Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function

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Astromoff, A. and Ptashne, M (1995). A variant of lambda repressor with an altered pattern of cooperative binding to DNA sites. Proc. Natl. Acad. Sci. USA 92, 8110-8114.[Abstract/Free Full Text]

Beddington, R. S. P., Morgernstern, J., Land, H. and Hogan, A (1989). An in situ transgenic enzyme marker for the midgestation mouse embryo and the visualization of inner cell mass clones during early organogenesis. Development 106, 37-46.[Abstract]

Beddington, R. S. P. and Robertson, E. J (1998). Anterior patterning in mouse. Trends Genet 14, 277-284.[Medline]

Beddington, R. S. P. and Robertson, E. J (1999). Axis development and early asymmetry in mammals. Cell 96, 195-209.[Medline]

Beddington, R. S. P. and Smith, J. C (1993). Control of vertebrate gastrulation: inducing signals and responding genes. Curr. Opin. Genet. Dev 3, 655-661.[Medline]

Belo, J. A., Bouwmeester, T., Leyns, L., Kertesz, N., Gallo, M., Follettie, M. and De Robertis, E. M (1997). Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech. Dev 68, 45-57.[Medline]

Biben, C., Stanley, E., Fabri, L., Kotecha, S., Rhinn, M., Drinkwater, C., Lah, M., Wang, C. C., Nash, A., Hilton, D (1998). Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev. Biol 194, 135-151.[Medline]

Blum, M., Gaunt, S. J., Cho, K. W., Steinbeisser, H., Blumberg, B., Bittner, D. and De Robertis, E. M (1992). Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69, 1097-1106.[Medline]

Bouwmeester, T., Kim, S., Sasai, Y., Lu, B. and De Robertis, E. M (1996). Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organiser. Nature 382, 595-601.[Medline]

Brickman, J. M., Adam, M. and Ptashne, M (1999). Interactions between an HMG-1 protein and members of the rel family. Proc. Natl. Acad. Sci. USA 96, 10679-10683.[Abstract/Free Full Text]

Carey, M., Lin, Y. S., Green, M. R. and Ptashne, M (1990). A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives. Nature 345, 361-364.[Medline]

Cho, K. W., Blumberg, B., Steinbeisser, H. and De Robertis, E. M (1991). Molecular nature of Spemann's organiser: the role of the Xenopus homeobox gene goosecoid. Cell 67, 1111-1120.[Medline]

Chomczynski, P. and Sacchi, N (1987). Single-step method of RNA isolationby acid guanidinium thiocyanate-phenol-chloroform extraction. Analyt. Biochem 162, 156-159.[Medline]

Cooke, J., Smith, J. C., Smith, E. J. and Yaqoob, M (1987). The organization of mesodermal pattern in Xenopus laevis : experiments using a Xenopus mesoderm-inducing factor. Development 101, 893-908.[Abstract/Free Full Text]

Crompton, M. R., Bartlett, T. J., MacGregor, A. D., Manfioletti, G., Buratti, E., Giancotti, V. and Goodwin, G. H (1992). Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells. Nucl. Acids Res 20, 5661-5667.[Abstract/Free Full Text]

Deardorff, M. A., Tan, C., Conrad, L. J. and Klein, P. S (1998). Frizzled-8 is expressed in the Spemann organiser and plays a role in early morphogenesis. Development 125, 2687-2700.[Abstract]

Ding, J., Yang, L., Yan, Y. T., Chen, A., Desai, N., Wynshaw-Boris, A. and Shen, M. M (1998). Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Nature 395, 702-707.[Medline]

Emami, K. H. and Carey, M (1992). A synergistic increase in potency of a multimerized VP16 transcriptional activation domain. EMBO J 11, 5005-5012.[Medline]

Fisher, J. P., Hope, S. A. and Hooper, M. L (1989). Factors influencing the differentiation of embryonal carcinoma and embryo-derived stem cells. Exp. Cell Res 182, 403-414.[Medline]

Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C. and Niehrs, C (1998). Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391, 357-362.[Medline]

Glinka, A., Wu, W., Onichtchouk, D., Blumenstock, C. and Niehrs, C (1997). Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus. Nature 389, 517-519.[Medline]

Harland, R. M (1991). In situ hybridization: an improved whole-mount method for Xenopus embryos. Methods Cell Biol 36, 685-695.[Medline]

Hemmati-Brivanlou, A. and Thomsen, G. H (1995). Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4. Dev. Genet 17, 78-89.[Medline]

Henry, G. L. and Melton, D. A (1998). Mixer, a homeobox gene required for endoderm development. Science 281, 91-96.[Abstract/Free Full Text]

Ho, C. Y., Houart, C., Wilson, S. W. and Stainier, D. Y (1999). A role for the extraembryonic yolk syncytial layer in patterning the zebrafish embryo suggested by properties of the hex gene. Curr. Biol 9, 1131-1134.[Medline]

