Rac1 mutations produce aberrant epithelial differentiation in the developing and adult mouse small intestine

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Stappenbeck, T. S.
	Articles by Gordon, J. I.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Stappenbeck, T. S.
	Articles by Gordon, J. I.

Aspenstr\232m, P (1999). Effectors of the Rho GTPases. Curr. Opin. Cell Biol 11, 95-102.[Medline]

Bjerknes, M. and Cheng, H (1981). The stem-cell zone of the small intestinal epithelium. I. Evidence from Paneth cells in the adult mouse. Am. J. Anat 160, 51-63.[Medline]

Bjerknes, M. and Cheng, H (1981). The stem-cell zone of the small intestinal epithelium. III. Evidence from columnar, enteroendocrine, and mucous cells in the adult mouse. Am. J. Anat 160, 77-91.[Medline]

Bjerknes, M. and Cheng, H (1999). Clonal analysis of mouse intestinal epithelial progenitors. Gastroenterology 116, 7-14.[Medline]

Bradford, M. M (1976). A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem 72, 254-259.

Braga, V. M. M., Machesky, L. M., Hall, A. and Hotchin, N. A (1997). The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol 137, 1421-1431.[Abstract/Free Full Text]

Bry, L., Falk, P., Huttner, K., Ouellette, A., Midvedt, T. and Gordon, J. I (1994). Paneth cell differentiation in the developing intestine of normal and transgenic mice. Proc. Natl. Acad. Sci. USA 91, 10335-10339.[Abstract/Free Full Text]

Calvert, R. and Pothier, P (1990). Migration of fetal intestinal intervillus cells in neonatal mice. Anat. Rec 227, 199-206.[Medline]

Cheng, H., Merzel, J. and Leblond, C. P (1969). Renewal of Paneth cells in the small intestine of the mouse. Am. J. Anat 126, 507-525.[Medline]

Cheng, H (1974). Origin, differentiation, and renewal of the four main epithelial cell types in the mouse small intestine. II. Mucous cells. Am. J. Anat 141, 481-502.[Medline]

Cheng, H (1974). Origin, differentiation, and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cells. Am. J. Anat 141, 521-536.[Medline]

Cheng, H. and Leblond, C. P (1974). Origin, differentiation, and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cells. Am. J. Anat 141, 461-480.[Medline]

Cheng, H. and Leblond, C. P (1974). Origin, differentiation, and renewal of the four main epithelial cell types in the mouse small intestine. III. Entero-endocrine cells. Am. J. Anat 141, 503-520.[Medline]

Cheng, H. and Leblond, C. P (1974). Origin, differentiation, and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial subtypes. Am. J. Anat 141, 537-561.[Medline]

Cohn, S. M., Simon, T. C., Roth, K. A., Birkenmeier, E. H. and Gordon, J. I (1992). Use of transgenic mice to map cis -acting elements in the intestinal fatty acid binding protein ( Fabpi ) that control its cell lineage-specific and regional patterns of expression along the duodenal-colonic and crypt-villus axes of the gut epithelium. J. Cell Biol 119, 27-44.[Abstract/Free Full Text]

Coso, O. A., Chiariello, M., Yu, J.-C., Teramoto, H., Crespo, P., Xu, N., Miki, T. and Gutkind, J. S (1995). The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81, 1137-1146.[Medline]

Eaton, S., Auvinen, P., Luo, L., Jan,Y. N., and Simons, K (1995). CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. J. Cell Biol 131, 151-164.[Abstract/Free Full Text]

Evan, G. I., Lewis, G. K., Ramsey, G. and Bishop, J. M (1985). Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol 5, 3610-3616.[Abstract/Free Full Text]

Falk, P., Roth, K. A. and Gordon, J. I (1994). Lectins are sensitive tools for defining the differentiation programs of mouse gut epithelial cell lineages. Am. J. Phys 266, 987-.

Garabedian, E. M., Roberts, L. J., McNevin, M. S. and Gordon, J. I (1997). Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J. Biol. Chem 272, 23729-23740.[Abstract/Free Full Text]

Hall, A (1998). Rho GTPases and the actin cytoskeleton. Science 279, 509-514.[Abstract/Free Full Text]

Hall, P. A., Coates, P. J., Ansari, B. and Hopwood, D (1994). Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J. Cell Sci 107, 3569-3577.[Abstract]

Harwig, S. S., Tan, L., Qu, X., Cho, Y., Eisenhauer, P. B. and Lehrer, R. I (1995). Bactericidal properties of murine intestinal phospholipase A2. J. Clin. Invest 95, 603-610.

