Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Fernandez-Teran, M.
	Articles by Ros, M. A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Fernandez-Teran, M.
	Articles by Ros, M. A.

Buscher, D., Bosse, B., Heymer, J. and Ruther, U (1997). Evidence for genetic control of Shh by Gli3 in mouse limb development. Mech. Dev 62, 175-182.[Medline]

Chang, D. T., Lopez, A., Von Kessler, D. P., Chang, C., Simandl, B. K., Zhao, R., Selding, M. F., Fallon, J. F. and Beachy, P. A (1994). Products, genetic linkage and limb patterning activity of a murine hedgehog gene. Development 120, 3339-3353.[Abstract]

Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Cordoen, J. l., Westphal, H. and Beachy, P. A (1996). Cyclopia and axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413.[Medline]

Cohn, M. J. and Tickle, C (1996). Limbs: a model for pattern formation within the vertebrate body plan. Trends Genet 12, 253-257.[Medline]

Cohn, M. J., Izpis\234a-Belmonte, J. C., Abud, H., Heath, J. K. and Tickle, C (1995). Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell 80, 739-746.[Medline]

Cross, J. C., Flannery, M. L., Blanar, M. A., Steingrimsson, E., Jenkins, N. A., Copeland, N. G., Ruttern, W. J. and Werb, Z (1995). Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development 121, 2513-2523.[Abstract]

Cserjesi, P., Brown, D., Lyons, G. E. and Olson, E. N (1995). Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev. Biol 170, 664-678.[Medline]

Duprez, D. M., Kostakopoulou, K., Francis-West, P. H., Tickle, C. and Brickell, P. M (1996). Activation of Fgf-4 and Hoxd gene expression by BMP-2 expressing cells in the developing chick limb. Development 122, 1821-1828.[Abstract]

Fallon, J. F., Lopez, A., Ros, M. A., Savage, M., Olwin, B. and Simandl, B. K (1994). FGF2: apical ectodermal ridge growth signal for the chick limb development. Science 264, 104-107.[Abstract/Free Full Text]

Goff, D. J. and Tabin, C. J (1997). Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth. Development 124, 627-636.[Abstract]

Graham, A. and McGonnell, I (1999). Limb development: Farewell to arms. Curr. Biol 9, 368-370.

Grieshammer, U, Minowada, G., Pisenti, J. M., Abbott, U. K. and Martin, G. R (1996). The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation. Development 122, 3851-3861.[Abstract]

Hamburger, V. and Hamilton, H (1951). A series of normal stages in the development of the chick embryos. J. Morph 88, 49-92.

Hollenger, S. M., Sternglanz,R., Cheng, P. F. and Weintraub, H (1995). Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol. Cell. Biol 15, 3813-1304.[Abstract]

Hui, C. C. and Joyner, A. L (1993). A mouse model of Greig cephalopolysyndactyly syndrome: the extra toes mutation contains an intragenic deletion of the Gli3 gene. Nature Genet 3, 241-246.[Medline]

Izpis\234a-Belmonte, J. C., Tickle, C., Dolle, P., Wolpert, L. and Duboule, D (1991). Expression of the homeobox Hox-4 genes and the specification of position in chick wing development. Nature 350, 585-589.[Medline]

Jan, L. Y. and Jan, Y. N (1993). HLH proteins, fly neurogenesis, and vertebrate neurogenesis. Cell 75, 827-830.[Medline]

Johnson, R. L. and Tabin, C. J. ( (1997). Molecular models for vertebrate limb development. Cell 90, 979-990.[Medline]

Knezevic, V., De Santo, R., Schughart, K., Huffstadt, U., Chiang, C., Mahon, K., and Mackem, S (1997). Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic Hedgehog in a positive feedback loop. Development 124, 4523-4536.[Abstract]

Laufer, E., Nelson, C., Johnson, R. L. Morgan, B. A. and Tabin, C (1994). Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79, 993-1003.[Medline]

Lewis, K. E., Drossopoulou, G. Paton, I. R., Morrice, D. R., Robertson, K. E., Burt, D. W., Ingham, P. W., and Tickle, C (1999). Expression of Ptc and gli genes in talpid3 suggests bifurcation in Shh pathway. Development 126, 2397-2407.[Abstract]

