Presenilin-1 regulates neuronal differentiation during neurogenesis

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				O. Reiner, A. Shmueli, and T. Sapir Neuronal Migration and Neurodegeneration: 2 Sides of the Same Coin Cereb Cortex, July 1, 2009; 19(suppl_1): i42 - i48. [Abstract] [Full Text] [PDF]

				H. Watanabe, M. J. Smith, E. Heilig, V. Beglopoulos, R. J. Kelleher III, and J. Shen Indirect Regulation of Presenilins in CREB-mediated Transcription J. Biol. Chem., May 15, 2009; 284(20): 13705 - 13713. [Abstract] [Full Text] [PDF]

				C. Q. Doe Neural stem cells: balancing self-renewal with differentiation Development, May 1, 2008; 135(9): 1575 - 1587. [Abstract] [Full Text] [PDF]

				J. Briscoe and B. G Novitch Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube Phil Trans R Soc B, January 12, 2008; 363(1489): 57 - 70. [Abstract] [Full Text] [PDF]

				J. Chen, A. Zacharek, A. Li, X. Cui, C. Roberts, M. Lu, and M. Chopp Atorvastatin Promotes Presenilin-1 Expression and Notch1 Activity and Increases Neural Progenitor Cell Proliferation After Stroke Stroke, January 1, 2008; 39(1): 220 - 226. [Abstract] [Full Text] [PDF]

				J. M. Ringman, J. O'Neill, D. Geschwind, L. Medina, L. G. Apostolova, Y. Rodriguez, B. Schaffer, A. Varpetian, B. Tseng, F. Ortiz, et al. Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations Brain, July 1, 2007; 130(7): 1767 - 1776. [Abstract] [Full Text] [PDF]

				U Shivraj Sohur, J. G Emsley, B. D Mitchell, and J. D Macklis Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells Phil Trans R Soc B, September 29, 2006; 361(1473): 1477 - 1497. [Abstract] [Full Text] [PDF]

				T. Yoshimatsu, D. Kawaguchi, K. Oishi, K. Takeda, S. Akira, N. Masuyama, and Y. Gotoh Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex Development, July 1, 2006; 133(13): 2553 - 2563. [Abstract] [Full Text] [PDF]

				M. Wines-Samuelson and J. Shen Presenilins in the Developing, Adult, and Aging Cerebral Cortex Neuroscientist, October 1, 2005; 11(5): 441 - 451. [Abstract] [PDF]

				P. H. Wen, R. De Gasperi, M. A. G. Sosa, A. B. Rocher, V. L. Friedrich Jr, P. R. Hof, and G. A. Elder Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice Development, September 1, 2005; 132(17): 3873 - 3883. [Abstract] [Full Text] [PDF]

				C. A. Saura, G. Chen, S. Malkani, S.-Y. Choi, R. H. Takahashi, D. Zhang, G. K. Gouras, A. Kirkwood, R. G. M. Morris, and J. Shen Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice J. Neurosci., July 20, 2005; 25(29): 6755 - 6764. [Abstract] [Full Text] [PDF]

				N. L. Chevallier, S. Soriano, D. E. Kang, E. Masliah, G. Hu, and E. H. Koo Perturbed Neurogenesis in the Adult Hippocampus Associated with Presenilin-1 A246E Mutation Am. J. Pathol., July 1, 2005; 167(1): 151 - 159. [Abstract] [Full Text] [PDF]

				D. Y. Kim, L. A. M. Ingano, B. W. Carey, W. H. Pettingell, and D. M. Kovacs Presenilin/{gamma}-Secretase-mediated Cleavage of the Voltage-gated Sodium Channel {beta}2-Subunit Regulates Cell Adhesion and Migration J. Biol. Chem., June 17, 2005; 280(24): 23251 - 23261. [Abstract] [Full Text] [PDF]

				V. Beglopoulos, X. Sun, C. A Saura, C. A. Lemere, R. D. Kim, and J. Shen Reduced {beta}-Amyloid Production and Increased Inflammatory Responses in Presenilin Conditional Knock-out Mice J. Biol. Chem., November 5, 2004; 279(45): 46907 - 46914. [Abstract] [Full Text] [PDF]

				S. Hitoshi, R. M. Seaberg, C. Koscik, T. Alexson, S. Kusunoki, I. Kanazawa, S. Tsuji, and D. van der Kooy Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling Genes & Dev., August 1, 2004; 18(15): 1806 - 1811. [Abstract] [Full Text] [PDF]