Heath, J. P (1996). Epithelial cell migration in the intestine. Cell Biol. Int 20, 139-146.[Medline]

Hermiston, M. L. and Gordon, J. I (1995). In vivo analysis of cadherin function in the mouse small intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J. Cell Biol 129, 489-506.[Abstract/Free Full Text]

Hermiston, M. L. and Gordon, J. I (1995). Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 270, 1203-1207.[Abstract/Free Full Text]

Hermiston, M. L., Wong, M. H. and Gordon, J. I (1996). Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration andprovides evidence for nonautonomous regulation of cell fate in a self-renewing system. Genes Dev 10, 985-996.[Abstract/Free Full Text]

Hill, C. S., Wynne, J. and Treisman, R (1995). The Rho family GTPases RhoA, Rac1, and Cdc42Hs regulate transcriptional activation by SRF. Cell 81, 1159-1170.[Medline]

Hooper, L. V., Xu, J., Falk, P. G., Midvedt, T., and Gordon, J. I (1999). A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem. Proc. Natl. Acad. Sci. USA 96, 9833-9838.[Abstract/Free Full Text]

Hordijk, P. L., ten Klooster, J. P., van der Kammen,R. A., Michiels, F., Oomen, L. C. and Collard, J. G (1997). Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science 278, 1464-1466.[Abstract/Free Full Text]

Jou, T. S. and Nelson, W. J (1998). Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J. Cell Biol 142, 85-100.[Abstract/Free Full Text]

Jou, T. S., Schneeberger, E. E. and Nelson, W. J (1998). Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J. Cell Biol 142, 101-115.[Abstract/Free Full Text]

Kaestner, K. H., Silberg, D. G., Traber, P. G., and Schultz, G (1997). The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation. Genes Dev 11, 1583-1595.[Abstract/Free Full Text]

Kaufmann, N., Wills, Z. P. and van Vactor, D (1998). Drosophila Rac1 controls motor axon guidance. Development 125, 453-461.[Abstract]

Keely, P. J., Westwick, J. K., Whitehead, I. P., Der, C. J. and Parise, L. V (1997). Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390, 632-636.[Medline]

Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P. J. and Clevers, H (1998). Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nature Genet 19, 379-383.[Medline]

Korinek, V., Barker, N., Willert, K., Molenaar, M., Roose, J., Wagenaar, G., Markman, M., Lamers, W., Destree,O. and Clevers, H (1998). Two members of the Tcf family implicated in Wnt/-catenin signaling during embryogenesis in the mouse. Mol. Cell. Biol 18, 1248-1256.[Abstract/Free Full Text]

Lamarche, N., Tapon, N., Stowers, L., Burbelo, P. D., Aspenstr\232m, P., Bridges, T., Chant, J. and Hall, A (1996). Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell 87, 519-529.[Medline]

Lefebvre, O., Sorokin, L., Kedinger, M. and Simon-Assmann, P (1999). Developmental expression and cellular origin of the laminin2. 4, and5 chains in the intestine. Dev. Biol 210, 135-150.[Medline]

Lores, P., Morin, L., Luna, R., and Gacon, G (1997). Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2 GTPase. Oncogene 15, 601-605.[Medline]

Luo, L., Hensch, T. K., Ackerman, L., Barbel, S., Jan, L. Y. and Jan, Y. N (1996). Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature 379, 837-840.[Medline]

Mackay D. J. and Hall, A (1998). Rho GTPases. J. Biol. Chem 273, 20685-20688.[Free Full Text]

Merzel, J., and Leblond, C. P (1969). Origin and renewal of goblet cells in the epithelium of the mouse small intestine. Am. J. Anat 124, 281-305.[Medline]

Minden, A., Lin, A., Claret, F.-X., Abo, A. and Karin, M (1995). Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81, 1147-1157.[Medline]

Moll, J., Sansig, G., Fattori, E. and van der Putten, H (1991). The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments. Oncogene 6, 863-866.[Medline]