Logan, C., Hornburch, A., Campbell, I. And Lumsden, A (1997). The role of Engrailed in establishing the dorsoventral axis of the chick limb. Development 124, 2317-2324.[Abstract]

Loomis, C. A., Harris, E., Michaud, J., Wurst, W., Hanks, M. and Joyner, A. L (1996). The mouse Engrailed-1 gene and ventral limb patterning. Nature 382, 360-363.[Medline]

Loomis, C. A., Kimmel, R. A., Tong, C. X., Michaud, J. and Joyner, A. L (1998). Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs. Development 125, 1137-1148.[Abstract]

Lopez-Mart\222nez, A., Chang, D. T., Chiang, C., Porter, J. A., Ros, M. A., Simandl, B. K., Beachy, P. A. and Fallon, J. F (1995). Limb-patterning activity and restricted posterior localization of the amino terminal product of Sonic hedgehog cleavage. Curr. Biol 5, 791-796.[Medline]

Lu, H.-C., Revelli, J.-P. Goering, L., Thaller, C. and Eichele, G (1997). Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb8 , a mediator of ZPA formation. Development 124, 1643-1651.[Abstract]

Mackem, S. and Knezevic, V (1999). Do 5Hoxd genes play a role in initiating or maintaining A-P polarizing signals in the limb?. Cell Tissue Res 296, 27-31.[Medline]

Mackem, S. and Mahon, K. A (1991). Ghox4.7: a chick homeobox gene expressed primarily in limb buds with limb-type difference in expression. Development 112, 791-806.[Abstract]

Marigo, V., Davey, R. A., Zuo, Y., Cunningham, J. M. and Tabin, C. J (1996). Biochemical evidence that patched is the hedgehog receptor. Nature 384, 176-179.[Medline]

Marigo, V. Scott, M. P., Johnson, R. L. Goodrich, L. V. and Tabin, C. J (1996). Conservation in Hedgehog signaling-induction of a chicken Patched homologue by Sonic hedgehog in the developing limb. Development 122, 1225-1233.[Abstract]

Marigo, V., Johnson, R. L., Vortkamp, A. and Tabin, C. J (1996). Sonic hedgehog differentially regulates expression of Gli and Gli3 during limb development. Dev. Biol 180, 273-283.[Medline]

Martin, G. R (1998). The roles of FGFs in the early development of vertebrate limbs. Gen. Dev 12, 1517-1586.

Masuya, H., Sagai, T., Morikawi, K. and Shiroishi, T (1997). Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse. Dev. Biol 182, 42-51.[Medline]

Masuya, H., Sagai, T., Wakana, S., Morikawi, K. and Shiroishi, T (1995). A duplicated zone of polarizing activity in polydactylous mouse mutants. Genes Dev 9, 1645-1653.[Abstract/Free Full Text]

Morgan, B. A. and Fekete, D. M (1996). Manipulating gene expression with replication-competent retroviruses. Methods Cell Biol 51, 185-218.[Medline]

Nelson, C. E., Morgan, B. A., Burke, A. C., Laufer, E., DiMambro, E., Murtaugh, L. C., Gonzales, E., Tessarollo, L., Parada, L. F. and Tabin,C (1996). Analysis of Hox gene expression in the chick limb bud. Development 122, 1449-1466.[Abstract]

Neumann, C. J. Grandel, H., Gaffield, W., Schulte-Meerker, S. and Nuslein-Volhard, C (1999). Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity. Development 126, 4817-4826.[Abstract]

Niswander, L., Jeffrey, S., Martin, G. R. and Tickle, C (1994). A positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature 371, 609-612.[Medline]

Nohno, T., Noji, S., Koyama, E., Ohyama, K., Myokai, F., Kuroiwa, A., Saito, T. and Taniguchi, S (1991). Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development. Cell 64, 1197-1201.[Medline]

Noramly, S., Pisenti, J., Abott, U., and Morgan, B. A (1996). Gene expression in the limbless mutant: polarized gene expression in the absence of Shh and an AER. Dev. Biol 179, 339-346.[Medline]