Hoppler, S., Brown, J. D. and Moon, R. T (1996). Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos. Genes Dev 10, 2805-2817.[Abstract/Free Full Text]

Hudson, C., Clements, D., Friday, R. V., Stott, D. and Woodland, H. R (1997). Xsox17alpha and-beta mediate endoderm formation in Xenopus. Cell 91, 397-405.[Medline]

Ishikawa, T., Yoshioka, H., Ohuchi, H., Noji, S. and Nohno, T (1995). Truncated type II receptor for BMP-4 induces secondary axial structures in Xenopus embryos. Biochem. Biophys. Res. Commun 216, 26-33.[Medline]

Itoh, K. and Sokol, S. Y (1999). Axis determination by inhibition of Wnt signaling in Xenopus. Genes Dev 13, 2328-2336.[Abstract/Free Full Text]

Jones, C. M. Thomas, P., Q., Smith, J. C. and Beddington, R. S. P (1999). An anterior signalling centre in Xenopus revealed by expression of the homeobox gene XHex. Curr. Biol 9, 946-954.[Medline]

Jones, C. M., Dale, L., Hogan, B. L., Wright, C. V. and Smith, J. C (1996). Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. Development 122, 1545-1554.[Abstract]

Jones, C. M. and Smith, J. C (1998). Establishment of a BMP-4 morphogen gradient by long-range inhibition. Dev Biol 194, 12-17.[Medline]

Knoetgen, H., Viebahn, C. and Kessel, M (1999). Head induction in the chick by primitive endoderm of mammalian, but not avian origin. Development 126, 815-825.[Abstract]

Leyns, L., Bouwmeester, T., Kim, S. H., Piccolo, S. and De Robertis, E. M (1997). Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organiser. Cell 88, 747-756.[Medline]

Mailhos, C., Andre, S., Mollereau, B., Goriely, A., Hemmati-Brivanlou, A. and Desplan, C (1998). Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators. Development 125, 937-947.[Abstract]

McMahon, J. A., Takada, S., Zimmerman, L. B., Fan, C. M., Harland, R. M. and McMahon, A. P (1998). Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev 12, 1438-1452.[Abstract/Free Full Text]

Mountford, P., Zevnik, B., Duwel, A., Nichols, J., Li, M., Dani, C., Robertson, M., Chambers, I. and Smith, A (1994). Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc. Natl. Acad. Sci. USA 91, 4303-4307.[Abstract/Free Full Text]

Neidle, S. and Goodwin, G. H (1994). A homology-based molecular model of the proline-rich homeodomain protein Prh, from haematopoietic cells. FEBS Lett 345, 93-98.[Medline]

Newman, C. S., Chia, F. and Krieg, P. A (1997). The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number. Mech. Dev 66, 83-93.[Medline]

Niehrs, C (1999). Head in the WNT: the molecular nature of Spemann's head organiser. Trends Genet 15, 314-319.[Medline]

Ohashi, Y., Brickman, J. M., Furman, E., Middleton, B. and Carey, M (1994). Modulating the potency of an activator in a yeast in vitro transcription system. Mol. Cell Biol 14, 2731-2739.[Abstract/Free Full Text]

Pearce, J. J., Penny, G. and Rossant, J (1999). A mouse cerberus/Dan-related gene family. Dev. Biol 209, 98-110.[Medline]

Piccolo, S., Agius, E., Leyns, L., Bhattacharyya, S., Grunz, H., Bouwmeester, T. and De Robertis, E. M (1999). The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397, 707-710.[Medline]

Piccolo, S., Sasai, Y., Lu, B. and De Robertis, E. M (1996). Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell 86, 589-598.[Medline]

Rupp, R. A., Snider, L. and Weintraub, H (1994). Xenopus embryos regulate the nuclear localization of XMyoD. Genes Dev 8, 1311-1323.[Abstract/Free Full Text]

Salic, A. N., Kroll, K. L., Evans, L. M. and Kirschner, M. W (1997). Sizzled: a secreted XWnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos. Development 124, 4739-4748.[Abstract]

Sasai, Y., Lu, B., Steinbeisser, H., Geissert, D., Gont, L. K. and De Robertis, E. M (1994). Xenopus chordin: a novel dorsalizing factor activated by organiser-specific homeobox genes. Cell 79, 779-790.[Medline]

Schier, A. F. and Gehring, W. J (1992). Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene. Nature 356, 804-807.[Medline]

Shawlot, W. and Behringer, R. R (1995). Requirement for Lim1 in head-organiser function. Nature 374, 425-430.[Medline]

Shawlot, W., Deng, J. M. and Behringer, R. R (1998). Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis. Proc. Natl. Acad. Sci. USA 95, 6198-6203.[Abstract/Free Full Text]