Mulherkar, R., Desai, S. J., Rao, R. S., Wagle, A. S. and Deo, M. G (1991). Expression of enhancing factor gene and its localization in mouse tissues. Histochemistry 96, 367-370.[Medline]

Mulherkar, R., Rao, R. S., Wagle, A. S., Patki, V. and Deo, M. G (1993). Enhancing factor, a Paneth cell specific protein from mouse small intestine: predicted amino acid sequence from RT-PCR amplified cDNA and its expression. Biochem. Biophys. Res. Comm 195, 1254-1263.[Medline]

Nobes, C. D. and Hall, A (1995). Rho, rac and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell 81, 53-62.[Medline]

Nobes, C. D. and Hall, A (1999). Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol 144, 1235-1244.[Abstract/Free Full Text]

Olson, M. F., Ashworth, A. and Hall, A (1995). An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269, 1270-1272.[Abstract/Free Full Text]

Ouellete, A. J (1997). Paneth cells and innate immunity in the crypt microenvironment. Gastroenterology 113, 1779-1784.[Medline]

Ramalho-Santos, M., Melton, D. A. and McMahon, A. P (2000). Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127, 2763-2772.[Abstract]

Ridley, A. J. and Hall, A (1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.[Medline]

Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.[Medline]

Ridley, A. J., Comoglio, P. M. and Hall, A (1995). Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac and Rho in MDCK cells. Mol. Cell. Biol 15, 1110-1122.[Abstract]

Roberts, A. W., Kim, C., Zhen, L., Lowe, J. B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J. D., Borneo, J. B., Bradford, G. B., Atkinson, S. J., Dinauer, M. C. and Williams, D. A (1999). Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity 10, 183-196.[Medline]

Sander, E. E., van Delft, S., ten Klooster, J. P., Reid, T., van der Kammen, R. A., Michiels, F., and Collard, J. G (1998). Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J. Cell Biol 143, 1385-1398.[Abstract/Free Full Text]

Schmidt, G. H., Winton, D. J. and Ponder, B. A (1988). Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine. Development 103, 785-790.[Abstract/Free Full Text]

Schmidt, G. H., Wilkinson, M. M. and Ponder, B. A (1985). Cell migration pathway in the intestinal epithelium: an in situ marker system using mouse aggregation chimeras. Cell 40, 425-429.[Medline]

Selsted, M. E., Miller, S. I., Henschen, A. H. and Ouellette, A. J (1992). Enteric defensins: antibiotic peptide components of intestinal host defense. J. Cell Biol 118, 929-936.[Abstract/Free Full Text]

Steven, R., Kubiseski, T. J., Zheng, H., Kulkarni, S., Mancillas, J., Ruiz Morales, A., Hogue, C. W., Pawson, T. and Culotti, J (1998). UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell 92, 785-795.[Medline]

Sugihara K., Nakatsuji, N., Nakamura, K., Nakao, K., Hashimoto, R., Otani, H., Sakagami, H., H., Kondo, H., Nozawa, S., Aiba, A. and Katsuki, M (1998). Rac1 is required for the formation of three germ layers during gastrulation. Oncogene 17, 3427-3433.[Medline]

Sulciner, D. J., Irani, K., Yu, Z. X., Ferrans, V. J., Goldschmidt-Clermont, P. and Finkel, T (1996). Rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation. Mol. Cell. Biol 16, 7115-7121.[Abstract]

Sweetser, D. A., Birkenmeier, E. H., Hoppe, P. C., McKeel, D. W. and Gordon, J. I (1988). Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes. Genes Dev 2, 1318-1332.[Abstract/Free Full Text]

Takaishi, K., Sasaki, T., Kotani, H., Nishioka, H. and Takai, Y (1997). Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J. Cell Biol 139, 1047-1059.[Abstract/Free Full Text]

Takano, H., Komuro, I., Oka, T., Shiojima, I., Hiroi, Y., Mizuno, T. and Yazaki, Y (1998). The Rho family G proteins play a critical role in muscle differentiation. Mol. Cell. Biol 18, 1580-1589.[Abstract/Free Full Text]

Troughton, W. D. and Trier, J. S (1969). Paneth and goblet cell renewal in mouse duodenal crypts. J. Cell Biol 41, 251-268.[Abstract/Free Full Text]