				A. Louvi, S. S. Sisodia, and E. A. Grove Presenilin 1 in migration and morphogenesis in the central nervous system Development, July 1, 2004; 131(13): 3093 - 3105. [Abstract] [Full Text] [PDF]

				Y. Hashimoto, O. Tsuji, K. Kanekura, S. Aiso, T. Niikura, M. Matsuoka, and I. Nishimoto The Gtx Homeodomain Transcription Factor Exerts Neuroprotection Using Its Homeodomain J. Biol. Chem., April 16, 2004; 279(16): 16767 - 16777. [Abstract] [Full Text] [PDF]

				J. G. Schulz, W. Annaert, J. Vandekerckhove, P. Zimmermann, B. De Strooper, and G. David Syndecan 3 Intramembrane Proteolysis Is Presenilin/{gamma}-Secretase-dependent and Modulates Cytosolic Signaling J. Biol. Chem., December 5, 2003; 278(49): 48651 - 48657. [Abstract] [Full Text] [PDF]

				P. Wang, F. A. Pereira, D. Beasley, and H. Zheng Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis Development, October 15, 2003; 130(20): 5019 - 5029. [Abstract] [Full Text] [PDF]

				A. M. KRICHEVSKY, K. S. KING, C. P. DONAHUE, K. KHRAPKO, and K. S. KOSIK A microRNA array reveals extensive regulation of microRNAs during brain development RNA, October 1, 2003; 9(10): 1274 - 1281. [Abstract] [Full Text] [PDF]

				J. Imitola, E. Y. Snyder, and S. J. Khoury Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis Physiol Genomics, August 15, 2003; 14(3): 171 - 197. [Abstract] [Full Text] [PDF]

				M.-T. Lai, E. Chen, M.-C. Crouthamel, J. DiMuzio-Mower, M. Xu, Q. Huang, E. Price, R. B. Register, X.-P. Shi, D. B. Donoviel, et al. Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping {gamma}-Secretase Activities J. Biol. Chem., June 13, 2003; 278(25): 22475 - 22481. [Abstract] [Full Text] [PDF]

				A. Chojnacki, T. Shimazaki, C. Gregg, G. Weinmaster, and S. Weiss Glycoprotein 130 Signaling Regulates Notch1 Expression and Activation in the Self-Renewal of Mammalian Forebrain Neural Stem Cells J. Neurosci., March 1, 2003; 23(5): 1730 - 1741. [Abstract] [Full Text] [PDF]

				X. Xia, P. Wang, X. Sun, S. Soriano, W.-K. Shum, H. Yamaguchi, M. E. Trumbauer, A. Takashima, E. H. Koo, and H. Zheng The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta -amyloid peptides through beta -catenin-independent mechanisms PNAS, June 25, 2002; 99(13): 8760 - 8765. [Abstract] [Full Text] [PDF]

				I. Dewachter, D. Reverse, N. Caluwaerts, L. Ris, C. Kuiperi, C. Van den Haute, K. Spittaels, L. Umans, L. Serneels, E. Thiry, et al. Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice J. Neurosci., May 1, 2002; 22(9): 3445 - 3453. [Abstract] [Full Text] [PDF]

				S. Hitoshi, T. Alexson, V. Tropepe, D. Donoviel, A. J. Elia, J. S. Nye, R. A. Conlon, T. W. Mak, A. Bernstein, and D. van der Kooy Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells Genes & Dev., April 1, 2002; 16(7): 846 - 858. [Abstract] [Full Text] [PDF]

				B. E. Berechid, M. Kitzmann, D. R. Foltz, A. H. Roach, D. Seiffert, L. A. Thompson, R. E. Olson, A. Bernstein, D. B. Donoviel, and J. S. Nye Identification and Characterization of Presenilin-independent Notch Signaling J. Biol. Chem., March 1, 2002; 277(10): 8154 - 8165. [Abstract] [Full Text] [PDF]

				C. H. Faux, A. M. Turnley, R. Epa, R. Cappai, and P. F. Bartlett Interactions between Fibroblast Growth Factors and Notch Regulate Neuronal Differentiation J. Neurosci., August 1, 2001; 21(15): 5587 - 5596. [Abstract] [Full Text] [PDF]