J. Wakil
Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero
PNAS, May 27, 2003; 100(11): 6358 - 6363.
[Abstract] [Full Text] [PDF]

M. J. Solloway and R. P. Harvey
Molecular pathways in myocardial development: a stem cell perspective
Cardiovasc Res, May 1, 2003; 58(2): 264 - 277.
[Abstract] [Full Text] [PDF]

E. Canalis, A. N. Economides, and E. Gazzerro
Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton
Endocr. Rev., April 1, 2003; 24(2): 218 - 235.
[Abstract] [Full Text] [PDF]

K. E. King, V. P. Iyemere, P. L. Weissberg, and C. M. Shanahan
Kruppel-like Factor 4 (KLF4/GKLF) Is a Target of Bone Morphogenetic Proteins and Transforming Growth Factor beta 1 in the Regulation of Vascular Smooth Muscle Cell Phenotype
J. Biol. Chem., March 21, 2003; 278(13): 11661 - 11669.
[Abstract] [Full Text] [PDF]

M. J. Walters, G. A. Wayman, J. C. Notis, R. H. Goodman, T. R. Soderling, and J. L. Christian
Calmodulin-dependent protein kinase IV mediated antagonism of BMP signaling regulates lineage and survival of hematopoietic progenitors
Development, March 5, 2003; 129(6): 1455 - 1466.
[Abstract] [Full Text] [PDF]

C. A. Adelman, S. Chattopadhyay, and J. J. Bieker
The BMP/BMPR/Smad

				S. A. Pangas, X. Li, L. Umans, A. Zwijsen, D. Huylebroeck, C. Gutierrez, D. Wang, J. F. Martin, S. P. Jamin, R. R. Behringer, et al. Conditional Deletion of Smad1 and Smad5 in Somatic Cells of Male and Female Gonads Leads to Metastatic Tumor Development in Mice Mol. Cell. Biol., January 1, 2008; 28(1): 248 - 257. [Abstract] [Full Text] [PDF]

				L. J. McReynolds, S. Gupta, M. E. Figueroa, M. C. Mullins, and T. Evans Smad1 and Smad5 differentially regulate embryonic hematopoiesis Blood, December 1, 2007; 110(12): 3881 - 3890. [Abstract] [Full Text] [PDF]

				J. L. Moody, S. Singbrant, G. Karlsson, U. Blank, M. Aspling, J. Flygare, D. Bryder, and S. Karlsson Endoglin Is Not Critical for Hematopoietic Stem Cell Engraftment and Reconstitution but Regulates Adult Erythroid Development Stem Cells, November 1, 2007; 25(11): 2809 - 2819. [Abstract] [Full Text] [PDF]

				J. Astorga and P. Carlsson Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4 Development, October 15, 2007; 134(20): 3753 - 3761. [Abstract] [Full Text] [PDF]

				D. Pan, T. Schomber, C. P. Kalberer, L. M. Terracciano, K. Hafen, W. Krenger, H. Hao-Shen, C. Deng, and R. C. Skoda Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice Blood, October 15, 2007; 110(8): 3049 - 3055. [Abstract] [Full Text] [PDF]

				L. A. Compton, D. A. Potash, C. B. Brown, and J. V. Barnett Coronary Vessel Development Is Dependent on the Type III Transforming Growth Factor {beta} Receptor Circ. Res., October 12, 2007; 101(8): 784 - 791. [Abstract] [Full Text] [PDF]

				D. Liu, J. Wang, B. Kinzel, M. Mueller, X. Mao, R. Valdez, Y. Liu, and E. Li Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity Blood, September 1, 2007; 110(5): 1502 - 1510. [Abstract] [Full Text] [PDF]

				L. Umans, L. Cox, M. Tjwa, V. Bito, L. Vermeire, K. Laperre, K. Sipido, L. Moons, D. Huylebroeck, and A. Zwijsen Inactivation of Smad5 in Endothelial Cells and Smooth Muscle Cells Demonstrates that Smad5 Is Required for Cardiac Homeostasis Am. J. Pathol., May 1, 2007; 170(5): 1460 - 1472. [Abstract] [Full Text] [PDF]

				B. T. Zafonte, S. Liu, M. Lynch-Kattman, I. Torregroza, L. Benvenuto, M. Kennedy, G. Keller, and T. Evans Smad1 expands the hemangioblast population within a limited developmental window Blood, January 15, 2007; 109(2): 516 - 523. [Abstract] [Full Text] [PDF]

				S. Singbrant, J. L. Moody, U. Blank, G. Karlsson, L. Umans, A. Zwijsen, and S. Karlsson Smad5 is dispensable for adult murine hematopoiesis Blood, December 1, 2006; 108(12): 3707 - 3712. [Abstract] [Full Text] [PDF]

				K.R. Barnett, C. Schilling, C.R. Greenfeld, D. Tomic, and J.A. Flaws Ovarian follicle development and transgenic mouse models Hum. Reprod. Update, September 1, 2006; 12(5): 537 - 555. [Abstract] [Full Text] [PDF]

				E. A. Bosman, K. A. Lawson, J. Debruyn, L. Beek, A. Francis, L. Schoonjans, D. Huylebroeck, and A. Zwijsen Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels Development, September 1, 2006; 133(17): 3399 - 3409. [Abstract] [Full Text] [PDF]