Weiser, M. M (1973). Intestinal epithelial cell surface membrane glycoprotein synthesis. J. Biol. Chem 248, 2536-2541.[Abstract/Free Full Text]

Wilson, C. L., Heppner, K. J., Labosky, P. A., Hogan, B. L. M. and Matrisian, L. M (1997). Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc. Natl. Acad. Sci. USA 94, 1402-1407.[Abstract/Free Full Text]

Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., Lopez-Boado, Y. S. and Stratman, J. L., Hultgren, S. J., Matrisian, L. M. and Parks, W. C (1999). Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286, 113-117.[Abstract/Free Full Text]

Wong, M. H., Rubinfeld, B. and Gordon, J. I (1998). Effects of forced expression of an NH2-terminal truncated-catenin on mouse intestinal epithelial homeostasis. J. Cell Biol 141, 765-777.[Abstract/Free Full Text]

This article has been cited by other articles:

M. J. Geske, X. Zhang, K. K. Patel, D. M. Ornitz, and T. S. Stappenbeck
Fgf9 signaling regulates small intestinal elongation and mesenchymal development
Development, September 1, 2008; 135(17): 2959 - 2968.
[Abstract] [Full Text] [PDF]

E. Lozano, M. A. M. Frasa, K. Smolarczyk, U. G. Knaus, and V. M. M. Braga
PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac
J. Cell Sci., April 1, 2008; 121(7): 933 - 938.
[Abstract] [Full Text] [PDF]

R. S. Dise, M. R. Frey, R. H. Whitehead, and D. B. Polk
Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration
Am J Physiol Gastrointest Liver Physiol, January 1, 2008; 294(1): G276 - G285.
[Abstract] [Full Text] [PDF]

C. L. Avvisato, X. Yang, S. Shah, B. Hoxter, W. Li, R. Gaynor, R. Pestell, A. Tozeren, and S. W. Byers
Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells
J. Cell Sci., August 1, 2007; 120(15): 2672 - 2682.
[Abstract] [Full Text] [PDF]

V. Barbaro, A. Testa, E. Di Iorio, F. Mavilio, G. Pellegrini, and M. De Luca
C/EBP{delta} regulates cell cycle and self-renewal of human limbal stem cells
J. Cell Biol., July 30, 2007; 177(6): 1037 - 1049.
[Abstract] [Full Text] [PDF]

B. Humar, R. Fukuzawa, V. Blair, A. Dunbier, H. More, A. Charlton, H. K. Yang, W. H. Kim, A. E. Reeve, I. Martin, et al.
Destabilized Adhesion in the Gastric Proliferative Zone and c-Src Kinase Activation Mark the Development of Early Diffuse Gastric Cancer
Cancer Res., March 15, 2007; 67(6): 2480 - 2489.
[Abstract] [Full Text] [PDF]

N. Omidvar, L. Pearn, A. K. Burnett, and R. L. Darley
Ral Is both Necessary and Sufficient for the Inhibition of Myeloid Differentiation Mediated by Ras
Mol. Cell. Biol., May 15, 2006; 26(10): 3966 - 3975.
[Abstract] [Full Text] [PDF]

X. Zhang, T. S. Stappenbeck, A. C. White, K. J. Lavine, J. I. Gordon, and D. M. Ornitz
Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development
Development, January 1, 2006; 133(1): 173 - 180.
[Abstract] [Full Text] [PDF]

Y. Wang, H. Iordanov, E. A. Swietlicki, L. Wang, C. Fritsch, T. Coleman, C. F. Semenkovich, M. S. Levin, and D. C. Rubin
Targeted Intestinal Overexpression of the Immediate Early Gene tis7 in Transgenic Mice Increases Triglyceride Absorption and Adiposity
J. Biol. Chem., October 14, 2005; 280(41): 34764 - 34775.
[Abstract] [Full Text] [PDF]

S. A. Benitah, M. Frye, M. Glogauer, and F. M. Watt
Stem Cell Depletion Through Epidermal Deletion of Rac1
Science, August 5, 2005; 309(5736): 933 - 935.
[Abstract] [Full Text] [PDF]

A. Z. Rizvi and M. H. Wong
Epithelial Stem Cells and Their Niche: There's No Place Like Home
Stem Cells, February 1, 2005; 23(2): 150 - 165.
[Abstract] [Full Text] [PDF]