Ohuchi, H., Nakagawa, Y., Yamamoto, A., Araga, A., Ohata, T., Ishimaru, Y., Yoshioka, H., Kuwana, T., Nohno, T., Yamasaki, M., Itoh, N. and Noji, S (1997). The mesenchymal factor, FGF-10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development 124, 2235-2244.[Abstract]

Oliver, G., Wehr, R., Jenkins, N. A., Copeland, N. G., Cheyette, B. N. R., Hartenstein, V., Zipursky, S. L. and Gruss P (1995). Homeobox genes and connective tissue patterning. Development 121, 693-705.[Abstract]

Olson, E. N. and Klein, W. H (1994). bHLH factors in muscle development: Dead lines and commitments, what to leave in an what to leave out. Genes Dev 8, 1-8.[Free Full Text]

Parr, B. A. and McMahon, A. P (1995). Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes in mouse limb. Nature 374, 350-353.[Medline]

Qu, S., Niswander, K. D., Qunsheng, J., van der Meer, R., Keeney, D. and Magnuson, M. A (1997). Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development 124, 3999-4008.[Abstract]

Qu, S., Tucker, S. C., Ehrlich, J. S., Levorse, J. M., Flaherty, L. A., Wisdom, R. and Vogt, T. F (1998). Mutations in mouse aristaless-like4 causes Strong's polydactyly. Development 125, 2711-2721.[Abstract]

Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.[Medline]

Riddle, R. D., Ensini, M., Nelson, C., Tsuchida, T., Jessell, T. M. and Tabin, C (1995). Induction of the LIM homeobox gene Lmx1 by Wnt7a establishes dorsoventral pattern in the vertebrate limb. Cell 83, 631-640.[Medline]

Ros, M. A., Lopez-Mart\222nez, A., Simandl, B. K., Rodriguez, C., Izpis\234a Belmonte, J. C., Dahn, R. and Fallon, J. F (1996). The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions. Development 122, 2319-2330.[Abstract]

Rowe, D. A. and Fallon, J. F (1982). The proximodistal determination of skeletal parts in the developing chick leg. J. Embryol. Exp. Morphol 68, 1-7.[Medline]

Ruiz i Altaba, A (1999). Gli proteins and Hedgehog signalling. Trends Genet 15, 418-425.[Medline]

Saunders, J. W., Jr (1948). The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm. J. Exp Zool 108, 363-403.

Schwabe, J. W. R., Rodriguez-Esteban and Izpis\234a-Belmonte, J. C (1998). Limbs are moving\311 where are they going?. Trends in Genetics 14, 229-235.[Medline]

Schimmang, T., Lemaistre, M., Vortkamp, A. and Ruther, U (1992). Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes ( Xt ). Development 116, 799-804.[Abstract]

Srivastava, D., Cserjesi, P. and Olson, E. N (1995). A subclass of bHLH proteins required for cardiogenesis. Science 270, 1995-1999.[Abstract/Free Full Text]

Srivastava, D., Thomas, T., Lin, Q., Kirby, M. L., Brown, D. and Olson, E. N (1997). Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nature Genet 16, 154-160.[Medline]

Stratford, T.,Kostakopoulou, K., and Maden, M (1997). Hoxb-8 has a role in establishing early anterior-posterior polarity in chick forelimb but not hindlimb. Development 124, 4225-4234.[Abstract]

Summerbell, D., Lewis, J. H. and Wolpert, L (1973). Positional information in chick limb morphogenesis. Nature 224, 492-496.

Summerbell, D (1974). A quantitatively analysis of the effect of excision of the AER from the chick limb-bud. J. Embryol. Exp. Morphol 32, 651-660.[Medline]

Takahashi, M., Tamura, K., Buscher, D., Masuya, H., Yonei-Tamura, S., Matsumoto, K., Naitoh-Matsuo, Takeuchi, J., Ogura, K., Shiroishi, T., Ogura, T., and Izpisua-Belmonte (1998). The role of Alx4 in the establishment of anteroposterior polarity during vertebrate limb development. Development 125, 4417-4425.[Abstract]

Thomas, T., Kurihara, H., Yamagashi, H., Kurihara, Y., Yazaki, Y., Olson, E. N. and Srivastava, D (1998). A signaling cascade involving endothelin-1, dHAND and Msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development 125, 3005-3014.[Abstract]