				C. Park, K. Lavine, Y. Mishina, C.-X. Deng, D. M. Ornitz, and K. Choi Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation Development, September 1, 2006; 133(17): 3473 - 3484. [Abstract] [Full Text] [PDF]

				R. L Jones, C. Stoikos, J. K Findlay, and L. A Salamonsen TGF-{beta} superfamily expression and actions in the endometrium and placenta. Reproduction, August 1, 2006; 132(2): 217 - 232. [Abstract] [Full Text] [PDF]

				C. Itman, S. Mendis, B. Barakat, and K. L. Loveland All in the family: TGF-{beta} family action in testis development. Reproduction, August 1, 2006; 132(2): 233 - 246. [Abstract] [Full Text] [PDF]

				D. T. Fritz, S. Jiang, J. Xu, and M. B. Rogers A Polymorphism in a Conserved Posttranscriptional Regulatory Motif Alters Bone Morphogenetic Protein 2 (BMP2) RNA:Protein Interactions Mol. Endocrinol., July 1, 2006; 20(7): 1574 - 1586. [Abstract] [Full Text] [PDF]

				H. Lindskog, E. Athley, E. Larsson, S. Lundin, M. Hellstrom, and P. Lindahl New Insights to Vascular Smooth Muscle Cell and Pericyte Differentiation of Mouse Embryonic Stem Cells In Vitro Arterioscler. Thromb. Vasc. Biol., July 1, 2006; 26(7): 1457 - 1464. [Abstract] [Full Text] [PDF]

				R. Li, A. Rosendahl, G. Brodin, A. M. Cheng, A. Ahgren, C. Sundquist, S. Kulkarni, T. Pawson, C.-H. Heldin, and R. L. Heuchel Deletion of Exon I of SMAD7 in Mice Results in Altered B Cell Responses. J. Immunol., June 1, 2006; 176(11): 6777 - 6784. [Abstract] [Full Text] [PDF]

				S. Gupta, H. Zhu, L. I. Zon, and T. Evans BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis Development, June 1, 2006; 133(11): 2177 - 2187. [Abstract] [Full Text] [PDF]

				M. Ku, S. Howard, W. Ni, G. Lagna, and A. Hata OAZ Regulates Bone Morphogenetic Protein Signaling through Smad6 Activation J. Biol. Chem., February 24, 2006; 281(8): 5277 - 5287. [Abstract] [Full Text] [PDF]

				E. A. Bosman, A. C. Penn, J. C. Ambrose, R. Kettleborough, D. L. Stemple, and K. P. Steel Multiple mutations in mouse Chd7 provide models for CHARGE syndrome Hum. Mol. Genet., November 15, 2005; 14(22): 3463 - 3476. [Abstract] [Full Text] [PDF]

				J.E. Ferguson III, R. W. Kelley, and C. Patterson Mechanisms of Endothelial Differentiation in Embryonic Vasculogenesis Arterioscler. Thromb. Vasc. Biol., November 1, 2005; 25(11): 2246 - 2254. [Abstract] [Full Text] [PDF]

				A. Armulik, A. Abramsson, and C. Betsholtz Endothelial/Pericyte Interactions Circ. Res., September 16, 2005; 97(6): 512 - 523. [Abstract] [Full Text] [PDF]

				T. M. Williams, M. E. Williams, J. H. Heaton, T. D. Gelehrter, and J. W. Innis Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability Nucleic Acids Res., August 8, 2005; 33(14): 4475 - 4484. [Abstract] [Full Text] [PDF]

				M. Hester, J. C. Thompson, J. Mills, Y. Liu, H. M. El-Hodiri, and M. Weinstein Smad1 and Smad8 Function Similarly in Mammalian Central Nervous System Development Mol. Cell. Biol., June 1, 2005; 25(11): 4683 - 4692. [Abstract] [Full Text] [PDF]

				C. Chen, H. Chen, J. Sun, P. Bringas Jr., Y. Chen, D. Warburton, and W. Shi Smad1 expression and function during mouse embryonic lung branching morphogenesis Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1033 - L1039. [Abstract] [Full Text] [PDF]

				F. Lebrin, M. Deckers, P. Bertolino, and P. ten Dijke TGF-{beta} receptor function in the endothelium Cardiovasc Res, February 15, 2005; 65(3): 599 - 608. [Abstract] [Full Text] [PDF]

				S. Sinha, M. H. Hoofnagle, P. A. Kingston, M. E. McCanna, and G. K. Owens Transforming growth factor-{beta}1 signaling contributes to development of smooth muscle cells from embryonic stem cells Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1560 - C1568. [Abstract] [Full Text] [PDF]

				D. T. Fritz, D. Liu, J. Xu, S. Jiang, and M. B. Rogers Conservation of Bmp2 Post-transcriptional Regulatory Mechanisms J. Biol. Chem., November 19, 2004; 279(47): 48950 - 48958. [Abstract] [Full Text] [PDF]

				R. M. Monteiro, S. M. C. de Sousa Lopes, O. Korchynskyi, P. t. Dijke, and C. L. Mummery Spatio-temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteins J. Cell Sci., September 15, 2004; 117(20): 4653 - 4663. [Abstract] [Full Text] [PDF]