Slack, J. M. W., Dale, L. and Smith, J. C (1984). Analysis of embryonic induction by using cell lineage markers. Phil. Trans. R. Soc. Lond. B 307, 331-336.[Medline]

Smith, A. G., Heath, J. K., Donaldson, D. D., Wong, G. G., Moreau, J., Stahl, M. and Rogers, D (1988). Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336, 688-690.[Medline]

Smith, J. C. and Slack, J. M. W (1983). Dorsalisation and neural induction: properties of the organiser in Xenopus laevis. J. Embryol. Exp. Morphol 78, 299-317.[Medline]

Smith, J. C. and Watt, F. M (1985). Biochemical specificity of Xenopus notochord. Differentiation 29, 109-115.[Medline]

Smith, S. T. and Jaynes, J. B (1996). A conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2-and msh-class homeoproteins, mediates active transcriptional repression in vivo. Development 122, 3141-3150.[Abstract]

Smith, W. C. and Harland, R. M (1991). Injected XWnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing centre. Cell 67, 753-765.[Medline]

Smith, W. C., Knecht, A. K., Wu, M. and Harland, R. M (1993). Secreted noggin protein mimics the Spemann organiser in dorsalizing Xenopus mesoderm. Nature 361, 547-549.[Medline]

Symes, K. and Smith, J. C (1987). Gastrulation movements provide an early marker of mesoderm induction in Xenopus laevis. Development 101, 339-349.[Abstract]

Tada, M., O'Reilly, M. A. and Smith, J. C (1997). Analysis of competenceand of Brachyury autoinduction by use of hormone-inducible Xbra. Development 124, 2225-2234.[Abstract]

Tam, P. P. and Steiner, K. A (1999). Anterior patterning by synergistic activity of the early gastrula organiser and the anterior germ layer tissues of the mouse embryo. Development 126, 5171-5179.[Abstract]

Tanaka, T., Inazu, T., Yamada, K., Myint, Z., Keng, V. W., Inoue, Y., Taniguchi, N. and Noguchi, T (1999). cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein. Biochem. J 339, 111-117.

Thomas, P., Brickman, J. M., Popperl, H., Krumlauf, R. and Beddington, R. S. P (1997). Axis duplication and anterior identity in the mouse embryo. Cold Spring Harb. Symp. Quant. Biol 62, 115-125.[Medline]

Thomas, P. Q., Brown, A. and Beddington, R. S. P (1998). Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development 125, 85-94.[Abstract]

Treisman, J., Gonczy, P., Vashishtha, M., Harris, E. and Desplan, C (1989). A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell 59, 553-562.[Medline]

Wakamiya, M., Lindsay, E. A., Rivera-Perez, J. A., Baldini, A. and Behringer, R. R (1998). Functional analysis of Gscl in the pathogenesis of the DiGeorge and velocardiofacial syndromes. Hum. Mol. Genet 7, 1835-1840.[Abstract/Free Full Text]

Wakamiya, M., Rivera-Perez, J. A., Baldini, A. and Behringer, R. R (1997). Goosecoid and goosecoid-related genes in mouse embryogenesis. Cold Spring Harb. Symp. Quant. Biol 62, 145-149.[Medline]

Wang, S., Krinks, M., Lin, K., Luyten, F. P. and Moos, M., Jr (1997). Frzb, a secreted protein expressed in the Spemann organiser, binds and inhibits Wnt-8. Cell 88, 757-766.[Medline]

Watabe, T., Kim, S., Candia, A., Rothbacher, U., Hashimoto, C., Inoue, K. and Cho, K. W (1995). Molecular mechanisms of Spemann's organiser formation: conserved growth factor synergy between Xenopus and mouse. Genes Dev 9, 3038-3050.[Abstract/Free Full Text]

Wilson, D., Sheng, G., Lecuit, T., Dostatni, N. and Desplan, C (1993). Cooperative dimerization of paired class homeo domains on DNA. Genes Dev 7, 2120-2134.[Abstract/Free Full Text]

Xu, Q., D'Amore, P. A. and Sokol, S. Y (1998). Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist. Development 125, 4767-4776.[Abstract]

Yamanaka, Y., Mizuno, T., Sasai, Y., Kishi, M., Takeda, H., Kim, C. H., Hibi, M. and Hirano, T (1998). A novel homeobox gene, dharma, can induce the organiser in a non-cell-autonomous manner. Genes Dev 12, 2345-2353.[Abstract/Free Full Text]

Yatskievych, T. A., Pascoe, S. and Antin, P. B (1999). Expression of the homebox gene Hex during early stages of chick embryo development. Mech. Dev 80, 107-109.[Medline]

Zorn, A. M., Butler, K. and Gurdon, J. B (1999). Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways. Dev. Biol 209, 282-297.[Medline]

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