B. B. Madison, K. Braunstein, E. Kuizon, K. Portman, X. T. Qiao, and D. L. Gumucio
Epithelial hedgehog signals pattern the intestinal crypt-villus axis
Development, January 15, 2005; 132(2): 279 - 289.
[Abstract] [Full Text] [PDF]

A. E. Moran, D. H. Hunt, S. H. Javid, M. Redston, A. M. Carothers, and M. M. Bertagnolli
Apc Deficiency Is Associated with Increased Egfr Activity in the Intestinal Enterocytes and Adenomas of C57BL/6J-Min/+ Mice
J. Biol. Chem., October 8, 2004; 279(41): 43261 - 43272.
[Abstract] [Full Text] [PDF]

J. C. H. Hardwick, M. van Santen, G. R. van den Brink, S. J. H. van Deventer, and M. P. Peppelenbosch
DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1
Carcinogenesis, July 1, 2004; 25(7): 1293 - 1298.
[Abstract] [Full Text] [PDF]

T. S. Stappenbeck, J. C. Mills, and J. I. Gordon
Molecular features of adult mouse small intestinal epithelial progenitors
PNAS, February 4, 2003; 100(3): 1004 - 1009.
[Abstract] [Full Text] [PDF]

M. H. Wong, J. Huelsken, W. Birchmeier, and J. I. Gordon
Selection of Multipotent Stem Cells during Morphogenesis of Small Intestinal Crypts of Lieberkuhn Is Perturbed by Stimulation of Lef-1/beta -Catenin Signaling
J. Biol. Chem., May 3, 2002; 277(18): 15843 - 15850.
[Abstract] [Full Text] [PDF]

J. P. Katz, N. Perreault, B. G. Goldstein, C. S. Lee, P. A. Labosky, V. W. Yang, and K. H. Kaestner
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
Development, January 6, 2002; 129(11): 2619 - 2628.
[Abstract] [Full Text] [PDF]

Q. Yang, N. A. Bermingham, M. J. Finegold, and H. Y. Zoghbi
Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine
Science, December 7, 2001; 294(5549): 2155 - 2158.
[Abstract] [Full Text] [PDF]

T. S. Stappenbeck and J. I. Gordon
Extranuclear sequestration of phospho-Jun N-terminal kinase and distorted villi produced by activated Rac1 in the intestinal epithelium of chimeric mice
Development, July 1, 2001; 128(13): 2603 - 2614.
[Abstract] [Full Text] [PDF]

M Ramalho-Santos, D. Melton, and A. McMahon
Hedgehog signals regulate multiple aspects of gastrointestinal development
Development, January 6, 2000; 127(12): 2763 - 2772.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Stappenbeck, T. S.

Articles by Gordon, J. I.

Search for Related Content

PubMed

PubMed Citation

Articles by Stappenbeck, T. S.

Articles by Gordon, J. I.

				E. Lozano, M. A. M. Frasa, K. Smolarczyk, U. G. Knaus, and V. M. M. Braga PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac J. Cell Sci., April 1, 2008; 121(7): 933 - 938. [Abstract] [Full Text] [PDF]

				R. S. Dise, M. R. Frey, R. H. Whitehead, and D. B. Polk Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration Am J Physiol Gastrointest Liver Physiol, January 1, 2008; 294(1): G276 - G285. [Abstract] [Full Text] [PDF]

				C. L. Avvisato, X. Yang, S. Shah, B. Hoxter, W. Li, R. Gaynor, R. Pestell, A. Tozeren, and S. W. Byers Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells J. Cell Sci., August 1, 2007; 120(15): 2672 - 2682. [Abstract] [Full Text] [PDF]

				V. Barbaro, A. Testa, E. Di Iorio, F. Mavilio, G. Pellegrini, and M. De Luca C/EBP{delta} regulates cell cycle and self-renewal of human limbal stem cells J. Cell Biol., July 30, 2007; 177(6): 1037 - 1049. [Abstract] [Full Text] [PDF]

				B. Humar, R. Fukuzawa, V. Blair, A. Dunbier, H. More, A. Charlton, H. K. Yang, W. H. Kim, A. E. Reeve, I. Martin, et al. Destabilized Adhesion in the Gastric Proliferative Zone and c-Src Kinase Activation Mark the Development of Early Diffuse Gastric Cancer Cancer Res., March 15, 2007; 67(6): 2480 - 2489. [Abstract] [Full Text] [PDF]

