Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function

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Ahlgren, U., Jonsson, J., Jonsson, L., Simu, K. and Edlund, H (1998). -cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 12, 1763-1768.[Abstract/Free Full Text]

Ahlgren, U., Pfaff, S. L., Jessell, T. M., Edlund, T. and Edlund, H (1997). Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature 385, 257-260.[Medline]

Ang, S. L. and Rossant, J (1994). HNF-3is essential for node and notochord formation in mouse development. Cell 78, 561-574.[Medline]

Bennett, M. V. and Goodenough, D. A (1978). Gap junctions, electrotonic coupling, and intercellular communication. Neurosci. Res. Program. Bull 16, 1-486.[Medline]

Bosco, D., Orci, L. and Meda, P (1989). Homologous but not heterologous contact increases the insulin secretion of individual pancreatic-cells. Exp. Cell Res 184, 72-80.[Medline]

Cirulli, V., Baetens, D., Rutishauser, U., Halban, P. A., Orci, L. and Rouiller, D. G (1994). Expression of neural cell adhesion molecule (N-CAM) in rat islets and its role in islet cell type segregation. J. Cell Sci 107, 1429-1436.[Abstract]

Cirulli, V., Crisa, L., Beattie, G. M., Mally, M. I., Lopez, A. D., Fannon, A., Ptasznik, A., Inverardi, L., Ricordi, C., Deerinck, T. et al., (1998). KSA antigen Ep-CAM mediates cell-cell adhesion of pancreatic epithelial cells: morphoregulatory roles in pancreatic islet development. J. Cell Biol 140, 1519-1534.[Abstract/Free Full Text]

Cockell, M., Stevenson, B. J., Strubin, M., Hagenbuchle, O. and Wellauer, P. K (1989). Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas. Mol. Cell. Biol 9, 2464-2476.[Abstract/Free Full Text]

Dahl, U., Sjodin, A. and Semb, H (1996). Cadherins regulate aggregation of pancreatic-cells in vivo. Development 122, 2895-2902.[Abstract]

Dutta, S., Bonner-Weir, S., Montminy, M. and Wright, C (1998). Regulatory factor linked to late-onset diabetes?. Nature 392, 560-.[Medline]

Edlund, H (1998). Transcribing pancreas. Diabetes 47, 1817-1823.[Abstract]

Esni, F., Taljedal, I. B., Perl, A. K., Cremer, H., Christofori, G. and Semb, H (1999). Neural cell adhesion molecule (N-CAM) is required for cell type segregation and normal ultrastructure in pancreatic islets. J. Cell Biol 144, 325-337.[Abstract/Free Full Text]

Gepts, W. and Lecompte, P. M (1981). The pancreatic islets in diabetes. Am. J. Med 70, 105-115.[Medline]

Gittes, G. K. and Rutter, W. J (1992). Onset of cell-specific gene expression in the developing mouse pancreas. Proc. Natl. Acad. Sci. USA 89, 1128-1132.[Abstract/Free Full Text]

Gu, D. and Sarvetnick, N (1993). Epithelial cell proliferation and islet neogenesis in IFN-transgenic mice. Development 118, 33-46.[Abstract]

Guillam, M. T., Hummler, E., Schaerer, E., Yeh, J. I., Birnbaum, M. J., Beermann, F., Schmidt, A., Deriaz, N., Thorens, B. and Wu, J. Y (1997). Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat. Genet 17, 327-330.[Medline]

Halban, P. A., Wollheim, C. B., Blondel, B., Meda, P., Niesor, E. N. and Mintz, D. H (1982). The possible importance of contact between pancreatic islet cells for the control of insulin release. Endocrinology 111, 86-94.[Abstract]

Henquin, J. C (1987). Regulation of insulin release by ionic and electrical events incells. Horm. Res 27, 168-178.[Medline]

Herrera, P. L., Huarte, J., Sanvito, F., Meda, P., Orci, L. and Vassalli, J. D (1991). Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development 113, 1257-1265.[Abstract]

Inoue, K., Cetkovic-Cvrlje, M., Eizirik, D. L. and Grill, V (1994). Irreversible loss of normal-cell regulation by glucose in neonatally streptozotocin diabetic rats. Diabetologia 37, 351-357.[Medline]

Jansson, L., Eizirik, D. L., Pipeleers, D. G., Borg, L. A., Hellerstrom, C. and Andersson, A (1995). Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice. J. Clin. Invest 96, 721-726.