Tickle, C (1981). The number of polarizing region cells required to specify additional digits in the developing chick wing. Nature 289, 295-298.[Medline]

Tickle, C., Summerbell, D. and Wolpert, L (1975). Positional signaling and specification of digits in chick limb morphogenesis. Nature 254, 199-202.[Medline]

Tickle, C., Lee, J. and Eichele, G (1985). A quantitative analysis of the effect of all-trans-retinoic acid on the pattern of chick wing development. Dev. Biol 109, 82-95.[Medline]

Vogel, A., Rodriguez, C., Warnken, W. and Izpis\234a-Belmonte, J. C (1995). Dorsal cell fate specified by chick Lmx1 during vertebrate limb development. Nature 378, 716-720.[Medline]

Wanek, N., Muneoka, K., Hollen-Dinsmore, G., Burton, R. and Bryant, S. V (1989). A staging system for mouse limb development. J. Exp. Zool 249, 41-49.[Medline]

Wanek, N., Gardiner, D. M., Muneoka, K. and Bryant, S. V (1991). Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud. Nature 350, 81-83.[Medline]

Yang, Y. and Niswander, L (1995). Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning. Cell 80, 939-947.[Medline]

Yang, Y., Drossopoulou, G., Chuang, P. T., Duprez, D., Mart\222, E., Bumcrot, D., Vargesson, N., Clarke, J., Niswander, L., McMahon, A. and Tickle, C (1997). Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development 124, 4393-4404.[Abstract]

Zu\226iga, A., Haramis, A.-P. G., McMahon, A. P. and Zeller, R (1999). Signal relay by BMP antagonism controls the SHH/FGF feedback loop in vertebrate limb buds. Nature 401, 598-602.[Medline]

This article has been cited by other articles:

J. M. Brito, M.-A. Teillet, and N. M. Le Douarin
Induction of mirror-image supernumerary jaws in chicken mandibular mesenchyme by Sonic Hedgehog-producing cells
Development, July 1, 2008; 135(13): 2311 - 2319.
[Abstract] [Full Text] [PDF]

B. A. Firulli, B. A. Redick, S. J. Conway, and A. B. Firulli
Mutations within Helix I of Twist1 Result in Distinct Limb Defects and Variation of DNA Binding Affinities
J. Biol. Chem., September 14, 2007; 282(37): 27536 - 27546.
[Abstract] [Full Text] [PDF]

P. Hill, B. Wang, and U. Ruther
The molecular basis of Pallister Hall associated polydactyly
Hum. Mol. Genet., September 1, 2007; 16(17): 2089 - 2096.
[Abstract] [Full Text] [PDF]

J. G. M. Thewissen, M. J. Cohn, L. S. Stevens, S. Bajpai, J. Heyning, and W. E. Horton Jr.
Developmental basis for hind-limb loss in dolphins and origin of the cetacean bodyplan
PNAS, May 30, 2006; 103(22): 8414 - 8418.
[Abstract] [Full Text] [PDF]

E. B. Johnson, R. E. Hammer, and J. Herz
Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice
Hum. Mol. Genet., November 15, 2005; 14(22): 3523 - 3538.
[Abstract] [Full Text] [PDF]

C. Rallis, J. Del Buono, and M. P. O. Logan
Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo
Development, April 15, 2005; 132(8): 1961 - 1970.
[Abstract] [Full Text] [PDF]

L.-B. Ruest, X. Xiang, K.-C. Lim, G. Levi, and D. E. Clouthier
Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity
Development, September 15, 2004; 131(18): 4413 - 4423.
[Abstract] [Full Text] [PDF]

F. A. Mic, I. O. Sirbu, and G. Duester
Retinoic Acid Synthesis Controlled by Raldh2 Is Required Early for Limb Bud Initiation and Then Later as a Proximodistal Signal during Apical Ectodermal Ridge Formation
J. Biol. Chem., June 18, 2004; 279(25): 26698 - 26706.
[Abstract] [Full Text] [PDF]

J. Zakany, M. Kmita, and D. Duboule
A Dual Role for Hox Genes in Limb Anterior-Posterior Asymmetry
Science, June 11, 2004; 304(5677): 1669 - 1672.
[Abstract] [Full Text] [PDF]