				N. Omidvar, L. Pearn, A. K. Burnett, and R. L. Darley Ral Is both Necessary and Sufficient for the Inhibition of Myeloid Differentiation Mediated by Ras Mol. Cell. Biol., May 15, 2006; 26(10): 3966 - 3975. [Abstract] [Full Text] [PDF]

				X. Zhang, T. S. Stappenbeck, A. C. White, K. J. Lavine, J. I. Gordon, and D. M. Ornitz Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development Development, January 1, 2006; 133(1): 173 - 180. [Abstract] [Full Text] [PDF]

				Y. Wang, H. Iordanov, E. A. Swietlicki, L. Wang, C. Fritsch, T. Coleman, C. F. Semenkovich, M. S. Levin, and D. C. Rubin Targeted Intestinal Overexpression of the Immediate Early Gene tis7 in Transgenic Mice Increases Triglyceride Absorption and Adiposity J. Biol. Chem., October 14, 2005; 280(41): 34764 - 34775. [Abstract] [Full Text] [PDF]

				S. A. Benitah, M. Frye, M. Glogauer, and F. M. Watt Stem Cell Depletion Through Epidermal Deletion of Rac1 Science, August 5, 2005; 309(5736): 933 - 935. [Abstract] [Full Text] [PDF]

				A. Z. Rizvi and M. H. Wong Epithelial Stem Cells and Their Niche: There's No Place Like Home Stem Cells, February 1, 2005; 23(2): 150 - 165. [Abstract] [Full Text] [PDF]

				B. B. Madison, K. Braunstein, E. Kuizon, K. Portman, X. T. Qiao, and D. L. Gumucio Epithelial hedgehog signals pattern the intestinal crypt-villus axis Development, January 15, 2005; 132(2): 279 - 289. [Abstract] [Full Text] [PDF]

				A. E. Moran, D. H. Hunt, S. H. Javid, M. Redston, A. M. Carothers, and M. M. Bertagnolli Apc Deficiency Is Associated with Increased Egfr Activity in the Intestinal Enterocytes and Adenomas of C57BL/6J-Min/+ Mice J. Biol. Chem., October 8, 2004; 279(41): 43261 - 43272. [Abstract] [Full Text] [PDF]

				J. C. H. Hardwick, M. van Santen, G. R. van den Brink, S. J. H. van Deventer, and M. P. Peppelenbosch DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1 Carcinogenesis, July 1, 2004; 25(7): 1293 - 1298. [Abstract] [Full Text] [PDF]

				T. S. Stappenbeck, J. C. Mills, and J. I. Gordon Molecular features of adult mouse small intestinal epithelial progenitors PNAS, February 4, 2003; 100(3): 1004 - 1009. [Abstract] [Full Text] [PDF]

				M. H. Wong, J. Huelsken, W. Birchmeier, and J. I. Gordon Selection of Multipotent Stem Cells during Morphogenesis of Small Intestinal Crypts of Lieberkuhn Is Perturbed by Stimulation of Lef-1/beta -Catenin Signaling J. Biol. Chem., May 3, 2002; 277(18): 15843 - 15850. [Abstract] [Full Text] [PDF]

				J. P. Katz, N. Perreault, B. G. Goldstein, C. S. Lee, P. A. Labosky, V. W. Yang, and K. H. Kaestner The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon Development, January 6, 2002; 129(11): 2619 - 2628. [Abstract] [Full Text] [PDF]

				Q. Yang, N. A. Bermingham, M. J. Finegold, and H. Y. Zoghbi Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine Science, December 7, 2001; 294(5549): 2155 - 2158. [Abstract] [Full Text] [PDF]

				T. S. Stappenbeck and J. I. Gordon Extranuclear sequestration of phospho-Jun N-terminal kinase and distorted villi produced by activated Rac1 in the intestinal epithelium of chimeric mice Development, July 1, 2001; 128(13): 2603 - 2614. [Abstract] [Full Text] [PDF]

				M Ramalho-Santos, D. Melton, and A. McMahon Hedgehog signals regulate multiple aspects of gastrointestinal development Development, January 6, 2000; 127(12): 2763 - 2772. [Abstract] [PDF]