Jonsson, J., Carlsson, L., Edlund, T. and Edlund, H (1994). Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371, 606-609.[Medline]

Krapp, A., Knofler, M., Frutiger, S., Hughes, G. J., Hagenbuchle, O. and Wellauer, P. K (1996). The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein. EMBO J 15, 4317-4329.[Medline]

Krapp, A., Knofler, M., Ledermann, B., Burki, K., Berney, C., Zoerkler, N., Hagenbuchle, O. and Wellauer, P. K (1998). The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev 12, 3752-3763.[Abstract/Free Full Text]

Landry, C., Clotman, F., Hioki, T., Oda, H., Picard, J. J., Lemaigre, F. P. and Rousseau, G. G (1997). HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors. Dev. Biol 192, 247-257.[Medline]

Larsson, L. I., Madsen, O. D., Serup, P., Jonsson, J. and Edlund, H (1996). Pancreatic-duodenal homeobox 1 \320 role in gastric endocrine patterning. Mech. Dev 60, 175-184.[Medline]

Leahy, J. L., Bonner-Weir, S. and Weir, G. C (1992). -cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion. Diabetes Care 15, 442-455.[Abstract]

Lemaigre, F. P., Durviaux, S. M., Truong, O., Lannoy, V. J., Hsuan, J. J. and Rousseau, G. G (1996). Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain. Proc. Natl. Acad. Sci. USA 93, 9460-9464.[Abstract/Free Full Text]

Madsen, O. D., Jensen, J., Petersen, H. V., Pedersen, E. E., Oster, A., Andersen, F. G., Jorgensen, M. C., Jensen, P. B., Larsson, L. I. and Serup, P (1997). Transcription factors contributing to the pancreatic-cell phenotype. Horm. Metab. Res 29, 265-270.[Medline]

Marynissen, G., Leclercq-Meyer, V., Sener, A. and Malaisse, W. J (1990). Perturbation of pancreatic islet function in glucose-infused rats. Metabolism 39, 87-95.[Medline]

Meissner, H. P (1976). Electrophysiological evidence for coupling betweencells of pancreatic islets. Nature 262, 502-504.[Medline]

Naya, F. J., Huang, H. P., Qiu, Y., Mutoh, H., DeMayo, F. J., Leiter, A. B.and Tsai, M. J (1997). Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 11, 2323-2334.[Abstract/Free Full Text]

Naya, F. J., Stellrecht, C. M. and Tsai, M. J (1995). Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev 9, 1009-1019.[Abstract/Free Full Text]

Offield, M. F., Jetton, T. L., Labosky, P. A., Ray, M., Stein, R. W., Magnuson, M. A., Hogan, B. L. and Wright, C. V (1996). PDX1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122, 983-995.[Abstract]

Orci, L., Thorens, B., Ravazzola, M. and Lodish, H. F (1989). Localization of the pancreaticcell glucose transporter to specific plasma membrane domains. Science 245, 295-297.[Abstract/Free Full Text]

Oster, A., Jensen, J., Serup, P., Galante, P., Madsen, O. D. and Larsson, L. I (1998). Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). J. Histochem. Cytochem 46, 707-715.[Abstract/Free Full Text]

Peshavaria, M., Gamer, L., Henderson, E., Teitelman, G., Wright, C. V. and Stein, R (1994). XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Mol. Endocrinol 8, 806-816.[Abstract]

Pierreux, C. E., Stafford, J., Demonte, D., Scott, D. K., Vandenhaute, J., O'Brien, R. M., Granner, D. K., Rousseau, G. G. and Lemaigre, F. P (1999). Antiglucocorticoid activity of hepatocyte nuclear factor-6. Proc. Natl. Acad. Sci. USA 96, 8961-8966.[Abstract/Free Full Text]

Rausa, F., Samadani, U., Ye, H., Lim, L., Fletcher, C. F., Jenkins, N. A., Copeland, N. G. and Costa, R. H (1997). The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3in the developing murine liver and pancreas. Dev. Biol 192, 228-246.[Medline]

Rouiller, D. G., Cirulli, V. and Halban, P. A (1990). Differences in aggregation properties and levels of the neural cell adhesion molecule (NCAM) between islet cell types. Exp. Cell Res 191, 305-312.[Medline]

Samadani, U. and Costa, R. H (1996). The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Mol. Cell Biol 16, 6273-6284.[Abstract]

Samols, E., Stagner, J. I., Ewart, R. B. and Marks, V (1988). The order of islet microvascular cellular perfusion is B\320A\320D in the perfused rat pancreas. J. Clin. Invest 82, 350-353.

Sander, M., Neubuser, A., Kalamaras, J., Ee, H. C., Martin, G. R. and German, M. S (1997). Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev 11, 1662-1673.[Abstract/Free Full Text]

Song, S. Y., Gannon, M., Washington, M. K., Scoggins, C. R., Meszoely, I. M., Goldenring, J. R., Marino, C. R., Sandgren, E. P., Coffey, R. J. Jr., Wright, C. V. et al., (1999). Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology 117, 1416-1426.[Medline]

Sosa-Pineda, B., Chowdhury, K., Torres, M., Oliver, G. and Gruss, P (1997). The Pax4 gene is essential for differentiation of insulin-producingcells in the mammalian pancreas. Nature 386, 399-402.[Medline]

St-Onge, L., Sosa-Pineda, B., Chowdhury, K., Mansouri, A. and Gruss, P (1997). Pax6 is required for differentiation of glucagon-producing-cells in mouse pancreas. Nature 387, 406-409.[Medline]

Stoffers, D. A., Ferrer, J., Clarke, W. L. and Habener, J. F (1997). Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat. Genet 17, 138-139.[Medline]