O. Krebs, C. M. Schreiner, W. J. Scott Jr, S. M. Bell, D. J. Robbins, J. A. Goetz, H. Alt, N. Hawes, E. Wolf, and J. Favor
Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud
Development, December 15, 2003; 130(24): 6037 - 6047.
[Abstract] [Full Text] [PDF]

M. A. Ros, R. D. Dahn, M. Fernandez-Teran, K. Rashka, N. C. Caruccio, S. M. Hasso, J. J. Bitgood, J. J. Lancman, and J. F. Fallon
The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb
Development, February 1, 2003; 130(3): 527 - 537.
[Abstract] [Full Text] [PDF]

P. Agarwal, J. N. Wylie, J. Galceran, O. Arkhitko, C. Li, C. Deng, R. Grosschedl, and B. G. Bruneau
Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo
Development, February 1, 2003; 130(3): 623 - 633.
[Abstract] [Full Text] [PDF]

A. Marcil, E. Dumontier, M. Chamberland, S. A. Camper, and J. Drouin
Pitx1 and Pitx2 are required for development of hindlimb buds
Development, January 1, 2003; 130(1): 45 - 55.
[Abstract] [Full Text] [PDF]

K. Niederreither, J. Vermot, B. Schuhbaur, P. Chambon, and P. Dolle
Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse
Development, August 1, 2002; 129(15): 3563 - 3574.
[Abstract] [Full Text] [PDF]

Y.-S. Dai and P. Cserjesi
The Basic Helix-Loop-Helix Factor, HAND2, Functions as a Transcriptional Activator by Binding to E-boxes as a Heterodimer
J. Biol. Chem., April 5, 2002; 277(15): 12604 - 12612.
[Abstract] [Full Text] [PDF]

P. te Welscher, M. Fernandez-Teran, M. A. Ros, and R. Zeller
Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling
Genes & Dev., February 15, 2002; 16(4): 421 - 426.
[Abstract] [Full Text] [PDF]

D. G. McFadden, J. McAnally, J. A. Richardson, J. Charite, and E. N. Olson
Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding
Development, January 7, 2002; 129(13): 3077 - 3088.
[Abstract] [Full Text] [PDF]

M. Dundar, T. M Gordon, I. Ozyazgan, F. Oguzkaya, Y. Ozkul, A. Cooke, A G. Wilkinson, S. Holloway, F. R Goodman, and J. L Tolmie
A novel acropectoral syndrome maps to chromosome 7q36
J. Med. Genet., May 1, 2001; 38(5): 304 - 309.
[Abstract] [Full Text]

J Charite, D. McFadden, and E. Olson
The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development
Development, January 6, 2000; 127(11): 2461 - 2470.
[Abstract] [PDF]

B. A. Firulli, D. B. Hadzic, J. R. McDaid, and A. B. Firulli
The Basic Helix-Loop-Helix Transcription factors dHAND and eHAND Exhibit Dimerization Characteristics That Suggest Complex Regulation of Function
J. Biol. Chem., October 20, 2000; 275(43): 33567 - 33573.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Fernandez-Teran, M.

Articles by Ros, M. A.

Search for Related Content

PubMed

PubMed Citation

Articles by Fernandez-Teran, M.

Articles by Ros, M. A.

				B. A. Firulli, B. A. Redick, S. J. Conway, and A. B. Firulli Mutations within Helix I of Twist1 Result in Distinct Limb Defects and Variation of DNA Binding Affinities J. Biol. Chem., September 14, 2007; 282(37): 27536 - 27546. [Abstract] [Full Text] [PDF]

				P. Hill, B. Wang, and U. Ruther The molecular basis of Pallister Hall associated polydactyly Hum. Mol. Genet., September 1, 2007; 16(17): 2089 - 2096. [Abstract] [Full Text] [PDF]

				J. G. M. Thewissen, M. J. Cohn, L. S. Stevens, S. Bajpai, J. Heyning, and W. E. Horton Jr. Developmental basis for hind-limb loss in dolphins and origin of the cetacean bodyplan PNAS, May 30, 2006; 103(22): 8414 - 8418. [Abstract] [Full Text] [PDF]

