Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function

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				A. Fukuda, Y. Kawaguchi, K. Furuyama, S. Kodama, M. Horiguchi, T. Kuhara, M. Kawaguchi, M. Terao, R. Doi, C. V.E. Wright, et al. Reduction of Ptf1a Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in Mice Diabetes, September 1, 2008; 57(9): 2421 - 2431. [Abstract] [Full Text] [PDF]

				M. J. Doyle and L. Sussel Nkx2.2 Regulates {beta}-Cell Function in the Mature Islet Diabetes, August 1, 2007; 56(8): 1999 - 2007. [Abstract] [Full Text] [PDF]

				P. O. Wiebe, J. D. Kormish, V. T. Roper, Y. Fujitani, N. I. Alston, K. S. Zaret, C. V. E. Wright, R. W. Stein, and M. Gannon Ptf1a Binds to and Activates Area III, a Highly Conserved Region of the Pdx1 Promoter That Mediates Early Pancreas-Wide Pdx1 Expression Mol. Cell. Biol., June 1, 2007; 27(11): 4093 - 4104. [Abstract] [Full Text] [PDF]

				Y. Kanetsuna, K. Takahashi, M. Nagata, M. A. Gannon, M. D. Breyer, R. C. Harris, and T. Takahashi Deficiency of Endothelial Nitric-Oxide Synthase Confers Susceptibility to Diabetic Nephropathy in Nephropathy-Resistant Inbred Mice Am. J. Pathol., May 1, 2007; 170(5): 1473 - 1484. [Abstract] [Full Text] [PDF]

				E. Tweedie, I. Artner, L. Crawford, G. Poffenberger, B. Thorens, R. Stein, A. C. Powers, and M. Gannon Maintenance of Hepatic Nuclear Factor 6 in Postnatal Islets Impairs Terminal Differentiation and Function of {beta}-Cells Diabetes, December 1, 2006; 55(12): 3264 - 3270. [Abstract] [Full Text] [PDF]

				Y. Kanetsuna, K. Hirano, M. Nagata, M. A. Gannon, K. Takahashi, R. C. Harris, M. D. Breyer, and T. Takahashi Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1315 - F1322. [Abstract] [Full Text] [PDF]

				V. Plaisance, A. Abderrahmani, V. Perret-Menoud, P. Jacquemin, F. Lemaigre, and R. Regazzi MicroRNA-9 Controls the Expression of Granuphilin/Slp4 and the Secretory Response of Insulin-producing Cells J. Biol. Chem., September 15, 2006; 281(37): 26932 - 26942. [Abstract] [Full Text] [PDF]

				H. Zhang, A. M. Ackermann, G. A. Gusarova, D. Lowe, X. Feng, U. G. Kopsombut, R. H. Costa, and M. Gannon The FoxM1 Transcription Factor Is Required to Maintain Pancreatic {beta}-Cell Mass Mol. Endocrinol., August 1, 2006; 20(8): 1853 - 1866. [Abstract] [Full Text] [PDF]

				Y. Fujitani, S. Fujitani, D. F. Boyer, M. Gannon, Y. Kawaguchi, M. Ray, M. Shiota, R. W. Stein, M. A. Magnuson, and C. V.E. Wright Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation Genes & Dev., January 15, 2006; 20(2): 253 - 266. [Abstract] [Full Text] [PDF]

				M. Brissova, M. J. Fowler, W. E. Nicholson, A. Chu, B. Hirshberg, D. M. Harlan, and A. C. Powers Assessment of Human Pancreatic Islet Architecture and Composition by Laser Scanning Confocal Microscopy J. Histochem. Cytochem., September 1, 2005; 53(9): 1087 - 1097. [Abstract] [Full Text] [PDF]

				E. B. Harmon, A. A. Apelqvist, N. G. Smart, X. Gu, D. H. Osborne, and S. K. Kim GDF11 modulates NGN3+ islet progenitor cell number and promotes {beta}-cell differentiation in pancreas development Development, December 15, 2004; 131(24): 6163 - 6174. [Abstract] [Full Text] [PDF]

				H. Thomas, S. Senkel, S. Erdmann, T. Arndt, G. Turan, L. Klein-Hitpass, and G. U. Ryffel Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4{alpha} and HNF1{beta} in a pancreatic {beta}-cell line Nucleic Acids Res., November 1, 2004; 32(19): e150 - e150. [Abstract] [Full Text] [PDF]

				C. Frigeri, C. C. Martin, C. A. Svitek, J. K. Oeser, J. C. Hutton, M. Gannon, and R. M. O'Brien The Proximal Islet-Specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein Autoantigen Promoter Is Sufficient to Initiate but not Maintain Transgene Expression in Mouse Islets in Vivo Diabetes, July 1, 2004; 53(7): 1754 - 1764. [Abstract] [Full Text] [PDF]

				L. Harndahl, N. Wierup, S. Enerback, H. Mulder, V. C. Manganiello, F. Sundler, E. Degerman, B. Ahren, and L. S. Holst {beta}-Cell-targeted Overexpression of Phosphodiesterase 3B in Mice Causes Impaired Insulin Secretion, Glucose Intolerance, and Deranged Islet Morphology J. Biol. Chem., April 9, 2004; 279(15): 15214 - 15222. [Abstract] [Full Text] [PDF]

				S. E. Samaras, M. A. Cissell, K. Gerrish, C. V. E. Wright, M. Gannon, and R. Stein Conserved Sequences in a Tissue-Specific Regulatory Region of the pdx-1 Gene Mediate Transcription in Pancreatic {beta} Cells: Role for Hepatocyte Nuclear Factor 3{beta} and Pax6 Mol. Cell. Biol., July 1, 2002; 22(13): 4702 - 4713. [Abstract] [Full Text] [PDF]