Stoffers, D. A., Zinkin, N. T., Stanojevic, V., Clarke, W. L. and Habener, J. F (1997). Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat. Genet 15, 106-110.[Medline]

Stoffers, D. A., Stanojevic, V. and Habener, J. F (1998). Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Invest 102, 232-241.[Medline]

Tal, M., Liang, Y., Najafi, H., Lodish, H. F. and Matschinsky, F. M (1992). Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets. J. Biol. Chem 267, 17241-17247.[Abstract/Free Full Text]

Tattersall, R (1998). Maturity-onset diabetes of the young: a clinical history. Diabet. Med 15, 11-14.[Medline]

Tattersall, R. B (1974). Mild familial diabetes with dominant inheritance. Q. J. Med 43, 339-357.[Abstract/Free Full Text]

Teitelman, G., Alpert, S., Polak, J. M., Martinez, A. and Hanahan, D (1993). Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118, 1031-1039.[Abstract]

Thorens, B., Sarkar, H. K., Kaback, H. R. and Lodish, H. F (1988). Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells. Cell 55, 281-290.[Medline]

Valera, A., Solanes, G., Fernandez-Alvarez, J., Pujol, A., Ferrer, J., Asins, G., Gomis, R. and Bosch, F (1994). Expression of GLUT-2 antisense RNA incells of transgenic mice leads to diabetes. J. Biol. Chem 269, 28543-28546.[Abstract/Free Full Text]

Wang, Z. and Gleichmann, H (1995). Glucose transporter 2 expression:prevention of streptozotocin-induced reduction in-cells with 5-thio-D-glucose. Exp. Clin. Endocrinol. Diabetes 103, 83-97.

Weinstein, D. C., Ruiz i Altaba, A., Chen, W. S., Hoodless, P., Prezioso, V. R., Jessell, T. M. and Darnell, J. E., Jr (1994). The winged-helix transcription factor HNF-3is required for notochord development in the mouse embryo. Cell 78, 575-588.[Medline]

Wu, K. L., Gannon, M., Peshavaria, M., Offield, M. F., Henderson, E., Ray, M., Marks, A., Gamer, L. W., Wright, C. V. and Stein, R (1997). Hepatocyte nuclear factor 3is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol. Cell Biol 17, 6002-6013.[Abstract]

Zangen, D. H., Bonner-Weir, S., Lee, C. H., Latimer, J. B., Miller, C. P., Habener, J. F. and Weir, G. C (1997). Reduced insulin, GLUT2, and IDX-1 in-cells after partial pancreatectomy. Diabetes 46, 258-264.[Abstract]

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				M. J. Doyle and L. Sussel Nkx2.2 Regulates {beta}-Cell Function in the Mature Islet Diabetes, August 1, 2007; 56(8): 1999 - 2007. [Abstract] [Full Text] [PDF]

				P. O. Wiebe, J. D. Kormish, V. T. Roper, Y. Fujitani, N. I. Alston, K. S. Zaret, C. V. E. Wright, R. W. Stein, and M. Gannon Ptf1a Binds to and Activates Area III, a Highly Conserved Region of the Pdx1 Promoter That Mediates Early Pancreas-Wide Pdx1 Expression Mol. Cell. Biol., June 1, 2007; 27(11): 4093 - 4104. [Abstract] [Full Text] [PDF]

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				H. Thomas, S. Senkel, S. Erdmann, T. Arndt, G. Turan, L. Klein-Hitpass, and G. U. Ryffel Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4{alpha} and HNF1{beta} in a pancreatic {beta}-cell line Nucleic Acids Res., November 1, 2004; 32(19): e150 - e150. [Abstract] [Full Text] [PDF]

				C. Frigeri, C. C. Martin, C. A. Svitek, J. K. Oeser, J. C. Hutton, M. Gannon, and R. M. O'Brien The Proximal Islet-Specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein Autoantigen Promoter Is Sufficient to Initiate but not Maintain Transgene Expression in Mouse Islets in Vivo Diabetes, July 1, 2004; 53(7): 1754 - 1764. [Abstract] [Full Text] [PDF]

				L. Harndahl, N. Wierup, S. Enerback, H. Mulder, V. C. Manganiello, F. Sundler, E. Degerman, B. Ahren, and L. S. Holst {beta}-Cell-targeted Overexpression of Phosphodiesterase 3B in Mice Causes Impaired Insulin Secretion, Glucose Intolerance, and Deranged Islet Morphology J. Biol. Chem., April 9, 2004; 279(15): 15214 - 15222. [Abstract] [Full Text] [PDF]

				S. E. Samaras, M. A. Cissell, K. Gerrish, C. V. E. Wright, M. Gannon, and R. Stein Conserved Sequences in a Tissue-Specific Regulatory Region of the pdx-1 Gene Mediate Transcription in Pancreatic {beta} Cells: Role for Hepatocyte Nuclear Factor 3{beta} and Pax6 Mol. Cell. Biol., July 1, 2002; 22(13): 4702 - 4713. [Abstract] [Full Text] [PDF]