				E. B. Johnson, R. E. Hammer, and J. Herz Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice Hum. Mol. Genet., November 15, 2005; 14(22): 3523 - 3538. [Abstract] [Full Text] [PDF]

				C. Rallis, J. Del Buono, and M. P. O. Logan Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo Development, April 15, 2005; 132(8): 1961 - 1970. [Abstract] [Full Text] [PDF]

				L.-B. Ruest, X. Xiang, K.-C. Lim, G. Levi, and D. E. Clouthier Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity Development, September 15, 2004; 131(18): 4413 - 4423. [Abstract] [Full Text] [PDF]

				F. A. Mic, I. O. Sirbu, and G. Duester Retinoic Acid Synthesis Controlled by Raldh2 Is Required Early for Limb Bud Initiation and Then Later as a Proximodistal Signal during Apical Ectodermal Ridge Formation J. Biol. Chem., June 18, 2004; 279(25): 26698 - 26706. [Abstract] [Full Text] [PDF]

				J. Zakany, M. Kmita, and D. Duboule A Dual Role for Hox Genes in Limb Anterior-Posterior Asymmetry Science, June 11, 2004; 304(5677): 1669 - 1672. [Abstract] [Full Text] [PDF]

				O. Krebs, C. M. Schreiner, W. J. Scott Jr, S. M. Bell, D. J. Robbins, J. A. Goetz, H. Alt, N. Hawes, E. Wolf, and J. Favor Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud Development, December 15, 2003; 130(24): 6037 - 6047. [Abstract] [Full Text] [PDF]

				M. A. Ros, R. D. Dahn, M. Fernandez-Teran, K. Rashka, N. C. Caruccio, S. M. Hasso, J. J. Bitgood, J. J. Lancman, and J. F. Fallon The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb Development, February 1, 2003; 130(3): 527 - 537. [Abstract] [Full Text] [PDF]

				P. Agarwal, J. N. Wylie, J. Galceran, O. Arkhitko, C. Li, C. Deng, R. Grosschedl, and B. G. Bruneau Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo Development, February 1, 2003; 130(3): 623 - 633. [Abstract] [Full Text] [PDF]

				A. Marcil, E. Dumontier, M. Chamberland, S. A. Camper, and J. Drouin Pitx1 and Pitx2 are required for development of hindlimb buds Development, January 1, 2003; 130(1): 45 - 55. [Abstract] [Full Text] [PDF]

				K. Niederreither, J. Vermot, B. Schuhbaur, P. Chambon, and P. Dolle Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse Development, August 1, 2002; 129(15): 3563 - 3574. [Abstract] [Full Text] [PDF]

				Y.-S. Dai and P. Cserjesi The Basic Helix-Loop-Helix Factor, HAND2, Functions as a Transcriptional Activator by Binding to E-boxes as a Heterodimer J. Biol. Chem., April 5, 2002; 277(15): 12604 - 12612. [Abstract] [Full Text] [PDF]

				P. te Welscher, M. Fernandez-Teran, M. A. Ros, and R. Zeller Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling Genes & Dev., February 15, 2002; 16(4): 421 - 426. [Abstract] [Full Text] [PDF]

				D. G. McFadden, J. McAnally, J. A. Richardson, J. Charite, and E. N. Olson Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding Development, January 7, 2002; 129(13): 3077 - 3088. [Abstract] [Full Text] [PDF]

				M. Dundar, T. M Gordon, I. Ozyazgan, F. Oguzkaya, Y. Ozkul, A. Cooke, A G. Wilkinson, S. Holloway, F. R Goodman, and J. L Tolmie A novel acropectoral syndrome maps to chromosome 7q36 J. Med. Genet., May 1, 2001; 38(5): 304 - 309. [Abstract] [Full Text]

				J Charite, D. McFadden, and E. Olson The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development Development, January 6, 2000; 127(11): 2461 - 2470. [Abstract] [PDF]

				B. A. Firulli, D. B. Hadzic, J. R. McDaid, and A. B. Firulli The Basic Helix-Loop-Helix Transcription factors dHAND and eHAND Exhibit Dimerization Characteristics That Suggest Complex Regulation of Function J. Biol. Chem., October 20, 2000; 275(43): 33567 - 33573. [Abstract] [Full Text] [PDF]